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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF4
Full Name:
Rho guanine nucleotide exchange factor 4
Alias:
APC-stimulated guanine nucleotide exchange factor
Type:
Mass (Da):
79067
Number AA:
690
UniProt ID:
Q9NR80
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
P
A
G
E
K
P
S
C
S
H
S
Q
K
A
Site 2
S14
A
G
E
K
P
S
C
S
H
S
Q
K
A
F
H
Site 3
S16
E
K
P
S
C
S
H
S
Q
K
A
F
H
M
E
Site 4
S53
T
V
R
G
E
A
P
S
Q
P
R
G
I
P
H
Site 5
S62
P
R
G
I
P
H
R
S
P
V
S
V
D
D
L
Site 6
S65
I
P
H
R
S
P
V
S
V
D
D
L
W
L
E
Site 7
T74
D
D
L
W
L
E
K
T
Q
R
K
K
L
Q
K
Site 8
T105
G
V
K
C
W
R
K
T
I
I
T
S
P
E
S
Site 9
T108
C
W
R
K
T
I
I
T
S
P
E
S
L
N
L
Site 10
S109
W
R
K
T
I
I
T
S
P
E
S
L
N
L
P
Site 11
S112
T
I
I
T
S
P
E
S
L
N
L
P
R
R
S
Site 12
S119
S
L
N
L
P
R
R
S
H
P
L
S
Q
S
A
Site 13
S123
P
R
R
S
H
P
L
S
Q
S
A
P
T
G
L
Site 14
S125
R
S
H
P
L
S
Q
S
A
P
T
G
L
N
H
Site 15
T139
H
M
G
W
P
E
H
T
P
G
T
A
M
P
D
Site 16
T142
W
P
E
H
T
P
G
T
A
M
P
D
G
A
L
Site 17
Y165
V
G
S
E
E
D
L
Y
D
D
L
H
S
S
S
Site 18
S170
D
L
Y
D
D
L
H
S
S
S
H
H
Y
S
H
Site 19
S171
L
Y
D
D
L
H
S
S
S
H
H
Y
S
H
P
Site 20
S172
Y
D
D
L
H
S
S
S
H
H
Y
S
H
P
G
Site 21
Y175
L
H
S
S
S
H
H
Y
S
H
P
G
G
G
G
Site 22
S176
H
S
S
S
H
H
Y
S
H
P
G
G
G
G
E
Site 23
T207
E
A
L
W
D
H
V
T
M
D
D
Q
E
L
G
Site 24
S246
G
E
G
W
F
P
A
S
F
V
R
L
R
V
N
Site 25
S280
G
G
A
E
A
Q
S
S
K
D
Q
M
R
T
N
Site 26
T295
V
I
N
E
I
L
S
T
E
R
D
Y
I
K
H
Site 27
Y299
I
L
S
T
E
R
D
Y
I
K
H
L
R
D
I
Site 28
Y310
L
R
D
I
C
E
G
Y
V
R
Q
C
R
K
R
Site 29
S322
R
K
R
A
D
M
F
S
E
E
Q
L
R
T
I
Site 30
T328
F
S
E
E
Q
L
R
T
I
F
G
N
I
E
D
Site 31
Y337
F
G
N
I
E
D
I
Y
R
C
Q
K
A
F
V
Site 32
S359
N
R
E
R
P
H
L
S
E
L
G
A
C
F
L
Site 33
Y378
D
F
Q
I
Y
S
E
Y
C
N
N
H
P
N
A
Site 34
S390
P
N
A
C
V
E
L
S
R
L
T
K
L
S
K
Site 35
T393
C
V
E
L
S
R
L
T
K
L
S
K
Y
V
Y
Site 36
S396
L
S
R
L
T
K
L
S
K
Y
V
Y
F
F
E
Site 37
Y440
Q
L
A
E
L
L
K
Y
T
H
P
Q
H
R
D
Site 38
S484
K
I
A
Q
W
Q
S
S
I
E
D
W
E
G
E
Site 39
S497
G
E
D
L
L
V
R
S
S
E
L
I
Y
S
G
Site 40
S498
E
D
L
L
V
R
S
S
E
L
I
Y
S
G
E
Site 41
S503
R
S
S
E
L
I
Y
S
G
E
L
T
R
V
T
Site 42
T507
L
I
Y
S
G
E
L
T
R
V
T
Q
P
Q
A
Site 43
T510
S
G
E
L
T
R
V
T
Q
P
Q
A
K
S
Q
Site 44
S516
V
T
Q
P
Q
A
K
S
Q
Q
R
M
F
F
L
Site 45
Y530
L
F
D
H
Q
L
I
Y
C
K
K
D
L
L
R
Site 46
Y542
L
L
R
R
D
V
L
Y
Y
K
G
R
L
D
M
Site 47
Y543
L
R
R
D
V
L
Y
Y
K
G
R
L
D
M
D
Site 48
S568
K
D
R
D
L
H
V
S
I
K
N
A
F
R
L
Site 49
T580
F
R
L
H
R
G
A
T
G
D
S
H
L
L
C
Site 50
S617
L
D
Q
E
T
G
F
S
I
T
E
L
Q
R
K
Site 51
Y647
K
A
V
G
R
P
C
Y
L
T
R
Q
K
H
P
Site 52
T649
V
G
R
P
C
Y
L
T
R
Q
K
H
P
A
L
Site 53
S658
Q
K
H
P
A
L
P
S
N
R
P
Q
Q
Q
V
Site 54
S676
A
E
P
R
R
K
P
S
T
F
W
H
S
I
S
Site 55
T677
E
P
R
R
K
P
S
T
F
W
H
S
I
S
R
Site 56
S681
K
P
S
T
F
W
H
S
I
S
R
L
A
P
F
Site 57
S683
S
T
F
W
H
S
I
S
R
L
A
P
F
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation