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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
aven
Full Name:
Cell death regulator Aven
Alias:
Apoptosis, caspase activation inhibitor; PDCD12; Programmed cell death 12
Type:
Apoptosis; Inhibitor protein
Mass (Da):
38506
Number AA:
362
UniProt ID:
Q9NQS1
International Prot ID:
IPI00006904
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005622
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
R
P
G
G
D
R
H
S
E
R
P
G
A
A
A
Site 2
S75
G
G
G
A
P
R
G
S
R
R
E
P
G
G
W
Site 3
S87
G
G
W
G
A
G
A
S
A
P
V
E
D
D
S
Site 4
S94
S
A
P
V
E
D
D
S
D
A
E
T
Y
G
E
Site 5
T98
E
D
D
S
D
A
E
T
Y
G
E
E
N
D
E
Site 6
Y99
D
D
S
D
A
E
T
Y
G
E
E
N
D
E
Q
Site 7
Y109
E
N
D
E
Q
G
N
Y
S
K
R
K
I
V
S
Site 8
S110
N
D
E
Q
G
N
Y
S
K
R
K
I
V
S
N
Site 9
S116
Y
S
K
R
K
I
V
S
N
W
D
R
Y
Q
D
Site 10
Y121
I
V
S
N
W
D
R
Y
Q
D
I
E
K
E
V
Site 11
S135
V
N
N
E
S
G
E
S
Q
R
G
T
D
F
S
Site 12
T139
S
G
E
S
Q
R
G
T
D
F
S
V
L
L
S
Site 13
S142
S
Q
R
G
T
D
F
S
V
L
L
S
S
A
G
Site 14
S147
D
F
S
V
L
L
S
S
A
G
D
S
F
S
Q
Site 15
S153
S
S
A
G
D
S
F
S
Q
F
R
F
A
E
E
Site 16
S165
A
E
E
K
E
W
D
S
E
A
S
C
P
K
Q
Site 17
S174
A
S
C
P
K
Q
N
S
A
F
Y
V
D
S
E
Site 18
Y177
P
K
Q
N
S
A
F
Y
V
D
S
E
L
L
V
Site 19
S261
L
L
G
K
D
N
P
S
P
G
P
S
R
D
S
Site 20
S265
D
N
P
S
P
G
P
S
R
D
S
Q
K
P
T
Site 21
S268
S
P
G
P
S
R
D
S
Q
K
P
T
S
P
L
Site 22
T272
S
R
D
S
Q
K
P
T
S
P
L
Q
S
A
G
Site 23
S273
R
D
S
Q
K
P
T
S
P
L
Q
S
A
G
D
Site 24
S277
K
P
T
S
P
L
Q
S
A
G
D
H
L
E
E
Site 25
S308
N
I
L
P
D
Q
T
S
Q
D
L
K
S
K
E
Site 26
S313
Q
T
S
Q
D
L
K
S
K
E
D
G
E
V
V
Site 27
S330
E
E
V
C
A
K
P
S
V
T
E
E
K
N
M
Site 28
T344
M
E
P
E
Q
P
S
T
S
K
N
V
T
E
E
Site 29
S345
E
P
E
Q
P
S
T
S
K
N
V
T
E
E
E
Site 30
T349
P
S
T
S
K
N
V
T
E
E
E
L
E
D
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation