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Updated November 2019
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Protein Info
Short Name:
TNRC6C
Full Name:
Trinucleotide repeat-containing gene 6C protein
Alias:
FLJ20015; KIAA1582; TNR6C; trinucleotide repeat containing 6C
Type:
Unknown function
Mass (Da):
175946
Number AA:
1690
UniProt ID:
Q9HCJ0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0031047
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
T
N
G
A
L
V
Q
S
P
S
N
Q
S
A
L
Site 2
S32
G
A
L
V
Q
S
P
S
N
Q
S
A
L
G
A
Site 3
S44
L
G
A
G
G
A
N
S
N
G
S
A
A
R
V
Site 4
S47
G
G
A
N
S
N
G
S
A
A
R
V
W
G
V
Site 5
S66
S
S
G
L
A
H
C
S
V
S
G
G
D
G
K
Site 6
S68
G
L
A
H
C
S
V
S
G
G
D
G
K
M
D
Site 7
T76
G
G
D
G
K
M
D
T
M
I
G
D
G
R
S
Site 8
T117
P
V
L
G
H
E
G
T
V
A
T
G
N
P
S
Site 9
T120
G
H
E
G
T
V
A
T
G
N
P
S
S
I
C
Site 10
S128
G
N
P
S
S
I
C
S
P
V
S
A
I
G
Q
Site 11
S159
G
N
L
L
P
Q
E
S
T
E
P
Q
T
S
T
Site 12
S165
E
S
T
E
P
Q
T
S
T
S
Q
N
V
S
F
Site 13
S167
T
E
P
Q
T
S
T
S
Q
N
V
S
F
S
A
Site 14
S171
T
S
T
S
Q
N
V
S
F
S
A
Q
P
Q
N
Site 15
T181
A
Q
P
Q
N
L
N
T
D
G
P
N
N
T
N
Site 16
S193
N
T
N
P
M
N
S
S
P
N
P
I
N
A
M
Site 17
S231
G
L
P
G
A
N
G
S
S
V
S
Q
V
S
G
Site 18
S232
L
P
G
A
N
G
S
S
V
S
Q
V
S
G
G
Site 19
S234
G
A
N
G
S
S
V
S
Q
V
S
G
G
S
A
Site 20
S245
G
G
S
A
E
G
I
S
N
S
V
W
G
L
S
Site 21
S247
S
A
E
G
I
S
N
S
V
W
G
L
S
P
G
Site 22
S252
S
N
S
V
W
G
L
S
P
G
N
P
A
T
G
Site 23
T258
L
S
P
G
N
P
A
T
G
N
S
N
S
G
F
Site 24
S261
G
N
P
A
T
G
N
S
N
S
G
F
S
Q
G
Site 25
S263
P
A
T
G
N
S
N
S
G
F
S
Q
G
N
G
Site 26
T272
F
S
Q
G
N
G
D
T
V
N
S
A
L
S
A
Site 27
S278
D
T
V
N
S
A
L
S
A
K
Q
N
G
S
S
Site 28
S286
A
K
Q
N
G
S
S
S
A
V
Q
K
E
G
S
Site 29
S300
S
G
G
N
A
W
D
S
G
P
P
A
G
P
G
Site 30
S315
I
L
A
W
G
R
G
S
G
N
N
G
V
G
N
Site 31
S332
S
G
A
W
G
H
P
S
R
S
T
S
N
G
V
Site 32
S334
A
W
G
H
P
S
R
S
T
S
N
G
V
N
G
Site 33
T335
W
G
H
P
S
R
S
T
S
N
G
V
N
G
E
Site 34
S336
G
H
P
S
R
S
T
S
N
G
V
N
G
E
W
Site 35
S351
G
K
P
P
N
Q
H
S
N
S
D
I
N
G
K
Site 36
S353
P
P
N
Q
H
S
N
S
D
I
N
G
K
G
S
Site 37
S360
S
D
I
N
G
K
G
S
T
G
W
E
S
P
S
Site 38
T361
D
I
N
G
K
G
S
T
G
W
E
S
P
S
V
Site 39
S365
K
G
S
T
G
W
E
S
P
S
V
T
S
Q
N
Site 40
S367
S
T
G
W
E
S
P
S
V
T
S
Q
N
P
T
Site 41
T369
G
W
E
S
P
S
V
T
S
Q
N
P
T
V
Q
Site 42
S370
W
E
S
P
S
V
T
S
Q
N
P
T
V
Q
P
Site 43
T374
S
V
T
S
Q
N
P
T
V
Q
P
G
G
E
H
Site 44
S384
P
G
G
E
H
M
N
S
W
A
K
A
A
S
S
Site 45
S391
S
W
A
K
A
A
S
S
G
T
T
A
S
E
G
Site 46
T394
K
A
A
S
S
G
T
T
A
S
E
G
S
S
D
Site 47
S396
A
S
S
G
T
T
A
S
E
G
S
S
D
G
S
Site 48
S399
G
T
T
A
S
E
G
S
S
D
G
S
G
N
H
Site 49
S400
T
T
A
S
E
G
S
S
D
G
S
G
N
H
N
Site 50
S403
S
E
G
S
S
D
G
S
G
N
H
N
E
G
S
Site 51
S410
S
G
N
H
N
E
G
S
T
G
R
E
G
T
G
Site 52
T416
G
S
T
G
R
E
G
T
G
E
G
R
R
R
D
Site 53
S445
D
L
D
P
R
V
L
S
N
T
G
W
G
Q
T
Site 54
T447
D
P
R
V
L
S
N
T
G
W
G
Q
T
P
V
Site 55
T452
S
N
T
G
W
G
Q
T
P
V
K
Q
N
T
A
Site 56
S465
T
A
W
E
F
E
E
S
P
R
S
E
R
K
N
Site 57
S468
E
F
E
E
S
P
R
S
E
R
K
N
D
N
G
Site 58
T476
E
R
K
N
D
N
G
T
E
A
W
G
C
A
A
Site 59
S496
S
G
G
K
N
D
G
S
I
M
N
S
T
N
T
Site 60
S500
N
D
G
S
I
M
N
S
T
N
T
S
S
V
S
Site 61
T501
D
G
S
I
M
N
S
T
N
T
S
S
V
S
G
Site 62
T503
S
I
M
N
S
T
N
T
S
S
V
S
G
W
V
Site 63
S504
I
M
N
S
T
N
T
S
S
V
S
G
W
V
N
Site 64
S505
M
N
S
T
N
T
S
S
V
S
G
W
V
N
A
Site 65
S526
A
N
T
G
W
G
D
S
N
N
K
A
P
S
G
Site 66
S532
D
S
N
N
K
A
P
S
G
P
G
V
W
G
D
Site 67
S540
G
P
G
V
W
G
D
S
I
S
S
T
A
V
S
Site 68
S554
S
T
A
A
A
A
K
S
G
H
A
W
S
G
A
Site 69
S559
A
K
S
G
H
A
W
S
G
A
A
N
Q
E
D
Site 70
S568
A
A
N
Q
E
D
K
S
P
T
W
G
E
P
P
Site 71
S579
G
E
P
P
K
P
K
S
Q
H
W
G
D
G
Q
Site 72
S593
Q
R
S
N
P
A
W
S
A
G
G
G
D
W
A
Site 73
S602
G
G
G
D
W
A
D
S
S
S
V
L
G
H
L
Site 74
S603
G
G
D
W
A
D
S
S
S
V
L
G
H
L
G
Site 75
S604
G
D
W
A
D
S
S
S
V
L
G
H
L
G
D
Site 76
S617
G
D
G
K
K
N
G
S
G
W
D
A
D
S
N
Site 77
S623
G
S
G
W
D
A
D
S
N
R
S
G
S
G
W
Site 78
S626
W
D
A
D
S
N
R
S
G
S
G
W
N
D
T
Site 79
S628
A
D
S
N
R
S
G
S
G
W
N
D
T
T
R
Site 80
T633
S
G
S
G
W
N
D
T
T
R
S
G
N
S
G
Site 81
T634
G
S
G
W
N
D
T
T
R
S
G
N
S
G
W
Site 82
S644
G
N
S
G
W
G
N
S
T
N
T
K
A
N
P
Site 83
T645
N
S
G
W
G
N
S
T
N
T
K
A
N
P
G
Site 84
T647
G
W
G
N
S
T
N
T
K
A
N
P
G
T
N
Site 85
T658
P
G
T
N
W
G
E
T
L
K
P
G
P
Q
Q
Site 86
S684
S
N
W
G
G
A
A
S
V
K
Q
T
G
T
G
Site 87
T688
G
A
A
S
V
K
Q
T
G
T
G
W
I
G
G
Site 88
S705
P
V
K
Q
K
D
S
S
E
A
T
G
W
E
E
Site 89
T708
Q
K
D
S
S
E
A
T
G
W
E
E
P
S
P
Site 90
S714
A
T
G
W
E
E
P
S
P
P
S
I
R
R
K
Site 91
S717
W
E
E
P
S
P
P
S
I
R
R
K
M
E
I
Site 92
T728
K
M
E
I
D
D
G
T
S
A
W
G
D
P
S
Site 93
S729
M
E
I
D
D
G
T
S
A
W
G
D
P
S
N
Site 94
Y737
A
W
G
D
P
S
N
Y
N
N
K
T
V
N
M
Site 95
T758
V
I
Q
S
S
T
T
T
N
T
T
T
T
T
T
Site 96
T777
N
T
T
H
R
V
E
T
P
P
P
H
Q
A
G
Site 97
S790
A
G
T
Q
L
N
R
S
P
L
L
G
P
G
R
Site 98
S800
L
G
P
G
R
K
V
S
S
G
W
G
E
M
P
Site 99
S801
G
P
G
R
K
V
S
S
G
W
G
E
M
P
N
Site 100
T813
M
P
N
V
H
S
K
T
E
N
S
W
G
E
P
Site 101
S816
V
H
S
K
T
E
N
S
W
G
E
P
S
S
P
Site 102
S821
E
N
S
W
G
E
P
S
S
P
S
T
L
V
D
Site 103
S822
N
S
W
G
E
P
S
S
P
S
T
L
V
D
N
Site 104
S824
W
G
E
P
S
S
P
S
T
L
V
D
N
G
T
Site 105
T825
G
E
P
S
S
P
S
T
L
V
D
N
G
T
A
Site 106
T831
S
T
L
V
D
N
G
T
A
A
W
G
K
P
P
Site 107
S839
A
A
W
G
K
P
P
S
S
G
S
G
W
G
D
Site 108
S840
A
W
G
K
P
P
S
S
G
S
G
W
G
D
H
Site 109
S842
G
K
P
P
S
S
G
S
G
W
G
D
H
P
A
Site 110
S872
S
A
L
C
K
P
A
S
K
S
M
Q
E
G
W
Site 111
S874
L
C
K
P
A
S
K
S
M
Q
E
G
W
G
S
Site 112
S881
S
M
Q
E
G
W
G
S
G
G
D
E
M
N
L
Site 113
S889
G
G
D
E
M
N
L
S
T
S
Q
W
E
D
E
Site 114
S891
D
E
M
N
L
S
T
S
Q
W
E
D
E
E
G
Site 115
S906
D
V
W
N
N
A
A
S
Q
E
S
T
S
S
C
Site 116
S909
N
N
A
A
S
Q
E
S
T
S
S
C
S
S
W
Site 117
T910
N
A
A
S
Q
E
S
T
S
S
C
S
S
W
G
Site 118
S911
A
A
S
Q
E
S
T
S
S
C
S
S
W
G
N
Site 119
S912
A
S
Q
E
S
T
S
S
C
S
S
W
G
N
A
Site 120
S915
E
S
T
S
S
C
S
S
W
G
N
A
P
K
K
Site 121
T948
S
R
L
I
K
Q
L
T
D
M
G
F
P
R
E
Site 122
S963
P
A
E
E
A
L
K
S
N
N
M
N
L
D
Q
Site 123
T990
D
K
R
G
L
G
V
T
D
H
N
G
M
A
A
Site 124
S1007
L
G
C
R
P
P
I
S
K
E
S
S
V
D
R
Site 125
S1011
P
P
I
S
K
E
S
S
V
D
R
P
T
F
L
Site 126
T1016
E
S
S
V
D
R
P
T
F
L
D
K
D
G
G
Site 127
T1029
G
G
L
V
E
E
P
T
P
S
P
F
L
P
S
Site 128
S1031
L
V
E
E
P
T
P
S
P
F
L
P
S
P
S
Site 129
S1038
S
P
F
L
P
S
P
S
L
K
L
P
L
S
H
Site 130
S1044
P
S
L
K
L
P
L
S
H
S
A
L
P
S
Q
Site 131
S1067
L
G
M
Q
N
L
N
S
S
R
Q
I
P
S
G
Site 132
S1073
N
S
S
R
Q
I
P
S
G
N
L
G
M
F
G
Site 133
S1103
P
P
V
Q
P
L
N
S
S
Q
P
S
L
R
A
Site 134
S1104
P
V
Q
P
L
N
S
S
Q
P
S
L
R
A
Q
Site 135
S1107
P
L
N
S
S
Q
P
S
L
R
A
Q
V
P
Q
Site 136
S1117
A
Q
V
P
Q
F
L
S
P
Q
V
Q
A
Q
L
Site 137
S1141
L
N
P
A
L
L
T
S
P
I
N
P
Q
H
M
Site 138
Y1155
M
T
M
L
N
Q
L
Y
Q
L
Q
L
A
Y
Q
Site 139
Y1161
L
Y
Q
L
Q
L
A
Y
Q
R
L
Q
I
Q
Q
Site 140
S1178
L
Q
A
Q
R
N
V
S
G
S
M
R
Q
Q
E
Site 141
S1180
A
Q
R
N
V
S
G
S
M
R
Q
Q
E
Q
Q
Site 142
T1193
Q
Q
V
A
R
T
I
T
N
L
Q
Q
Q
I
Q
Site 143
S1225
P
P
P
P
P
H
L
S
L
H
P
S
A
G
K
Site 144
S1229
P
H
L
S
L
H
P
S
A
G
K
S
A
M
D
Site 145
S1233
L
H
P
S
A
G
K
S
A
M
D
S
F
P
S
Site 146
S1237
A
G
K
S
A
M
D
S
F
P
S
H
P
Q
T
Site 147
S1240
S
A
M
D
S
F
P
S
H
P
Q
T
P
G
L
Site 148
T1244
S
F
P
S
H
P
Q
T
P
G
L
P
D
L
Q
Site 149
T1252
P
G
L
P
D
L
Q
T
K
E
Q
Q
S
S
P
Site 150
S1258
Q
T
K
E
Q
Q
S
S
P
N
T
F
A
P
Y
Site 151
T1261
E
Q
Q
S
S
P
N
T
F
A
P
Y
P
L
A
Site 152
Y1265
S
P
N
T
F
A
P
Y
P
L
A
G
L
N
P
Site 153
T1282
N
V
N
S
M
D
M
T
G
G
L
S
V
K
D
Site 154
S1286
M
D
M
T
G
G
L
S
V
K
D
P
S
Q
S
Site 155
S1291
G
L
S
V
K
D
P
S
Q
S
Q
S
R
L
P
Site 156
S1293
S
V
K
D
P
S
Q
S
Q
S
R
L
P
Q
W
Site 157
S1295
K
D
P
S
Q
S
Q
S
R
L
P
Q
W
T
H
Site 158
T1301
Q
S
R
L
P
Q
W
T
H
P
N
S
M
D
N
Site 159
S1305
P
Q
W
T
H
P
N
S
M
D
N
L
P
S
A
Site 160
S1311
N
S
M
D
N
L
P
S
A
A
S
P
L
E
Q
Site 161
S1314
D
N
L
P
S
A
A
S
P
L
E
Q
N
P
S
Site 162
S1321
S
P
L
E
Q
N
P
S
K
H
G
A
I
P
G
Site 163
S1338
S
I
G
P
P
G
K
S
S
I
D
D
S
Y
G
Site 164
S1339
I
G
P
P
G
K
S
S
I
D
D
S
Y
G
R
Site 165
S1343
G
K
S
S
I
D
D
S
Y
G
R
Y
D
L
I
Site 166
Y1344
K
S
S
I
D
D
S
Y
G
R
Y
D
L
I
Q
Site 167
Y1347
I
D
D
S
Y
G
R
Y
D
L
I
Q
N
S
E
Site 168
S1353
R
Y
D
L
I
Q
N
S
E
S
P
A
S
P
P
Site 169
S1355
D
L
I
Q
N
S
E
S
P
A
S
P
P
V
A
Site 170
S1358
Q
N
S
E
S
P
A
S
P
P
V
A
V
P
H
Site 171
S1366
P
P
V
A
V
P
H
S
W
S
R
A
K
S
D
Site 172
S1368
V
A
V
P
H
S
W
S
R
A
K
S
D
S
D
Site 173
S1372
H
S
W
S
R
A
K
S
D
S
D
K
I
S
N
Site 174
S1374
W
S
R
A
K
S
D
S
D
K
I
S
N
G
S
Site 175
S1378
K
S
D
S
D
K
I
S
N
G
S
S
I
N
W
Site 176
S1382
D
K
I
S
N
G
S
S
I
N
W
P
P
E
F
Site 177
T1410
P
E
N
D
P
D
V
T
P
G
S
V
P
T
G
Site 178
S1413
D
P
D
V
T
P
G
S
V
P
T
G
P
T
I
Site 179
T1423
T
G
P
T
I
N
T
T
I
Q
D
V
N
R
Y
Site 180
Y1430
T
I
Q
D
V
N
R
Y
L
L
K
S
G
G
K
Site 181
S1434
V
N
R
Y
L
L
K
S
G
G
K
L
S
D
I
Site 182
S1439
L
K
S
G
G
K
L
S
D
I
K
S
T
W
S
Site 183
S1443
G
K
L
S
D
I
K
S
T
W
S
S
G
P
T
Site 184
T1444
K
L
S
D
I
K
S
T
W
S
S
G
P
T
S
Site 185
S1446
S
D
I
K
S
T
W
S
S
G
P
T
S
H
T
Site 186
S1447
D
I
K
S
T
W
S
S
G
P
T
S
H
T
Q
Site 187
T1450
S
T
W
S
S
G
P
T
S
H
T
Q
A
S
L
Site 188
S1451
T
W
S
S
G
P
T
S
H
T
Q
A
S
L
S
Site 189
T1453
S
S
G
P
T
S
H
T
Q
A
S
L
S
H
E
Site 190
S1456
P
T
S
H
T
Q
A
S
L
S
H
E
L
W
K
Site 191
S1458
S
H
T
Q
A
S
L
S
H
E
L
W
K
V
P
Site 192
S1468
L
W
K
V
P
R
N
S
T
A
P
T
R
P
P
Site 193
T1469
W
K
V
P
R
N
S
T
A
P
T
R
P
P
P
Site 194
T1472
P
R
N
S
T
A
P
T
R
P
P
P
G
L
T
Site 195
T1479
T
R
P
P
P
G
L
T
N
P
K
P
S
S
T
Site 196
S1485
L
T
N
P
K
P
S
S
T
W
G
A
S
P
L
Site 197
T1486
T
N
P
K
P
S
S
T
W
G
A
S
P
L
G
Site 198
S1490
P
S
S
T
W
G
A
S
P
L
G
W
T
S
S
Site 199
T1495
G
A
S
P
L
G
W
T
S
S
Y
S
S
G
S
Site 200
S1496
A
S
P
L
G
W
T
S
S
Y
S
S
G
S
A
Site 201
S1497
S
P
L
G
W
T
S
S
Y
S
S
G
S
A
W
Site 202
Y1498
P
L
G
W
T
S
S
Y
S
S
G
S
A
W
S
Site 203
S1499
L
G
W
T
S
S
Y
S
S
G
S
A
W
S
T
Site 204
S1500
G
W
T
S
S
Y
S
S
G
S
A
W
S
T
D
Site 205
S1502
T
S
S
Y
S
S
G
S
A
W
S
T
D
T
S
Site 206
S1505
Y
S
S
G
S
A
W
S
T
D
T
S
G
R
T
Site 207
T1506
S
S
G
S
A
W
S
T
D
T
S
G
R
T
S
Site 208
T1508
G
S
A
W
S
T
D
T
S
G
R
T
S
S
W
Site 209
S1509
S
A
W
S
T
D
T
S
G
R
T
S
S
W
L
Site 210
S1513
T
D
T
S
G
R
T
S
S
W
L
V
L
R
N
Site 211
S1514
D
T
S
G
R
T
S
S
W
L
V
L
R
N
L
Site 212
T1522
W
L
V
L
R
N
L
T
P
Q
I
D
G
S
T
Site 213
S1528
L
T
P
Q
I
D
G
S
T
L
R
T
L
C
L
Site 214
T1529
T
P
Q
I
D
G
S
T
L
R
T
L
C
L
Q
Site 215
T1532
I
D
G
S
T
L
R
T
L
C
L
Q
H
G
P
Site 216
Y1556
Q
G
N
A
V
V
R
Y
S
S
K
E
E
A
A
Site 217
S1557
G
N
A
V
V
R
Y
S
S
K
E
E
A
A
K
Site 218
S1558
N
A
V
V
R
Y
S
S
K
E
E
A
A
K
A
Site 219
T1602
Q
G
Q
A
L
P
P
T
S
S
W
Q
S
S
S
Site 220
S1603
G
Q
A
L
P
P
T
S
S
W
Q
S
S
S
A
Site 221
S1604
Q
A
L
P
P
T
S
S
W
Q
S
S
S
A
S
Site 222
S1607
P
P
T
S
S
W
Q
S
S
S
A
S
S
Q
P
Site 223
S1608
P
T
S
S
W
Q
S
S
S
A
S
S
Q
P
R
Site 224
S1609
T
S
S
W
Q
S
S
S
A
S
S
Q
P
R
L
Site 225
S1611
S
W
Q
S
S
S
A
S
S
Q
P
R
L
S
A
Site 226
S1612
W
Q
S
S
S
A
S
S
Q
P
R
L
S
A
A
Site 227
S1617
A
S
S
Q
P
R
L
S
A
A
G
S
S
H
G
Site 228
S1621
P
R
L
S
A
A
G
S
S
H
G
L
V
R
S
Site 229
S1628
S
S
H
G
L
V
R
S
D
A
G
H
W
N
A
Site 230
S1643
P
C
L
G
G
K
G
S
S
E
L
L
W
G
G
Site 231
Y1654
L
W
G
G
V
P
Q
Y
S
S
S
L
W
G
P
Site 232
S1655
W
G
G
V
P
Q
Y
S
S
S
L
W
G
P
P
Site 233
S1656
G
G
V
P
Q
Y
S
S
S
L
W
G
P
P
S
Site 234
S1657
G
V
P
Q
Y
S
S
S
L
W
G
P
P
S
A
Site 235
S1663
S
S
L
W
G
P
P
S
A
D
D
S
R
V
I
Site 236
S1667
G
P
P
S
A
D
D
S
R
V
I
G
S
P
T
Site 237
S1672
D
D
S
R
V
I
G
S
P
T
P
L
T
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation