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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACSS1
Full Name:
Acetyl-coenzyme A synthetase 2-like, mitochondrial
Alias:
ACAS2L; AceCS2L; Acetate-CoA ligase 2; Acetyl-CoA synthetase 2; ACS2L; DJ568C11.3; EC 6.2.1.1; MGC33843
Type:
Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate; EC 6.2.1.1; Ligase
Mass (Da):
74857
Number AA:
689
UniProt ID:
Q9NUB1
International Prot ID:
IPI00216932
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0016208
GO:0005524
GO:0003987
PhosphoSite+
KinaseNET
Biological Process:
GO:0006085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
L
G
S
L
R
G
L
S
G
Q
P
A
R
P
P
Site 2
S32
A
R
P
P
C
G
V
S
A
P
R
R
A
A
S
Site 3
S39
S
A
P
R
R
A
A
S
G
P
S
G
S
A
P
Site 4
S57
A
A
A
A
Q
P
G
S
Y
P
A
L
S
A
Q
Site 5
Y58
A
A
A
Q
P
G
S
Y
P
A
L
S
A
Q
A
Site 6
S62
P
G
S
Y
P
A
L
S
A
Q
A
A
R
E
P
Site 7
T80
W
G
P
L
A
R
D
T
L
V
W
D
T
P
Y
Site 8
S111
L
G
G
Q
L
N
V
S
V
N
C
L
D
Q
H
Site 9
S122
L
D
Q
H
V
R
K
S
P
E
S
V
A
L
I
Site 10
S125
H
V
R
K
S
P
E
S
V
A
L
I
W
E
R
Site 11
T137
W
E
R
D
E
P
G
T
E
V
R
I
T
Y
R
Site 12
T142
P
G
T
E
V
R
I
T
Y
R
E
L
L
E
T
Site 13
Y143
G
T
E
V
R
I
T
Y
R
E
L
L
E
T
T
Site 14
T149
T
Y
R
E
L
L
E
T
T
C
R
L
A
N
T
Site 15
T156
T
T
C
R
L
A
N
T
L
K
R
H
G
V
H
Site 16
S203
F
A
G
F
S
A
E
S
L
A
G
R
I
N
D
Site 17
S282
D
P
V
C
A
P
E
S
M
G
S
E
D
M
L
Site 18
T363
T
S
V
L
F
E
S
T
P
V
Y
P
N
A
G
Site 19
Y366
L
F
E
S
T
P
V
Y
P
N
A
G
R
Y
W
Site 20
T375
N
A
G
R
Y
W
E
T
V
E
R
L
K
I
N
Site 21
Y385
R
L
K
I
N
Q
F
Y
G
A
P
T
A
V
R
Site 22
Y405
G
D
A
W
V
K
K
Y
D
R
S
S
L
R
T
Site 23
S408
W
V
K
K
Y
D
R
S
S
L
R
T
L
G
S
Site 24
S409
V
K
K
Y
D
R
S
S
L
R
T
L
G
S
V
Site 25
T412
Y
D
R
S
S
L
R
T
L
G
S
V
G
E
P
Site 26
S415
S
S
L
R
T
L
G
S
V
G
E
P
I
N
C
Site 27
S435
L
H
R
V
V
G
D
S
R
C
T
L
V
D
T
Site 28
Y511
P
G
M
A
R
T
I
Y
G
D
H
Q
R
F
V
Site 29
Y521
H
Q
R
F
V
D
A
Y
F
K
A
Y
P
G
Y
Site 30
Y525
V
D
A
Y
F
K
A
Y
P
G
Y
Y
F
T
G
Site 31
Y528
Y
F
K
A
Y
P
G
Y
Y
F
T
G
D
G
A
Site 32
Y529
F
K
A
Y
P
G
Y
Y
F
T
G
D
G
A
Y
Site 33
Y536
Y
F
T
G
D
G
A
Y
R
T
E
G
G
Y
Y
Site 34
Y542
A
Y
R
T
E
G
G
Y
Y
Q
I
T
G
R
M
Site 35
Y543
Y
R
T
E
G
G
Y
Y
Q
I
T
G
R
M
D
Site 36
T562
I
S
G
H
R
L
G
T
A
E
I
E
D
A
I
Site 37
S578
D
H
P
A
V
P
E
S
A
V
I
G
Y
P
H
Site 38
Y583
P
E
S
A
V
I
G
Y
P
H
D
I
K
G
E
Site 39
S605
V
K
D
S
A
G
D
S
D
V
V
V
Q
E
L
Site 40
Y623
V
A
T
K
I
A
K
Y
A
V
P
D
E
I
L
Site 41
T638
V
V
K
R
L
P
K
T
R
S
G
K
V
M
R
Site 42
S640
K
R
L
P
K
T
R
S
G
K
V
M
R
R
L
Site 43
S654
L
L
R
K
I
I
T
S
E
A
Q
E
L
G
D
Site 44
T662
E
A
Q
E
L
G
D
T
T
T
L
E
D
P
S
Site 45
T664
Q
E
L
G
D
T
T
T
L
E
D
P
S
I
I
Site 46
Y678
I
A
E
I
L
S
V
Y
Q
K
C
K
D
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation