PhosphoNET

           
Protein Info 
   
Short Name:  SIX2
Full Name:  Homeobox protein SIX2
Alias:  Sine oculis homeobox homolog 2
Type: 
Mass (Da):  32286
Number AA:  291
UniProt ID:  Q9NPC8
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S48EHLHKNESVLKAKAV
Site 2Y67RGNFRELYKILESHQ
Site 3S72ELYKILESHQFSPHN
Site 4S76ILESHQFSPHNHAKL
Site 5Y109PLGAVGKYRVRRKFP
Site 6S120RKFPLPRSIWDGEET
Site 7Y129WDGEETSYCFKEKSR
Site 8S135SYCFKEKSRSVLREW
Site 9S137CFKEKSRSVLREWYA
Site 10Y143RSVLREWYAHNPYPS
Site 11Y148EWYAHNPYPSPREKR
Site 12S150YAHNPYPSPREKREL
Site 13S193ERENNENSNSNSHNP
Site 14S195ENNENSNSNSHNPLN
Site 15S197NENSNSNSHNPLNGS
Site 16S204SHNPLNGSGKSVLGS
Site 17S207PLNGSGKSVLGSSED
Site 18S211SGKSVLGSSEDEKTP
Site 19S212GKSVLGSSEDEKTPS
Site 20T217GSSEDEKTPSGTPDH
Site 21S219SEDEKTPSGTPDHSS
Site 22T221DEKTPSGTPDHSSSS
Site 23S225PSGTPDHSSSSPALL
Site 24S226SGTPDHSSSSPALLL
Site 25S227GTPDHSSSSPALLLS
Site 26S228TPDHSSSSPALLLSP
Site 27S242PPPPGLPSLHSLGHP
Site 28S245PGLPSLHSLGHPPGP
Site 29S277HHHGLQDSILNPMSA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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