KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
XPNPEP1
Full Name:
Xaa-Pro aminopeptidase 1
Alias:
Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; SAmp; Soluble aminopeptidase P; X- prolyl aminopeptidase 1, soluble; XPNPEP; XPNPEPL; XPNPEPL1; XPP1; X-Pro aminopeptidase 1; X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Type:
EC 3.4.11.9; Protease
Mass (Da):
69787
Number AA:
622
UniProt ID:
Q9NQW7
International Prot ID:
IPI00179291
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0030145
GO:0008235
PhosphoSite+
KinaseNET
Biological Process:
GO:0009987
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
R
Q
A
M
R
N
S
E
Y
V
T
E
P
I
Site 2
Y22
Q
A
M
R
N
S
E
Y
V
T
E
P
I
Q
A
Site 3
T24
M
R
N
S
E
Y
V
T
E
P
I
Q
A
Y
I
Site 4
S40
P
S
G
D
A
H
Q
S
E
Y
I
A
P
C
D
Site 5
Y42
G
D
A
H
Q
S
E
Y
I
A
P
C
D
C
R
Site 6
S54
D
C
R
R
A
F
V
S
G
F
D
G
S
A
G
Site 7
Y78
A
M
W
T
D
G
R
Y
F
L
Q
A
A
K
Q
Site 8
T100
M
K
M
G
L
K
D
T
P
T
Q
E
D
W
L
Site 9
T102
M
G
L
K
D
T
P
T
Q
E
D
W
L
V
S
Site 10
S109
T
Q
E
D
W
L
V
S
V
L
P
E
G
S
R
Site 11
Y128
P
L
I
I
P
T
D
Y
W
K
K
M
A
K
V
Site 12
T156
N
L
V
D
K
I
W
T
D
R
P
E
R
P
C
Site 13
S177
G
L
D
Y
T
G
I
S
W
K
D
K
V
A
D
Site 14
S214
W
L
F
N
L
R
G
S
D
V
E
H
N
P
V
Site 15
S246
G
D
R
I
D
A
P
S
V
K
E
H
L
L
L
Site 16
Y268
Y
R
I
Q
V
H
P
Y
K
S
I
L
S
E
L
Site 17
S270
I
Q
V
H
P
Y
K
S
I
L
S
E
L
K
A
Site 18
S283
K
A
L
C
A
D
L
S
P
R
E
K
V
W
V
Site 19
S291
P
R
E
K
V
W
V
S
D
K
A
S
Y
A
V
Site 20
Y296
W
V
S
D
K
A
S
Y
A
V
S
E
T
I
P
Site 21
S299
D
K
A
S
Y
A
V
S
E
T
I
P
K
D
H
Site 22
Y312
D
H
R
C
C
M
P
Y
T
P
I
C
I
A
K
Site 23
T358
E
V
P
K
G
G
V
T
E
I
S
A
A
D
K
Site 24
S361
K
G
G
V
T
E
I
S
A
A
D
K
A
E
E
Site 25
S385
D
L
S
F
P
T
I
S
S
T
G
P
N
G
A
Site 26
S386
L
S
F
P
T
I
S
S
T
G
P
N
G
A
I
Site 27
Y396
P
N
G
A
I
I
H
Y
A
P
V
P
E
T
N
Site 28
T402
H
Y
A
P
V
P
E
T
N
R
T
L
S
L
D
Site 29
T405
P
V
P
E
T
N
R
T
L
S
L
D
E
V
Y
Site 30
S407
P
E
T
N
R
T
L
S
L
D
E
V
Y
L
I
Site 31
Y412
T
L
S
L
D
E
V
Y
L
I
D
S
G
A
Q
Site 32
Y420
L
I
D
S
G
A
Q
Y
K
D
G
T
T
D
V
Site 33
T424
G
A
Q
Y
K
D
G
T
T
D
V
T
R
T
M
Site 34
T425
A
Q
Y
K
D
G
T
T
D
V
T
R
T
M
H
Site 35
T428
K
D
G
T
T
D
V
T
R
T
M
H
F
G
T
Site 36
T430
G
T
T
D
V
T
R
T
M
H
F
G
T
P
T
Site 37
T435
T
R
T
M
H
F
G
T
P
T
A
Y
E
K
E
Site 38
T445
A
Y
E
K
E
C
F
T
Y
V
L
K
G
H
I
Site 39
Y446
Y
E
K
E
C
F
T
Y
V
L
K
G
H
I
A
Site 40
S470
T
K
G
H
L
L
D
S
F
A
R
S
A
L
W
Site 41
S479
A
R
S
A
L
W
D
S
G
L
D
Y
L
H
G
Site 42
Y483
L
W
D
S
G
L
D
Y
L
H
G
T
G
H
G
Site 43
T487
G
L
D
Y
L
H
G
T
G
H
G
V
G
S
F
Site 44
S493
G
T
G
H
G
V
G
S
F
L
N
V
H
E
G
Site 45
Y506
E
G
P
C
G
I
S
Y
K
T
F
S
D
E
P
Site 46
T508
P
C
G
I
S
Y
K
T
F
S
D
E
P
L
E
Site 47
S510
G
I
S
Y
K
T
F
S
D
E
P
L
E
A
G
Site 48
T521
L
E
A
G
M
I
V
T
D
E
P
G
Y
Y
E
Site 49
Y526
I
V
T
D
E
P
G
Y
Y
E
D
G
A
F
G
Site 50
Y527
V
T
D
E
P
G
Y
Y
E
D
G
A
F
G
I
Site 51
Y549
V
V
P
V
K
T
K
Y
N
F
N
N
R
G
S
Site 52
S556
Y
N
F
N
N
R
G
S
L
T
F
E
P
L
T
Site 53
S576
T
K
M
I
D
V
D
S
L
T
D
K
E
C
D
Site 54
Y588
E
C
D
W
L
N
N
Y
H
L
T
C
R
D
V
Site 55
T616
L
E
W
L
I
R
E
T
Q
P
I
S
K
Q
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation