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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLR8
Full Name:
Toll-like receptor 8
Alias:
CD288; CD288 antigen; Toll-like receptor 8
Type:
Receptor, misc.
Mass (Da):
119830
Number AA:
UniProt ID:
Q9NR97
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0010008
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005121
GO:0003725
PhosphoSite+
KinaseNET
Biological Process:
GO:0007249
GO:0051607
GO:0009597
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S368
R
N
F
S
K
L
L
S
L
R
A
L
H
L
R
Site 2
T762
A
L
E
T
K
T
T
T
K
L
S
M
L
E
L
Site 3
S765
T
K
T
T
T
K
L
S
M
L
E
L
H
G
N
Site 4
S872
A
K
V
K
G
Y
R
S
L
S
T
S
Q
T
F
Site 5
S874
V
K
G
Y
R
S
L
S
T
S
Q
T
F
Y
D
Site 6
T875
K
G
Y
R
S
L
S
T
S
Q
T
F
Y
D
A
Site 7
S876
G
Y
R
S
L
S
T
S
Q
T
F
Y
D
A
Y
Site 8
T878
R
S
L
S
T
S
Q
T
F
Y
D
A
Y
I
S
Site 9
Y880
L
S
T
S
Q
T
F
Y
D
A
Y
I
S
Y
D
Site 10
Y883
S
Q
T
F
Y
D
A
Y
I
S
Y
D
T
K
D
Site 11
Y886
F
Y
D
A
Y
I
S
Y
D
T
K
D
A
S
V
Site 12
T888
D
A
Y
I
S
Y
D
T
K
D
A
S
V
T
D
Site 13
S892
S
Y
D
T
K
D
A
S
V
T
D
W
V
I
N
Site 14
S935
I
I
D
N
L
M
Q
S
I
N
Q
S
K
K
T
Site 15
T942
S
I
N
Q
S
K
K
T
V
F
V
L
T
K
K
Site 16
Y950
V
F
V
L
T
K
K
Y
A
K
S
W
N
F
K
Site 17
S987
L
E
P
V
L
Q
H
S
Q
Y
L
R
L
R
Q
Site 18
Y989
P
V
L
Q
H
S
Q
Y
L
R
L
R
Q
R
I
Site 19
S999
L
R
Q
R
I
C
K
S
S
I
L
Q
W
P
D
Site 20
T1024
T
L
R
N
V
V
L
T
E
N
D
S
R
Y
N
Site 21
Y1030
L
T
E
N
D
S
R
Y
N
N
M
Y
V
D
S
Site 22
Y1034
D
S
R
Y
N
N
M
Y
V
D
S
I
K
Q
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation