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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CELSR2
Full Name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alias:
CDHF10; CELR2; EGFL2; EGF-like-domain, multiple 2; Epidermal growth factor-like 2; Flamingo 1; Flamingo1; MEGF3; Multiple epidermal growth factor-like domains 3
Type:
Plasma membrane, Cytoplasm, Integral membrane protein
Mass (Da):
317453
Number AA:
2923
UniProt ID:
Q9HCU4
International Prot ID:
IPI00015346
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0048813
GO:0007156
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
R
S
P
A
T
G
V
P
L
P
T
P
Site 2
S39
D
Q
V
G
P
C
R
S
L
G
S
R
G
R
G
Site 3
S42
G
P
C
R
S
L
G
S
R
G
R
G
S
S
G
Site 4
S47
L
G
S
R
G
R
G
S
S
G
A
C
A
P
M
Site 5
S48
G
S
R
G
R
G
S
S
G
A
C
A
P
M
G
Site 6
Y68
S
A
S
N
L
W
L
Y
T
S
R
C
R
D
A
Site 7
T69
A
S
N
L
W
L
Y
T
S
R
C
R
D
A
G
Site 8
S70
S
N
L
W
L
Y
T
S
R
C
R
D
A
G
T
Site 9
T77
S
R
C
R
D
A
G
T
E
L
T
G
H
L
V
Site 10
T80
R
D
A
G
T
E
L
T
G
H
L
V
P
H
H
Site 11
S97
L
R
V
W
C
P
E
S
E
A
H
I
P
L
P
Site 12
T130
L
S
P
Q
G
K
L
T
L
P
E
E
H
P
C
Site 13
S147
A
P
R
L
R
C
Q
S
C
K
L
A
Q
A
P
Site 14
S162
G
L
R
A
G
E
R
S
P
E
E
S
L
G
G
Site 15
S166
G
E
R
S
P
E
E
S
L
G
G
R
R
K
R
Site 16
S185
A
P
Q
F
Q
P
P
S
Y
Q
A
T
V
P
E
Site 17
Y186
P
Q
F
Q
P
P
S
Y
Q
A
T
V
P
E
N
Site 18
T189
Q
P
P
S
Y
Q
A
T
V
P
E
N
Q
P
A
Site 19
T198
P
E
N
Q
P
A
G
T
P
V
A
S
L
R
A
Site 20
S202
P
A
G
T
P
V
A
S
L
R
A
I
D
P
D
Site 21
Y218
G
E
A
G
R
L
E
Y
T
M
D
A
L
F
D
Site 22
S226
T
M
D
A
L
F
D
S
R
S
N
Q
F
F
S
Site 23
S228
D
A
L
F
D
S
R
S
N
Q
F
F
S
L
D
Site 24
S233
S
R
S
N
Q
F
F
S
L
D
P
V
T
G
A
Site 25
T251
A
E
E
L
D
R
E
T
K
S
T
H
V
F
R
Site 26
S253
E
L
D
R
E
T
K
S
T
H
V
F
R
V
T
Site 27
T254
L
D
R
E
T
K
S
T
H
V
F
R
V
T
A
Site 28
T260
S
T
H
V
F
R
V
T
A
Q
D
H
G
M
P
Site 29
S270
D
H
G
M
P
R
R
S
A
L
A
T
L
T
I
Site 30
Y294
P
V
F
E
Q
Q
E
Y
K
E
S
L
R
E
N
Site 31
S297
E
Q
Q
E
Y
K
E
S
L
R
E
N
L
E
V
Site 32
T310
E
V
G
Y
E
V
L
T
V
R
A
T
D
G
D
Site 33
T314
E
V
L
T
V
R
A
T
D
G
D
A
P
P
N
Site 34
Y326
P
P
N
A
N
I
L
Y
R
L
L
E
G
S
G
Site 35
S332
L
Y
R
L
L
E
G
S
G
G
S
P
S
E
V
Site 36
S337
E
G
S
G
G
S
P
S
E
V
F
E
I
D
P
Site 37
S346
V
F
E
I
D
P
R
S
G
V
I
R
T
R
G
Site 38
S362
V
D
R
E
E
V
E
S
Y
Q
L
T
V
E
A
Site 39
Y363
D
R
E
E
V
E
S
Y
Q
L
T
V
E
A
S
Site 40
T366
E
V
E
S
Y
Q
L
T
V
E
A
S
D
Q
G
Site 41
S370
Y
Q
L
T
V
E
A
S
D
Q
G
R
D
P
G
Site 42
S380
G
R
D
P
G
P
R
S
T
T
A
A
V
F
L
Site 43
T381
R
D
P
G
P
R
S
T
T
A
A
V
F
L
S
Site 44
S388
T
T
A
A
V
F
L
S
V
E
D
D
N
D
N
Site 45
Y404
P
Q
F
S
E
K
R
Y
V
V
Q
V
R
E
D
Site 46
T413
V
Q
V
R
E
D
V
T
P
G
A
P
V
L
R
Site 47
T422
G
A
P
V
L
R
V
T
A
S
D
R
D
K
G
Site 48
S424
P
V
L
R
V
T
A
S
D
R
D
K
G
S
N
Site 49
S430
A
S
D
R
D
K
G
S
N
A
V
V
H
Y
S
Site 50
Y448
G
N
A
R
G
Q
F
Y
L
D
A
Q
T
G
A
Site 51
S460
T
G
A
L
D
V
V
S
P
L
D
Y
E
T
T
Site 52
Y464
D
V
V
S
P
L
D
Y
E
T
T
K
E
Y
T
Site 53
T467
S
P
L
D
Y
E
T
T
K
E
Y
T
L
R
V
Site 54
Y470
D
Y
E
T
T
K
E
Y
T
L
R
V
R
A
Q
Site 55
T471
Y
E
T
T
K
E
Y
T
L
R
V
R
A
Q
D
Site 56
S485
D
G
G
R
P
P
L
S
N
V
S
G
L
V
T
Site 57
Y542
G
D
N
A
R
L
E
Y
R
L
A
G
V
G
H
Site 58
S563
N
N
G
T
G
W
I
S
V
A
A
E
L
D
R
Site 59
Y576
D
R
E
E
V
D
F
Y
S
F
G
V
E
A
R
Site 60
S577
R
E
E
V
D
F
Y
S
F
G
V
E
A
R
D
Site 61
T587
V
E
A
R
D
H
G
T
P
A
L
T
A
S
A
Site 62
Y615
P
T
F
T
Q
P
E
Y
T
V
R
L
N
E
D
Site 63
S641
A
V
D
R
D
A
H
S
V
I
T
Y
Q
I
T
Site 64
Y645
D
A
H
S
V
I
T
Y
Q
I
T
S
G
N
T
Site 65
S657
G
N
T
R
N
R
F
S
I
T
S
Q
S
G
G
Site 66
S660
R
N
R
F
S
I
T
S
Q
S
G
G
G
L
V
Site 67
Y675
S
L
A
L
P
L
D
Y
K
L
E
R
Q
Y
V
Site 68
Y681
D
Y
K
L
E
R
Q
Y
V
L
A
V
T
A
S
Site 69
T695
S
D
G
T
R
Q
D
T
A
Q
I
V
V
N
V
Site 70
T707
V
N
V
T
D
A
N
T
H
R
P
V
F
Q
S
Site 71
T718
V
F
Q
S
S
H
Y
T
V
N
V
N
E
D
R
Site 72
T741
I
S
A
T
D
E
D
T
G
E
N
A
R
I
T
Site 73
T748
T
G
E
N
A
R
I
T
Y
F
M
E
D
S
I
Site 74
Y749
G
E
N
A
R
I
T
Y
F
M
E
D
S
I
P
Site 75
T764
Q
F
R
I
D
A
D
T
G
A
V
T
T
Q
A
Site 76
Y775
T
T
Q
A
E
L
D
Y
E
D
Q
V
S
Y
T
Site 77
S780
L
D
Y
E
D
Q
V
S
Y
T
L
A
I
T
A
Site 78
S796
D
N
G
I
P
Q
K
S
D
T
T
Y
L
E
I
Site 79
T798
G
I
P
Q
K
S
D
T
T
Y
L
E
I
L
V
Site 80
Y800
P
Q
K
S
D
T
T
Y
L
E
I
L
V
N
D
Site 81
S819
A
P
Q
F
L
R
D
S
Y
Q
G
S
V
Y
E
Site 82
Y820
P
Q
F
L
R
D
S
Y
Q
G
S
V
Y
E
D
Site 83
S823
L
R
D
S
Y
Q
G
S
V
Y
E
D
V
P
P
Site 84
Y825
D
S
Y
Q
G
S
V
Y
E
D
V
P
P
F
T
Site 85
T840
S
V
L
Q
I
S
A
T
D
R
D
S
G
L
N
Site 86
S844
I
S
A
T
D
R
D
S
G
L
N
G
R
V
F
Site 87
Y852
G
L
N
G
R
V
F
Y
T
F
Q
G
G
D
D
Site 88
T853
L
N
G
R
V
F
Y
T
F
Q
G
G
D
D
G
Site 89
S868
D
G
D
F
I
V
E
S
T
S
G
I
V
R
T
Site 90
T875
S
T
S
G
I
V
R
T
L
R
R
L
D
R
E
Site 91
Y887
D
R
E
N
V
A
Q
Y
V
L
R
A
Y
A
V
Site 92
Y892
A
Q
Y
V
L
R
A
Y
A
V
D
K
G
M
P
Site 93
T903
K
G
M
P
P
A
R
T
P
M
E
V
T
V
T
Site 94
T944
G
L
A
V
A
R
V
T
A
T
D
P
D
E
G
Site 95
T952
A
T
D
P
D
E
G
T
N
A
Q
I
M
Y
Q
Site 96
Y986
T
A
L
V
D
L
D
Y
E
D
R
P
E
Y
V
Site 97
Y992
D
Y
E
D
R
P
E
Y
V
L
V
I
Q
A
T
Site 98
Y1033
F
E
I
L
F
N
N
Y
V
T
N
R
S
S
S
Site 99
T1035
I
L
F
N
N
Y
V
T
N
R
S
S
S
F
P
Site 100
S1038
N
N
Y
V
T
N
R
S
S
S
F
P
G
G
A
Site 101
S1039
N
Y
V
T
N
R
S
S
S
F
P
G
G
A
I
Site 102
S1040
Y
V
T
N
R
S
S
S
F
P
G
G
A
I
G
Site 103
S1057
P
A
H
D
P
D
I
S
D
S
L
T
Y
S
F
Site 104
S1059
H
D
P
D
I
S
D
S
L
T
Y
S
F
E
R
Site 105
T1061
P
D
I
S
D
S
L
T
Y
S
F
E
R
G
N
Site 106
S1063
I
S
D
S
L
T
Y
S
F
E
R
G
N
E
L
Site 107
S1085
S
T
G
E
L
K
L
S
R
A
L
D
N
N
R
Site 108
S1128
T
D
E
M
L
T
H
S
I
T
L
R
L
E
D
Site 109
T1130
E
M
L
T
H
S
I
T
L
R
L
E
D
M
S
Site 110
S1137
T
L
R
L
E
D
M
S
P
E
R
F
L
S
P
Site 111
T1173
V
F
N
V
Q
R
D
T
D
A
P
G
G
H
I
Site 112
Y1210
E
D
L
Q
E
R
L
Y
L
N
R
S
L
L
T
Site 113
Y1240
L
R
E
P
C
E
N
Y
M
R
C
V
S
V
L
Site 114
S1245
E
N
Y
M
R
C
V
S
V
L
R
F
D
S
S
Site 115
Y1284
P
P
G
F
T
G
D
Y
C
E
T
E
V
D
L
Site 116
Y1293
E
T
E
V
D
L
C
Y
S
R
P
C
G
P
H
Site 117
S1294
T
E
V
D
L
C
Y
S
R
P
C
G
P
H
G
Site 118
S1305
G
P
H
G
R
C
R
S
R
E
G
G
Y
T
C
Site 119
T1311
R
S
R
E
G
G
Y
T
C
L
C
R
D
G
Y
Site 120
Y1318
T
C
L
C
R
D
G
Y
T
G
E
H
C
E
V
Site 121
S1326
T
G
E
H
C
E
V
S
A
R
S
G
R
C
T
Site 122
S1329
H
C
E
V
S
A
R
S
G
R
C
T
P
G
V
Site 123
T1333
S
A
R
S
G
R
C
T
P
G
V
C
K
N
G
Site 124
Y1364
S
G
D
F
E
K
P
Y
C
Q
V
T
T
R
S
Site 125
T1368
E
K
P
Y
C
Q
V
T
T
R
S
F
P
A
H
Site 126
S1376
T
R
S
F
P
A
H
S
F
I
T
F
R
G
L
Site 127
T1379
F
P
A
H
S
F
I
T
F
R
G
L
R
Q
R
Site 128
S1394
F
H
F
T
L
A
L
S
F
A
T
K
E
R
D
Site 129
Y1406
E
R
D
G
L
L
L
Y
N
G
R
F
N
E
K
Site 130
T1429
I
Q
E
Q
V
Q
L
T
F
S
A
G
E
S
T
Site 131
S1431
E
Q
V
Q
L
T
F
S
A
G
E
S
T
T
T
Site 132
T1438
S
A
G
E
S
T
T
T
V
S
P
F
V
P
G
Site 133
T1454
V
S
D
G
Q
W
H
T
V
Q
L
K
Y
Y
N
Site 134
Y1459
W
H
T
V
Q
L
K
Y
Y
N
K
P
L
L
G
Site 135
Y1460
H
T
V
Q
L
K
Y
Y
N
K
P
L
L
G
Q
Site 136
S1475
T
G
L
P
Q
G
P
S
E
Q
K
V
A
V
V
Site 137
S1503
G
S
V
L
G
N
Y
S
C
A
A
Q
G
T
Q
Site 138
S1516
T
Q
G
G
S
K
K
S
L
D
L
T
G
P
L
Site 139
S1534
G
V
P
D
L
P
E
S
F
P
V
R
M
R
Q
Site 140
T1567
D
F
I
A
N
N
G
T
V
P
G
C
P
A
K
Site 141
S1608
P
L
G
F
G
G
K
S
C
A
Q
E
M
A
N
Site 142
S1622
N
P
Q
H
F
L
G
S
S
L
V
A
W
H
G
Site 143
S1662
Q
A
I
T
R
G
R
S
T
I
T
L
Q
L
R
Site 144
T1663
A
I
T
R
G
R
S
T
I
T
L
Q
L
R
E
Site 145
S1676
R
E
G
H
V
M
L
S
V
E
G
T
G
L
Q
Site 146
S1685
E
G
T
G
L
Q
A
S
S
L
R
L
E
P
G
Site 147
S1686
G
T
G
L
Q
A
S
S
L
R
L
E
P
G
R
Site 148
S1718
G
P
G
H
A
I
L
S
F
D
Y
G
Q
Q
R
Site 149
Y1721
H
A
I
L
S
F
D
Y
G
Q
Q
R
A
E
G
Site 150
S1768
C
L
Q
G
V
R
V
S
D
T
P
E
G
V
N
Site 151
T1770
Q
G
V
R
V
S
D
T
P
E
G
V
N
S
L
Site 152
S1776
D
T
P
E
G
V
N
S
L
D
P
S
H
G
E
Site 153
S1780
G
V
N
S
L
D
P
S
H
G
E
S
I
N
V
Site 154
S1784
L
D
P
S
H
G
E
S
I
N
V
E
Q
G
C
Site 155
S1792
I
N
V
E
Q
G
C
S
L
P
D
P
C
D
S
Site 156
S1799
S
L
P
D
P
C
D
S
N
P
C
P
A
N
S
Site 157
Y1815
C
S
N
D
W
D
S
Y
S
C
S
C
D
P
G
Site 158
Y1823
S
C
S
C
D
P
G
Y
Y
G
D
N
C
T
N
Site 159
S1841
L
N
P
C
E
H
Q
S
V
C
T
R
K
P
S
Site 160
S1848
S
V
C
T
R
K
P
S
A
P
H
G
Y
T
C
Site 161
Y1853
K
P
S
A
P
H
G
Y
T
C
E
C
P
P
N
Site 162
T1854
P
S
A
P
H
G
Y
T
C
E
C
P
P
N
Y
Site 163
Y1861
T
C
E
C
P
P
N
Y
L
G
P
Y
C
E
T
Site 164
Y1865
P
P
N
Y
L
G
P
Y
C
E
T
R
I
D
Q
Site 165
Y1913
C
H
C
K
E
N
H
Y
R
P
P
G
S
P
T
Site 166
S1918
N
H
Y
R
P
P
G
S
P
T
C
L
L
C
D
Site 167
S1931
C
D
C
Y
P
T
G
S
L
S
R
V
C
D
P
Site 168
S1933
C
Y
P
T
G
S
L
S
R
V
C
D
P
E
D
Site 169
Y1973
T
N
G
C
E
V
N
Y
D
S
C
P
R
A
I
Site 170
S1975
G
C
E
V
N
Y
D
S
C
P
R
A
I
E
A
Site 171
S2003
A
A
P
C
P
K
G
S
F
G
T
A
V
R
H
Site 172
S2027
P
N
L
F
N
C
T
S
I
T
F
S
E
L
K
Site 173
S2031
N
C
T
S
I
T
F
S
E
L
K
G
F
A
E
Site 174
S2045
E
R
L
Q
R
N
E
S
G
L
D
S
G
R
S
Site 175
S2049
R
N
E
S
G
L
D
S
G
R
S
Q
Q
L
A
Site 176
S2052
S
G
L
D
S
G
R
S
Q
Q
L
A
L
L
L
Site 177
Y2069
A
T
Q
H
T
A
G
Y
F
G
S
D
V
K
V
Site 178
S2072
H
T
A
G
Y
F
G
S
D
V
K
V
A
Y
Q
Site 179
S2089
T
R
L
L
A
H
E
S
T
Q
R
G
F
G
L
Site 180
T2090
R
L
L
A
H
E
S
T
Q
R
G
F
G
L
S
Site 181
S2097
T
Q
R
G
F
G
L
S
A
T
Q
D
V
H
F
Site 182
T2099
R
G
F
G
L
S
A
T
Q
D
V
H
F
T
E
Site 183
T2118
V
G
S
A
L
L
D
T
A
N
K
R
H
W
E
Site 184
T2155
L
A
Q
N
M
R
H
T
Y
L
S
P
F
T
I
Site 185
Y2156
A
Q
N
M
R
H
T
Y
L
S
P
F
T
I
V
Site 186
S2158
N
M
R
H
T
Y
L
S
P
F
T
I
V
T
P
Site 187
Y2187
A
G
A
K
L
P
R
Y
E
A
L
R
G
E
Q
Site 188
T2200
E
Q
P
P
D
L
E
T
T
V
I
L
P
E
S
Site 189
T2201
Q
P
P
D
L
E
T
T
V
I
L
P
E
S
V
Site 190
S2207
T
T
V
I
L
P
E
S
V
F
R
E
T
P
P
Site 191
T2212
P
E
S
V
F
R
E
T
P
P
V
V
R
P
A
Site 192
S2241
Q
R
R
H
P
E
L
S
Q
G
E
A
V
A
S
Site 193
Y2263
A
G
L
L
P
H
N
Y
D
P
D
K
R
S
L
Site 194
S2269
N
Y
D
P
D
K
R
S
L
R
V
P
K
R
P
Site 195
S2286
N
T
P
V
V
S
I
S
V
H
D
D
E
E
L
Site 196
T2303
R
A
L
D
K
P
V
T
V
Q
F
R
L
L
E
Site 197
S2329
W
N
H
S
I
L
V
S
G
T
G
G
W
S
A
Site 198
S2366
F
A
V
L
M
D
V
S
R
R
E
N
G
E
I
Site 199
S2406
T
L
L
R
I
L
R
S
N
Q
H
G
I
R
R
Site 200
T2469
L
H
L
Y
R
A
L
T
E
V
R
D
V
N
T
Site 201
T2476
T
E
V
R
D
V
N
T
G
P
M
R
F
Y
Y
Site 202
Y2505
V
G
L
D
P
E
G
Y
G
N
P
D
F
C
W
Site 203
S2545
Y
I
L
A
A
R
A
S
C
A
A
Q
R
Q
G
Site 204
S2560
F
E
K
K
G
P
V
S
G
L
Q
P
S
F
A
Site 205
S2625
K
A
L
K
L
A
C
S
R
K
P
S
P
D
P
Site 206
S2629
L
A
C
S
R
K
P
S
P
D
P
A
L
T
T
Site 207
T2635
P
S
P
D
P
A
L
T
T
K
S
T
L
T
S
Site 208
T2636
S
P
D
P
A
L
T
T
K
S
T
L
T
S
S
Site 209
S2638
D
P
A
L
T
T
K
S
T
L
T
S
S
Y
N
Site 210
T2639
P
A
L
T
T
K
S
T
L
T
S
S
Y
N
C
Site 211
S2642
T
T
K
S
T
L
T
S
S
Y
N
C
P
S
P
Site 212
S2643
T
K
S
T
L
T
S
S
Y
N
C
P
S
P
Y
Site 213
Y2644
K
S
T
L
T
S
S
Y
N
C
P
S
P
Y
A
Site 214
S2648
T
S
S
Y
N
C
P
S
P
Y
A
D
G
R
L
Site 215
Y2650
S
Y
N
C
P
S
P
Y
A
D
G
R
L
Y
Q
Site 216
Y2656
P
Y
A
D
G
R
L
Y
Q
P
Y
G
D
S
A
Site 217
Y2659
D
G
R
L
Y
Q
P
Y
G
D
S
A
G
S
L
Site 218
S2662
L
Y
Q
P
Y
G
D
S
A
G
S
L
H
S
T
Site 219
S2665
P
Y
G
D
S
A
G
S
L
H
S
T
S
R
S
Site 220
S2668
D
S
A
G
S
L
H
S
T
S
R
S
G
K
S
Site 221
T2669
S
A
G
S
L
H
S
T
S
R
S
G
K
S
Q
Site 222
S2670
A
G
S
L
H
S
T
S
R
S
G
K
S
Q
P
Site 223
S2672
S
L
H
S
T
S
R
S
G
K
S
Q
P
S
Y
Site 224
S2675
S
T
S
R
S
G
K
S
Q
P
S
Y
I
P
F
Site 225
S2678
R
S
G
K
S
Q
P
S
Y
I
P
F
L
L
R
Site 226
Y2679
S
G
K
S
Q
P
S
Y
I
P
F
L
L
R
E
Site 227
S2688
P
F
L
L
R
E
E
S
A
L
N
P
G
Q
G
Site 228
S2704
P
G
L
G
D
P
G
S
L
F
L
E
G
Q
D
Site 229
T2718
D
Q
Q
H
D
P
D
T
D
S
D
S
D
L
S
Site 230
S2720
Q
H
D
P
D
T
D
S
D
S
D
L
S
L
E
Site 231
S2722
D
P
D
T
D
S
D
S
D
L
S
L
E
D
D
Site 232
S2725
T
D
S
D
S
D
L
S
L
E
D
D
Q
S
G
Site 233
S2731
L
S
L
E
D
D
Q
S
G
S
Y
A
S
T
H
Site 234
S2733
L
E
D
D
Q
S
G
S
Y
A
S
T
H
S
S
Site 235
Y2734
E
D
D
Q
S
G
S
Y
A
S
T
H
S
S
D
Site 236
S2736
D
Q
S
G
S
Y
A
S
T
H
S
S
D
S
E
Site 237
T2737
Q
S
G
S
Y
A
S
T
H
S
S
D
S
E
E
Site 238
S2740
S
Y
A
S
T
H
S
S
D
S
E
E
E
E
E
Site 239
S2742
A
S
T
H
S
S
D
S
E
E
E
E
E
E
E
Site 240
S2763
P
G
E
Q
G
W
D
S
L
L
G
P
G
A
E
Site 241
S2776
A
E
R
L
P
L
H
S
T
P
K
D
G
G
P
Site 242
T2777
E
R
L
P
L
H
S
T
P
K
D
G
G
P
G
Site 243
T2796
P
W
P
G
D
F
G
T
T
A
K
E
S
S
G
Site 244
S2802
G
T
T
A
K
E
S
S
G
N
G
A
P
E
E
Site 245
S2819
R
E
N
G
D
A
L
S
R
E
G
S
L
G
P
Site 246
S2823
D
A
L
S
R
E
G
S
L
G
P
L
P
G
S
Site 247
S2830
S
L
G
P
L
P
G
S
S
A
Q
P
H
K
G
Site 248
S2831
L
G
P
L
P
G
S
S
A
Q
P
H
K
G
I
Site 249
T2846
L
K
K
K
C
L
P
T
I
S
E
K
S
S
L
Site 250
S2848
K
K
C
L
P
T
I
S
E
K
S
S
L
L
R
Site 251
S2852
P
T
I
S
E
K
S
S
L
L
R
L
P
L
E
Site 252
T2862
R
L
P
L
E
Q
C
T
G
S
S
R
G
S
S
Site 253
S2864
P
L
E
Q
C
T
G
S
S
R
G
S
S
A
S
Site 254
S2865
L
E
Q
C
T
G
S
S
R
G
S
S
A
S
E
Site 255
S2868
C
T
G
S
S
R
G
S
S
A
S
E
G
S
R
Site 256
S2869
T
G
S
S
R
G
S
S
A
S
E
G
S
R
G
Site 257
S2871
S
S
R
G
S
S
A
S
E
G
S
R
G
G
P
Site 258
S2887
P
R
P
P
P
R
Q
S
L
Q
E
Q
L
N
G
Site 259
S2911
A
G
T
V
D
E
D
S
S
G
S
E
F
L
F
Site 260
S2912
G
T
V
D
E
D
S
S
G
S
E
F
L
F
F
Site 261
S2914
V
D
E
D
S
S
G
S
E
F
L
F
F
N
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation