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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CISH
Full Name:
Cytokine-inducible SH2-containing protein
Alias:
CIS-1;Protein G18;Suppressor of cytokine signaling
Type:
Mass (Da):
28663
Number AA:
258
UniProt ID:
Q9NSE2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
L
L
A
V
E
R
T
G
Q
R
P
L
W
A
Site 2
S26
Q
R
P
L
W
A
P
S
L
E
L
P
K
P
V
Site 3
T50
L
E
E
V
A
E
G
T
P
A
Q
T
E
S
E
Site 4
S56
G
T
P
A
Q
T
E
S
E
P
K
V
L
D
P
Site 5
Y76
C
I
A
K
T
F
S
Y
L
R
E
S
G
W
Y
Site 6
Y83
Y
L
R
E
S
G
W
Y
W
G
S
I
T
A
S
Site 7
S86
E
S
G
W
Y
W
G
S
I
T
A
S
E
A
R
Site 8
S90
Y
W
G
S
I
T
A
S
E
A
R
Q
H
L
Q
Site 9
T103
L
Q
K
M
P
E
G
T
F
L
V
R
D
S
T
Site 10
S109
G
T
F
L
V
R
D
S
T
H
P
S
Y
L
F
Site 11
T110
T
F
L
V
R
D
S
T
H
P
S
Y
L
F
T
Site 12
S113
V
R
D
S
T
H
P
S
Y
L
F
T
L
S
V
Site 13
Y114
R
D
S
T
H
P
S
Y
L
F
T
L
S
V
K
Site 14
T117
T
H
P
S
Y
L
F
T
L
S
V
K
T
T
R
Site 15
S119
P
S
Y
L
F
T
L
S
V
K
T
T
R
G
P
Site 16
T122
L
F
T
L
S
V
K
T
T
R
G
P
T
N
V
Site 17
T123
F
T
L
S
V
K
T
T
R
G
P
T
N
V
R
Site 18
T127
V
K
T
T
R
G
P
T
N
V
R
I
E
Y
A
Site 19
Y133
P
T
N
V
R
I
E
Y
A
D
S
S
F
R
L
Site 20
S136
V
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
Site 21
S137
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
C
Site 22
S142
D
S
S
F
R
L
D
S
N
C
L
S
R
P
R
Site 23
S146
R
L
D
S
N
C
L
S
R
P
R
I
L
A
F
Site 24
S166
L
V
Q
H
Y
V
A
S
C
T
A
D
T
R
S
Site 25
T171
V
A
S
C
T
A
D
T
R
S
D
S
P
D
P
Site 26
S173
S
C
T
A
D
T
R
S
D
S
P
D
P
A
P
Site 27
S175
T
A
D
T
R
S
D
S
P
D
P
A
P
T
P
Site 28
T181
D
S
P
D
P
A
P
T
P
A
L
P
M
P
K
Site 29
S193
M
P
K
E
D
A
P
S
D
P
A
L
P
A
P
Site 30
S218
V
Q
P
F
V
R
R
S
S
A
R
S
L
Q
H
Site 31
S219
Q
P
F
V
R
R
S
S
A
R
S
L
Q
H
L
Site 32
S222
V
R
R
S
S
A
R
S
L
Q
H
L
C
R
L
Site 33
Y250
L
P
R
R
M
A
D
Y
L
R
Q
Y
P
F
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation