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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2B3
Full Name:
Translation initiation factor eIF-2B subunit gamma
Alias:
EI2BG; EIF-2B; EIF-2B GDP-GTP exchange factor; EIF2Bgamma; Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; Translation initiation factor eIF-2B gamma
Type:
Translation
Mass (Da):
50240
Number AA:
452
UniProt ID:
Q9NR50
International Prot ID:
IPI00006504
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005851
Uniprot
OncoNet
Molecular Function:
GO:0016779
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0032057
GO:0014003
GO:0009749
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
V
G
G
G
S
R
M
T
D
L
T
S
S
I
P
Site 2
T20
G
S
R
M
T
D
L
T
S
S
I
P
K
P
L
Site 3
S21
S
R
M
T
D
L
T
S
S
I
P
K
P
L
L
Site 4
S22
R
M
T
D
L
T
S
S
I
P
K
P
L
L
P
Site 5
Y38
G
N
K
P
L
I
W
Y
P
L
N
L
L
E
R
Site 6
T86
P
D
D
A
D
M
G
T
A
D
S
L
R
Y
I
Site 7
S89
A
D
M
G
T
A
D
S
L
R
Y
I
Y
P
K
Site 8
Y92
G
T
A
D
S
L
R
Y
I
Y
P
K
L
K
T
Site 9
Y94
A
D
S
L
R
Y
I
Y
P
K
L
K
T
D
V
Site 10
S138
L
M
R
K
G
Q
D
S
I
E
P
V
P
G
Q
Site 11
S162
R
D
F
I
G
V
D
S
T
G
K
R
L
L
F
Site 12
S185
E
E
L
V
I
K
G
S
I
L
Q
K
H
P
R
Site 13
T197
H
P
R
I
R
F
H
T
G
L
V
D
A
H
L
Site 14
Y210
H
L
Y
C
L
K
K
Y
I
V
D
F
L
M
E
Site 15
S220
D
F
L
M
E
N
G
S
I
T
S
I
R
S
E
Site 16
S223
M
E
N
G
S
I
T
S
I
R
S
E
L
I
P
Site 17
Y231
I
R
S
E
L
I
P
Y
L
V
R
K
Q
F
S
Site 18
S238
Y
L
V
R
K
Q
F
S
S
A
S
S
Q
Q
G
Site 19
S239
L
V
R
K
Q
F
S
S
A
S
S
Q
Q
G
Q
Site 20
S242
K
Q
F
S
S
A
S
S
Q
Q
G
Q
E
E
K
Site 21
S260
L
K
K
K
E
L
K
S
L
D
I
Y
S
F
I
Site 22
Y264
E
L
K
S
L
D
I
Y
S
F
I
K
E
A
N
Site 23
S265
L
K
S
L
D
I
Y
S
F
I
K
E
A
N
T
Site 24
S294
G
D
R
W
E
D
L
S
R
S
Q
V
R
C
Y
Site 25
Y301
S
R
S
Q
V
R
C
Y
V
H
I
M
K
E
G
Site 26
Y319
R
V
S
T
L
G
L
Y
M
E
A
N
R
Q
V
Site 27
S331
R
Q
V
P
K
L
L
S
A
L
C
P
E
E
P
Site 28
S356
K
H
L
V
G
V
D
S
L
I
G
P
E
T
Q
Site 29
T362
D
S
L
I
G
P
E
T
Q
I
G
E
K
S
S
Site 30
S368
E
T
Q
I
G
E
K
S
S
I
K
R
S
V
I
Site 31
S369
T
Q
I
G
E
K
S
S
I
K
R
S
V
I
G
Site 32
S373
E
K
S
S
I
K
R
S
V
I
G
S
S
C
L
Site 33
S377
I
K
R
S
V
I
G
S
S
C
L
I
K
D
R
Site 34
S407
E
G
S
N
I
Q
G
S
V
I
C
N
N
A
V
Site 35
S428
I
K
D
C
L
I
G
S
G
Q
R
I
E
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation