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Updated November 2019
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Protein Info
Short Name:
MYO5C
Full Name:
Myosin-Vc
Alias:
MGC74969; Myosin 5C; Myosin Vc; Myosin-5C
Type:
Myosin complex protein
Mass (Da):
202810
Number AA:
1742
UniProt ID:
Q9NQX4
International Prot ID:
IPI00016007
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0051015
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
V
A
E
L
Y
T
Q
Y
N
R
V
W
I
P
D
Site 2
S24
D
P
E
E
V
W
K
S
A
E
I
A
K
D
Y
Site 3
Y31
S
A
E
I
A
K
D
Y
R
V
G
D
K
V
L
Site 4
T46
R
L
L
L
E
D
G
T
E
L
D
Y
S
V
N
Site 5
Y50
E
D
G
T
E
L
D
Y
S
V
N
P
E
S
L
Site 6
S51
D
G
T
E
L
D
Y
S
V
N
P
E
S
L
P
Site 7
S56
D
Y
S
V
N
P
E
S
L
P
P
L
R
N
P
Site 8
T73
L
V
G
E
N
D
L
T
A
L
S
Y
L
H
E
Site 9
S76
E
N
D
L
T
A
L
S
Y
L
H
E
P
A
V
Site 10
Y111
I
L
V
A
M
N
P
Y
K
Q
L
P
I
Y
G
Site 11
Y125
G
D
A
I
I
H
A
Y
S
G
Q
N
M
G
D
Site 12
S126
D
A
I
I
H
A
Y
S
G
Q
N
M
G
D
M
Site 13
S156
A
R
N
N
R
N
Q
S
I
I
V
S
G
E
S
Site 14
S160
R
N
Q
S
I
I
V
S
G
E
S
G
A
G
K
Site 15
T168
G
E
S
G
A
G
K
T
V
S
A
R
Y
A
M
Site 16
S170
S
G
A
G
K
T
V
S
A
R
Y
A
M
R
Y
Site 17
Y177
S
A
R
Y
A
M
R
Y
F
A
T
V
S
K
S
Site 18
T180
Y
A
M
R
Y
F
A
T
V
S
K
S
G
S
N
Site 19
S182
M
R
Y
F
A
T
V
S
K
S
G
S
N
A
H
Site 20
S184
Y
F
A
T
V
S
K
S
G
S
N
A
H
V
E
Site 21
S186
A
T
V
S
K
S
G
S
N
A
H
V
E
D
K
Site 22
T209
E
A
V
G
N
A
K
T
T
R
N
D
N
S
S
Site 23
S215
K
T
T
R
N
D
N
S
S
R
F
G
K
Y
T
Site 24
S216
T
T
R
N
D
N
S
S
R
F
G
K
Y
T
E
Site 25
Y221
N
S
S
R
F
G
K
Y
T
E
I
S
F
D
E
Site 26
T222
S
S
R
F
G
K
Y
T
E
I
S
F
D
E
Q
Site 27
S225
F
G
K
Y
T
E
I
S
F
D
E
Q
N
Q
I
Site 28
S238
Q
I
I
G
A
N
M
S
T
Y
L
L
E
K
S
Site 29
Y240
I
G
A
N
M
S
T
Y
L
L
E
K
S
R
V
Site 30
S245
S
T
Y
L
L
E
K
S
R
V
V
F
Q
S
E
Site 31
S251
K
S
R
V
V
F
Q
S
E
N
E
R
N
Y
H
Site 32
Y257
Q
S
E
N
E
R
N
Y
H
I
F
Y
Q
L
C
Site 33
Y261
E
R
N
Y
H
I
F
Y
Q
L
C
A
S
A
Q
Site 34
S270
L
C
A
S
A
Q
Q
S
E
F
K
H
L
K
L
Site 35
S279
F
K
H
L
K
L
G
S
A
E
E
F
N
Y
T
Site 36
Y285
G
S
A
E
E
F
N
Y
T
R
M
G
G
N
T
Site 37
T286
S
A
E
E
F
N
Y
T
R
M
G
G
N
T
V
Site 38
T292
Y
T
R
M
G
G
N
T
V
I
E
G
V
N
D
Site 39
T306
D
R
A
E
M
V
E
T
Q
K
T
F
T
L
L
Site 40
T309
E
M
V
E
T
Q
K
T
F
T
L
L
G
F
K
Site 41
S347
A
V
G
N
E
R
S
S
V
S
E
D
D
S
H
Site 42
S349
G
N
E
R
S
S
V
S
E
D
D
S
H
L
K
Site 43
S353
S
S
V
S
E
D
D
S
H
L
K
V
F
C
E
Site 44
S381
C
N
R
K
I
V
T
S
S
E
T
V
V
K
P
Site 45
S382
N
R
K
I
V
T
S
S
E
T
V
V
K
P
M
Site 46
T384
K
I
V
T
S
S
E
T
V
V
K
P
M
T
R
Site 47
T441
L
D
I
Y
G
F
E
T
F
D
V
N
S
F
E
Site 48
Y475
F
K
L
E
Q
E
E
Y
M
K
E
D
I
P
W
Site 49
Y488
P
W
T
L
I
D
F
Y
D
N
Q
P
V
I
D
Site 50
T517
E
C
L
L
P
H
G
T
D
E
N
W
P
Q
K
Site 51
Y526
E
N
W
P
Q
K
L
Y
N
N
F
V
N
R
N
Site 52
S542
L
F
E
K
P
R
M
S
N
T
S
F
V
I
Q
Site 53
S545
K
P
R
M
S
N
T
S
F
V
I
Q
H
F
A
Site 54
Y557
H
F
A
D
K
V
E
Y
K
C
E
G
F
L
E
Site 55
T569
F
L
E
K
N
R
D
T
V
Y
D
M
L
V
E
Site 56
Y571
E
K
N
R
D
T
V
Y
D
M
L
V
E
I
L
Site 57
T595
N
F
F
Q
E
N
P
T
P
P
S
P
F
G
S
Site 58
S598
Q
E
N
P
T
P
P
S
P
F
G
S
M
I
T
Site 59
S602
T
P
P
S
P
F
G
S
M
I
T
V
K
S
A
Site 60
S608
G
S
M
I
T
V
K
S
A
K
Q
V
I
K
P
Site 61
S617
K
Q
V
I
K
P
N
S
K
H
F
R
T
T
V
Site 62
T622
P
N
S
K
H
F
R
T
T
V
G
S
K
F
R
Site 63
T623
N
S
K
H
F
R
T
T
V
G
S
K
F
R
S
Site 64
S626
H
F
R
T
T
V
G
S
K
F
R
S
S
L
Y
Site 65
Y633
S
K
F
R
S
S
L
Y
L
L
M
E
T
L
N
Site 66
Y646
L
N
A
T
T
P
H
Y
V
R
C
I
K
P
N
Site 67
S663
K
L
P
F
E
F
D
S
K
R
I
V
Q
Q
L
Site 68
S682
V
L
E
T
I
R
I
S
A
Q
S
Y
P
S
R
Site 69
S685
T
I
R
I
S
A
Q
S
Y
P
S
R
W
T
Y
Site 70
Y686
I
R
I
S
A
Q
S
Y
P
S
R
W
T
Y
I
Site 71
T691
Q
S
Y
P
S
R
W
T
Y
I
E
F
Y
S
R
Site 72
Y692
S
Y
P
S
R
W
T
Y
I
E
F
Y
S
R
Y
Site 73
Y696
R
W
T
Y
I
E
F
Y
S
R
Y
G
I
L
M
Site 74
T704
S
R
Y
G
I
L
M
T
K
Q
E
L
S
F
S
Site 75
S709
L
M
T
K
Q
E
L
S
F
S
D
K
K
E
V
Site 76
S711
T
K
Q
E
L
S
F
S
D
K
K
E
V
C
K
Site 77
Y731
L
I
Q
D
S
N
Q
Y
Q
F
G
K
T
K
I
Site 78
Y747
F
R
A
G
Q
V
A
Y
L
E
K
L
R
L
D
Site 79
S759
R
L
D
K
L
R
Q
S
C
V
M
V
Q
K
H
Site 80
Y821
I
Q
K
H
C
R
G
Y
L
V
R
S
L
Y
Q
Site 81
Y850
G
F
L
A
R
R
R
Y
R
K
M
L
E
E
H
Site 82
S877
L
A
R
R
R
F
Q
S
I
R
R
F
V
L
N
Site 83
S914
G
L
V
E
K
L
T
S
L
A
A
L
R
A
G
Site 84
T938
A
E
L
E
K
A
A
T
H
R
R
N
Y
E
E
Site 85
Y943
A
A
T
H
R
R
N
Y
E
E
K
G
K
R
Y
Site 86
S966
A
K
L
Q
K
H
N
S
E
L
E
T
Q
K
E
Site 87
T970
K
H
N
S
E
L
E
T
Q
K
E
Q
I
Q
L
Site 88
T994
K
E
K
M
D
N
L
T
K
Q
L
F
D
D
V
Site 89
S1014
Q
R
M
L
L
E
K
S
F
E
L
K
T
Q
D
Site 90
Y1022
F
E
L
K
T
Q
D
Y
E
K
Q
I
Q
S
L
Site 91
S1054
V
E
G
E
H
V
T
S
D
G
L
K
A
E
V
Site 92
S1065
K
A
E
V
A
R
L
S
K
Q
V
K
T
I
S
Site 93
T1070
R
L
S
K
Q
V
K
T
I
S
E
F
E
K
E
Site 94
S1072
S
K
Q
V
K
T
I
S
E
F
E
K
E
I
E
Site 95
S1094
D
V
E
K
H
V
Q
S
Q
K
R
E
M
R
E
Site 96
S1104
R
E
M
R
E
K
M
S
E
I
T
K
Q
L
L
Site 97
S1121
Y
D
I
E
D
V
R
S
R
L
S
V
E
D
L
Site 98
S1124
E
D
V
R
S
R
L
S
V
E
D
L
E
H
L
Site 99
Y1141
D
G
E
L
W
F
A
Y
E
G
L
K
K
A
T
Site 100
S1153
K
A
T
R
V
L
E
S
H
F
Q
S
Q
K
D
Site 101
S1157
V
L
E
S
H
F
Q
S
Q
K
D
C
Y
E
K
Site 102
Y1162
F
Q
S
Q
K
D
C
Y
E
K
E
I
E
A
L
Site 103
T1205
R
H
E
V
T
R
L
T
S
E
N
M
M
I
P
Site 104
S1206
H
E
V
T
R
L
T
S
E
N
M
M
I
P
D
Site 105
S1247
K
G
K
L
E
E
L
S
N
Q
L
H
R
S
Q
Site 106
S1253
L
S
N
Q
L
H
R
S
Q
E
E
E
G
T
Q
Site 107
T1259
R
S
Q
E
E
E
G
T
Q
R
K
A
L
E
A
Site 108
T1314
R
Q
E
A
S
R
L
T
L
E
N
R
D
L
E
Site 109
T1340
K
L
Q
D
Q
V
K
T
L
S
K
T
I
G
K
Site 110
S1342
Q
D
Q
V
K
T
L
S
K
T
I
G
K
A
N
Site 111
S1353
G
K
A
N
D
V
H
S
S
S
G
P
K
E
Y
Site 112
S1355
A
N
D
V
H
S
S
S
G
P
K
E
Y
L
G
Site 113
Y1360
S
S
S
G
P
K
E
Y
L
G
M
L
Q
Y
K
Site 114
Y1366
E
Y
L
G
M
L
Q
Y
K
R
E
D
E
A
K
Site 115
S1418
N
D
A
N
M
L
K
S
L
M
N
S
T
I
N
Site 116
S1422
M
L
K
S
L
M
N
S
T
I
N
G
I
K
Q
Site 117
S1459
L
N
C
L
K
Q
Y
S
G
E
E
E
F
M
K
Site 118
S1483
C
L
N
N
F
D
L
S
E
Y
R
Q
I
L
S
Site 119
S1490
S
E
Y
R
Q
I
L
S
D
V
A
I
R
I
Y
Site 120
S1521
P
G
M
L
E
Y
E
S
L
Q
G
I
S
G
L
Site 121
S1537
P
T
G
F
R
K
R
S
S
S
I
D
D
T
D
Site 122
S1538
T
G
F
R
K
R
S
S
S
I
D
D
T
D
G
Site 123
S1539
G
F
R
K
R
S
S
S
I
D
D
T
D
G
Y
Site 124
T1543
R
S
S
S
I
D
D
T
D
G
Y
T
M
T
S
Site 125
Y1546
S
I
D
D
T
D
G
Y
T
M
T
S
V
L
Q
Site 126
T1547
I
D
D
T
D
G
Y
T
M
T
S
V
L
Q
Q
Site 127
S1550
T
D
G
Y
T
M
T
S
V
L
Q
Q
L
S
Y
Site 128
Y1612
Q
I
R
C
N
I
S
Y
L
E
E
W
L
K
D
Site 129
S1625
K
D
K
N
L
Q
N
S
L
A
K
E
T
L
E
Site 130
T1630
Q
N
S
L
A
K
E
T
L
E
P
L
S
Q
A
Site 131
S1635
K
E
T
L
E
P
L
S
Q
A
A
W
L
L
Q
Site 132
S1649
Q
V
K
K
T
T
D
S
D
A
K
E
I
Y
E
Site 133
Y1655
D
S
D
A
K
E
I
Y
E
R
C
T
S
L
S
Site 134
T1659
K
E
I
Y
E
R
C
T
S
L
S
A
V
Q
I
Site 135
Y1673
I
I
K
I
L
N
S
Y
T
P
I
D
D
F
E
Site 136
T1674
I
K
I
L
N
S
Y
T
P
I
D
D
F
E
K
Site 137
T1684
D
D
F
E
K
R
V
T
P
S
F
V
R
K
V
Site 138
S1686
F
E
K
R
V
T
P
S
F
V
R
K
V
Q
A
Site 139
S1697
K
V
Q
A
L
L
N
S
R
E
D
S
S
Q
L
Site 140
S1701
L
L
N
S
R
E
D
S
S
Q
L
M
L
D
T
Site 141
S1702
L
N
S
R
E
D
S
S
Q
L
M
L
D
T
K
Site 142
T1708
S
S
Q
L
M
L
D
T
K
Y
L
F
Q
V
T
Site 143
T1715
T
K
Y
L
F
Q
V
T
F
P
F
T
P
S
P
Site 144
T1719
F
Q
V
T
F
P
F
T
P
S
P
H
A
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation