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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLM
Full Name:
DNA-directed DNA/RNA polymerase mu
Alias:
DPOLM; EC 2.7.7.7; Pol iota; Pol Mu; Tdt-N
Type:
DNA repair
Mass (Da):
54816
Number AA:
494
UniProt ID:
Q9NP87
International Prot ID:
IPI00002325
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003912
GO:0003887
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
R
R
R
A
R
V
G
S
P
S
G
D
A
A
S
Site 2
S14
R
A
R
V
G
S
P
S
G
D
A
A
S
S
T
Site 3
S19
S
P
S
G
D
A
A
S
S
T
P
P
S
T
R
Site 4
S20
P
S
G
D
A
A
S
S
T
P
P
S
T
R
F
Site 5
T21
S
G
D
A
A
S
S
T
P
P
S
T
R
F
P
Site 6
S24
A
A
S
S
T
P
P
S
T
R
F
P
G
V
A
Site 7
T25
A
S
S
T
P
P
S
T
R
F
P
G
V
A
I
Site 8
S42
V
E
P
R
M
G
R
S
R
R
A
F
L
T
G
Site 9
T48
R
S
R
R
A
F
L
T
G
L
A
R
S
K
G
Site 10
T67
D
A
C
S
S
E
A
T
H
V
V
M
E
E
T
Site 11
S81
T
S
A
E
E
A
V
S
W
Q
E
R
R
M
A
Site 12
T95
A
A
A
P
P
G
C
T
P
P
A
L
L
D
I
Site 13
S108
D
I
S
W
L
T
E
S
L
G
A
G
Q
P
V
Site 14
S134
G
P
R
K
G
P
L
S
P
A
W
M
P
A
Y
Site 15
Y141
S
P
A
W
M
P
A
Y
A
C
Q
R
P
T
P
Site 16
T147
A
Y
A
C
Q
R
P
T
P
L
T
H
H
N
T
Site 17
T150
C
Q
R
P
T
P
L
T
H
H
N
T
G
L
S
Site 18
S172
E
A
A
G
F
E
G
S
E
G
R
L
L
T
F
Site 19
T194
K
A
L
P
S
P
V
T
T
L
S
Q
L
Q
G
Site 20
S197
P
S
P
V
T
T
L
S
Q
L
Q
G
L
P
H
Site 21
S209
L
P
H
F
G
E
H
S
S
R
V
V
Q
E
L
Site 22
S210
P
H
F
G
E
H
S
S
R
V
V
Q
E
L
L
Site 23
S231
E
V
E
R
V
R
R
S
E
R
Y
Q
T
M
K
Site 24
Y234
R
V
R
R
S
E
R
Y
Q
T
M
K
L
F
T
Site 25
T236
R
R
S
E
R
Y
Q
T
M
K
L
F
T
Q
I
Site 26
T250
I
F
G
V
G
V
K
T
A
D
R
W
Y
R
E
Site 27
Y255
V
K
T
A
D
R
W
Y
R
E
G
L
R
T
L
Site 28
T261
W
Y
R
E
G
L
R
T
L
D
D
L
R
E
Q
Site 29
S287
L
Q
H
H
Q
D
L
S
T
P
V
L
R
S
D
Site 30
T288
Q
H
H
Q
D
L
S
T
P
V
L
R
S
D
V
Site 31
S293
L
S
T
P
V
L
R
S
D
V
D
A
L
Q
Q
Site 32
T318
P
G
A
T
V
T
L
T
G
G
F
R
R
G
K
Site 33
Y362
Q
D
Q
G
L
I
L
Y
H
Q
H
Q
H
S
C
Site 34
S372
H
Q
H
S
C
C
E
S
P
T
R
L
A
Q
Q
Site 35
S380
P
T
R
L
A
Q
Q
S
H
M
D
A
F
E
R
Site 36
S405
P
G
A
A
V
G
G
S
T
R
P
C
P
S
W
Site 37
S411
G
S
T
R
P
C
P
S
W
K
A
V
R
V
D
Site 38
S437
A
L
L
G
W
T
G
S
K
L
F
Q
R
E
L
Site 39
S448
Q
R
E
L
R
R
F
S
R
K
E
K
G
L
W
Site 40
T468
L
F
D
P
E
Q
K
T
F
F
Q
A
A
S
E
Site 41
Y486
F
R
H
L
G
L
E
Y
L
P
P
E
Q
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation