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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HELLS
Full Name:
Lymphoid-specific helicase
Alias:
EC 3.6.1.-; LSH; Nbla10143; PASG; Proliferation-associated SNF2-like; SMARCA6; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
Type:
Apoptosis; EC 3.6.1.-; Helicase
Mass (Da):
97074
Number AA:
838
UniProt ID:
Q9NRZ9
International Prot ID:
IPI00844388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000775
GO:0000785
GO:0000792
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0001775
GO:0002376
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
R
P
A
G
S
G
G
S
E
A
P
A
M
V
E
Site 2
S55
M
L
E
K
A
R
M
S
W
D
R
E
S
T
E
Site 3
S60
R
M
S
W
D
R
E
S
T
E
I
R
Y
R
R
Site 4
T61
M
S
W
D
R
E
S
T
E
I
R
Y
R
R
L
Site 5
Y65
R
E
S
T
E
I
R
Y
R
R
L
Q
H
L
L
Site 6
S75
L
Q
H
L
L
E
K
S
N
I
Y
S
K
F
L
Site 7
S79
L
E
K
S
N
I
Y
S
K
F
L
L
T
K
M
Site 8
S106
K
L
E
R
K
K
E
S
L
K
V
K
K
G
K
Site 9
S115
K
V
K
K
G
K
N
S
I
D
A
S
E
E
K
Site 10
S119
G
K
N
S
I
D
A
S
E
E
K
P
V
M
R
Site 11
S135
K
R
G
R
E
D
E
S
Y
N
I
S
E
V
M
Site 12
Y136
R
G
R
E
D
E
S
Y
N
I
S
E
V
M
S
Site 13
S139
E
D
E
S
Y
N
I
S
E
V
M
S
K
E
E
Site 14
S143
Y
N
I
S
E
V
M
S
K
E
E
I
L
S
V
Site 15
S149
M
S
K
E
E
I
L
S
V
A
K
K
N
K
K
Site 16
S163
K
E
N
E
D
E
N
S
S
S
T
N
L
C
V
Site 17
S165
N
E
D
E
N
S
S
S
T
N
L
C
V
E
D
Site 18
S179
D
L
Q
K
N
K
D
S
N
S
I
I
K
D
R
Site 19
S181
Q
K
N
K
D
S
N
S
I
I
K
D
R
L
S
Site 20
S188
S
I
I
K
D
R
L
S
E
T
V
R
Q
N
T
Site 21
T190
I
K
D
R
L
S
E
T
V
R
Q
N
T
K
F
Site 22
T195
S
E
T
V
R
Q
N
T
K
F
F
F
D
P
V
Site 23
T294
M
A
E
F
K
R
F
T
P
D
I
P
T
M
L
Site 24
T299
R
F
T
P
D
I
P
T
M
L
Y
H
G
T
Q
Site 25
Y302
P
D
I
P
T
M
L
Y
H
G
T
Q
E
E
R
Site 26
Y317
Q
K
L
V
R
N
I
Y
K
R
K
G
T
L
Q
Site 27
T322
N
I
Y
K
R
K
G
T
L
Q
I
H
P
V
V
Site 28
T382
A
D
N
K
L
L
L
T
G
T
P
L
Q
N
N
Site 29
T384
N
K
L
L
L
T
G
T
P
L
Q
N
N
L
S
Site 30
S391
T
P
L
Q
N
N
L
S
E
L
W
S
L
L
N
Site 31
S413
D
D
L
K
S
F
E
S
W
F
D
I
T
S
L
Site 32
S419
E
S
W
F
D
I
T
S
L
S
E
T
A
E
D
Site 33
T423
D
I
T
S
L
S
E
T
A
E
D
I
I
A
K
Site 34
Y469
P
K
R
E
V
V
V
Y
A
P
L
S
K
K
Q
Site 35
S473
V
V
V
Y
A
P
L
S
K
K
Q
E
I
F
Y
Site 36
Y480
S
K
K
Q
E
I
F
Y
T
A
I
V
N
R
T
Site 37
T481
K
K
Q
E
I
F
Y
T
A
I
V
N
R
T
I
Site 38
T487
Y
T
A
I
V
N
R
T
I
A
N
M
F
G
S
Site 39
T499
F
G
S
S
E
K
E
T
I
E
L
S
P
T
G
Site 40
S503
E
K
E
T
I
E
L
S
P
T
G
R
P
K
R
Site 41
T505
E
T
I
E
L
S
P
T
G
R
P
K
R
R
T
Site 42
T512
T
G
R
P
K
R
R
T
R
K
S
I
N
Y
S
Site 43
S515
P
K
R
R
T
R
K
S
I
N
Y
S
K
I
D
Site 44
Y518
R
T
R
K
S
I
N
Y
S
K
I
D
D
F
P
Site 45
S519
T
R
K
S
I
N
Y
S
K
I
D
D
F
P
N
Site 46
S533
N
E
L
E
K
L
I
S
Q
I
Q
P
E
V
D
Site 47
Y575
R
K
C
C
N
H
P
Y
L
I
E
Y
P
I
D
Site 48
Y579
N
H
P
Y
L
I
E
Y
P
I
D
P
V
T
Q
Site 49
T585
E
Y
P
I
D
P
V
T
Q
E
F
K
I
D
E
Site 50
T596
K
I
D
E
E
L
V
T
N
S
G
K
F
L
I
Site 51
S598
D
E
E
L
V
T
N
S
G
K
F
L
I
L
D
Site 52
S643
H
L
R
D
F
N
F
S
R
L
D
G
S
M
S
Site 53
S648
N
F
S
R
L
D
G
S
M
S
Y
S
E
R
E
Site 54
S650
S
R
L
D
G
S
M
S
Y
S
E
R
E
K
N
Site 55
Y651
R
L
D
G
S
M
S
Y
S
E
R
E
K
N
M
Site 56
S652
L
D
G
S
M
S
Y
S
E
R
E
K
N
M
H
Site 57
S660
E
R
E
K
N
M
H
S
F
N
T
D
P
E
V
Site 58
Y692
A
A
D
T
V
I
I
Y
D
S
D
W
N
P
Q
Site 59
S700
D
S
D
W
N
P
Q
S
D
L
Q
A
Q
D
R
Site 60
T714
R
C
H
R
I
G
Q
T
K
P
V
V
V
Y
R
Site 61
S762
G
Q
S
G
L
N
L
S
K
N
F
L
D
P
K
Site 62
S777
E
L
M
E
L
L
K
S
R
D
Y
E
R
E
I
Site 63
Y780
E
L
L
K
S
R
D
Y
E
R
E
I
K
G
S
Site 64
S787
Y
E
R
E
I
K
G
S
R
E
K
V
I
S
D
Site 65
S793
G
S
R
E
K
V
I
S
D
K
D
L
E
L
L
Site 66
S804
L
E
L
L
L
D
R
S
D
L
I
D
Q
M
N
Site 67
S813
L
I
D
Q
M
N
A
S
G
P
I
K
E
K
M
Site 68
S829
I
F
K
I
L
E
N
S
E
D
S
S
P
E
C
Site 69
S832
I
L
E
N
S
E
D
S
S
P
E
C
L
F
_
Site 70
S833
L
E
N
S
E
D
S
S
P
E
C
L
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation