KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SPINK5
Full Name:
Serine protease inhibitor Kazal-type 5
Alias:
Lympho-epithelial Kazal-type-related inhibitor
Type:
Mass (Da):
120714
Number AA:
1064
UniProt ID:
Q9NQ38
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S76
I
L
E
K
E
A
K
S
Q
K
R
A
R
H
L
Site 2
T90
L
A
R
A
P
K
A
T
A
P
T
E
L
N
C
Site 3
Y115
D
F
I
C
P
D
Y
Y
E
A
V
C
G
T
D
Site 4
T125
V
C
G
T
D
G
K
T
Y
D
N
R
C
A
L
Site 5
Y126
C
G
T
D
G
K
T
Y
D
N
R
C
A
L
C
Site 6
T139
L
C
A
E
N
A
K
T
G
S
Q
I
G
V
K
Site 7
S141
A
E
N
A
K
T
G
S
Q
I
G
V
K
S
E
Site 8
S147
G
S
Q
I
G
V
K
S
E
G
E
C
K
S
S
Site 9
S153
K
S
E
G
E
C
K
S
S
N
P
E
Q
D
V
Site 10
S154
S
E
G
E
C
K
S
S
N
P
E
Q
D
V
C
Site 11
T189
V
L
G
P
D
G
K
T
H
G
N
K
C
A
M
Site 12
Y228
E
K
D
F
C
K
E
Y
E
K
Q
V
R
N
G
Site 13
T240
R
N
G
R
L
F
C
T
R
E
S
D
P
V
R
Site 14
S243
R
L
F
C
T
R
E
S
D
P
V
R
G
P
D
Site 15
S270
E
I
F
K
Q
R
F
S
E
E
N
S
K
T
D
Site 16
S274
Q
R
F
S
E
E
N
S
K
T
D
Q
N
L
G
Site 17
T276
F
S
E
E
N
S
K
T
D
Q
N
L
G
K
A
Site 18
T287
L
G
K
A
E
E
K
T
K
V
K
R
E
I
V
Site 19
S298
R
E
I
V
K
L
C
S
Q
Y
Q
N
Q
A
K
Site 20
Y336
L
C
S
M
C
Q
A
Y
F
Q
A
E
N
E
E
Site 21
S357
R
A
R
N
K
R
E
S
G
K
A
T
S
Y
A
Site 22
T361
K
R
E
S
G
K
A
T
S
Y
A
E
L
C
S
Site 23
S362
R
E
S
G
K
A
T
S
Y
A
E
L
C
S
E
Site 24
Y363
E
S
G
K
A
T
S
Y
A
E
L
C
S
E
Y
Site 25
S368
T
S
Y
A
E
L
C
S
E
Y
R
K
L
V
R
Site 26
S421
K
K
K
K
E
G
K
S
R
N
K
R
Q
S
K
Site 27
S427
K
S
R
N
K
R
Q
S
K
S
T
A
S
F
E
Site 28
S429
R
N
K
R
Q
S
K
S
T
A
S
F
E
E
L
Site 29
T430
N
K
R
Q
S
K
S
T
A
S
F
E
E
L
C
Site 30
S432
R
Q
S
K
S
T
A
S
F
E
E
L
C
S
E
Site 31
S438
A
S
F
E
E
L
C
S
E
Y
R
K
S
R
K
Site 32
S443
L
C
S
E
Y
R
K
S
R
K
N
G
R
L
F
Site 33
T507
R
D
Q
V
R
N
G
T
L
I
C
T
R
E
H
Site 34
Y573
L
C
S
E
Y
R
H
Y
V
R
N
G
R
L
P
Site 35
T582
R
N
G
R
L
P
C
T
R
E
N
D
P
I
E
Site 36
T660
V
R
G
P
D
G
K
T
H
G
N
K
C
A
M
Site 37
S695
R
N
A
A
G
H
G
S
S
G
G
G
G
G
N
Site 38
T703
S
G
G
G
G
G
N
T
Q
D
E
C
A
E
Y
Site 39
Y710
T
Q
D
E
C
A
E
Y
R
E
Q
M
K
N
G
Site 40
S720
Q
M
K
N
G
R
L
S
C
T
R
E
S
D
P
Site 41
S725
R
L
S
C
T
R
E
S
D
P
V
R
D
A
D
Site 42
Y736
R
D
A
D
G
K
S
Y
N
N
Q
C
T
M
C
Site 43
Y757
E
A
E
R
K
N
E
Y
S
R
S
R
S
N
G
Site 44
S758
A
E
R
K
N
E
Y
S
R
S
R
S
N
G
T
Site 45
S760
R
K
N
E
Y
S
R
S
R
S
N
G
T
G
S
Site 46
S762
N
E
Y
S
R
S
R
S
N
G
T
G
S
E
S
Site 47
T765
S
R
S
R
S
N
G
T
G
S
E
S
G
K
D
Site 48
S767
S
R
S
N
G
T
G
S
E
S
G
K
D
T
C
Site 49
S769
S
N
G
T
G
S
E
S
G
K
D
T
C
D
E
Site 50
T773
G
S
E
S
G
K
D
T
C
D
E
F
R
S
Q
Site 51
S779
D
T
C
D
E
F
R
S
Q
M
K
N
G
K
L
Site 52
S792
K
L
I
C
T
R
E
S
D
P
V
R
G
P
D
Site 53
T802
V
R
G
P
D
G
K
T
H
G
N
K
C
T
M
Site 54
S830
K
K
E
D
E
D
R
S
N
T
G
E
R
S
N
Site 55
T832
E
D
E
D
R
S
N
T
G
E
R
S
N
T
G
Site 56
T838
N
T
G
E
R
S
N
T
G
E
R
S
N
D
K
Site 57
S842
R
S
N
T
G
E
R
S
N
D
K
E
D
L
C
Site 58
S854
D
L
C
R
E
F
R
S
M
Q
R
N
G
K
L
Site 59
Y874
N
N
P
V
R
G
P
Y
G
K
M
H
I
N
K
Site 60
S904
K
K
K
D
E
E
K
S
S
S
K
P
S
N
N
Site 61
S905
K
K
D
E
E
K
S
S
S
K
P
S
N
N
A
Site 62
S906
K
D
E
E
K
S
S
S
K
P
S
N
N
A
K
Site 63
S909
E
K
S
S
S
K
P
S
N
N
A
K
D
E
C
Site 64
Y922
E
C
S
E
F
R
N
Y
I
R
N
N
E
L
I
Site 65
S971
A
K
L
Q
E
K
P
S
H
V
R
A
S
Q
E
Site 66
S976
K
P
S
H
V
R
A
S
Q
E
E
D
S
P
D
Site 67
S981
R
A
S
Q
E
E
D
S
P
D
S
F
S
S
L
Site 68
S984
Q
E
E
D
S
P
D
S
F
S
S
L
D
S
E
Site 69
S986
E
D
S
P
D
S
F
S
S
L
D
S
E
M
C
Site 70
S987
D
S
P
D
S
F
S
S
L
D
S
E
M
C
K
Site 71
S990
D
S
F
S
S
L
D
S
E
M
C
K
D
Y
R
Site 72
Y996
D
S
E
M
C
K
D
Y
R
V
L
P
R
I
G
Site 73
Y1004
R
V
L
P
R
I
G
Y
L
C
P
K
D
L
K
Site 74
T1036
H
E
N
L
I
R
Q
T
N
T
H
I
R
S
T
Site 75
T1038
N
L
I
R
Q
T
N
T
H
I
R
S
T
G
K
Site 76
T1043
T
N
T
H
I
R
S
T
G
K
C
E
E
S
S
Site 77
S1049
S
T
G
K
C
E
E
S
S
T
P
G
T
T
A
Site 78
S1050
T
G
K
C
E
E
S
S
T
P
G
T
T
A
A
Site 79
T1051
G
K
C
E
E
S
S
T
P
G
T
T
A
A
S
Site 80
T1054
E
E
S
S
T
P
G
T
T
A
A
S
M
P
P
Site 81
S1058
T
P
G
T
T
A
A
S
M
P
P
S
D
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation