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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARFGAP3
Full Name:
ADP-ribosylation factor GTPase-activating protein 3
Alias:
ADP-ribosylation factor GTPase activating protein 3; ARFG3; ARFGAP1; ARG3
Type:
GTPase-activating protein for G protein
Mass (Da):
56928
Number AA:
516
UniProt ID:
Q9NP61
International Prot ID:
IPI00299263
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0008565
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0009306
GO:0032312
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
P
S
K
Q
D
I
L
T
I
F
K
R
L
R
S
Site 2
S18
T
I
F
K
R
L
R
S
V
P
T
N
K
V
C
Site 3
S34
D
C
G
A
K
N
P
S
W
A
S
I
T
Y
G
Site 4
S54
D
C
S
G
S
H
R
S
L
G
V
H
L
S
F
Site 5
S64
V
H
L
S
F
I
R
S
T
E
L
D
S
N
W
Site 6
T65
H
L
S
F
I
R
S
T
E
L
D
S
N
W
S
Site 7
S86
M
Q
V
G
G
N
A
S
A
S
S
F
F
H
Q
Site 8
S88
V
G
G
N
A
S
A
S
S
F
F
H
Q
H
G
Site 9
S89
G
G
N
A
S
A
S
S
F
F
H
Q
H
G
C
Site 10
T101
H
G
C
S
T
N
D
T
N
A
K
Y
N
S
R
Site 11
Y105
T
N
D
T
N
A
K
Y
N
S
R
A
A
Q
L
Site 12
Y113
N
S
R
A
A
Q
L
Y
R
E
K
I
K
S
L
Site 13
S119
L
Y
R
E
K
I
K
S
L
A
S
Q
A
T
R
Site 14
S122
E
K
I
K
S
L
A
S
Q
A
T
R
K
H
G
Site 15
S143
S
C
V
V
P
P
L
S
P
P
P
K
E
E
D
Site 16
S154
K
E
E
D
F
F
A
S
H
V
S
P
E
V
S
Site 17
S157
D
F
F
A
S
H
V
S
P
E
V
S
D
T
A
Site 18
S161
S
H
V
S
P
E
V
S
D
T
A
W
A
S
A
Site 19
S167
V
S
D
T
A
W
A
S
A
I
A
E
P
S
S
Site 20
S173
A
S
A
I
A
E
P
S
S
L
T
S
R
P
V
Site 21
S174
S
A
I
A
E
P
S
S
L
T
S
R
P
V
E
Site 22
S177
A
E
P
S
S
L
T
S
R
P
V
E
T
T
L
Site 23
T183
T
S
R
P
V
E
T
T
L
E
N
N
E
G
G
Site 24
S196
G
G
Q
E
Q
G
P
S
V
E
G
L
N
V
P
Site 25
S212
K
A
T
L
E
V
S
S
I
I
K
K
K
P
N
Site 26
S231
G
L
G
A
K
K
G
S
L
G
A
Q
K
L
A
Site 27
S266
E
D
L
A
K
V
V
S
K
E
E
S
I
V
S
Site 28
S270
K
V
V
S
K
E
E
S
I
V
S
S
L
R
L
Site 29
S273
S
K
E
E
S
I
V
S
S
L
R
L
A
Y
K
Site 30
S274
K
E
E
S
I
V
S
S
L
R
L
A
Y
K
D
Site 31
Y279
V
S
S
L
R
L
A
Y
K
D
L
E
I
Q
M
Site 32
S302
S
G
K
K
N
V
D
S
D
R
L
G
M
G
F
Site 33
S317
G
N
C
R
S
V
I
S
H
S
V
T
S
D
M
Site 34
S319
C
R
S
V
I
S
H
S
V
T
S
D
M
Q
T
Site 35
T321
S
V
I
S
H
S
V
T
S
D
M
Q
T
I
E
Site 36
S322
V
I
S
H
S
V
T
S
D
M
Q
T
I
E
Q
Site 37
T326
S
V
T
S
D
M
Q
T
I
E
Q
E
S
P
I
Site 38
S331
M
Q
T
I
E
Q
E
S
P
I
M
A
K
P
R
Site 39
Y341
M
A
K
P
R
K
K
Y
N
D
D
S
D
D
S
Site 40
S345
R
K
K
Y
N
D
D
S
D
D
S
Y
F
T
S
Site 41
S348
Y
N
D
D
S
D
D
S
Y
F
T
S
S
S
S
Site 42
Y349
N
D
D
S
D
D
S
Y
F
T
S
S
S
S
Y
Site 43
T351
D
S
D
D
S
Y
F
T
S
S
S
S
Y
F
D
Site 44
S352
S
D
D
S
Y
F
T
S
S
S
S
Y
F
D
E
Site 45
S354
D
S
Y
F
T
S
S
S
S
Y
F
D
E
P
V
Site 46
S355
S
Y
F
T
S
S
S
S
Y
F
D
E
P
V
E
Site 47
Y356
Y
F
T
S
S
S
S
Y
F
D
E
P
V
E
L
Site 48
S365
D
E
P
V
E
L
R
S
S
S
F
S
S
W
D
Site 49
S366
E
P
V
E
L
R
S
S
S
F
S
S
W
D
D
Site 50
S367
P
V
E
L
R
S
S
S
F
S
S
W
D
D
S
Site 51
S369
E
L
R
S
S
S
F
S
S
W
D
D
S
S
D
Site 52
S370
L
R
S
S
S
F
S
S
W
D
D
S
S
D
S
Site 53
S374
S
F
S
S
W
D
D
S
S
D
S
Y
W
K
K
Site 54
S375
F
S
S
W
D
D
S
S
D
S
Y
W
K
K
E
Site 55
S377
S
W
D
D
S
S
D
S
Y
W
K
K
E
T
S
Site 56
Y378
W
D
D
S
S
D
S
Y
W
K
K
E
T
S
K
Site 57
S384
S
Y
W
K
K
E
T
S
K
D
T
E
T
V
L
Site 58
T389
E
T
S
K
D
T
E
T
V
L
K
T
T
G
Y
Site 59
T393
D
T
E
T
V
L
K
T
T
G
Y
S
D
R
P
Site 60
Y396
T
V
L
K
T
T
G
Y
S
D
R
P
T
A
R
Site 61
S397
V
L
K
T
T
G
Y
S
D
R
P
T
A
R
R
Site 62
T401
T
G
Y
S
D
R
P
T
A
R
R
K
P
D
Y
Site 63
Y408
T
A
R
R
K
P
D
Y
E
P
V
E
N
T
D
Site 64
S428
F
G
N
V
K
A
I
S
S
D
M
Y
F
G
R
Site 65
S429
G
N
V
K
A
I
S
S
D
M
Y
F
G
R
Q
Site 66
Y432
K
A
I
S
S
D
M
Y
F
G
R
Q
S
Q
A
Site 67
S437
D
M
Y
F
G
R
Q
S
Q
A
D
Y
E
T
R
Site 68
Y441
G
R
Q
S
Q
A
D
Y
E
T
R
A
R
L
E
Site 69
S451
R
A
R
L
E
R
L
S
A
S
S
S
I
S
S
Site 70
S453
R
L
E
R
L
S
A
S
S
S
I
S
S
A
D
Site 71
S454
L
E
R
L
S
A
S
S
S
I
S
S
A
D
L
Site 72
S455
E
R
L
S
A
S
S
S
I
S
S
A
D
L
F
Site 73
S457
L
S
A
S
S
S
I
S
S
A
D
L
F
E
E
Site 74
S458
S
A
S
S
S
I
S
S
A
D
L
F
E
E
P
Site 75
Y473
R
K
Q
P
A
G
N
Y
S
L
S
S
V
L
P
Site 76
S474
K
Q
P
A
G
N
Y
S
L
S
S
V
L
P
N
Site 77
S476
P
A
G
N
Y
S
L
S
S
V
L
P
N
A
P
Site 78
S477
A
G
N
Y
S
L
S
S
V
L
P
N
A
P
D
Site 79
S494
Q
F
K
Q
G
V
R
S
V
A
G
K
L
S
V
Site 80
S500
R
S
V
A
G
K
L
S
V
F
A
N
G
V
V
Site 81
S509
F
A
N
G
V
V
T
S
I
Q
D
R
Y
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation