PhosphoNET

           
Protein Info 
   
Short Name:  ASH1L
Full Name:  Probable histone-lysine N-methyltransferase ASH1L
Alias:  absent small and homeotic disks protein 1; absent, small, or homeotic-like; ash1; ash1 (absent, small, or homeotic)-like; ASH1L1; huASH1; KMT2H; Probable histone-lysine N-methyltransferase ASH1L: Absent small and homeotic disks protein 1 homolog: ASH1-like protein: Lysine N-methyltransferase 2H
Type:  Methyltransferase; EC 2.1.1.43; Adhesion; Amino Acid Metabolism - lysine degradation; Transcription factor
Mass (Da):  332790
Number AA:  2969
UniProt ID:  Q9NR48
International Prot ID:  IPI00020546
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634  GO:0005923  GO:0005794 Uniprot OncoNet
Molecular Function:  GO:0003677  GO:0003702  GO:0018024 PhosphoSite+ KinaseNET
Biological Process:  GO:0006323  GO:0007267  GO:0016568 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S13TAMLGLGSDSEGFSR
Site 2S15MLGLGSDSEGFSRKS
Site 3S19GSDSEGFSRKSPSAI
Site 4S22SEGFSRKSPSAISTG
Site 5S24GFSRKSPSAISTGTL
Site 6T28KSPSAISTGTLVSKR
Site 7T30PSAISTGTLVSKREV
Site 8S33ISTGTLVSKREVELE
Site 9T67AGKDDGLTDAQQQFS
Site 10T78QQFSVKETNFSEGNL
Site 11S81SVKETNFSEGNLKLK
Site 12Y106PPKNLENYVCRPAIK
Site 13T114VCRPAIKTTIKHPRK
Site 14S125HPRKALKSGKMTDEK
Site 15T129ALKSGKMTDEKNEHC
Site 16S138EKNEHCPSKRDPSKL
Site 17S143CPSKRDPSKLYKKAD
Site 18S167EEVIRLHSQGENNPL
Site 19S175QGENNPLSKKLSPVH
Site 20S179NPLSKKLSPVHSEMA
Site 21S183KKLSPVHSEMADYIN
Site 22Y188VHSEMADYINATPST
Site 23S194DYINATPSTLLGSRD
Site 24T195YINATPSTLLGSRDP
Site 25T226KLAQLIATCPPSKSS
Site 26S230LIATCPPSKSSKTKP
Site 27S232ATCPPSKSSKTKPKK
Site 28T235PPSKSSKTKPKKLGT
Site 29T242TKPKKLGTGTTAGLV
Site 30T244PKKLGTGTTAGLVSK
Site 31S250GTTAGLVSKDLIRKA
Site 32T284STAVGLVTKDPGKKP
Site 33S304VGLVNKDSVKKLGTG
Site 34T329GKKPGTITTVGLLSK
Site 35T330KKPGTITTVGLLSKD
Site 36S335ITTVGLLSKDSGKKL
Site 37S338VGLLSKDSGKKLGIG
Site 38S355PGLVHKESGKKLGLG
Site 39S441EPLKASCSTNINNQE
Site 40S449TNINNQESQELSESL
Site 41S453NQESQELSESLKDSA
Site 42S455ESQELSESLKDSATS
Site 43S459LSESLKDSATSKTFE
Site 44T461ESLKDSATSKTFEKN
Site 45T464KDSATSKTFEKNVVR
Site 46S476VVRQNKESILEKFSV
Site 47S482ESILEKFSVRKEIIN
Site 48S505GTCIQQDSFSSSEKG
Site 49S507CIQQDSFSSSEKGSY
Site 50S509QQDSFSSSEKGSYET
Site 51S513FSSSEKGSYETSKHE
Site 52Y514SSSEKGSYETSKHEK
Site 53S517EKGSYETSKHEKQPP
Site 54Y526HEKQPPVYCTSPDFK
Site 55S529QPPVYCTSPDFKMGG
Site 56S541MGGASDVSTAKSPFS
Site 57T542GGASDVSTAKSPFSA
Site 58S545SDVSTAKSPFSAVGE
Site 59S548STAKSPFSAVGESNL
Site 60S553PFSAVGESNLPSPSP
Site 61S557VGESNLPSPSPTVSV
Site 62S559ESNLPSPSPTVSVNP
Site 63T561NLPSPSPTVSVNPLT
Site 64S563PSPSPTVSVNPLTRS
Site 65T568TVSVNPLTRSPPETS
Site 66S570SVNPLTRSPPETSSQ
Site 67T574LTRSPPETSSQLAPN
Site 68S576RSPPETSSQLAPNPL
Site 69S587PNPLLLSSTTELIEE
Site 70S598LIEEISESVGKNQFT
Site 71S617HLNVGHRSVGHSISI
Site 72S621GHRSVGHSISIECKG
Site 73S623RSVGHSISIECKGID
Site 74S636IDKEVNDSKTTHIDI
Site 75T638KEVNDSKTTHIDIPR
Site 76S647HIDIPRISSSLGKKP
Site 77S648IDIPRISSSLGKKPS
Site 78S649DIPRISSSLGKKPSL
Site 79S655SSLGKKPSLTSESSI
Site 80T657LGKKPSLTSESSIHT
Site 81S658GKKPSLTSESSIHTI
Site 82S661PSLTSESSIHTITPS
Site 83T664TSESSIHTITPSVVN
Site 84S688FLKLGAVSASDKHCQ
Site 85S699KHCQVAESLSTSLQS
Site 86S701CQVAESLSTSLQSKP
Site 87S703VAESLSTSLQSKPLK
Site 88T720KGRKPRWTKVVARST
Site 89S726WTKVVARSTCRSPKG
Site 90T727TKVVARSTCRSPKGL
Site 91S730VARSTCRSPKGLELE
Site 92S739KGLELERSELFKNVS
Site 93S746SELFKNVSCSSLSNS
Site 94S748LFKNVSCSSLSNSNS
Site 95S749FKNVSCSSLSNSNSE
Site 96S751NVSCSSLSNSNSEPA
Site 97S753SCSSLSNSNSEPAKF
Site 98S755SSLSNSNSEPAKFMK
Site 99S768MKNIGPPSFVDHDFL
Site 100S783KRRLPKLSKSTAPSL
Site 101S785RLPKLSKSTAPSLAL
Site 102S789LSKSTAPSLALLADS
Site 103S796SLALLADSEKPSHKS
Site 104S800LADSEKPSHKSFATH
Site 105S803SEKPSHKSFATHKLS
Site 106T806PSHKSFATHKLSSSM
Site 107S810SFATHKLSSSMCVSS
Site 108S811FATHKLSSSMCVSSD
Site 109S812ATHKLSSSMCVSSDL
Site 110S821CVSSDLLSDIYKPKR
Site 111Y824SDLLSDIYKPKRGRP
Site 112S833PKRGRPKSKEMPQLE
Site 113S852RTLKIPASKVFSLQS
Site 114S856IPASKVFSLQSKEEQ
Site 115S859SKVFSLQSKEEQEPP
Site 116S876QPEIEIPSFKQGLSV
Site 117S882PSFKQGLSVSPFPKK
Site 118S884FKQGLSVSPFPKKRG
Site 119S899RPKRQMRSPVKMKPP
Site 120T916SVAPFVATESPSKLE
Site 121S918APFVATESPSKLESE
Site 122S920FVATESPSKLESESD
Site 123S924ESPSKLESESDNHRS
Site 124S926PSKLESESDNHRSSS
Site 125S931SESDNHRSSSDFFES
Site 126S932ESDNHRSSSDFFESE
Site 127S933SDNHRSSSDFFESED
Site 128S938SSSDFFESEDQLQDP
Site 129S951DPDDLDDSHRPSVCS
Site 130S955LDDSHRPSVCSMSDL
Site 131S958SHRPSVCSMSDLEME
Site 132S960RPSVCSMSDLEMEPD
Site 133T981NNGQLMKTIIRKINK
Site 134T991RKINKMKTLKRKKLL
Site 135S1003KLLNQILSSSVESSN
Site 136S1004LLNQILSSSVESSNK
Site 137S1005LNQILSSSVESSNKG
Site 138S1008ILSSSVESSNKGKVQ
Site 139S1009LSSSVESSNKGKVQS
Site 140S1016SNKGKVQSKLHNTVS
Site 141T1021VQSKLHNTVSSLAAT
Site 142S1040LGQQINVSKKGTIYI
Site 143T1044INVSKKGTIYIGKRR
Site 144Y1046VSKKGTIYIGKRRGR
Site 145T1057RRGRKPKTVLNGILS
Site 146S1098PLLPSSASSSEILPS
Site 147S1099LLPSSASSSEILPSP
Site 148S1100LPSSASSSEILPSPI
Site 149S1105SSSEILPSPICSQSS
Site 150S1109ILPSPICSQSSGTSG
Site 151S1111PSPICSQSSGTSGGQ
Site 152S1112SPICSQSSGTSGGQS
Site 153S1115CSQSSGTSGGQSPVS
Site 154S1119SGTSGGQSPVSSDAG
Site 155S1122SGGQSPVSSDAGFVE
Site 156S1123GGQSPVSSDAGFVEP
Site 157Y1135VEPSSVPYLHLHSRQ
Site 158S1140VPYLHLHSRQGSMIQ
Site 159S1144HLHSRQGSMIQTLAM
Site 160T1148RQGSMIQTLAMKKAS
Site 161S1162SKGRRRLSPPTLLPN
Site 162T1165RRRLSPPTLLPNSPS
Site 163S1170PPTLLPNSPSHLSEL
Site 164S1172TLLPNSPSHLSELTS
Site 165S1175PNSPSHLSELTSLKE
Site 166T1178PSHLSELTSLKEATP
Site 167S1179SHLSELTSLKEATPS
Site 168T1184LTSLKEATPSPISES
Site 169S1186SLKEATPSPISESHS
Site 170S1189EATPSPISESHSDET
Site 171S1191TPSPISESHSDETIP
Site 172S1193SPISESHSDETIPSD
Site 173T1196SESHSDETIPSDSGI
Site 174S1199HSDETIPSDSGIGTD
Site 175T1205PSDSGIGTDNNSTSD
Site 176S1209GIGTDNNSTSDRAEK
Site 177S1211GTDNNSTSDRAEKFC
Site 178S1226GQKKRRHSFEHVSLI
Site 179S1231RHSFEHVSLIPPETS
Site 180T1239LIPPETSTVLSSLKE
Site 181S1242PETSTVLSSLKEKHK
Site 182Y1259CKRRNHDYLSYDKMK
Site 183S1261RRNHDYLSYDKMKRQ
Site 184Y1276KRKRKKKYPQLRNRQ
Site 185S1296AELEELISRLSEIRI
Site 186S1299EELISRLSEIRITHR
Site 187T1304RLSEIRITHRSHHFI
Site 188Y1328RINFNSFYTHPSFPL
Site 189T1329INFNSFYTHPSFPLD
Site 190S1332NSFYTHPSFPLDPLH
Site 191Y1340FPLDPLHYIRKPDLK
Site 192S1374HSLSFPLSSTGFYPS
Site 193S1375SLSFPLSSTGFYPSY
Site 194T1376LSFPLSSTGFYPSYG
Site 195Y1379PLSSTGFYPSYGMPY
Site 196S1381SSTGFYPSYGMPYSP
Site 197Y1382STGFYPSYGMPYSPS
Site 198S1387PSYGMPYSPSPLTAA
Site 199S1389YGMPYSPSPLTAAPI
Site 200Y1400AAPIGLGYYGRYPPT
Site 201Y1401APIGLGYYGRYPPTL
Site 202Y1404GLGYYGRYPPTLYPP
Site 203T1407YYGRYPPTLYPPPPS
Site 204Y1409GRYPPTLYPPPPSPS
Site 205S1414TLYPPPPSPSFTTPL
Site 206S1416YPPPPSPSFTTPLPP
Site 207T1418PPPSPSFTTPLPPPS
Site 208T1419PPSPSFTTPLPPPSY
Site 209S1425TTPLPPPSYMHAGHL
Site 210Y1426TPLPPPSYMHAGHLL
Site 211Y1439LLLNPAKYHKKKHKL
Site 212T1454LRQEAFLTTSRTPLL
Site 213S1456QEAFLTTSRTPLLSM
Site 214S1462TSRTPLLSMSTYPSV
Site 215S1464RTPLLSMSTYPSVPP
Site 216T1465TPLLSMSTYPSVPPE
Site 217Y1466PLLSMSTYPSVPPEM
Site 218S1468LSMSTYPSVPPEMAY
Site 219Y1475SVPPEMAYGWMVEHK
Site 220S1495KHREHRSSEQPQVSM
Site 221S1501SSEQPQVSMDTGSSR
Site 222T1504QPQVSMDTGSSRSVL
Site 223S1506QVSMDTGSSRSVLES
Site 224S1507VSMDTGSSRSVLESL
Site 225S1509MDTGSSRSVLESLKR
Site 226S1513SSRSVLESLKRYRFG
Site 227Y1517VLESLKRYRFGKDAV
Site 228S1539EKHRCHMSCPHLSPS
Site 229S1544HMSCPHLSPSKSLIN
Site 230S1546SCPHLSPSKSLINRE
Site 231S1548PHLSPSKSLINREEQ
Site 232S1562QWVHREPSESSPLAL
Site 233S1564VHREPSESSPLALGL
Site 234S1565HREPSESSPLALGLQ
Site 235S1580TPLQIDCSESSPSLS
Site 236S1582LQIDCSESSPSLSLG
Site 237S1583QIDCSESSPSLSLGG
Site 238S1585DCSESSPSLSLGGFT
Site 239S1587SESSPSLSLGGFTPN
Site 240T1592SLSLGGFTPNSEPAS
Site 241S1595LGGFTPNSEPASSDE
Site 242S1599TPNSEPASSDEHTNL
Site 243S1600PNSEPASSDEHTNLF
Site 244T1604PASSDEHTNLFTSAI
Site 245S1609EHTNLFTSAIGSCRV
Site 246S1617AIGSCRVSNPNSSGR
Site 247S1621CRVSNPNSSGRKKLT
Site 248S1622RVSNPNSSGRKKLTD
Site 249T1628SSGRKKLTDSPGLFS
Site 250S1630GRKKLTDSPGLFSAQ
Site 251T1639GLFSAQDTSLNRLHR
Site 252S1640LFSAQDTSLNRLHRK
Site 253S1649NRLHRKESLPSNERA
Site 254T1659SNERAVQTLAGSQPT
Site 255S1663AVQTLAGSQPTSDKP
Site 256S1667LAGSQPTSDKPSQRP
Site 257S1671QPTSDKPSQRPSEST
Site 258S1675DKPSQRPSESTNCSP
Site 259S1677PSQRPSESTNCSPTR
Site 260T1678SQRPSESTNCSPTRK
Site 261S1681PSESTNCSPTRKRSS
Site 262T1683ESTNCSPTRKRSSSE
Site 263S1687CSPTRKRSSSESTSS
Site 264S1688SPTRKRSSSESTSST
Site 265S1689PTRKRSSSESTSSTV
Site 266S1691RKRSSSESTSSTVNG
Site 267T1692KRSSSESTSSTVNGV
Site 268S1693RSSSESTSSTVNGVP
Site 269S1694SSSESTSSTVNGVPS
Site 270T1695SSESTSSTVNGVPSR
Site 271S1701STVNGVPSRSPRLVA
Site 272S1703VNGVPSRSPRLVASG
Site 273S1709RSPRLVASGDDSVDS
Site 274S1713LVASGDDSVDSLLQR
Site 275S1716SGDDSVDSLLQRMVQ
Site 276S1742DAVIATASAPPSSSP
Site 277S1746ATASAPPSSSPGRSH
Site 278S1747TASAPPSSSPGRSHS
Site 279S1748ASAPPSSSPGRSHSK
Site 280S1752PSSSPGRSHSKDRTL
Site 281S1754SSPGRSHSKDRTLGK
Site 282T1758RSHSKDRTLGKPDSL
Site 283S1778TSDSCNNSISLLSEK
Site 284S1780DSCNNSISLLSEKLT
Site 285S1783NNSISLLSEKLTSSC
Site 286T1787SLLSEKLTSSCSPHH
Site 287S1788LLSEKLTSSCSPHHI
Site 288S1789LSEKLTSSCSPHHIK
Site 289S1791EKLTSSCSPHHIKRS
Site 290S1798SPHHIKRSVVEAMQR
Site 291Y1813QARKMCNYDKILATK
Site 292S1943EEQENNKSFNEAPVE
Site 293S1953EAPVEIPSPSETPAK
Site 294S1955PVEIPSPSETPAKPS
Site 295T1957EIPSPSETPAKPSEP
Site 296S1962SETPAKPSEPESTLQ
Site 297S1966AKPSEPESTLQPVLS
Site 298T1967KPSEPESTLQPVLSL
Site 299S1973STLQPVLSLIPREKK
Site 300Y1989PRPPKKKYQKAGLYS
Site 301Y1995KYQKAGLYSDVYKTT
Site 302Y1999AGLYSDVYKTTDPKS
Site 303T2001LYSDVYKTTDPKSRL
Site 304T2002YSDVYKTTDPKSRLI
Site 305S2006YKTTDPKSRLIQLKK
Site 306Y2018LKKEKLEYTPGEHEY
Site 307T2019KKEKLEYTPGEHEYG
Site 308Y2042VFFVSGKYLRQKRID
Site 309Y2054RIDFQLPYDILWQWK
Site 310Y2066QWKHNQLYKKPDVPL
Site 311Y2074KKPDVPLYKKIRSNV
Site 312Y2082KKIRSNVYVDVKPLS
Site 313S2089YVDVKPLSGYEATTC
Site 314Y2091DVKPLSGYEATTCNC
Site 315T2105CKKPDDDTRKGCVDD
Site 316S2180EYLGEVVSEQEFRNR
Site 317Y2192RNRMIEQYHNHSDHY
Site 318Y2199YHNHSDHYCLNLDSG
Site 319S2211DSGMVIDSYRMGNEA
Site 320Y2212SGMVIDSYRMGNEAR
Site 321Y2258PAGTELTYDYNFHSF
Site 322Y2260GTELTYDYNFHSFNV
Site 323S2288RGIIGGKSQRVNGLT
Site 324T2295SQRVNGLTSSKNSQP
Site 325S2296QRVNGLTSSKNSQPM
Site 326S2297RVNGLTSSKNSQPMA
Site 327S2300GLTSSKNSQPMATHK
Site 328T2305KNSQPMATHKKSGRS
Site 329S2309PMATHKKSGRSKEKR
Site 330S2318RSKEKRKSKHKLKKR
Site 331S2330KKRRGHLSEEPSENI
Site 332S2334GHLSEEPSENINTPT
Site 333T2339EPSENINTPTRLTPQ
Site 334T2344INTPTRLTPQLQMKP
Site 335S2353QLQMKPMSNRERNFV
Site 336T2384KQEEVKHTSDNIHSA
Site 337S2385QEEVKHTSDNIHSAS
Site 338S2392SDNIHSASLYTRWNG
Site 339Y2394NIHSASLYTRWNGIC
Site 340T2421TQFSALQTARSVRTR
Site 341S2424SALQTARSVRTRRLA
Site 342S2458EICDGIISYKDSSRQ
Site 343Y2459ICDGIISYKDSSRQA
Site 344S2462GIISYKDSSRQALAA
Site 345Y2483PKKKNADYYEKISDP
Site 346Y2484KKKNADYYEKISDPL
Site 347Y2504EKQILTGYYKTVEAF
Site 348T2507ILTGYYKTVEAFDAD
Site 349Y2525VFRNAEKYYGRKSPV
Site 350Y2526FRNAEKYYGRKSPVG
Site 351S2530EKYYGRKSPVGRDVC
Site 352Y2543VCRLRKAYYNARHEA
Site 353Y2544CRLRKAYYNARHEAS
Site 354S2563EIVGETASEADSSET
Site 355S2567ETASEADSSETSVSE
Site 356S2568TASEADSSETSVSEK
Site 357S2571EADSSETSVSEKENG
Site 358S2573DSSETSVSEKENGHE
Site 359Y2645PMIPRPHYAQPGCVY
Site 360Y2670LRQGDCVYLMRDSRR
Site 361S2675CVYLMRDSRRTPDGH
Site 362T2678LMRDSRRTPDGHPVR
Site 363S2687DGHPVRQSYRLLSHI
Site 364Y2688GHPVRQSYRLLSHIN
Site 365S2692RQSYRLLSHINRDKL
Site 366Y2722RFAFGHHYFRPHETH
Site 367S2731RPHETHHSPSRRFYH
Site 368Y2737HSPSRRFYHNELFRV
Site 369Y2767CVLDLYTYCKGRPKG
Site 370Y2781GVKEQDVYICDYRLD
Site 371Y2785QDVYICDYRLDKSAH
Site 372Y2802YKIHRNRYPVCTKPY
Site 373Y2809YPVCTKPYAFDHFPK
Site 374T2819DHFPKKLTPKKDFSP
Site 375S2825LTPKKDFSPHYVPDN
Site 376Y2828KKDFSPHYVPDNYKR
Site 377Y2833PHYVPDNYKRNGGRS
Site 378S2840YKRNGGRSSWKSERS
Site 379S2841KRNGGRSSWKSERSK
Site 380S2844GGRSSWKSERSKPPL
Site 381S2847SSWKSERSKPPLKDL
Site 382S2870LIEEVLASQEQAANE
Site 383T2900VSEGEKKTEESSQEP
Site 384S2904EKKTEESSQEPQSTC
Site 385S2909ESSQEPQSTCTPEER
Site 386T2910SSQEPQSTCTPEERR
Site 387T2912QEPQSTCTPEERRHN
Site 388T2944GKNAIDVTYLLEEGS
Site 389Y2945KNAIDVTYLLEEGSG
Site 390S2951TYLLEEGSGRKLRRR
Site 391T2959GRKLRRRTLFIPENS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation