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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PREB
Full Name:
Prolactin regulatory element-binding protein
Alias:
Mammalian guanine nucleotide exchange factor mSec12
Type:
Mass (Da):
45468
Number AA:
417
UniProt ID:
Q9HCU5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
R
R
R
A
P
E
L
Y
R
A
P
F
P
L
Y
Site 2
Y17
Y
R
A
P
F
P
L
Y
A
L
Q
V
D
P
S
Site 3
T39
G
G
G
G
A
A
K
T
G
I
K
N
G
V
H
Site 4
S58
E
L
I
N
G
R
L
S
A
S
L
L
H
S
H
Site 5
S60
I
N
G
R
L
S
A
S
L
L
H
S
H
D
T
Site 6
S64
L
S
A
S
L
L
H
S
H
D
T
E
T
R
A
Site 7
T67
S
L
L
H
S
H
D
T
E
T
R
A
T
M
N
Site 8
T72
H
D
T
E
T
R
A
T
M
N
L
A
L
A
G
Site 9
S110
N
K
A
E
K
A
G
S
K
E
Q
G
P
R
Q
Site 10
T149
E
N
L
Q
A
V
Q
T
D
F
S
S
D
P
L
Site 11
S152
Q
A
V
Q
T
D
F
S
S
D
P
L
Q
K
V
Site 12
S153
A
V
Q
T
D
F
S
S
D
P
L
Q
K
V
V
Site 13
Y177
A
T
G
G
T
D
G
Y
V
R
V
W
K
V
P
Site 14
T212
G
P
D
G
K
L
V
T
V
G
R
D
L
K
A
Site 15
S220
V
G
R
D
L
K
A
S
V
W
Q
K
D
Q
L
Site 16
T239
H
W
Q
E
N
G
P
T
F
S
S
T
P
Y
R
Site 17
T243
N
G
P
T
F
S
S
T
P
Y
R
Y
Q
A
C
Site 18
Y245
P
T
F
S
S
T
P
Y
R
Y
Q
A
C
R
F
Site 19
Y247
F
S
S
T
P
Y
R
Y
Q
A
C
R
F
G
Q
Site 20
T266
P
A
G
L
R
L
F
T
V
Q
I
P
H
K
R
Site 21
Y281
L
R
Q
P
P
P
C
Y
L
T
A
W
D
G
S
Site 22
S297
F
L
P
L
R
T
K
S
C
G
H
E
V
V
S
Site 23
T347
E
A
H
G
I
V
V
T
D
V
A
F
L
P
E
Site 24
S364
R
G
P
E
L
L
G
S
H
E
T
A
L
F
S
Site 25
S385
C
Q
L
H
L
L
P
S
R
R
S
V
P
V
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation