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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D22B
Full Name:
TBC1 domain family member 22B
Alias:
C6orf197; DJ744I24.2; FLJ20337; TB22B; TBC1 domain family, member 22B
Type:
GTPase activating protein, Rab
Mass (Da):
59081
Number AA:
505
UniProt ID:
Q9NU19
International Prot ID:
IPI00002515
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
S
K
Q
F
W
K
R
S
A
K
L
P
G
S
I
Site 2
S19
R
S
A
K
L
P
G
S
I
Q
P
V
Y
G
A
Site 3
Y24
P
G
S
I
Q
P
V
Y
G
A
Q
H
P
P
L
Site 4
T36
P
P
L
D
P
R
L
T
K
N
F
I
K
E
R
Site 5
T48
K
E
R
S
K
V
N
T
V
P
L
K
N
K
K
Site 6
S58
L
K
N
K
K
A
S
S
F
H
E
F
A
R
N
Site 7
S67
H
E
F
A
R
N
T
S
D
A
W
D
I
G
D
Site 8
S81
D
D
E
E
E
D
F
S
S
P
S
F
Q
T
L
Site 9
S82
D
E
E
E
D
F
S
S
P
S
F
Q
T
L
N
Site 10
S84
E
E
D
F
S
S
P
S
F
Q
T
L
N
S
K
Site 11
S114
L
R
V
K
P
E
R
S
Q
S
T
T
S
D
V
Site 12
S116
V
K
P
E
R
S
Q
S
T
T
S
D
V
P
A
Site 13
T117
K
P
E
R
S
Q
S
T
T
S
D
V
P
A
N
Site 14
T118
P
E
R
S
Q
S
T
T
S
D
V
P
A
N
Y
Site 15
S119
E
R
S
Q
S
T
T
S
D
V
P
A
N
Y
K
Site 16
Y125
T
S
D
V
P
A
N
Y
K
V
I
K
S
S
S
Site 17
S130
A
N
Y
K
V
I
K
S
S
S
D
A
Q
L
S
Site 18
S132
Y
K
V
I
K
S
S
S
D
A
Q
L
S
R
N
Site 19
S137
S
S
S
D
A
Q
L
S
R
N
S
S
D
T
C
Site 20
S140
D
A
Q
L
S
R
N
S
S
D
T
C
L
R
N
Site 21
S141
A
Q
L
S
R
N
S
S
D
T
C
L
R
N
P
Site 22
T143
L
S
R
N
S
S
D
T
C
L
R
N
P
L
H
Site 23
S154
N
P
L
H
K
Q
Q
S
L
P
L
R
P
I
I
Site 24
S168
I
P
L
V
A
R
I
S
D
Q
N
A
S
G
A
Site 25
T179
A
S
G
A
P
P
M
T
V
R
E
K
T
R
L
Site 26
T184
P
M
T
V
R
E
K
T
R
L
E
K
F
R
Q
Site 27
S195
K
F
R
Q
L
L
S
S
Q
N
T
D
L
D
E
Site 28
T198
Q
L
L
S
S
Q
N
T
D
L
D
E
L
R
K
Site 29
S207
L
D
E
L
R
K
C
S
W
P
G
V
P
R
E
Site 30
T219
P
R
E
V
R
P
I
T
W
R
L
L
S
G
Y
Site 31
Y226
T
W
R
L
L
S
G
Y
L
P
A
N
T
E
R
Site 32
T231
S
G
Y
L
P
A
N
T
E
R
R
K
L
T
L
Site 33
T237
N
T
E
R
R
K
L
T
L
Q
R
K
R
E
E
Site 34
Y245
L
Q
R
K
R
E
E
Y
F
G
F
I
E
Q
Y
Site 35
Y252
Y
F
G
F
I
E
Q
Y
Y
D
S
R
N
E
E
Site 36
Y253
F
G
F
I
E
Q
Y
Y
D
S
R
N
E
E
H
Site 37
Y265
E
E
H
H
Q
D
T
Y
R
Q
I
H
I
D
I
Site 38
Y307
I
R
H
P
A
S
G
Y
V
Q
G
I
N
D
L
Site 39
T337
D
V
E
N
F
D
V
T
N
L
S
Q
D
M
L
Site 40
S340
N
F
D
V
T
N
L
S
Q
D
M
L
R
S
I
Site 41
S351
L
R
S
I
E
A
D
S
F
W
C
M
S
K
L
Site 42
Y366
L
D
G
I
Q
D
N
Y
T
F
A
Q
P
G
I
Site 43
T367
D
G
I
Q
D
N
Y
T
F
A
Q
P
G
I
Q
Site 44
S385
K
A
L
E
E
L
V
S
R
I
D
E
Q
V
H
Site 45
Y398
V
H
N
H
F
R
R
Y
E
V
E
Y
L
Q
F
Site 46
Y402
F
R
R
Y
E
V
E
Y
L
Q
F
A
F
R
W
Site 47
T423
R
E
L
P
L
R
C
T
I
R
L
W
D
T
Y
Site 48
T429
C
T
I
R
L
W
D
T
Y
Q
S
E
P
E
G
Site 49
Y430
T
I
R
L
W
D
T
Y
Q
S
E
P
E
G
F
Site 50
S432
R
L
W
D
T
Y
Q
S
E
P
E
G
F
S
H
Site 51
Y494
A
E
A
Y
R
L
K
Y
M
F
A
D
A
P
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation