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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2C4
Full Name:
Protein argonaute-4
Alias:
AGO4; argonaute 4; eukaryotic translation initiation factor 2C, 4; FLJ20033; I2C4; KIAA1567
Type:
Translation protein, initiation complex
Mass (Da):
97097
Number AA:
861
UniProt ID:
Q9HCK5
International Prot ID:
IPI00030602
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006402
GO:0035278
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
G
P
G
P
P
A
S
L
F
Q
P
P
R
R
Site 2
T23
P
R
R
P
G
L
G
T
V
G
K
P
I
R
L
Site 3
Y45
Q
I
P
K
I
D
V
Y
H
Y
D
V
D
I
K
Site 4
Y47
P
K
I
D
V
Y
H
Y
D
V
D
I
K
P
E
Site 5
T67
V
N
R
E
V
V
D
T
M
V
R
H
F
K
M
Site 6
Y84
F
G
D
R
Q
P
G
Y
D
G
K
R
N
M
Y
Site 7
Y91
Y
D
G
K
R
N
M
Y
T
A
H
P
L
P
I
Site 8
T92
D
G
K
R
N
M
Y
T
A
H
P
L
P
I
G
Site 9
T108
D
R
V
D
M
E
V
T
L
P
G
E
G
K
D
Site 10
T117
P
G
E
G
K
D
Q
T
F
K
V
S
V
Q
W
Site 11
S161
V
I
T
R
H
L
P
S
M
R
Y
T
P
V
G
Site 12
Y164
R
H
L
P
S
M
R
Y
T
P
V
G
R
S
F
Site 13
T165
H
L
P
S
M
R
Y
T
P
V
G
R
S
F
F
Site 14
S170
R
Y
T
P
V
G
R
S
F
F
S
P
P
E
G
Site 15
S173
P
V
G
R
S
F
F
S
P
P
E
G
Y
Y
H
Site 16
Y178
F
F
S
P
P
E
G
Y
Y
H
P
L
G
G
G
Site 17
Y179
F
S
P
P
E
G
Y
Y
H
P
L
G
G
G
R
Site 18
T241
N
E
Q
T
K
P
L
T
D
S
Q
R
V
K
F
Site 19
S243
Q
T
K
P
L
T
D
S
Q
R
V
K
F
T
K
Site 20
T260
R
G
L
K
V
E
V
T
H
C
G
Q
M
K
R
Site 21
Y269
C
G
Q
M
K
R
K
Y
R
V
C
N
V
T
R
Site 22
T275
K
Y
R
V
C
N
V
T
R
R
P
A
S
H
Q
Site 23
S280
N
V
T
R
R
P
A
S
H
Q
T
F
P
L
Q
Site 24
T283
R
R
P
A
S
H
Q
T
F
P
L
Q
L
E
N
Site 25
Y301
M
E
C
T
V
A
Q
Y
F
K
Q
K
Y
S
L
Site 26
Y312
K
Y
S
L
Q
L
K
Y
P
H
L
P
C
L
Q
Site 27
T327
V
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
Site 28
Y328
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
N
Site 29
T347
Q
R
C
I
K
K
L
T
D
N
Q
T
S
T
M
Site 30
T351
K
K
L
T
D
N
Q
T
S
T
M
I
K
A
T
Site 31
S352
K
L
T
D
N
Q
T
S
T
M
I
K
A
T
A
Site 32
T358
T
S
T
M
I
K
A
T
A
R
S
A
P
D
R
Site 33
S370
P
D
R
Q
E
E
I
S
R
L
V
K
S
N
S
Site 34
S375
E
I
S
R
L
V
K
S
N
S
M
V
G
G
P
Site 35
S377
S
R
L
V
K
S
N
S
M
V
G
G
P
D
P
Site 36
T401
H
N
E
M
T
E
L
T
G
R
V
L
P
A
P
Site 37
T418
Q
Y
G
G
R
N
K
T
V
A
T
P
N
Q
G
Site 38
T421
G
R
N
K
T
V
A
T
P
N
Q
G
V
W
D
Site 39
Y435
D
M
R
G
K
Q
F
Y
A
G
I
E
I
K
V
Site 40
S461
C
R
E
D
L
L
K
S
F
T
D
Q
L
R
K
Site 41
S470
T
D
Q
L
R
K
I
S
K
D
A
G
M
P
I
Site 42
Y486
G
Q
P
C
F
C
K
Y
A
Q
G
A
D
S
V
Site 43
S492
K
Y
A
Q
G
A
D
S
V
E
P
M
F
K
H
Site 44
T518
V
V
I
L
P
G
K
T
P
V
Y
A
E
V
K
Site 45
Y521
L
P
G
K
T
P
V
Y
A
E
V
K
R
V
G
Site 46
S548
V
K
N
V
V
K
T
S
P
Q
T
L
S
N
L
Site 47
S553
K
T
S
P
Q
T
L
S
N
L
C
L
K
I
N
Site 48
S577
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Site 49
S602
A
G
D
G
K
K
P
S
I
A
A
V
V
G
S
Site 50
S609
S
I
A
A
V
V
G
S
M
D
G
H
P
S
R
Site 51
S615
G
S
M
D
G
H
P
S
R
Y
C
A
T
V
R
Site 52
T620
H
P
S
R
Y
C
A
T
V
R
V
Q
T
S
R
Site 53
T625
C
A
T
V
R
V
Q
T
S
R
Q
E
I
S
Q
Site 54
S631
Q
T
S
R
Q
E
I
S
Q
E
L
L
Y
S
Q
Site 55
S637
I
S
Q
E
L
L
Y
S
Q
E
V
I
Q
D
L
Site 56
T645
Q
E
V
I
Q
D
L
T
N
M
V
R
E
L
L
Site 57
Y656
R
E
L
L
I
Q
F
Y
K
S
T
R
F
K
P
Site 58
S658
L
L
I
Q
F
Y
K
S
T
R
F
K
P
T
R
Site 59
Y668
F
K
P
T
R
I
I
Y
Y
R
G
G
V
S
E
Site 60
S695
A
I
R
K
A
C
I
S
L
E
E
D
Y
R
P
Site 61
Y700
C
I
S
L
E
E
D
Y
R
P
G
I
T
Y
I
Site 62
Y706
D
Y
R
P
G
I
T
Y
I
V
V
Q
K
R
H
Site 63
T715
V
V
Q
K
R
H
H
T
R
L
F
C
A
D
K
Site 64
T723
R
L
F
C
A
D
K
T
E
R
V
G
K
S
G
Site 65
T736
S
G
N
V
P
A
G
T
T
V
D
S
T
I
T
Site 66
S740
P
A
G
T
T
V
D
S
T
I
T
H
P
S
E
Site 67
T741
A
G
T
T
V
D
S
T
I
T
H
P
S
E
F
Site 68
Y751
H
P
S
E
F
D
F
Y
L
C
S
H
A
G
I
Site 69
T761
S
H
A
G
I
Q
G
T
S
R
P
S
H
Y
Q
Site 70
S765
I
Q
G
T
S
R
P
S
H
Y
Q
V
L
W
D
Site 71
T791
L
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
Site 72
Y792
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
V
Site 73
S798
T
Y
V
R
C
T
R
S
V
S
I
P
A
P
A
Site 74
S800
V
R
C
T
R
S
V
S
I
P
A
P
A
Y
Y
Site 75
Y817
L
V
A
F
R
A
R
Y
H
L
V
D
K
D
H
Site 76
S826
L
V
D
K
D
H
D
S
A
E
G
S
H
V
S
Site 77
S830
D
H
D
S
A
E
G
S
H
V
S
G
Q
S
N
Site 78
S833
S
A
E
G
S
H
V
S
G
Q
S
N
G
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation