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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DUOX2
Full Name:
Dual oxidase 2
Alias:
Large NOX 2;Long NOX 2;NADH/NADPH thyroid oxidase p138-tox;NADPH oxidase/peroxidase DUOX2;NADPH thyroid oxidase 2;Thyroid oxidase 2;p138 thyroid oxidase
Type:
Mass (Da):
175364
Number AA:
1548
UniProt ID:
Q9NRD8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
T
G
S
L
G
P
S
G
S
Q
D
A
L
S
Site 2
S25
G
S
L
G
P
S
G
S
Q
D
A
L
S
L
P
Site 3
S30
S
G
S
Q
D
A
L
S
L
P
W
E
V
Q
R
Site 4
Y38
L
P
W
E
V
Q
R
Y
D
G
W
F
N
N
L
Site 5
Y65
Q
R
R
V
P
A
N
Y
A
D
G
V
Y
Q
A
Site 6
Y70
A
N
Y
A
D
G
V
Y
Q
A
L
E
E
P
Q
Site 7
S85
L
P
N
P
R
R
L
S
N
A
A
T
R
G
I
Site 8
T89
R
R
L
S
N
A
A
T
R
G
I
A
G
L
P
Site 9
S155
V
V
L
P
F
Q
R
S
R
W
D
P
E
T
G
Site 10
T161
R
S
R
W
D
P
E
T
G
R
S
P
S
N
P
Site 11
S164
W
D
P
E
T
G
R
S
P
S
N
P
R
D
L
Site 12
S166
P
E
T
G
R
S
P
S
N
P
R
D
L
A
N
Site 13
S182
V
T
G
W
L
D
G
S
A
I
Y
G
S
S
H
Site 14
Y185
W
L
D
G
S
A
I
Y
G
S
S
H
S
W
S
Site 15
S187
D
G
S
A
I
Y
G
S
S
H
S
W
S
D
A
Site 16
S188
G
S
A
I
Y
G
S
S
H
S
W
S
D
A
L
Site 17
S190
A
I
Y
G
S
S
H
S
W
S
D
A
L
R
S
Site 18
S192
Y
G
S
S
H
S
W
S
D
A
L
R
S
F
S
Site 19
S197
S
W
S
D
A
L
R
S
F
S
G
G
Q
L
A
Site 20
S199
S
D
A
L
R
S
F
S
G
G
Q
L
A
S
G
Site 21
S205
F
S
G
G
Q
L
A
S
G
P
D
P
A
F
P
Site 22
S215
D
P
A
F
P
R
D
S
Q
N
P
L
L
M
W
Site 23
T229
W
A
A
P
D
P
A
T
G
Q
N
G
P
R
G
Site 24
Y238
Q
N
G
P
R
G
L
Y
A
F
G
A
E
R
G
Site 25
Y261
L
G
L
L
W
F
R
Y
H
N
L
W
A
Q
R
Site 26
Y293
R
K
R
V
I
A
T
Y
Q
N
I
A
V
Y
E
Site 27
T309
L
P
S
F
L
Q
K
T
L
P
E
Y
T
G
Y
Site 28
Y313
L
Q
K
T
L
P
E
Y
T
G
Y
R
P
F
L
Site 29
Y316
T
L
P
E
Y
T
G
Y
R
P
F
L
D
P
S
Site 30
Y345
T
M
V
P
P
G
V
Y
M
R
N
A
S
C
H
Site 31
S364
L
N
K
G
F
Q
S
S
Q
A
L
R
V
C
N
Site 32
Y373
A
L
R
V
C
N
N
Y
W
I
R
E
N
P
N
Site 33
Y413
V
V
E
D
L
R
D
Y
W
P
G
P
G
K
F
Site 34
T423
G
P
G
K
F
S
R
T
D
Y
V
A
S
S
I
Site 35
Y425
G
K
F
S
R
T
D
Y
V
A
S
S
I
Q
R
Site 36
S440
G
R
D
M
G
L
P
S
Y
S
Q
A
L
L
A
Site 37
S457
L
D
I
P
R
N
W
S
D
L
N
P
N
V
D
Site 38
Y475
L
E
A
T
A
A
L
Y
N
Q
D
L
S
Q
L
Site 39
Y517
R
L
R
D
G
D
R
Y
W
F
E
N
T
R
N
Site 40
S528
N
T
R
N
G
L
F
S
K
K
E
I
E
D
I
Site 41
T538
E
I
E
D
I
R
N
T
T
L
R
D
V
L
V
Site 42
T575
C
P
Q
P
K
Q
L
T
T
D
G
L
P
Q
C
Site 43
Y621
L
L
S
G
V
V
A
Y
F
R
G
R
E
H
K
Site 44
S660
P
G
P
K
E
R
S
S
P
I
I
I
Q
L
L
Site 45
S698
Q
Q
V
N
L
I
L
S
N
N
R
G
C
R
T
Site 46
S721
Y
D
L
V
L
L
F
S
S
E
E
E
R
G
A
Site 47
T789
I
N
Q
A
D
A
G
T
L
P
L
D
S
S
Q
Site 48
S795
G
T
L
P
L
D
S
S
Q
K
V
R
E
A
L
Site 49
S807
E
A
L
T
C
E
L
S
R
A
E
F
A
E
S
Site 50
S814
S
R
A
E
F
A
E
S
L
G
L
K
P
Q
D
Site 51
S829
M
F
V
E
S
M
F
S
L
A
D
K
D
G
N
Site 52
Y838
A
D
K
D
G
N
G
Y
L
S
F
R
E
F
L
Site 53
S840
K
D
G
N
G
Y
L
S
F
R
E
F
L
D
I
Site 54
S855
L
V
V
F
M
K
G
S
P
E
D
K
S
R
L
Site 55
S860
K
G
S
P
E
D
K
S
R
L
M
F
T
M
Y
Site 56
Y867
S
R
L
M
F
T
M
Y
D
L
D
E
N
G
F
Site 57
S876
L
D
E
N
G
F
L
S
K
D
E
F
F
T
M
Site 58
T882
L
S
K
D
E
F
F
T
M
M
R
S
F
I
E
Site 59
S906
Q
L
A
E
V
V
E
S
M
F
R
E
S
G
F
Site 60
S911
V
E
S
M
F
R
E
S
G
F
Q
D
K
E
E
Site 61
S933
F
M
L
R
D
H
D
S
E
L
R
F
T
Q
L
Site 62
T938
H
D
S
E
L
R
F
T
Q
L
C
V
K
G
G
Site 63
S965
Q
N
I
S
C
R
V
S
F
I
T
R
T
P
G
Site 64
T968
S
C
R
V
S
F
I
T
R
T
P
G
E
R
S
Site 65
T970
R
V
S
F
I
T
R
T
P
G
E
R
S
H
P
Site 66
S975
T
R
T
P
G
E
R
S
H
P
Q
G
L
G
P
Site 67
T1007
G
K
K
A
A
V
P
T
P
R
L
Y
T
E
A
Site 68
Y1011
A
V
P
T
P
R
L
Y
T
E
A
L
Q
E
K
Site 69
T1012
V
P
T
P
R
L
Y
T
E
A
L
Q
E
K
M
Site 70
Y1031
L
A
Q
K
L
Q
Q
Y
K
R
F
V
E
N
Y
Site 71
Y1038
Y
K
R
F
V
E
N
Y
R
R
H
I
V
C
V
Site 72
Y1063
F
A
D
R
A
Y
Y
Y
G
F
A
L
P
P
S
Site 73
Y1117
R
E
T
F
L
N
R
Y
V
P
F
D
A
A
V
Site 74
S1173
N
V
F
V
N
D
G
S
K
L
P
Q
K
F
Y
Site 75
S1214
S
H
H
F
R
R
R
S
F
R
G
F
W
L
T
Site 76
S1264
Y
G
G
D
K
L
V
S
L
S
R
K
K
V
E
Site 77
S1266
G
D
K
L
V
S
L
S
R
K
K
V
E
I
S
Site 78
S1273
S
R
K
K
V
E
I
S
V
V
K
A
E
L
L
Site 79
Y1286
L
L
P
S
G
V
T
Y
L
Q
F
Q
R
P
Q
Site 80
Y1297
Q
R
P
Q
G
F
E
Y
K
S
G
Q
W
V
R
Site 81
T1319
T
T
E
Y
H
P
F
T
L
T
S
A
P
H
E
Site 82
T1321
E
Y
H
P
F
T
L
T
S
A
P
H
E
D
T
Site 83
T1328
T
S
A
P
H
E
D
T
L
S
L
H
I
R
A
Site 84
S1330
A
P
H
E
D
T
L
S
L
H
I
R
A
V
G
Site 85
T1340
I
R
A
V
G
P
W
T
T
R
L
R
E
I
Y
Site 86
Y1347
T
T
R
L
R
E
I
Y
S
S
P
K
G
N
G
Site 87
S1348
T
R
L
R
E
I
Y
S
S
P
K
G
N
G
C
Site 88
S1349
R
L
R
E
I
Y
S
S
P
K
G
N
G
C
A
Site 89
Y1358
K
G
N
G
C
A
G
Y
P
K
L
Y
L
D
G
Site 90
Y1362
C
A
G
Y
P
K
L
Y
L
D
G
P
F
G
E
Site 91
S1394
I
G
V
T
P
F
A
S
I
L
K
D
L
V
F
Site 92
T1463
E
K
F
D
L
R
T
T
M
L
Y
I
C
E
R
Site 93
Y1466
D
L
R
T
T
M
L
Y
I
C
E
R
H
F
Q
Site 94
S1486
S
L
F
T
G
L
R
S
I
T
H
F
G
R
P
Site 95
T1488
F
T
G
L
R
S
I
T
H
F
G
R
P
P
F
Site 96
S1501
P
F
E
P
F
F
N
S
L
Q
E
V
H
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation