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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIC8A
Full Name:
Synembryn-A
Alias:
Resistance to inhibitors of cholinesterase 8 A; Resistance to inhibitors of cholinesterase 8 homolog A; RIC8; Ric-8A; Synembryn
Type:
Guanine nucleotide exchange factor, misc.
Mass (Da):
59612
Number AA:
530
UniProt ID:
Q9NPQ8
International Prot ID:
IPI00746360
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
V
I
M
E
A
L
R
S
Y
N
Q
E
H
S
Q
Site 2
Y25
I
M
E
A
L
R
S
Y
N
Q
E
H
S
Q
S
Site 3
S30
R
S
Y
N
Q
E
H
S
Q
S
F
T
F
D
D
Site 4
S32
Y
N
Q
E
H
S
Q
S
F
T
F
D
D
A
Q
Site 5
T34
Q
E
H
S
Q
S
F
T
F
D
D
A
Q
Q
E
Site 6
S61
L
E
Q
G
L
P
P
S
H
R
V
I
W
L
Q
Site 7
S69
H
R
V
I
W
L
Q
S
V
R
I
L
S
R
D
Site 8
S74
L
Q
S
V
R
I
L
S
R
D
R
N
C
L
D
Site 9
T84
R
N
C
L
D
P
F
T
S
R
Q
S
L
Q
A
Site 10
S85
N
C
L
D
P
F
T
S
R
Q
S
L
Q
A
L
Site 11
S88
D
P
F
T
S
R
Q
S
L
Q
A
L
A
C
Y
Site 12
S101
C
Y
A
D
I
S
V
S
E
G
S
V
P
E
S
Site 13
S104
D
I
S
V
S
E
G
S
V
P
E
S
A
D
M
Site 14
S108
S
E
G
S
V
P
E
S
A
D
M
D
V
V
L
Site 15
Y151
L
T
E
R
V
G
L
Y
R
E
R
S
F
P
H
Site 16
S155
V
G
L
Y
R
E
R
S
F
P
H
D
V
Q
F
Site 17
T199
L
T
D
T
L
E
L
T
L
G
V
T
P
E
G
Site 18
T203
L
E
L
T
L
G
V
T
P
E
G
N
P
P
T
Site 19
T210
T
P
E
G
N
P
P
T
L
L
P
S
Q
E
T
Site 20
S214
N
P
P
T
L
L
P
S
Q
E
T
E
R
A
M
Site 21
S234
L
F
N
I
T
L
D
S
I
K
G
E
V
D
E
Site 22
Y247
D
E
E
D
A
A
L
Y
R
H
L
G
T
L
L
Site 23
T267
I
A
T
A
G
D
R
T
E
E
F
H
G
H
A
Site 24
T291
K
C
L
D
V
L
L
T
L
E
P
H
G
D
S
Site 25
S298
T
L
E
P
H
G
D
S
T
E
F
M
G
V
N
Site 26
T299
L
E
P
H
G
D
S
T
E
F
M
G
V
N
M
Site 27
T323
L
E
K
R
L
H
K
T
H
R
L
K
E
S
V
Site 28
S329
K
T
H
R
L
K
E
S
V
A
P
V
L
S
V
Site 29
T364
P
P
L
R
D
V
R
T
R
P
E
V
G
E
M
Site 30
T381
N
K
L
V
R
L
M
T
H
L
D
T
D
V
K
Site 31
T385
R
L
M
T
H
L
D
T
D
V
K
R
V
A
A
Site 32
Y409
S
V
P
R
F
I
K
Y
T
G
Y
G
N
A
A
Site 33
T410
V
P
R
F
I
K
Y
T
G
Y
G
N
A
A
G
Site 34
Y412
R
F
I
K
Y
T
G
Y
G
N
A
A
G
L
L
Site 35
Y434
G
G
R
P
E
G
Q
Y
S
E
D
E
D
T
D
Site 36
S435
G
R
P
E
G
Q
Y
S
E
D
E
D
T
D
T
Site 37
T440
Q
Y
S
E
D
E
D
T
D
T
D
E
Y
K
E
Site 38
T442
S
E
D
E
D
T
D
T
D
E
Y
K
E
A
K
Site 39
Y445
E
D
T
D
T
D
E
Y
K
E
A
K
A
S
I
Site 40
S451
E
Y
K
E
A
K
A
S
I
N
P
V
T
G
R
Site 41
T456
K
A
S
I
N
P
V
T
G
R
V
E
E
K
P
Site 42
S490
V
T
M
F
D
K
L
S
R
N
R
V
I
Q
P
Site 43
S501
V
I
Q
P
M
G
M
S
P
R
G
H
L
T
S
Site 44
T507
M
S
P
R
G
H
L
T
S
L
Q
D
A
M
C
Site 45
S508
S
P
R
G
H
L
T
S
L
Q
D
A
M
C
E
Site 46
T516
L
Q
D
A
M
C
E
T
M
E
Q
Q
L
S
S
Site 47
S522
E
T
M
E
Q
Q
L
S
S
D
P
D
S
D
P
Site 48
S523
T
M
E
Q
Q
L
S
S
D
P
D
S
D
P
D
Site 49
S527
Q
L
S
S
D
P
D
S
D
P
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation