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Updated November 2019
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Protein Info
Short Name:
Enamelin
Full Name:
Enamelin
Alias:
ENAM
Type:
Extracellular matrix protein
Mass (Da):
128745
Number AA:
1142
UniProt ID:
Q9NRM1
International Prot ID:
IPI00016685
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0030345
PhosphoSite+
KinaseNET
Biological Process:
GO:0030282
GO:0042476
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
V
L
R
C
R
L
G
T
S
F
P
K
L
D
N
Site 2
S11
L
R
C
R
L
G
T
S
F
P
K
L
D
N
L
Site 3
S37
F
L
G
L
L
G
N
S
V
A
M
P
M
H
M
Site 4
S51
M
P
R
M
P
G
F
S
S
K
S
E
E
M
M
Site 5
S52
P
R
M
P
G
F
S
S
K
S
E
E
M
M
R
Site 6
S54
M
P
G
F
S
S
K
S
E
E
M
M
R
Y
N
Site 7
Y60
K
S
E
E
M
M
R
Y
N
Q
F
N
F
M
N
Site 8
T101
W
P
Q
P
P
P
N
T
W
H
P
R
K
S
S
Site 9
S107
N
T
W
H
P
R
K
S
S
A
P
K
R
H
N
Site 10
S108
T
W
H
P
R
K
S
S
A
P
K
R
H
N
K
Site 11
T119
R
H
N
K
T
D
Q
T
Q
E
T
Q
K
P
N
Site 12
T122
K
T
D
Q
T
Q
E
T
Q
K
P
N
Q
T
Q
Site 13
T128
E
T
Q
K
P
N
Q
T
Q
S
K
K
P
P
Q
Site 14
S143
K
R
P
L
K
Q
P
S
H
N
Q
P
Q
P
E
Site 15
Y169
F
G
N
G
L
F
P
Y
Q
Q
P
P
W
Q
I
Site 16
Y185
Q
R
L
P
P
P
G
Y
G
R
P
P
I
S
N
Site 17
S191
G
Y
G
R
P
P
I
S
N
E
E
G
G
N
P
Site 18
Y199
N
E
E
G
G
N
P
Y
F
G
Y
F
G
Y
H
Site 19
Y202
G
G
N
P
Y
F
G
Y
F
G
Y
H
G
F
G
Site 20
Y205
P
Y
F
G
Y
F
G
Y
H
G
F
G
G
R
P
Site 21
Y214
G
F
G
G
R
P
P
Y
Y
S
E
E
M
F
E
Site 22
Y215
F
G
G
R
P
P
Y
Y
S
E
E
M
F
E
Q
Site 23
S216
G
G
R
P
P
Y
Y
S
E
E
M
F
E
Q
D
Site 24
S237
E
D
P
P
K
A
E
S
P
G
T
E
P
T
A
Site 25
T240
P
K
A
E
S
P
G
T
E
P
T
A
N
S
T
Site 26
S246
G
T
E
P
T
A
N
S
T
V
T
E
T
N
S
Site 27
T249
P
T
A
N
S
T
V
T
E
T
N
S
T
Q
P
Site 28
S253
S
T
V
T
E
T
N
S
T
Q
P
N
P
K
G
Site 29
T254
T
V
T
E
T
N
S
T
Q
P
N
P
K
G
S
Site 30
S261
T
Q
P
N
P
K
G
S
Q
G
G
N
D
T
S
Site 31
S268
S
Q
G
G
N
D
T
S
P
T
G
N
S
T
P
Site 32
T270
G
G
N
D
T
S
P
T
G
N
S
T
P
G
L
Site 33
S273
D
T
S
P
T
G
N
S
T
P
G
L
N
T
G
Site 34
T274
T
S
P
T
G
N
S
T
P
G
L
N
T
G
N
Site 35
S298
P
L
P
A
V
N
A
S
G
Q
G
G
P
G
S
Site 36
S305
S
G
Q
G
G
P
G
S
Q
I
P
W
R
P
S
Site 37
S312
S
Q
I
P
W
R
P
S
Q
P
N
I
R
E
N
Site 38
Y322
N
I
R
E
N
H
P
Y
P
N
I
R
N
F
P
Site 39
Y335
F
P
S
G
R
Q
W
Y
F
T
G
T
V
M
G
Site 40
Y350
H
R
Q
N
R
P
F
Y
R
N
Q
Q
V
Q
R
Site 41
Y379
A
R
P
G
N
P
V
Y
H
K
A
Y
P
P
T
Site 42
Y383
N
P
V
Y
H
K
A
Y
P
P
T
S
R
G
N
Site 43
T386
Y
H
K
A
Y
P
P
T
S
R
G
N
Y
P
N
Site 44
S387
H
K
A
Y
P
P
T
S
R
G
N
Y
P
N
Y
Site 45
Y391
P
P
T
S
R
G
N
Y
P
N
Y
A
G
N
P
Site 46
Y394
S
R
G
N
Y
P
N
Y
A
G
N
P
A
N
L
Site 47
T416
N
K
H
P
V
G
T
T
V
A
P
L
G
P
K
Site 48
T451
K
E
Q
I
I
V
P
T
K
N
P
T
S
P
W
Site 49
S456
V
P
T
K
N
P
T
S
P
W
R
N
S
Q
Q
Site 50
S461
P
T
S
P
W
R
N
S
Q
Q
Y
E
V
N
K
Site 51
Y464
P
W
R
N
S
Q
Q
Y
E
V
N
K
S
N
Y
Site 52
S469
Q
Q
Y
E
V
N
K
S
N
Y
K
L
P
H
S
Site 53
Y471
Y
E
V
N
K
S
N
Y
K
L
P
H
S
E
G
Site 54
S476
S
N
Y
K
L
P
H
S
E
G
Y
M
P
V
P
Site 55
Y495
V
D
Q
H
E
N
S
Y
Y
P
R
G
D
S
R
Site 56
Y496
D
Q
H
E
N
S
Y
Y
P
R
G
D
S
R
K
Site 57
S501
S
Y
Y
P
R
G
D
S
R
K
V
P
N
S
D
Site 58
S507
D
S
R
K
V
P
N
S
D
G
Q
T
Q
S
Q
Site 59
T511
V
P
N
S
D
G
Q
T
Q
S
Q
N
L
P
K
Site 60
S513
N
S
D
G
Q
T
Q
S
Q
N
L
P
K
G
I
Site 61
S524
P
K
G
I
V
L
G
S
R
R
M
P
Y
E
S
Site 62
Y529
L
G
S
R
R
M
P
Y
E
S
E
T
N
Q
S
Site 63
S531
S
R
R
M
P
Y
E
S
E
T
N
Q
S
E
L
Site 64
S536
Y
E
S
E
T
N
Q
S
E
L
K
H
S
S
Y
Site 65
Y543
S
E
L
K
H
S
S
Y
Q
P
A
V
Y
P
E
Site 66
Y548
S
S
Y
Q
P
A
V
Y
P
E
E
I
P
S
P
Site 67
S554
V
Y
P
E
E
I
P
S
P
A
K
E
H
F
P
Site 68
S573
T
W
D
H
Q
E
I
S
P
P
F
K
E
D
P
Site 69
S591
E
E
H
L
P
H
P
S
H
G
S
R
G
S
V
Site 70
S597
P
S
H
G
S
R
G
S
V
F
Y
P
E
Y
N
Site 71
Y600
G
S
R
G
S
V
F
Y
P
E
Y
N
P
Y
D
Site 72
Y603
G
S
V
F
Y
P
E
Y
N
P
Y
D
P
R
E
Site 73
Y606
F
Y
P
E
Y
N
P
Y
D
P
R
E
N
S
P
Site 74
S612
P
Y
D
P
R
E
N
S
P
Y
L
R
G
N
T
Site 75
Y614
D
P
R
E
N
S
P
Y
L
R
G
N
T
W
D
Site 76
T619
S
P
Y
L
R
G
N
T
W
D
E
R
D
D
S
Site 77
S626
T
W
D
E
R
D
D
S
P
N
T
M
G
Q
K
Site 78
T629
E
R
D
D
S
P
N
T
M
G
Q
K
E
S
P
Site 79
S635
N
T
M
G
Q
K
E
S
P
L
Y
P
I
N
T
Site 80
Y638
G
Q
K
E
S
P
L
Y
P
I
N
T
P
D
Q
Site 81
T642
S
P
L
Y
P
I
N
T
P
D
Q
K
E
I
V
Site 82
Y651
D
Q
K
E
I
V
P
Y
N
E
E
D
P
V
D
Site 83
T660
E
E
D
P
V
D
P
T
G
D
E
V
F
P
G
Site 84
S676
N
R
W
G
E
E
L
S
F
K
G
G
P
T
V
Site 85
T682
L
S
F
K
G
G
P
T
V
R
H
Y
E
G
E
Site 86
Y686
G
G
P
T
V
R
H
Y
E
G
E
Q
Y
T
S
Site 87
Y691
R
H
Y
E
G
E
Q
Y
T
S
N
Q
P
K
E
Site 88
S693
Y
E
G
E
Q
Y
T
S
N
Q
P
K
E
Y
L
Site 89
Y699
T
S
N
Q
P
K
E
Y
L
P
Y
S
L
D
N
Site 90
Y702
Q
P
K
E
Y
L
P
Y
S
L
D
N
P
S
K
Site 91
S703
P
K
E
Y
L
P
Y
S
L
D
N
P
S
K
P
Site 92
S708
P
Y
S
L
D
N
P
S
K
P
R
E
D
F
Y
Site 93
Y715
S
K
P
R
E
D
F
Y
Y
S
E
F
Y
P
W
Site 94
Y716
K
P
R
E
D
F
Y
Y
S
E
F
Y
P
W
S
Site 95
Y720
D
F
Y
Y
S
E
F
Y
P
W
S
P
D
E
N
Site 96
S723
Y
S
E
F
Y
P
W
S
P
D
E
N
F
P
S
Site 97
S730
S
P
D
E
N
F
P
S
Y
N
T
A
S
T
M
Site 98
Y731
P
D
E
N
F
P
S
Y
N
T
A
S
T
M
P
Site 99
S735
F
P
S
Y
N
T
A
S
T
M
P
P
P
I
E
Site 100
T736
P
S
Y
N
T
A
S
T
M
P
P
P
I
E
S
Site 101
Y746
P
P
I
E
S
R
G
Y
Y
V
N
N
A
A
G
Site 102
Y747
P
I
E
S
R
G
Y
Y
V
N
N
A
A
G
P
Site 103
T758
A
A
G
P
E
E
S
T
L
F
P
S
R
N
S
Site 104
S762
E
E
S
T
L
F
P
S
R
N
S
W
D
H
R
Site 105
S765
T
L
F
P
S
R
N
S
W
D
H
R
I
Q
A
Site 106
Y781
G
Q
R
E
R
R
P
Y
F
N
R
N
I
W
D
Site 107
Y809
D
Q
K
G
N
Q
P
Y
Y
S
N
T
P
A
G
Site 108
Y810
Q
K
G
N
Q
P
Y
Y
S
N
T
P
A
G
L
Site 109
S811
K
G
N
Q
P
Y
Y
S
N
T
P
A
G
L
Q
Site 110
T813
N
Q
P
Y
Y
S
N
T
P
A
G
L
Q
K
N
Site 111
Y831
H
E
G
E
N
L
N
Y
G
M
Q
I
T
R
M
Site 112
T836
L
N
Y
G
M
Q
I
T
R
M
N
S
P
E
R
Site 113
S840
M
Q
I
T
R
M
N
S
P
E
R
E
H
S
S
Site 114
S846
N
S
P
E
R
E
H
S
S
F
P
N
F
I
P
Site 115
S847
S
P
E
R
E
H
S
S
F
P
N
F
I
P
P
Site 116
S855
F
P
N
F
I
P
P
S
Y
P
S
G
Q
K
E
Site 117
Y856
P
N
F
I
P
P
S
Y
P
S
G
Q
K
E
A
Site 118
S858
F
I
P
P
S
Y
P
S
G
Q
K
E
A
H
L
Site 119
S869
E
A
H
L
F
H
L
S
Q
R
G
S
C
C
A
Site 120
S873
F
H
L
S
Q
R
G
S
C
C
A
G
S
S
T
Site 121
S878
R
G
S
C
C
A
G
S
S
T
G
P
K
D
N
Site 122
S879
G
S
C
C
A
G
S
S
T
G
P
K
D
N
P
Site 123
Y892
N
P
L
A
L
Q
D
Y
T
P
S
Y
G
L
A
Site 124
T893
P
L
A
L
Q
D
Y
T
P
S
Y
G
L
A
P
Site 125
S895
A
L
Q
D
Y
T
P
S
Y
G
L
A
P
G
E
Site 126
Y896
L
Q
D
Y
T
P
S
Y
G
L
A
P
G
E
N
Site 127
T906
A
P
G
E
N
Q
D
T
S
P
L
Y
T
D
G
Site 128
S907
P
G
E
N
Q
D
T
S
P
L
Y
T
D
G
S
Site 129
Y910
N
Q
D
T
S
P
L
Y
T
D
G
S
H
T
K
Site 130
T911
Q
D
T
S
P
L
Y
T
D
G
S
H
T
K
Q
Site 131
S914
S
P
L
Y
T
D
G
S
H
T
K
Q
T
R
D
Site 132
S924
K
Q
T
R
D
I
I
S
P
T
S
I
L
P
G
Site 133
S927
R
D
I
I
S
P
T
S
I
L
P
G
Q
R
N
Site 134
S935
I
L
P
G
Q
R
N
S
S
E
K
R
E
S
Q
Site 135
S936
L
P
G
Q
R
N
S
S
E
K
R
E
S
Q
N
Site 136
S941
N
S
S
E
K
R
E
S
Q
N
P
F
R
D
D
Site 137
S950
N
P
F
R
D
D
V
S
T
L
R
R
N
T
P
Site 138
T951
P
F
R
D
D
V
S
T
L
R
R
N
T
P
C
Site 139
T956
V
S
T
L
R
R
N
T
P
C
S
I
K
N
Q
Site 140
S959
L
R
R
N
T
P
C
S
I
K
N
Q
L
G
Q
Site 141
S976
I
M
P
F
P
E
A
S
S
L
Q
S
K
N
T
Site 142
S977
M
P
F
P
E
A
S
S
L
Q
S
K
N
T
P
Site 143
S980
P
E
A
S
S
L
Q
S
K
N
T
P
C
L
K
Site 144
T983
S
S
L
Q
S
K
N
T
P
C
L
K
N
D
L
Site 145
T1011
D
N
Q
L
N
E
R
T
V
D
L
T
P
E
Q
Site 146
T1015
N
E
R
T
V
D
L
T
P
E
Q
L
V
I
G
Site 147
T1023
P
E
Q
L
V
I
G
T
P
D
E
G
S
N
P
Site 148
S1028
I
G
T
P
D
E
G
S
N
P
E
G
I
Q
S
Site 149
S1035
S
N
P
E
G
I
Q
S
Q
V
Q
E
N
E
S
Site 150
S1042
S
Q
V
Q
E
N
E
S
E
R
Q
Q
Q
R
P
Site 151
S1050
E
R
Q
Q
Q
R
P
S
N
I
L
H
L
P
C
Site 152
S1060
L
H
L
P
C
F
G
S
K
L
A
K
H
H
S
Site 153
S1067
S
K
L
A
K
H
H
S
S
T
T
G
T
P
S
Site 154
S1068
K
L
A
K
H
H
S
S
T
T
G
T
P
S
S
Site 155
T1070
A
K
H
H
S
S
T
T
G
T
P
S
S
D
G
Site 156
T1072
H
H
S
S
T
T
G
T
P
S
S
D
G
R
Q
Site 157
S1074
S
S
T
T
G
T
P
S
S
D
G
R
Q
S
P
Site 158
S1075
S
T
T
G
T
P
S
S
D
G
R
Q
S
P
F
Site 159
S1080
P
S
S
D
G
R
Q
S
P
F
D
G
D
S
I
Site 160
S1086
Q
S
P
F
D
G
D
S
I
T
P
T
E
N
P
Site 161
T1088
P
F
D
G
D
S
I
T
P
T
E
N
P
N
T
Site 162
T1090
D
G
D
S
I
T
P
T
E
N
P
N
T
L
V
Site 163
T1095
T
P
T
E
N
P
N
T
L
V
E
L
A
T
E
Site 164
S1107
A
T
E
E
Q
F
K
S
I
N
V
D
P
L
D
Site 165
S1119
P
L
D
A
D
E
H
S
P
F
E
F
L
Q
R
Site 166
T1128
F
E
F
L
Q
R
G
T
N
V
Q
D
Q
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation