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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PNPLA8
Full Name:
Calcium-independent phospholipase A2-gamma
Alias:
Intracellular membrane-associated calcium-independent phospholipase A2 gamma; IPLA2(GAMMA); IPLA2-2; IPLA2G; IPLA2-gamma; Patatin-like phospholipase domain containing 8; Patatin-like phospholipase domain-containing protein 8
Type:
Phospholipase; EC 3.1.1.5
Mass (Da):
88480
Number AA:
UniProt ID:
Q9NP80
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0047499
GO:0004622
PhosphoSite+
KinaseNET
Biological Process:
GO:0006631
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
Y
L
L
S
N
A
R
S
V
C
G
K
Q
R
S
Site 2
S26
S
V
C
G
K
Q
R
S
K
Q
L
Y
F
L
F
Site 3
Y30
K
Q
R
S
K
Q
L
Y
F
L
F
S
P
K
H
Site 4
Y38
F
L
F
S
P
K
H
Y
W
R
I
S
H
I
S
Site 5
S68
K
S
E
A
H
S
C
S
K
H
C
Y
S
P
S
Site 6
Y72
H
S
C
S
K
H
C
Y
S
P
S
N
H
G
L
Site 7
S73
S
C
S
K
H
C
Y
S
P
S
N
H
G
L
H
Site 8
S89
G
I
L
K
L
S
T
S
A
P
K
G
L
T
K
Site 9
S102
T
K
V
N
I
C
M
S
R
I
K
S
T
L
N
Site 10
S106
I
C
M
S
R
I
K
S
T
L
N
S
V
S
K
Site 11
S110
R
I
K
S
T
L
N
S
V
S
K
A
V
F
G
Site 12
S112
K
S
T
L
N
S
V
S
K
A
V
F
G
N
Q
Site 13
S133
L
A
Q
F
K
P
S
S
Q
I
L
R
K
V
S
Site 14
S140
S
Q
I
L
R
K
V
S
D
S
G
W
L
K
Q
Site 15
S142
I
L
R
K
V
S
D
S
G
W
L
K
Q
K
N
Site 16
S156
N
I
K
Q
A
I
K
S
L
K
K
Y
S
D
K
Site 17
Y160
A
I
K
S
L
K
K
Y
S
D
K
S
A
E
K
Site 18
S164
L
K
K
Y
S
D
K
S
A
E
K
S
P
F
P
Site 19
S168
S
D
K
S
A
E
K
S
P
F
P
E
E
K
S
Site 20
S188
E
E
D
I
G
K
R
S
L
F
H
Y
T
S
S
Site 21
Y192
G
K
R
S
L
F
H
Y
T
S
S
I
T
T
K
Site 22
S194
R
S
L
F
H
Y
T
S
S
I
T
T
K
F
G
Site 23
S195
S
L
F
H
Y
T
S
S
I
T
T
K
F
G
D
Site 24
T198
H
Y
T
S
S
I
T
T
K
F
G
D
S
F
Y
Site 25
Y205
T
K
F
G
D
S
F
Y
F
L
S
N
H
I
N
Site 26
Y214
L
S
N
H
I
N
S
Y
F
K
R
K
E
K
M
Site 27
S222
F
K
R
K
E
K
M
S
Q
Q
K
E
N
E
H
Site 28
S234
N
E
H
F
R
D
K
S
E
L
E
D
K
K
V
Site 29
S248
V
E
E
G
K
L
R
S
P
D
P
G
I
L
A
Site 30
Y256
P
D
P
G
I
L
A
Y
K
P
G
S
E
S
V
Site 31
S260
I
L
A
Y
K
P
G
S
E
S
V
H
T
V
D
Site 32
T265
P
G
S
E
S
V
H
T
V
D
K
P
T
S
P
Site 33
S271
H
T
V
D
K
P
T
S
P
S
A
I
P
D
V
Site 34
S282
I
P
D
V
L
Q
V
S
T
K
Q
S
I
A
N
Site 35
S286
L
Q
V
S
T
K
Q
S
I
A
N
F
L
S
R
Site 36
S292
Q
S
I
A
N
F
L
S
R
P
T
E
G
V
Q
Site 37
Y315
G
L
V
P
K
L
K
Y
D
S
K
S
Q
S
E
Site 38
S317
V
P
K
L
K
Y
D
S
K
S
Q
S
E
E
Q
Site 39
S319
K
L
K
Y
D
S
K
S
Q
S
E
E
Q
E
E
Site 40
S321
K
Y
D
S
K
S
Q
S
E
E
Q
E
E
P
A
Site 41
T330
E
Q
E
E
P
A
K
T
D
Q
A
V
S
K
D
Site 42
S347
A
E
E
K
K
R
L
S
L
Q
R
E
K
I
I
Site 43
S358
E
K
I
I
A
R
V
S
I
D
N
R
T
R
A
Site 44
T374
V
Q
A
L
R
R
T
T
D
P
K
L
C
I
T
Site 45
T381
T
D
P
K
L
C
I
T
R
V
E
E
L
T
F
Site 46
T419
L
R
Q
I
K
D
E
T
L
Q
A
A
V
R
E
Site 47
S446
G
R
G
I
R
I
L
S
I
D
G
G
G
T
R
Site 48
T468
L
R
K
L
V
E
L
T
Q
K
P
V
H
Q
L
Site 49
Y506
L
D
E
C
E
E
L
Y
R
K
L
G
S
D
V
Site 50
S511
E
L
Y
R
K
L
G
S
D
V
F
S
Q
N
V
Site 51
T522
S
Q
N
V
I
V
G
T
V
K
M
S
W
S
H
Site 52
Y583
K
A
F
V
F
R
N
Y
G
H
F
P
G
I
N
Site 53
Y593
F
P
G
I
N
S
H
Y
L
G
G
C
Q
Y
K
Site 54
T660
E
C
I
V
S
L
G
T
G
R
Y
E
S
D
V
Site 55
Y663
V
S
L
G
T
G
R
Y
E
S
D
V
R
N
T
Site 56
S665
L
G
T
G
R
Y
E
S
D
V
R
N
T
V
T
Site 57
T670
Y
E
S
D
V
R
N
T
V
T
Y
T
S
L
K
Site 58
Y673
D
V
R
N
T
V
T
Y
T
S
L
K
T
K
L
Site 59
S675
R
N
T
V
T
Y
T
S
L
K
T
K
L
S
N
Site 60
S681
T
S
L
K
T
K
L
S
N
V
I
N
S
A
T
Site 61
T705
D
G
L
L
P
P
D
T
Y
F
R
F
N
P
V
Site 62
Y737
L
Q
L
E
G
L
K
Y
I
E
R
N
E
Q
K
Site 63
S753
K
K
V
A
K
I
L
S
Q
E
K
T
T
L
Q
Site 64
T757
K
I
L
S
Q
E
K
T
T
L
Q
K
I
N
D
Site 65
Y773
I
K
L
K
T
D
M
Y
E
G
L
P
F
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation