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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACSS2
Full Name:
Acetyl-coenzyme A synthetase, cytoplasmic
Alias:
ACAS2; AceCS; ACS; ACSA; Acyl-CoA synthetase short-chain family member 2; DJ1161H23.1; EC 6.2.1.1
Type:
Ligase, Energy - reductive carboxylate cycle (CO2 fixation), Carbohydrates - pyruvate metabolism, Carbohydrates - propanoate metabolism, Carbohydrates - glycolysis and gluconeogenesis
Mass (Da):
78580
Number AA:
701
UniProt ID:
Q9NR19
International Prot ID:
IPI00413730
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016208
GO:0005524
GO:0003987
PhosphoSite+
KinaseNET
Biological Process:
GO:0008610
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
P
E
E
R
V
R
S
G
S
G
S
R
G
Q
Site 2
S12
E
E
R
V
R
S
G
S
G
S
R
G
Q
E
E
Site 3
S14
R
V
R
S
G
S
G
S
R
G
Q
E
E
A
G
Site 4
S28
G
A
G
G
R
A
R
S
W
S
P
P
P
E
V
Site 5
S30
G
G
R
A
R
S
W
S
P
P
P
E
V
S
R
Site 6
S36
W
S
P
P
P
E
V
S
R
S
A
H
V
P
S
Site 7
S38
P
P
P
E
V
S
R
S
A
H
V
P
S
L
Q
Site 8
S43
S
R
S
A
H
V
P
S
L
Q
R
Y
R
E
L
Site 9
Y47
H
V
P
S
L
Q
R
Y
R
E
L
H
R
R
S
Site 10
S54
Y
R
E
L
H
R
R
S
V
E
E
P
R
E
F
Site 11
T73
A
K
E
F
Y
W
K
T
P
C
P
G
P
F
L
Site 12
T87
L
R
Y
N
F
D
V
T
K
G
K
I
F
I
E
Site 13
T100
I
E
W
M
K
G
A
T
T
N
I
C
Y
N
V
Site 14
Y124
L
G
D
K
V
A
F
Y
W
E
G
N
E
P
G
Site 15
T133
E
G
N
E
P
G
E
T
T
Q
I
T
Y
H
Q
Site 16
T137
P
G
E
T
T
Q
I
T
Y
H
Q
L
L
V
Q
Site 17
Y218
L
I
T
T
D
A
F
Y
R
G
E
K
L
V
N
Site 18
S263
A
E
L
G
M
G
D
S
T
S
Q
S
P
P
I
Site 19
T264
E
L
G
M
G
D
S
T
S
Q
S
P
P
I
K
Site 20
S265
L
G
M
G
D
S
T
S
Q
S
P
P
I
K
R
Site 21
S267
M
G
D
S
T
S
Q
S
P
P
I
K
R
S
C
Site 22
S273
Q
S
P
P
I
K
R
S
C
P
D
V
Q
I
S
Site 23
Y315
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
Site 24
S319
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
Site 25
Y370
T
G
H
S
Y
V
T
Y
G
P
L
A
N
G
A
Site 26
Y388
L
F
E
G
I
P
T
Y
P
D
V
N
R
L
W
Site 27
S396
P
D
V
N
R
L
W
S
I
V
D
K
Y
K
V
Site 28
Y401
L
W
S
I
V
D
K
Y
K
V
T
K
F
Y
T
Site 29
Y407
K
Y
K
V
T
K
F
Y
T
A
P
T
A
I
R
Site 30
T425
K
F
G
D
E
P
V
T
K
H
S
R
A
S
L
Site 31
Y450
N
P
E
A
W
L
W
Y
H
R
V
V
G
A
Q
Site 32
T476
E
T
G
G
H
M
L
T
P
L
P
G
A
T
P
Site 33
T482
L
T
P
L
P
G
A
T
P
M
K
P
G
S
A
Site 34
Y515
L
E
G
E
A
E
G
Y
L
V
F
K
Q
P
W
Site 35
Y530
P
G
I
M
R
T
V
Y
G
N
H
E
R
F
E
Site 36
T538
G
N
H
E
R
F
E
T
T
Y
F
K
K
F
P
Site 37
Y540
H
E
R
F
E
T
T
Y
F
K
K
F
P
G
Y
Site 38
Y547
Y
F
K
K
F
P
G
Y
Y
V
T
G
D
G
C
Site 39
Y548
F
K
K
F
P
G
Y
Y
V
T
G
D
G
C
Q
Site 40
Y561
C
Q
R
D
Q
D
G
Y
Y
W
I
T
G
R
I
Site 41
Y562
Q
R
D
Q
D
G
Y
Y
W
I
T
G
R
I
D
Site 42
S580
N
V
S
G
H
L
L
S
T
A
E
V
E
S
A
Site 43
T622
V
T
L
C
D
G
H
T
F
S
P
K
L
T
E
Site 44
S624
L
C
D
G
H
T
F
S
P
K
L
T
E
E
L
Site 45
T628
H
T
F
S
P
K
L
T
E
E
L
K
K
Q
I
Site 46
T644
E
K
I
G
P
I
A
T
P
D
Y
I
Q
N
A
Site 47
Y647
G
P
I
A
T
P
D
Y
I
Q
N
A
P
G
L
Site 48
T657
N
A
P
G
L
P
K
T
R
S
G
K
I
M
R
Site 49
S659
P
G
L
P
K
T
R
S
G
K
I
M
R
R
V
Site 50
S681
D
H
D
L
G
D
M
S
T
V
A
D
P
S
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation