KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HEFL
Full Name:
Cas scaffolding protein family member 4
Alias:
C20ORF32; CT032; CT32; HEF1-Efs-p130Cas-like; HEF-like protein; HEPL
Type:
Adaptor/scaffold
Mass (Da):
87144
Number AA:
786
UniProt ID:
Q9NQ75
International Prot ID:
IPI00160340
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0000155
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
Y
D
N
C
P
D
C
S
D
E
L
A
F
S
R
Site 2
T72
A
N
R
L
Q
I
L
T
E
V
A
A
D
R
P
Site 3
S93
G
L
E
E
A
P
A
S
S
E
E
T
Y
Q
V
Site 4
Y98
P
A
S
S
E
E
T
Y
Q
V
P
T
L
P
R
Site 5
T102
E
E
T
Y
Q
V
P
T
L
P
R
P
P
T
P
Site 6
T108
P
T
L
P
R
P
P
T
P
G
P
V
Y
E
Q
Site 7
Y113
P
P
T
P
G
P
V
Y
E
Q
M
R
S
W
A
Site 8
S118
P
V
Y
E
Q
M
R
S
W
A
E
G
P
Q
P
Site 9
Y131
Q
P
P
T
A
Q
V
Y
E
F
P
D
P
P
T
Site 10
T138
Y
E
F
P
D
P
P
T
S
A
R
I
I
C
E
Site 11
S139
E
F
P
D
P
P
T
S
A
R
I
I
C
E
K
Site 12
T147
A
R
I
I
C
E
K
T
L
S
F
P
K
Q
A
Site 13
S149
I
I
C
E
K
T
L
S
F
P
K
Q
A
I
L
Site 14
T157
F
P
K
Q
A
I
L
T
L
P
R
P
V
R
A
Site 15
S165
L
P
R
P
V
R
A
S
L
P
T
L
P
S
Q
Site 16
T168
P
V
R
A
S
L
P
T
L
P
S
Q
V
Y
D
Site 17
S171
A
S
L
P
T
L
P
S
Q
V
Y
D
V
P
T
Site 18
Y174
P
T
L
P
S
Q
V
Y
D
V
P
T
Q
H
R
Site 19
T178
S
Q
V
Y
D
V
P
T
Q
H
R
G
P
V
V
Site 20
Y195
E
P
E
K
Q
Q
L
Y
D
I
P
A
S
P
K
Site 21
S200
Q
L
Y
D
I
P
A
S
P
K
K
A
G
L
H
Site 22
S211
A
G
L
H
P
P
D
S
Q
A
S
G
Q
G
V
Site 23
Y231
T
T
L
R
R
G
G
Y
S
T
L
P
N
P
Q
Site 24
S232
T
L
R
R
G
G
Y
S
T
L
P
N
P
Q
K
Site 25
T233
L
R
R
G
G
Y
S
T
L
P
N
P
Q
K
S
Site 26
Y244
P
Q
K
S
E
W
I
Y
D
T
P
V
S
P
G
Site 27
T246
K
S
E
W
I
Y
D
T
P
V
S
P
G
K
A
Site 28
S249
W
I
Y
D
T
P
V
S
P
G
K
A
S
V
R
Site 29
S254
P
V
S
P
G
K
A
S
V
R
N
T
P
L
T
Site 30
T258
G
K
A
S
V
R
N
T
P
L
T
S
F
A
E
Site 31
T261
S
V
R
N
T
P
L
T
S
F
A
E
E
S
R
Site 32
S262
V
R
N
T
P
L
T
S
F
A
E
E
S
R
P
Site 33
S274
S
R
P
H
A
L
P
S
S
S
S
T
F
Y
N
Site 34
S275
R
P
H
A
L
P
S
S
S
S
T
F
Y
N
P
Site 35
S276
P
H
A
L
P
S
S
S
S
T
F
Y
N
P
P
Site 36
S277
H
A
L
P
S
S
S
S
T
F
Y
N
P
P
S
Site 37
T278
A
L
P
S
S
S
S
T
F
Y
N
P
P
S
G
Site 38
Y280
P
S
S
S
S
T
F
Y
N
P
P
S
G
R
S
Site 39
S284
S
T
F
Y
N
P
P
S
G
R
S
R
S
L
T
Site 40
S289
P
P
S
G
R
S
R
S
L
T
P
Q
L
N
N
Site 41
T291
S
G
R
S
R
S
L
T
P
Q
L
N
N
N
V
Site 42
S305
V
P
M
Q
K
K
L
S
L
P
E
I
P
S
Y
Site 43
S311
L
S
L
P
E
I
P
S
Y
G
F
L
V
P
R
Site 44
Y312
S
L
P
E
I
P
S
Y
G
F
L
V
P
R
G
Site 45
S328
F
P
L
D
E
D
V
S
Y
K
V
P
S
S
F
Site 46
Y329
P
L
D
E
D
V
S
Y
K
V
P
S
S
F
L
Site 47
T345
P
R
V
E
Q
Q
N
T
K
P
N
I
Y
D
I
Site 48
Y350
Q
N
T
K
P
N
I
Y
D
I
P
K
A
T
S
Site 49
T356
I
Y
D
I
P
K
A
T
S
S
V
S
Q
A
G
Site 50
S358
D
I
P
K
A
T
S
S
V
S
Q
A
G
K
E
Site 51
S360
P
K
A
T
S
S
V
S
Q
A
G
K
E
L
E
Site 52
S376
A
K
E
V
S
E
N
S
A
G
H
N
S
S
W
Site 53
S381
E
N
S
A
G
H
N
S
S
W
F
S
R
R
T
Site 54
S382
N
S
A
G
H
N
S
S
W
F
S
R
R
T
T
Site 55
S385
G
H
N
S
S
W
F
S
R
R
T
T
S
P
S
Site 56
T388
S
S
W
F
S
R
R
T
T
S
P
S
P
E
P
Site 57
T389
S
W
F
S
R
R
T
T
S
P
S
P
E
P
D
Site 58
S390
W
F
S
R
R
T
T
S
P
S
P
E
P
D
R
Site 59
S392
S
R
R
T
T
S
P
S
P
E
P
D
R
L
S
Site 60
S399
S
P
E
P
D
R
L
S
G
S
S
S
D
S
R
Site 61
S401
E
P
D
R
L
S
G
S
S
S
D
S
R
A
S
Site 62
S402
P
D
R
L
S
G
S
S
S
D
S
R
A
S
I
Site 63
S403
D
R
L
S
G
S
S
S
D
S
R
A
S
I
V
Site 64
S405
L
S
G
S
S
S
D
S
R
A
S
I
V
S
S
Site 65
S408
S
S
S
D
S
R
A
S
I
V
S
S
C
S
T
Site 66
S411
D
S
R
A
S
I
V
S
S
C
S
T
T
S
T
Site 67
S412
S
R
A
S
I
V
S
S
C
S
T
T
S
T
D
Site 68
S414
A
S
I
V
S
S
C
S
T
T
S
T
D
D
S
Site 69
T415
S
I
V
S
S
C
S
T
T
S
T
D
D
S
S
Site 70
T416
I
V
S
S
C
S
T
T
S
T
D
D
S
S
S
Site 71
S417
V
S
S
C
S
T
T
S
T
D
D
S
S
S
S
Site 72
T418
S
S
C
S
T
T
S
T
D
D
S
S
S
S
S
Site 73
S421
S
T
T
S
T
D
D
S
S
S
S
S
S
E
E
Site 74
S422
T
T
S
T
D
D
S
S
S
S
S
S
E
E
S
Site 75
S423
T
S
T
D
D
S
S
S
S
S
S
E
E
S
A
Site 76
S424
S
T
D
D
S
S
S
S
S
S
E
E
S
A
K
Site 77
S425
T
D
D
S
S
S
S
S
S
E
E
S
A
K
E
Site 78
S426
D
D
S
S
S
S
S
S
E
E
S
A
K
E
L
Site 79
S429
S
S
S
S
S
E
E
S
A
K
E
L
S
L
D
Site 80
S434
E
E
S
A
K
E
L
S
L
D
L
D
V
A
K
Site 81
S463
A
G
L
M
L
F
V
S
R
K
W
R
F
R
D
Site 82
Y471
R
K
W
R
F
R
D
Y
L
E
A
N
I
D
A
Site 83
S482
N
I
D
A
I
H
R
S
T
D
H
I
E
E
S
Site 84
T483
I
D
A
I
H
R
S
T
D
H
I
E
E
S
V
Site 85
S489
S
T
D
H
I
E
E
S
V
R
E
F
L
D
F
Site 86
T503
F
A
R
G
V
H
G
T
A
C
N
L
T
D
S
Site 87
T508
H
G
T
A
C
N
L
T
D
S
N
L
Q
N
R
Site 88
T522
R
I
R
D
Q
M
Q
T
I
S
N
S
Y
R
I
Site 89
S526
Q
M
Q
T
I
S
N
S
Y
R
I
L
L
E
T
Site 90
T533
S
Y
R
I
L
L
E
T
K
E
S
L
D
N
R
Site 91
S536
I
L
L
E
T
K
E
S
L
D
N
R
N
W
P
Site 92
T549
W
P
L
E
V
L
V
T
D
S
V
Q
N
S
P
Site 93
S551
L
E
V
L
V
T
D
S
V
Q
N
S
P
D
D
Site 94
S555
V
T
D
S
V
Q
N
S
P
D
D
L
E
R
F
Site 95
S578
E
D
I
K
R
F
A
S
I
V
I
A
N
G
R
Site 96
T597
R
N
C
E
K
E
E
T
V
Q
L
T
P
N
A
Site 97
T601
K
E
E
T
V
Q
L
T
P
N
A
E
F
K
C
Site 98
Y611
A
E
F
K
C
E
K
Y
I
Q
P
P
Q
R
E
Site 99
T619
I
Q
P
P
Q
R
E
T
E
S
H
Q
K
S
T
Site 100
S621
P
P
Q
R
E
T
E
S
H
Q
K
S
T
P
S
Site 101
S625
E
T
E
S
H
Q
K
S
T
P
S
T
K
Q
R
Site 102
T626
T
E
S
H
Q
K
S
T
P
S
T
K
Q
R
E
Site 103
T629
H
Q
K
S
T
P
S
T
K
Q
R
E
D
E
H
Site 104
S637
K
Q
R
E
D
E
H
S
S
E
L
L
K
K
N
Site 105
S661
G
P
L
I
P
Q
P
S
S
Q
Q
T
P
E
R
Site 106
S662
P
L
I
P
Q
P
S
S
Q
Q
T
P
E
R
K
Site 107
T665
P
Q
P
S
S
Q
Q
T
P
E
R
K
P
R
L
Site 108
S673
P
E
R
K
P
R
L
S
E
H
C
R
L
Y
F
Site 109
Y679
L
S
E
H
C
R
L
Y
F
G
A
L
F
K
A
Site 110
S693
A
I
S
A
F
H
G
S
L
S
S
S
Q
P
A
Site 111
S695
S
A
F
H
G
S
L
S
S
S
Q
P
A
E
I
Site 112
S697
F
H
G
S
L
S
S
S
Q
P
A
E
I
I
T
Site 113
T719
V
G
Q
K
L
V
D
T
L
C
M
E
T
Q
E
Site 114
S737
R
N
E
I
L
R
G
S
S
H
L
C
S
L
L
Site 115
S738
N
E
I
L
R
G
S
S
H
L
C
S
L
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation