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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPHN
Full Name:
Gephyrin
Alias:
GEPH; Gephyrin (GPH); GPH; KIAA1385
Type:
Adaptor/scaffold
Mass (Da):
79748
Number AA:
736
UniProt ID:
Q9NQX3
International Prot ID:
IPI00016006
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0000287
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0006777
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
R
N
L
A
E
D
R
S
G
I
N
L
K
D
L
Site 2
S47
K
D
L
V
Q
D
P
S
L
L
G
G
T
I
S
Site 3
T52
D
P
S
L
L
G
G
T
I
S
A
Y
K
I
V
Site 4
S54
S
L
L
G
G
T
I
S
A
Y
K
I
V
P
D
Site 5
T96
G
F
A
P
R
D
V
T
P
E
A
T
K
E
V
Site 6
T100
R
D
V
T
P
E
A
T
K
E
V
I
E
R
E
Site 7
T139
V
C
G
I
R
G
K
T
L
I
I
N
L
P
G
Site 8
S147
L
I
I
N
L
P
G
S
K
K
G
S
Q
E
C
Site 9
S151
L
P
G
S
K
K
G
S
Q
E
C
F
Q
F
I
Site 10
S188
D
E
L
E
D
L
P
S
P
P
P
P
L
S
P
Site 11
S194
P
S
P
P
P
P
L
S
P
P
P
T
T
S
P
Site 12
T198
P
P
L
S
P
P
P
T
T
S
P
H
K
Q
T
Site 13
T199
P
L
S
P
P
P
T
T
S
P
H
K
Q
T
E
Site 14
S200
L
S
P
P
P
T
T
S
P
H
K
Q
T
E
D
Site 15
T205
T
T
S
P
H
K
Q
T
E
D
K
G
V
Q
C
Site 16
S222
E
E
E
E
K
K
D
S
G
V
A
S
T
E
D
Site 17
S226
K
K
D
S
G
V
A
S
T
E
D
S
S
S
S
Site 18
T227
K
D
S
G
V
A
S
T
E
D
S
S
S
S
H
Site 19
S230
G
V
A
S
T
E
D
S
S
S
S
H
I
T
A
Site 20
S232
A
S
T
E
D
S
S
S
S
H
I
T
A
A
A
Site 21
T236
D
S
S
S
S
H
I
T
A
A
A
I
A
A
K
Site 22
S250
K
I
P
D
S
I
I
S
R
G
V
Q
V
L
P
Site 23
T260
V
Q
V
L
P
R
D
T
A
S
L
S
T
T
P
Site 24
S262
V
L
P
R
D
T
A
S
L
S
T
T
P
S
E
Site 25
S264
P
R
D
T
A
S
L
S
T
T
P
S
E
S
P
Site 26
T265
R
D
T
A
S
L
S
T
T
P
S
E
S
P
R
Site 27
T266
D
T
A
S
L
S
T
T
P
S
E
S
P
R
A
Site 28
S268
A
S
L
S
T
T
P
S
E
S
P
R
A
Q
A
Site 29
S270
L
S
T
T
P
S
E
S
P
R
A
Q
A
T
S
Site 30
T276
E
S
P
R
A
Q
A
T
S
R
L
S
T
A
S
Site 31
S277
S
P
R
A
Q
A
T
S
R
L
S
T
A
S
C
Site 32
S280
A
Q
A
T
S
R
L
S
T
A
S
C
P
T
P
Site 33
T281
Q
A
T
S
R
L
S
T
A
S
C
P
T
P
K
Site 34
S283
T
S
R
L
S
T
A
S
C
P
T
P
K
V
Q
Site 35
T286
L
S
T
A
S
C
P
T
P
K
V
Q
S
R
C
Site 36
S291
C
P
T
P
K
V
Q
S
R
C
S
S
K
E
N
Site 37
S294
P
K
V
Q
S
R
C
S
S
K
E
N
I
L
R
Site 38
S295
K
V
Q
S
R
C
S
S
K
E
N
I
L
R
A
Site 39
S303
K
E
N
I
L
R
A
S
H
S
A
V
D
I
T
Site 40
S305
N
I
L
R
A
S
H
S
A
V
D
I
T
K
V
Site 41
T310
S
H
S
A
V
D
I
T
K
V
A
R
R
H
R
Site 42
S319
V
A
R
R
H
R
M
S
P
F
P
L
T
S
M
Site 43
T324
R
M
S
P
F
P
L
T
S
M
D
K
A
F
I
Site 44
Y347
L
G
T
E
I
I
N
Y
R
D
G
M
G
R
V
Site 45
Y360
R
V
L
A
Q
D
V
Y
A
K
D
N
L
P
P
Site 46
S371
N
L
P
P
F
P
A
S
V
K
D
G
Y
A
V
Site 47
Y376
P
A
S
V
K
D
G
Y
A
V
R
A
A
D
G
Site 48
S393
D
R
F
I
I
G
E
S
Q
A
G
E
Q
P
T
Site 49
T402
A
G
E
Q
P
T
Q
T
V
M
P
G
Q
V
M
Site 50
S436
D
T
E
L
I
R
E
S
D
D
G
T
E
E
L
Site 51
T440
I
R
E
S
D
D
G
T
E
E
L
E
V
R
I
Site 52
S480
K
G
T
H
M
G
P
S
E
I
G
L
L
A
T
Site 53
S525
L
P
G
K
I
R
D
S
N
R
S
T
L
L
A
Site 54
S528
K
I
R
D
S
N
R
S
T
L
L
A
T
I
Q
Site 55
T529
I
R
D
S
N
R
S
T
L
L
A
T
I
Q
E
Site 56
Y539
A
T
I
Q
E
H
G
Y
P
T
I
N
L
G
I
Site 57
Y581
V
S
M
G
E
K
D
Y
L
K
Q
V
L
D
I
Site 58
T607
F
M
K
P
G
L
P
T
T
F
A
T
L
D
I
Site 59
T655
G
I
L
D
P
R
P
T
I
I
K
A
R
L
S
Site 60
Y673
K
L
D
P
R
P
E
Y
H
R
C
I
L
T
W
Site 61
S691
E
P
L
P
W
A
Q
S
T
G
N
Q
M
S
S
Site 62
T692
P
L
P
W
A
Q
S
T
G
N
Q
M
S
S
R
Site 63
S697
Q
S
T
G
N
Q
M
S
S
R
L
M
S
M
R
Site 64
S698
S
T
G
N
Q
M
S
S
R
L
M
S
M
R
S
Site 65
S702
Q
M
S
S
R
L
M
S
M
R
S
A
N
G
L
Site 66
T716
L
L
M
L
P
P
K
T
E
Q
Y
V
E
L
H
Site 67
Y719
L
P
P
K
T
E
Q
Y
V
E
L
H
K
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation