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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAN2C1
Full Name:
Alpha-mannosidase 2C1
Alias:
Alpha mannosidase 6A8B;Alpha-D-mannoside mannohydrolase;Mannosidase alpha class 2C member 1
Type:
Mass (Da):
115835
Number AA:
1040
UniProt ID:
Q9NTJ4
International Prot ID:
IPI00783434
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004559
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006013
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
A
L
K
H
W
R
T
T
L
E
R
V
E
K
F
Site 2
S22
E
R
V
E
K
F
V
S
P
L
Y
F
T
D
C
Site 3
Y25
E
K
F
V
S
P
L
Y
F
T
D
C
N
L
R
Site 4
T50
A
V
L
S
S
F
L
T
P
E
R
L
P
Y
Q
Site 5
Y56
L
T
P
E
R
L
P
Y
Q
E
A
V
Q
R
D
Site 6
S72
R
P
A
Q
V
G
D
S
F
G
P
T
W
W
T
Site 7
T126
L
T
K
E
G
E
K
T
S
Y
V
L
T
D
R
Site 8
Y128
K
E
G
E
K
T
S
Y
V
L
T
D
R
L
G
Site 9
T131
E
K
T
S
Y
V
L
T
D
R
L
G
E
R
D
Site 10
S141
L
G
E
R
D
P
R
S
L
T
L
Y
V
E
V
Site 11
T143
E
R
D
P
R
S
L
T
L
Y
V
E
V
A
C
Site 12
Y145
D
P
R
S
L
T
L
Y
V
E
V
A
C
N
G
Site 13
S209
L
G
K
D
N
Q
R
S
F
Q
A
L
Y
T
A
Site 14
Y214
Q
R
S
F
Q
A
L
Y
T
A
N
Q
M
V
N
Site 15
T230
C
D
P
A
Q
P
E
T
F
P
V
A
Q
A
L
Site 16
S239
P
V
A
Q
A
L
A
S
R
F
F
G
Q
H
G
Site 17
T252
H
G
G
E
S
Q
H
T
I
H
A
T
G
H
C
Site 18
S279
T
V
R
K
C
A
R
S
W
V
T
A
L
Q
L
Site 19
S308
Q
Q
L
E
W
V
K
S
R
Y
P
G
L
Y
S
Site 20
Y310
L
E
W
V
K
S
R
Y
P
G
L
Y
S
R
I
Site 21
Y314
K
S
R
Y
P
G
L
Y
S
R
I
Q
E
F
A
Site 22
S342
E
M
D
G
N
L
P
S
G
E
A
M
V
R
Q
Site 23
T373
S
E
F
W
L
P
D
T
F
G
Y
S
A
Q
L
Site 24
T394
C
G
I
R
R
F
L
T
Q
K
L
S
W
N
L
Site 25
S398
R
F
L
T
Q
K
L
S
W
N
L
V
N
S
F
Site 26
S429
V
H
F
P
P
G
D
S
Y
G
M
Q
G
S
V
Site 27
Y430
H
F
P
P
G
D
S
Y
G
M
Q
G
S
V
E
Site 28
S435
D
S
Y
G
M
Q
G
S
V
E
E
V
L
K
T
Site 29
T442
S
V
E
E
V
L
K
T
V
A
N
N
R
D
K
Site 30
S455
D
K
G
R
A
N
H
S
A
F
L
F
G
F
G
Site 31
T471
G
G
G
G
P
T
Q
T
M
L
D
R
L
K
R
Site 32
S480
L
D
R
L
K
R
L
S
N
T
D
G
L
P
R
Site 33
T482
R
L
K
R
L
S
N
T
D
G
L
P
R
V
Q
Site 34
S491
G
L
P
R
V
Q
L
S
S
P
R
Q
L
F
S
Site 35
S492
L
P
R
V
Q
L
S
S
P
R
Q
L
F
S
A
Site 36
S498
S
S
P
R
Q
L
F
S
A
L
E
S
D
S
E
Site 37
S502
Q
L
F
S
A
L
E
S
D
S
E
Q
L
C
T
Site 38
S504
F
S
A
L
E
S
D
S
E
Q
L
C
T
W
V
Site 39
Y559
A
R
S
A
Q
F
L
Y
P
A
A
Q
L
Q
H
Site 40
Y596
A
E
E
A
M
C
H
Y
E
D
I
R
S
H
G
Site 41
T605
D
I
R
S
H
G
N
T
L
L
S
A
A
A
A
Site 42
S667
A
P
V
P
P
P
T
S
L
Q
P
L
L
P
Q
Site 43
S686
V
V
Q
E
T
D
G
S
V
T
L
D
N
G
I
Site 44
T701
I
R
V
K
L
D
P
T
G
R
L
T
S
L
V
Site 45
S712
T
S
L
V
L
V
A
S
G
R
E
A
I
A
E
Site 46
Y744
D
A
W
D
V
M
D
Y
H
L
E
T
R
K
P
Site 47
T748
V
M
D
Y
H
L
E
T
R
K
P
V
L
G
Q
Site 48
S778
A
W
F
L
L
Q
I
S
P
N
S
R
L
S
Q
Site 49
S784
I
S
P
N
S
R
L
S
Q
E
V
V
L
D
V
Site 50
S821
E
F
P
A
R
V
R
S
S
Q
A
T
Y
E
I
Site 51
S822
F
P
A
R
V
R
S
S
Q
A
T
Y
E
I
Q
Site 52
T825
R
V
R
S
S
Q
A
T
Y
E
I
Q
F
G
H
Site 53
Y826
V
R
S
S
Q
A
T
Y
E
I
Q
F
G
H
L
Site 54
S859
A
H
R
W
M
D
L
S
E
H
G
F
G
L
A
Site 55
Y873
A
L
L
N
D
C
K
Y
G
A
S
V
R
G
S
Site 56
S876
N
D
C
K
Y
G
A
S
V
R
G
S
I
L
S
Site 57
T896
A
P
K
A
P
D
A
T
A
D
T
G
R
H
E
Site 58
T899
A
P
D
A
T
A
D
T
G
R
H
E
F
T
Y
Site 59
T905
D
T
G
R
H
E
F
T
Y
A
L
M
P
H
K
Site 60
Y906
T
G
R
H
E
F
T
Y
A
L
M
P
H
K
G
Site 61
S944
P
S
P
A
P
A
T
S
W
S
A
F
S
V
S
Site 62
S946
P
A
P
A
T
S
W
S
A
F
S
V
S
S
P
Site 63
T959
S
P
A
V
V
L
E
T
V
K
Q
A
E
S
S
Site 64
S966
T
V
K
Q
A
E
S
S
P
Q
R
R
S
L
V
Site 65
S971
E
S
S
P
Q
R
R
S
L
V
L
R
L
Y
E
Site 66
Y977
R
S
L
V
L
R
L
Y
E
A
H
G
S
H
V
Site 67
T1013
P
D
P
A
G
H
L
T
L
R
D
N
R
L
K
Site 68
T1022
R
D
N
R
L
K
L
T
F
S
P
F
Q
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation