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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TYW1
Full Name:
tRNA wybutosine-synthesizing protein 1 homolog
Alias:
Radical S-adenosyl methionine and flavodoxin domain-containing protein 1;tRNA-yW-synthesizing protein
Type:
Mass (Da):
83702
Number AA:
732
UniProt ID:
Q9NV66
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
D
P
S
A
D
T
W
D
L
F
S
P
L
Site 2
S53
G
K
N
L
Q
E
K
S
V
P
K
A
A
Q
D
Site 3
T63
K
A
A
Q
D
L
M
T
N
G
Y
V
S
L
Q
Site 4
Y66
Q
D
L
M
T
N
G
Y
V
S
L
Q
E
K
D
Site 5
S85
G
V
K
I
F
Y
G
S
Q
T
G
T
A
K
G
Site 6
T89
F
Y
G
S
Q
T
G
T
A
K
G
F
A
T
V
Site 7
Y116
A
I
I
N
L
K
E
Y
D
P
D
D
H
L
I
Site 8
Y168
D
F
R
F
G
K
T
Y
L
K
G
M
R
Y
A
Site 9
Y184
F
G
L
G
N
S
A
Y
A
S
H
F
N
K
V
Site 10
S186
L
G
N
S
A
Y
A
S
H
F
N
K
V
G
K
Site 11
S209
L
G
A
H
R
V
M
S
R
G
E
G
D
C
D
Site 12
S220
G
D
C
D
V
V
K
S
K
H
G
S
I
E
A
Site 13
S224
V
V
K
S
K
H
G
S
I
E
A
D
F
R
A
Site 14
S238
A
W
K
T
K
F
I
S
Q
L
Q
A
L
Q
K
Site 15
S251
Q
K
G
E
R
K
K
S
C
G
G
H
C
K
K
Site 16
S263
C
K
K
G
K
C
E
S
H
Q
H
G
S
E
E
Site 17
S268
C
E
S
H
Q
H
G
S
E
E
R
E
E
G
S
Site 18
T286
D
E
L
H
H
R
D
T
E
E
E
E
P
F
E
Site 19
S294
E
E
E
E
P
F
E
S
S
S
E
E
E
F
G
Site 20
S296
E
E
P
F
E
S
S
S
E
E
E
F
G
G
E
Site 21
S307
F
G
G
E
D
H
Q
S
L
N
S
I
V
D
V
Site 22
S338
K
E
Q
Q
E
E
K
S
G
L
F
R
N
M
G
Site 23
T357
G
E
R
R
A
M
I
T
P
A
L
R
E
A
L
Site 24
Y369
E
A
L
T
K
Q
G
Y
Q
L
I
G
S
H
S
Site 25
S374
Q
G
Y
Q
L
I
G
S
H
S
G
V
K
L
C
Site 26
T384
G
V
K
L
C
R
W
T
K
S
M
L
R
G
R
Site 27
S386
K
L
C
R
W
T
K
S
M
L
R
G
R
G
G
Site 28
Y395
L
R
G
R
G
G
C
Y
K
H
T
F
Y
G
I
Site 29
T411
S
H
R
C
M
E
T
T
P
S
L
A
C
A
N
Site 30
T476
E
R
F
E
E
G
M
T
V
K
H
C
A
L
S
Site 31
S532
P
V
T
Q
L
Y
V
S
V
D
A
S
T
K
D
Site 32
S536
L
Y
V
S
V
D
A
S
T
K
D
S
L
K
K
Site 33
S540
V
D
A
S
T
K
D
S
L
K
K
I
D
R
P
Site 34
Y572
V
K
Q
Q
R
T
V
Y
R
L
T
L
V
K
A
Site 35
T575
Q
R
T
V
Y
R
L
T
L
V
K
A
W
N
V
Site 36
T606
F
I
E
V
K
G
V
T
Y
C
G
E
S
S
A
Site 37
Y607
I
E
V
K
G
V
T
Y
C
G
E
S
S
A
S
Site 38
S615
C
G
E
S
S
A
S
S
L
T
M
A
H
V
P
Site 39
T617
E
S
S
A
S
S
L
T
M
A
H
V
P
W
H
Site 40
Y682
F
Q
E
L
I
Q
E
Y
E
D
S
G
G
S
K
Site 41
S685
L
I
Q
E
Y
E
D
S
G
G
S
K
T
F
S
Site 42
S688
E
Y
E
D
S
G
G
S
K
T
F
S
A
K
D
Site 43
T690
E
D
S
G
G
S
K
T
F
S
A
K
D
Y
M
Site 44
S692
S
G
G
S
K
T
F
S
A
K
D
Y
M
A
R
Site 45
Y696
K
T
F
S
A
K
D
Y
M
A
R
T
P
H
W
Site 46
S709
H
W
A
L
F
G
A
S
E
R
G
F
D
P
K
Site 47
T718
R
G
F
D
P
K
D
T
R
H
Q
R
K
N
K
Site 48
S726
R
H
Q
R
K
N
K
S
K
A
I
S
G
C
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation