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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DYRK4
Full Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4
Alias:
Dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 4; EC 2.7.12.1; Kinase DYRK4
Type:
EC 2.7.12.1; Protein kinase, dual-specificity; EC 2.7.1.-;
CMGC
group; DYRK family; Dyrk2 subfamily
Mass (Da):
59608
Number AA:
520
UniProt ID:
Q9NR20
International Prot ID:
IPI00396286
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Q259-P273, human) pY262+pT263+pY264+pS267+pY270 phosphopeptide - Powder PE-04ATD55#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATD55
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
A
S
E
L
K
A
S
E
I
P
F
H
P
S
Site 2
T19
P
F
H
P
S
I
K
T
Q
D
P
K
A
E
E
Site 3
S28
D
P
K
A
E
E
K
S
P
K
K
Q
K
V
T
Site 4
T37
K
K
Q
K
V
T
L
T
A
A
E
A
L
K
L
Site 5
S50
K
L
F
K
N
Q
L
S
P
Y
E
Q
S
E
I
Site 6
Y52
F
K
N
Q
L
S
P
Y
E
Q
S
E
I
L
G
Site 7
T75
L
E
A
K
K
L
D
T
A
P
E
K
F
S
K
Site 8
T83
A
P
E
K
F
S
K
T
S
F
D
D
E
H
G
Site 9
S84
P
E
K
F
S
K
T
S
F
D
D
E
H
G
F
Site 10
Y92
F
D
D
E
H
G
F
Y
L
K
V
L
H
D
H
Site 11
Y104
H
D
H
I
A
Y
R
Y
E
V
L
E
T
I
G
Site 12
T109
Y
R
Y
E
V
L
E
T
I
G
K
G
S
F
G
Site 13
Y164
K
K
D
K
D
N
T
Y
N
V
V
H
M
K
D
Site 14
Y191
E
L
L
G
I
N
L
Y
E
L
M
K
N
N
N
Site 15
S203
N
N
N
F
Q
G
F
S
L
S
I
V
R
R
F
Site 16
T211
L
S
I
V
R
R
F
T
L
S
V
L
K
C
L
Site 17
S213
I
V
R
R
F
T
L
S
V
L
K
C
L
Q
M
Site 18
S222
L
K
C
L
Q
M
L
S
V
E
K
I
I
H
C
Site 19
Y239
K
P
E
N
I
V
L
Y
Q
K
G
Q
A
S
V
Site 20
S245
L
Y
Q
K
G
Q
A
S
V
K
V
I
D
F
G
Site 21
Y262
C
Y
E
H
Q
K
V
Y
T
Y
I
Q
S
R
F
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Q259-P273, human) pY262+pT263+pY264+pS267+pY270 phosphopeptide - Powder PE-04ATD55#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATD55
Site 22
T263
Y
E
H
Q
K
V
Y
T
Y
I
Q
S
R
F
Y
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Q259-P273, human) pY262+pT263+pY264+pS267+pY270 phosphopeptide - Powder PE-04ATD55#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATD55
Site 23
Y264
E
H
Q
K
V
Y
T
Y
I
Q
S
R
F
Y
R
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Q259-P273, human) pY262+pT263+pY264+pS267+pY270 phosphopeptide - Powder PE-04ATD55#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATD55
Site 24
S267
K
V
Y
T
Y
I
Q
S
R
F
Y
R
S
P
E
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Q259-P273, human) pY262+pT263+pY264+pS267+pY270 phosphopeptide - Powder PE-04ATD55#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATD55
Site 25
Y270
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Q259-P273, human) pY262+pT263+pY264+pS267+pY270 phosphopeptide - Powder PE-04ATD55#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATD55
Site 26
S272
I
Q
S
R
F
Y
R
S
P
E
V
I
L
G
H
Site 27
Y301
T
A
E
L
Y
T
G
Y
P
L
F
P
G
E
N
Site 28
T330
P
P
A
G
F
I
Q
T
A
S
R
R
Q
T
F
Site 29
S332
A
G
F
I
Q
T
A
S
R
R
Q
T
F
F
D
Site 30
T336
Q
T
A
S
R
R
Q
T
F
F
D
S
K
G
F
Site 31
T348
K
G
F
P
K
N
I
T
N
N
R
G
K
K
R
Site 32
Y356
N
N
R
G
K
K
R
Y
P
D
S
K
D
L
T
Site 33
S359
G
K
K
R
Y
P
D
S
K
D
L
T
M
V
L
Site 34
T363
Y
P
D
S
K
D
L
T
M
V
L
K
T
Y
D
Site 35
S372
V
L
K
T
Y
D
T
S
F
L
D
F
L
R
R
Site 36
S386
R
C
L
V
W
E
P
S
L
R
M
T
P
D
Q
Site 37
T390
W
E
P
S
L
R
M
T
P
D
Q
A
L
K
H
Site 38
T414
K
P
Q
P
R
P
Q
T
L
R
K
S
N
S
F
Site 39
S418
R
P
Q
T
L
R
K
S
N
S
F
F
P
S
E
Site 40
S420
Q
T
L
R
K
S
N
S
F
F
P
S
E
T
R
Site 41
S424
K
S
N
S
F
F
P
S
E
T
R
K
D
K
V
Site 42
S437
K
V
Q
G
C
H
H
S
S
R
K
A
D
E
I
Site 43
S455
T
T
E
K
T
K
D
S
P
T
K
H
V
Q
H
Site 44
T457
E
K
T
K
D
S
P
T
K
H
V
Q
H
S
G
Site 45
T500
V
G
A
E
V
S
M
T
S
P
G
Q
S
K
N
Site 46
S501
G
A
E
V
S
M
T
S
P
G
Q
S
K
N
F
Site 47
S505
S
M
T
S
P
G
Q
S
K
N
F
S
L
K
N
Site 48
S509
P
G
Q
S
K
N
F
S
L
K
N
T
N
V
L
Site 49
T513
K
N
F
S
L
K
N
T
N
V
L
P
P
I
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation