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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MXRA5
Full Name:
Matrix-remodeling-associated protein 5
Alias:
Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan
Type:
Mass (Da):
312280
Number AA:
2828
UniProt ID:
Q9NR99
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
C
T
F
R
S
L
A
S
V
P
A
G
I
A
K
Site 2
S66
R
I
N
L
G
F
N
S
I
Q
A
L
S
E
T
Site 3
S103
D
G
A
L
R
D
L
S
S
L
Q
V
F
K
F
Site 4
T119
Y
N
K
L
R
V
I
T
G
Q
T
L
Q
G
L
Site 5
S172
Q
L
H
P
S
T
F
S
T
F
T
F
L
D
Y
Site 6
Y213
M
P
L
L
E
N
L
Y
L
Q
G
N
P
W
T
Site 7
Y247
K
C
K
K
D
K
A
Y
E
G
G
Q
L
C
A
Site 8
T274
I
H
K
L
K
D
M
T
C
L
K
P
S
I
E
Site 9
S279
D
M
T
C
L
K
P
S
I
E
S
P
L
R
Q
Site 10
S282
C
L
K
P
S
I
E
S
P
L
R
Q
N
R
S
Site 11
S289
S
P
L
R
Q
N
R
S
R
S
I
E
E
E
Q
Site 12
S291
L
R
Q
N
R
S
R
S
I
E
E
E
Q
E
Q
Site 13
S304
E
Q
E
E
D
G
G
S
Q
L
I
L
E
K
F
Site 14
S319
Q
L
P
Q
W
S
I
S
L
N
M
T
D
E
H
Site 15
Y343
I
K
K
P
M
D
V
Y
K
I
H
L
N
Q
T
Site 16
T370
L
D
F
E
C
P
M
T
R
E
N
Y
E
K
L
Site 17
Y374
C
P
M
T
R
E
N
Y
E
K
L
W
K
L
I
Site 18
Y383
K
L
W
K
L
I
A
Y
Y
S
E
V
P
V
K
Site 19
S398
L
H
R
E
L
M
L
S
K
D
P
R
V
S
Y
Site 20
S404
L
S
K
D
P
R
V
S
Y
Q
Y
R
Q
D
A
Site 21
Y405
S
K
D
P
R
V
S
Y
Q
Y
R
Q
D
A
D
Site 22
Y417
D
A
D
E
E
A
L
Y
Y
T
G
V
R
A
Q
Site 23
Y418
A
D
E
E
A
L
Y
Y
T
G
V
R
A
Q
I
Site 24
S446
I
Q
L
N
R
R
Q
S
T
A
K
K
V
L
L
Site 25
T447
Q
L
N
R
R
Q
S
T
A
K
K
V
L
L
S
Site 26
S454
T
A
K
K
V
L
L
S
Y
Y
T
Q
Y
S
Q
Site 27
Y455
A
K
K
V
L
L
S
Y
Y
T
Q
Y
S
Q
T
Site 28
Y456
K
K
V
L
L
S
Y
Y
T
Q
Y
S
Q
T
I
Site 29
T457
K
V
L
L
S
Y
Y
T
Q
Y
S
Q
T
I
S
Site 30
S460
L
S
Y
Y
T
Q
Y
S
Q
T
I
S
T
K
D
Site 31
S464
T
Q
Y
S
Q
T
I
S
T
K
D
T
R
Q
A
Site 32
T468
Q
T
I
S
T
K
D
T
R
Q
A
R
G
R
S
Site 33
S475
T
R
Q
A
R
G
R
S
W
V
M
I
E
P
S
Site 34
T490
G
A
V
Q
R
D
Q
T
V
L
E
G
G
P
C
Site 35
S500
E
G
G
P
C
Q
L
S
C
N
V
K
A
S
E
Site 36
S506
L
S
C
N
V
K
A
S
E
S
P
S
I
F
W
Site 37
S530
A
P
M
D
D
P
D
S
K
F
S
I
L
S
S
Site 38
S533
D
D
P
D
S
K
F
S
I
L
S
S
G
W
L
Site 39
S537
S
K
F
S
I
L
S
S
G
W
L
R
I
K
S
Site 40
S544
S
G
W
L
R
I
K
S
M
E
P
S
D
S
G
Site 41
S548
R
I
K
S
M
E
P
S
D
S
G
L
Y
Q
C
Site 42
S550
K
S
M
E
P
S
D
S
G
L
Y
Q
C
I
A
Site 43
Y553
E
P
S
D
S
G
L
Y
Q
C
I
A
Q
V
R
Site 44
Y568
D
E
M
D
R
M
V
Y
R
V
L
V
Q
S
P
Site 45
S574
V
Y
R
V
L
V
Q
S
P
S
T
Q
P
A
E
Site 46
S576
R
V
L
V
Q
S
P
S
T
Q
P
A
E
K
D
Site 47
T584
T
Q
P
A
E
K
D
T
V
T
I
G
K
N
P
Site 48
T586
P
A
E
K
D
T
V
T
I
G
K
N
P
G
E
Site 49
S610
A
I
P
E
A
H
L
S
W
I
L
P
N
R
R
Site 50
S644
S
I
P
K
V
Q
V
S
D
S
G
Y
Y
R
C
Site 51
S646
P
K
V
Q
V
S
D
S
G
Y
Y
R
C
V
A
Site 52
Y648
V
Q
V
S
D
S
G
Y
Y
R
C
V
A
V
N
Site 53
T663
Q
Q
G
A
D
H
F
T
V
G
I
T
V
T
K
Site 54
T667
D
H
F
T
V
G
I
T
V
T
K
K
G
S
G
Site 55
S673
I
T
V
T
K
K
G
S
G
L
P
S
K
R
G
Site 56
S677
K
K
G
S
G
L
P
S
K
R
G
R
R
P
G
Site 57
S689
R
P
G
A
K
A
L
S
R
V
R
E
D
I
V
Site 58
T710
G
M
G
D
E
E
N
T
S
R
R
L
L
H
P
Site 59
S711
M
G
D
E
E
N
T
S
R
R
L
L
H
P
K
Site 60
S767
E
G
R
R
V
F
E
S
R
R
R
I
N
M
A
Site 61
T799
G
K
N
L
P
K
G
T
E
V
P
P
L
I
K
Site 62
T807
E
V
P
P
L
I
K
T
T
S
P
P
S
L
S
Site 63
S809
P
P
L
I
K
T
T
S
P
P
S
L
S
L
E
Site 64
S812
I
K
T
T
S
P
P
S
L
S
L
E
V
T
P
Site 65
S814
T
T
S
P
P
S
L
S
L
E
V
T
P
P
F
Site 66
S825
T
P
P
F
P
A
V
S
P
P
S
A
S
P
V
Site 67
S830
A
V
S
P
P
S
A
S
P
V
Q
T
V
T
S
Site 68
T834
P
S
A
S
P
V
Q
T
V
T
S
A
E
E
S
Site 69
S837
S
P
V
Q
T
V
T
S
A
E
E
S
S
A
D
Site 70
T882
V
E
P
E
V
T
S
T
P
L
E
E
V
V
D
Site 71
S892
E
E
V
V
D
D
L
S
E
K
T
E
E
I
T
Site 72
S900
E
K
T
E
E
I
T
S
T
E
G
D
L
K
G
Site 73
T901
K
T
E
E
I
T
S
T
E
G
D
L
K
G
T
Site 74
T908
T
E
G
D
L
K
G
T
A
A
P
T
L
I
S
Site 75
T912
L
K
G
T
A
A
P
T
L
I
S
E
P
Y
E
Site 76
S915
T
A
A
P
T
L
I
S
E
P
Y
E
P
S
P
Site 77
Y918
P
T
L
I
S
E
P
Y
E
P
S
P
T
L
H
Site 78
S921
I
S
E
P
Y
E
P
S
P
T
L
H
T
L
D
Site 79
T923
E
P
Y
E
P
S
P
T
L
H
T
L
D
T
V
Site 80
T926
E
P
S
P
T
L
H
T
L
D
T
V
Y
E
K
Site 81
T929
P
T
L
H
T
L
D
T
V
Y
E
K
P
T
H
Site 82
Y931
L
H
T
L
D
T
V
Y
E
K
P
T
H
E
E
Site 83
T941
P
T
H
E
E
T
A
T
E
G
W
S
A
A
D
Site 84
S951
W
S
A
A
D
V
G
S
S
P
E
P
T
S
S
Site 85
S952
S
A
A
D
V
G
S
S
P
E
P
T
S
S
E
Site 86
T956
V
G
S
S
P
E
P
T
S
S
E
Y
E
P
P
Site 87
S957
G
S
S
P
E
P
T
S
S
E
Y
E
P
P
L
Site 88
S958
S
S
P
E
P
T
S
S
E
Y
E
P
P
L
D
Site 89
Y960
P
E
P
T
S
S
E
Y
E
P
P
L
D
A
V
Site 90
S968
E
P
P
L
D
A
V
S
L
A
E
S
E
P
M
Site 91
S972
D
A
V
S
L
A
E
S
E
P
M
Q
Y
F
D
Site 92
Y977
A
E
S
E
P
M
Q
Y
F
D
P
D
L
E
T
Site 93
S986
D
P
D
L
E
T
K
S
Q
P
D
E
D
K
M
Site 94
T997
E
D
K
M
K
E
D
T
F
A
H
L
T
P
T
Site 95
T1002
E
D
T
F
A
H
L
T
P
T
P
T
I
W
V
Site 96
T1004
T
F
A
H
L
T
P
T
P
T
I
W
V
N
D
Site 97
T1006
A
H
L
T
P
T
P
T
I
W
V
N
D
S
S
Site 98
S1012
P
T
I
W
V
N
D
S
S
T
S
Q
L
F
E
Site 99
S1013
T
I
W
V
N
D
S
S
T
S
Q
L
F
E
D
Site 100
S1021
T
S
Q
L
F
E
D
S
T
I
G
E
P
G
V
Site 101
T1022
S
Q
L
F
E
D
S
T
I
G
E
P
G
V
P
Site 102
S1046
D
N
I
H
L
V
K
S
S
L
S
T
Q
D
T
Site 103
S1047
N
I
H
L
V
K
S
S
L
S
T
Q
D
T
L
Site 104
S1049
H
L
V
K
S
S
L
S
T
Q
D
T
L
L
I
Site 105
T1053
S
S
L
S
T
Q
D
T
L
L
I
K
K
G
M
Site 106
S1064
K
K
G
M
K
E
M
S
Q
T
L
Q
G
G
N
Site 107
T1066
G
M
K
E
M
S
Q
T
L
Q
G
G
N
M
L
Site 108
T1078
N
M
L
E
G
D
P
T
H
S
R
S
S
E
S
Site 109
S1080
L
E
G
D
P
T
H
S
R
S
S
E
S
E
G
Site 110
S1082
G
D
P
T
H
S
R
S
S
E
S
E
G
Q
E
Site 111
S1083
D
P
T
H
S
R
S
S
E
S
E
G
Q
E
S
Site 112
S1090
S
E
S
E
G
Q
E
S
K
S
I
T
L
P
D
Site 113
S1092
S
E
G
Q
E
S
K
S
I
T
L
P
D
S
T
Site 114
T1094
G
Q
E
S
K
S
I
T
L
P
D
S
T
L
G
Site 115
S1105
S
T
L
G
I
M
S
S
M
S
P
V
K
K
P
Site 116
S1107
L
G
I
M
S
S
M
S
P
V
K
K
P
A
E
Site 117
T1125
G
T
L
L
D
K
D
T
T
T
V
T
T
T
P
Site 118
T1126
T
L
L
D
K
D
T
T
T
V
T
T
T
P
R
Site 119
T1127
L
L
D
K
D
T
T
T
V
T
T
T
P
R
Q
Site 120
T1129
D
K
D
T
T
T
V
T
T
T
P
R
Q
K
V
Site 121
T1131
D
T
T
T
V
T
T
T
P
R
Q
K
V
A
P
Site 122
S1139
P
R
Q
K
V
A
P
S
S
T
M
S
T
H
P
Site 123
S1140
R
Q
K
V
A
P
S
S
T
M
S
T
H
P
S
Site 124
T1141
Q
K
V
A
P
S
S
T
M
S
T
H
P
S
R
Site 125
S1143
V
A
P
S
S
T
M
S
T
H
P
S
R
R
R
Site 126
T1144
A
P
S
S
T
M
S
T
H
P
S
R
R
R
P
Site 127
S1147
S
T
M
S
T
H
P
S
R
R
R
P
N
G
R
Site 128
T1169
F
R
H
R
H
K
Q
T
P
P
T
T
F
A
P
Site 129
T1172
R
H
K
Q
T
P
P
T
T
F
A
P
S
E
T
Site 130
T1173
H
K
Q
T
P
P
T
T
F
A
P
S
E
T
F
Site 131
S1177
P
P
T
T
F
A
P
S
E
T
F
S
T
Q
P
Site 132
T1179
T
T
F
A
P
S
E
T
F
S
T
Q
P
T
Q
Site 133
S1181
F
A
P
S
E
T
F
S
T
Q
P
T
Q
A
P
Site 134
T1182
A
P
S
E
T
F
S
T
Q
P
T
Q
A
P
D
Site 135
T1185
E
T
F
S
T
Q
P
T
Q
A
P
D
I
K
I
Site 136
S1193
Q
A
P
D
I
K
I
S
S
Q
V
E
S
S
L
Site 137
S1198
K
I
S
S
Q
V
E
S
S
L
V
P
T
A
W
Site 138
T1209
P
T
A
W
V
D
N
T
V
N
T
P
K
Q
L
Site 139
T1212
W
V
D
N
T
V
N
T
P
K
Q
L
E
M
E
Site 140
T1229
A
E
P
T
S
K
G
T
P
R
R
K
H
G
K
Site 141
Y1243
K
R
P
N
K
H
R
Y
T
P
S
T
V
S
S
Site 142
T1244
R
P
N
K
H
R
Y
T
P
S
T
V
S
S
R
Site 143
S1246
N
K
H
R
Y
T
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T
D
K
D
A
G
D
Y
L
C
V
A
R
N
K
Site 296
Y2231
R
N
K
V
G
D
D
Y
V
V
L
K
V
D
V
Site 297
S2276
G
L
P
N
P
E
I
S
W
S
L
P
D
G
S
Site 298
S2278
P
N
P
E
I
S
W
S
L
P
D
G
S
L
V
Site 299
S2283
S
W
S
L
P
D
G
S
L
V
N
S
F
M
Q
Site 300
S2287
P
D
G
S
L
V
N
S
F
M
Q
S
D
D
S
Site 301
S2291
L
V
N
S
F
M
Q
S
D
D
S
G
G
R
T
Site 302
S2294
S
F
M
Q
S
D
D
S
G
G
R
T
K
R
Y
Site 303
T2298
S
D
D
S
G
G
R
T
K
R
Y
V
V
F
N
Site 304
Y2301
S
G
G
R
T
K
R
Y
V
V
F
N
N
G
T
Site 305
Y2310
V
F
N
N
G
T
L
Y
F
N
E
V
G
M
R
Site 306
Y2322
G
M
R
E
E
G
D
Y
T
C
F
A
E
N
Q
Site 307
T2347
K
V
V
T
A
P
A
T
I
R
N
K
T
Y
L
Site 308
T2352
P
A
T
I
R
N
K
T
Y
L
A
V
Q
V
P
Site 309
Y2353
A
T
I
R
N
K
T
Y
L
A
V
Q
V
P
Y
Site 310
S2382
M
P
K
V
T
W
L
S
P
T
N
K
V
I
P
Site 311
S2391
T
N
K
V
I
P
T
S
S
E
K
Y
Q
I
Y
Site 312
Y2395
I
P
T
S
S
E
K
Y
Q
I
Y
Q
D
G
T
Site 313
Y2398
S
S
E
K
Y
Q
I
Y
Q
D
G
T
L
L
I
Site 314
S2411
L
I
Q
K
A
Q
R
S
D
S
G
N
Y
T
C
Site 315
S2413
Q
K
A
Q
R
S
D
S
G
N
Y
T
C
L
V
Site 316
Y2416
Q
R
S
D
S
G
N
Y
T
C
L
V
R
N
S
Site 317
T2417
R
S
D
S
G
N
Y
T
C
L
V
R
N
S
A
Site 318
S2423
Y
T
C
L
V
R
N
S
A
G
E
D
R
K
T
Site 319
T2430
S
A
G
E
D
R
K
T
V
W
I
H
V
N
V
Site 320
T2450
N
G
N
P
N
P
I
T
T
V
R
E
I
A
A
Site 321
T2496
P
Y
Y
G
N
R
I
T
V
H
G
N
G
S
L
Site 322
S2502
I
T
V
H
G
N
G
S
L
D
I
R
S
L
R
Site 323
S2507
N
G
S
L
D
I
R
S
L
R
K
S
D
S
V
Site 324
S2511
D
I
R
S
L
R
K
S
D
S
V
Q
L
V
C
Site 325
S2513
R
S
L
R
K
S
D
S
V
Q
L
V
C
M
A
Site 326
T2553
D
P
I
S
E
K
I
T
A
M
A
G
H
T
I
Site 327
S2565
H
T
I
S
L
N
C
S
A
A
G
T
P
T
P
Site 328
Y2594
G
Q
Q
L
Q
R
F
Y
H
K
A
D
G
M
L
Site 329
T2625
A
R
N
A
A
G
H
T
E
R
L
V
S
L
K
Site 330
S2630
G
H
T
E
R
L
V
S
L
K
V
G
L
K
P
Site 331
T2660
E
T
L
K
L
P
C
T
P
P
G
A
G
Q
G
Site 332
S2670
G
A
G
Q
G
R
F
S
W
T
L
P
N
G
M
Site 333
T2672
G
Q
G
R
F
S
W
T
L
P
N
G
M
H
L
Site 334
S2689
P
Q
T
L
G
R
V
S
L
L
D
N
G
T
L
Site 335
S2702
T
L
T
V
R
E
A
S
V
F
D
R
G
T
Y
Site 336
T2708
A
S
V
F
D
R
G
T
Y
V
C
R
M
E
T
Site 337
Y2709
S
V
F
D
R
G
T
Y
V
C
R
M
E
T
E
Site 338
T2715
T
Y
V
C
R
M
E
T
E
Y
G
P
S
V
T
Site 339
Y2717
V
C
R
M
E
T
E
Y
G
P
S
V
T
S
I
Site 340
S2720
M
E
T
E
Y
G
P
S
V
T
S
I
P
V
I
Site 341
S2737
A
Y
P
P
R
I
T
S
E
P
T
P
V
I
Y
Site 342
T2740
P
R
I
T
S
E
P
T
P
V
I
Y
T
R
P
Site 343
Y2744
S
E
P
T
P
V
I
Y
T
R
P
G
N
T
V
Site 344
T2766
G
I
P
K
A
D
I
T
W
E
L
P
D
K
S
Site 345
S2773
T
W
E
L
P
D
K
S
H
L
K
A
G
V
Q
Site 346
Y2784
A
G
V
Q
A
R
L
Y
G
N
R
F
L
H
P
Site 347
S2794
R
F
L
H
P
Q
G
S
L
T
I
Q
H
A
T
Site 348
T2796
L
H
P
Q
G
S
L
T
I
Q
H
A
T
Q
R
Site 349
T2801
S
L
T
I
Q
H
A
T
Q
R
D
A
G
F
Y
Site 350
Y2808
T
Q
R
D
A
G
F
Y
K
C
M
A
K
N
I
Site 351
S2818
M
A
K
N
I
L
G
S
D
S
K
T
T
Y
I
Site 352
S2820
K
N
I
L
G
S
D
S
K
T
T
Y
I
H
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation