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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ISYNA1
Full Name:
Inositol-3-phosphate synthase 1
Alias:
Myo-inositol 1-phosphate synthase A1;Myo-inositol-1-phosphate synthase
Type:
Mass (Da):
61049
Number AA:
558
UniProt ID:
Q9NPH2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0004512
PhosphoSite+
KinaseNET
Biological Process:
GO:0006021
GO:0008654
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
V
E
S
P
D
V
V
Y
G
P
E
A
I
E
A
Site 2
Y25
P
E
A
I
E
A
Q
Y
E
Y
R
T
T
R
V
Site 3
T29
E
A
Q
Y
E
Y
R
T
T
R
V
S
R
E
G
Site 4
T30
A
Q
Y
E
Y
R
T
T
R
V
S
R
E
G
G
Site 5
S33
E
Y
R
T
T
R
V
S
R
E
G
G
V
L
K
Site 6
T44
G
V
L
K
V
H
P
T
S
T
R
F
T
F
R
Site 7
S45
V
L
K
V
H
P
T
S
T
R
F
T
F
R
T
Site 8
T49
H
P
T
S
T
R
F
T
F
R
T
A
R
Q
V
Site 9
T52
S
T
R
F
T
F
R
T
A
R
Q
V
P
R
L
Site 10
S86
L
A
N
R
L
R
L
S
W
P
T
R
S
G
R
Site 11
T89
R
L
R
L
S
W
P
T
R
S
G
R
K
E
A
Site 12
S91
R
L
S
W
P
T
R
S
G
R
K
E
A
N
Y
Site 13
Y98
S
G
R
K
E
A
N
Y
Y
G
S
L
T
Q
A
Site 14
Y99
G
R
K
E
A
N
Y
Y
G
S
L
T
Q
A
G
Site 15
S101
K
E
A
N
Y
Y
G
S
L
T
Q
A
G
T
V
Site 16
T103
A
N
Y
Y
G
S
L
T
Q
A
G
T
V
S
L
Site 17
S177
E
A
L
R
P
R
P
S
V
Y
I
P
E
F
I
Site 18
S189
E
F
I
A
A
N
Q
S
A
R
A
D
N
L
I
Site 19
S199
A
D
N
L
I
P
G
S
R
A
Q
Q
L
E
Q
Site 20
S216
R
D
I
R
D
F
R
S
S
A
G
L
D
K
V
Site 21
S217
D
I
R
D
F
R
S
S
A
G
L
D
K
V
I
Site 22
T283
L
N
G
S
P
Q
N
T
L
V
P
G
A
L
E
Site 23
S306
V
G
G
D
D
F
K
S
G
Q
T
K
V
K
S
Site 24
S328
G
S
G
L
K
T
M
S
I
V
S
Y
N
H
L
Site 25
Y332
K
T
M
S
I
V
S
Y
N
H
L
G
N
N
D
Site 26
S344
N
N
D
G
E
N
L
S
A
P
L
Q
F
R
S
Site 27
S351
S
A
P
L
Q
F
R
S
K
E
V
S
K
S
N
Site 28
S355
Q
F
R
S
K
E
V
S
K
S
N
V
V
D
D
Site 29
S357
R
S
K
E
V
S
K
S
N
V
V
D
D
M
V
Site 30
Y371
V
Q
S
N
P
V
L
Y
T
P
G
E
E
P
D
Site 31
T372
Q
S
N
P
V
L
Y
T
P
G
E
E
P
D
H
Site 32
S392
Y
V
P
Y
V
G
D
S
K
R
A
L
D
E
Y
Site 33
Y399
S
K
R
A
L
D
E
Y
T
S
E
L
M
L
G
Site 34
T400
K
R
A
L
D
E
Y
T
S
E
L
M
L
G
G
Site 35
S401
R
A
L
D
E
Y
T
S
E
L
M
L
G
G
T
Site 36
T452
D
M
D
P
E
P
Q
T
F
H
P
V
L
S
L
Site 37
S473
A
P
L
V
P
P
G
S
P
V
V
N
A
L
F
Site 38
S484
N
A
L
F
R
Q
R
S
C
I
E
N
I
L
R
Site 39
S514
K
M
E
R
P
G
P
S
L
K
R
V
G
P
V
Site 40
Y525
V
G
P
V
A
A
T
Y
P
M
L
N
K
K
G
Site 41
T538
K
G
P
V
P
A
A
T
N
G
C
T
G
D
A
Site 42
T557
Q
E
E
P
P
M
P
T
T
_
_
_
_
_
_
Site 43
T558
E
E
P
P
M
P
T
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation