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Updated November 2019
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Protein Info
Short Name:
KIAA1632
Full Name:
UPF0493 protein KIAA1632
Alias:
Type:
Mass (Da):
292481
Number AA:
2579
UniProt ID:
Q9HCE0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
A
K
A
S
R
T
K
T
K
E
K
K
K
Y
E
Site 2
Y26
K
T
K
E
K
K
K
Y
E
T
P
Q
R
E
E
Site 3
T28
K
E
K
K
K
Y
E
T
P
Q
R
E
E
S
S
Site 4
S34
E
T
P
Q
R
E
E
S
S
E
V
S
L
P
K
Site 5
S35
T
P
Q
R
E
E
S
S
E
V
S
L
P
K
T
Site 6
S38
R
E
E
S
S
E
V
S
L
P
K
T
S
R
E
Site 7
T42
S
E
V
S
L
P
K
T
S
R
E
Q
E
I
P
Site 8
S50
S
R
E
Q
E
I
P
S
L
A
C
E
F
K
G
Site 9
S66
H
L
K
V
V
T
D
S
Q
L
Q
D
D
A
S
Site 10
S73
S
Q
L
Q
D
D
A
S
G
Q
N
E
S
E
M
Site 11
T89
D
V
P
L
T
S
L
T
I
S
N
E
E
S
L
Site 12
S91
P
L
T
S
L
T
I
S
N
E
E
S
L
T
C
Site 13
S95
L
T
I
S
N
E
E
S
L
T
C
N
T
E
P
Site 14
T97
I
S
N
E
E
S
L
T
C
N
T
E
P
P
K
Site 15
T100
E
E
S
L
T
C
N
T
E
P
P
K
E
G
G
Site 16
T119
C
V
G
D
S
A
V
T
P
K
V
H
P
G
D
Site 17
T134
N
V
G
T
K
V
E
T
P
K
N
F
T
E
V
Site 18
S146
T
E
V
E
E
N
M
S
V
Q
G
G
L
S
E
Site 19
S152
M
S
V
Q
G
G
L
S
E
S
A
P
Q
S
N
Site 20
S154
V
Q
G
G
L
S
E
S
A
P
Q
S
N
F
S
Site 21
S158
L
S
E
S
A
P
Q
S
N
F
S
Y
T
Q
P
Site 22
S161
S
A
P
Q
S
N
F
S
Y
T
Q
P
A
M
E
Site 23
Y162
A
P
Q
S
N
F
S
Y
T
Q
P
A
M
E
N
Site 24
T175
E
N
I
Q
V
R
E
T
Q
N
S
K
E
D
K
Site 25
S178
Q
V
R
E
T
Q
N
S
K
E
D
K
Q
G
L
Site 26
S188
D
K
Q
G
L
V
C
S
S
E
V
P
Q
N
V
Site 27
S199
P
Q
N
V
G
L
Q
S
S
C
P
A
K
H
G
Site 28
S200
Q
N
V
G
L
Q
S
S
C
P
A
K
H
G
F
Site 29
T209
P
A
K
H
G
F
Q
T
P
R
V
K
K
L
Y
Site 30
Y216
T
P
R
V
K
K
L
Y
P
Q
L
P
A
E
I
Site 31
S239
A
V
K
P
L
L
R
S
E
R
L
Y
P
E
L
Site 32
Y243
L
L
R
S
E
R
L
Y
P
E
L
P
S
Q
L
Site 33
S248
R
L
Y
P
E
L
P
S
Q
L
E
L
V
P
F
Site 34
S267
L
K
I
L
E
P
G
S
W
L
E
N
V
E
S
Site 35
S274
S
W
L
E
N
V
E
S
Y
L
E
E
F
D
S
Site 36
Y275
W
L
E
N
V
E
S
Y
L
E
E
F
D
S
M
Site 37
S281
S
Y
L
E
E
F
D
S
M
A
H
Q
D
R
H
Site 38
Y297
F
Y
E
L
L
L
N
Y
S
R
C
R
K
Q
L
Site 39
S298
Y
E
L
L
L
N
Y
S
R
C
R
K
Q
L
L
Site 40
S316
A
E
L
L
T
L
T
S
D
C
Q
N
A
K
S
Site 41
Y348
D
Q
V
K
V
F
S
Y
H
R
Y
Q
R
V
E
Site 42
Y351
K
V
F
S
Y
H
R
Y
Q
R
V
E
M
N
E
Site 43
S372
K
K
L
F
D
A
K
S
E
H
L
H
Q
T
L
Site 44
T378
K
S
E
H
L
H
Q
T
L
A
L
H
S
Y
T
Site 45
S383
H
Q
T
L
A
L
H
S
Y
T
S
V
L
S
R
Site 46
S389
H
S
Y
T
S
V
L
S
R
L
Q
V
E
S
Y
Site 47
S409
S
S
S
A
V
L
R
S
S
A
I
H
Q
Q
G
Site 48
S410
S
S
A
V
L
R
S
S
A
I
H
Q
Q
G
R
Site 49
S419
I
H
Q
Q
G
R
A
S
K
Q
T
E
S
I
P
Site 50
T422
Q
G
R
A
S
K
Q
T
E
S
I
P
S
D
L
Site 51
S424
R
A
S
K
Q
T
E
S
I
P
S
D
L
C
Q
Site 52
S427
K
Q
T
E
S
I
P
S
D
L
C
Q
L
K
E
Site 53
T450
T
R
R
V
N
E
D
T
Q
F
H
D
D
I
L
Site 54
S507
I
K
V
L
H
N
P
S
G
V
F
H
F
M
Q
Site 55
S521
Q
S
L
A
L
L
M
S
P
V
K
N
R
A
E
Site 56
S536
F
M
C
H
M
K
P
S
E
R
K
P
S
S
S
Site 57
S541
K
P
S
E
R
K
P
S
S
S
G
P
G
S
G
Site 58
S542
P
S
E
R
K
P
S
S
S
G
P
G
S
G
T
Site 59
S543
S
E
R
K
P
S
S
S
G
P
G
S
G
T
W
Site 60
S547
P
S
S
S
G
P
G
S
G
T
W
T
L
V
D
Site 61
T551
G
P
G
S
G
T
W
T
L
V
D
E
G
G
E
Site 62
T565
E
E
D
E
D
P
E
T
S
W
I
L
L
N
E
Site 63
Y600
G
F
K
A
K
G
D
Y
L
P
E
T
T
R
P
Site 64
T604
K
G
D
Y
L
P
E
T
T
R
P
Q
E
M
M
Site 65
T630
L
L
A
V
G
L
E
T
F
N
R
A
R
Y
R
Site 66
Y636
E
T
F
N
R
A
R
Y
R
Q
F
V
K
R
I
Site 67
Y661
V
S
D
H
W
A
Q
Y
V
S
H
N
Q
G
S
Site 68
Y675
S
G
L
A
Q
Q
P
Y
S
M
E
K
L
Q
V
Site 69
S676
G
L
A
Q
Q
P
Y
S
M
E
K
L
Q
V
E
Site 70
S739
S
E
N
L
Q
Q
L
S
S
S
L
Q
P
A
Q
Site 71
S740
E
N
L
Q
Q
L
S
S
S
L
Q
P
A
Q
C
Site 72
S741
N
L
Q
Q
L
S
S
S
L
Q
P
A
Q
C
K
Site 73
S765
T
N
F
E
K
C
L
S
S
M
N
S
S
E
E
Site 74
S766
N
F
E
K
C
L
S
S
M
N
S
S
E
E
I
Site 75
T788
Q
M
A
Q
A
R
R
T
N
V
D
E
D
F
I
Site 76
Y807
L
E
I
Y
E
V
S
Y
V
T
L
S
T
R
E
Site 77
S811
E
V
S
Y
V
T
L
S
T
R
E
T
F
S
K
Site 78
T815
V
T
L
S
T
R
E
T
F
S
K
V
G
R
E
Site 79
S817
L
S
T
R
E
T
F
S
K
V
G
R
E
L
L
Site 80
T826
V
G
R
E
L
L
G
T
I
T
A
V
H
P
E
Site 81
T828
R
E
L
L
G
T
I
T
A
V
H
P
E
I
I
Site 82
Y863
L
F
K
E
L
P
L
Y
L
W
Q
P
S
A
S
Site 83
S870
Y
L
W
Q
P
S
A
S
E
I
A
V
I
R
D
Site 84
Y930
V
L
E
A
Y
Q
K
Y
L
A
Q
K
P
Y
A
Site 85
S941
K
P
Y
A
G
I
L
S
E
S
M
K
Q
V
S
Site 86
S948
S
E
S
M
K
Q
V
S
Y
L
A
S
I
V
R
Site 87
Y949
E
S
M
K
Q
V
S
Y
L
A
S
I
V
R
Y
Site 88
S952
K
Q
V
S
Y
L
A
S
I
V
R
Y
G
E
T
Site 89
T959
S
I
V
R
Y
G
E
T
P
E
T
S
F
N
Q
Site 90
Y982
L
K
L
H
K
N
D
Y
G
I
Q
P
N
C
P
Site 91
T1001
S
V
T
V
P
D
M
T
E
S
P
T
F
H
P
Site 92
S1003
T
V
P
D
M
T
E
S
P
T
F
H
P
L
L
Site 93
T1005
P
D
M
T
E
S
P
T
F
H
P
L
L
K
A
Site 94
T1056
V
Q
S
R
H
L
R
T
V
V
H
V
L
D
K
Site 95
Y1074
L
F
Y
P
C
Q
Y
Y
L
L
K
N
E
Q
F
Site 96
T1100
S
G
V
P
Q
G
V
T
Q
Q
V
T
H
K
V
Site 97
T1104
Q
G
V
T
Q
Q
V
T
H
K
V
A
Q
H
L
Site 98
S1132
S
M
I
Q
A
H
I
S
V
S
T
Q
P
N
E
Site 99
Y1190
D
C
I
Q
K
L
L
Y
Q
Q
H
K
N
A
L
Site 100
Y1199
Q
H
K
N
A
L
G
Y
H
C
D
R
S
L
L
Site 101
S1249
E
S
I
F
E
E
D
S
Q
L
R
R
V
I
E
Site 102
T1266
L
V
I
N
S
A
F
T
P
D
Q
A
L
K
K
Site 103
T1276
Q
A
L
K
K
A
Q
T
Q
L
K
L
P
I
V
Site 104
T1301
W
A
H
Q
A
L
V
T
P
S
D
H
P
L
L
Site 105
Y1319
W
Q
K
F
F
L
L
Y
L
H
R
P
G
P
Q
Site 106
Y1327
L
H
R
P
G
P
Q
Y
G
L
P
I
D
G
C
Site 107
T1357
K
E
M
K
R
R
L
T
E
V
A
D
F
H
H
Site 108
S1383
G
S
E
G
L
P
E
S
H
S
G
T
P
G
Y
Site 109
S1385
E
G
L
P
E
S
H
S
G
T
P
G
Y
L
T
Site 110
T1387
L
P
E
S
H
S
G
T
P
G
Y
L
T
S
P
Site 111
Y1390
S
H
S
G
T
P
G
Y
L
T
S
P
E
L
H
Site 112
T1392
S
G
T
P
G
Y
L
T
S
P
E
L
H
K
E
Site 113
S1393
G
T
P
G
Y
L
T
S
P
E
L
H
K
E
L
Site 114
T1421
E
N
F
Q
K
G
D
T
Y
I
P
S
L
P
K
Site 115
Y1422
N
F
Q
K
G
D
T
Y
I
P
S
L
P
K
H
Site 116
S1425
K
G
D
T
Y
I
P
S
L
P
K
H
Y
D
I
Site 117
Y1449
Q
Q
D
L
W
M
E
Y
L
N
M
E
R
I
Y
Site 118
Y1456
Y
L
N
M
E
R
I
Y
H
E
F
Q
E
T
V
Site 119
T1462
I
Y
H
E
F
Q
E
T
V
G
L
W
T
Q
A
Site 120
S1473
W
T
Q
A
K
L
E
S
H
S
T
P
C
S
L
Site 121
S1475
Q
A
K
L
E
S
H
S
T
P
C
S
L
S
V
Site 122
T1476
A
K
L
E
S
H
S
T
P
C
S
L
S
V
Q
Site 123
S1479
E
S
H
S
T
P
C
S
L
S
V
Q
L
D
F
Site 124
S1481
H
S
T
P
C
S
L
S
V
Q
L
D
F
T
D
Site 125
S1498
L
A
K
E
R
V
L
S
N
L
R
K
H
E
A
Site 126
S1556
R
T
A
A
L
R
E
S
Q
Q
V
A
L
D
G
Site 127
T1568
L
D
G
E
L
L
D
T
M
P
K
Q
Y
V
N
Site 128
Y1573
L
D
T
M
P
K
Q
Y
V
N
R
E
E
Q
T
Site 129
T1581
V
N
R
E
E
Q
T
T
L
H
L
E
C
R
G
Site 130
S1589
L
H
L
E
C
R
G
S
S
G
K
K
C
Q
G
Site 131
S1590
H
L
E
C
R
G
S
S
G
K
K
C
Q
G
A
Site 132
T1662
N
A
Y
K
L
Q
P
T
P
G
I
Q
K
V
G
Site 133
Y1679
L
F
F
T
I
V
D
Y
V
S
D
E
T
Q
R
Site 134
S1681
F
T
I
V
D
Y
V
S
D
E
T
Q
R
H
P
Site 135
T1684
V
D
Y
V
S
D
E
T
Q
R
H
P
P
T
R
Site 136
T1690
E
T
Q
R
H
P
P
T
R
Q
F
F
T
S
C
Site 137
T1719
E
C
R
K
V
L
E
T
I
L
K
N
S
R
L
Site 138
S1755
E
Q
V
V
K
F
L
S
E
D
N
S
D
M
I
Site 139
S1776
F
D
L
K
Q
W
L
S
A
T
K
P
P
L
S
Site 140
T1778
L
K
Q
W
L
S
A
T
K
P
P
L
S
D
R
Site 141
S1783
S
A
T
K
P
P
L
S
D
R
T
R
L
L
E
Site 142
Y1824
H
W
T
Y
L
L
L
Y
Q
F
P
D
Q
Y
S
Site 143
Y1830
L
Y
Q
F
P
D
Q
Y
S
D
I
L
R
L
L
Site 144
S1847
S
S
A
E
Q
L
L
S
P
E
C
W
K
A
T
Site 145
S1880
E
G
A
V
L
P
S
S
S
D
A
L
L
S
D
Site 146
S1881
G
A
V
L
P
S
S
S
D
A
L
L
S
D
K
Site 147
S1886
S
S
S
D
A
L
L
S
D
K
Q
V
M
E
T
Site 148
Y1902
Q
W
L
S
D
F
F
Y
K
L
R
L
S
K
M
Site 149
S1907
F
F
Y
K
L
R
L
S
K
M
D
F
K
S
F
Site 150
S1913
L
S
K
M
D
F
K
S
F
G
L
F
S
K
W
Site 151
S1921
F
G
L
F
S
K
W
S
P
Y
M
A
D
V
K
Site 152
T1951
T
C
L
A
Q
D
P
T
A
S
R
K
T
V
L
Site 153
T1956
D
P
T
A
S
R
K
T
V
L
K
S
L
H
S
Site 154
S1960
S
R
K
T
V
L
K
S
L
H
S
V
I
I
Q
Site 155
S1981
L
V
L
E
D
N
E
S
S
Q
Q
R
H
Y
P
Site 156
S1982
V
L
E
D
N
E
S
S
Q
Q
R
H
Y
P
W
Site 157
Y1987
E
S
S
Q
Q
R
H
Y
P
W
L
E
S
D
T
Site 158
S1992
R
H
Y
P
W
L
E
S
D
T
V
V
A
S
S
Site 159
S2010
L
F
T
D
C
I
D
S
L
H
E
S
F
K
D
Site 160
S2014
C
I
D
S
L
H
E
S
F
K
D
K
L
L
P
Site 161
Y2049
K
M
P
E
F
I
L
Y
A
F
H
S
T
Y
R
Site 162
T2054
I
L
Y
A
F
H
S
T
Y
R
K
L
P
W
K
Site 163
S2102
V
N
W
V
S
V
L
S
D
A
W
N
S
S
P
Site 164
S2108
L
S
D
A
W
N
S
S
P
H
P
E
T
R
S
Site 165
T2113
N
S
S
P
H
P
E
T
R
S
M
I
V
C
L
Site 166
S2143
Q
T
D
S
P
L
L
S
L
L
G
Q
T
S
S
Site 167
S2166
V
S
Y
Q
S
V
L
S
Y
F
S
S
H
Y
P
Site 168
Y2167
S
Y
Q
S
V
L
S
Y
F
S
S
H
Y
P
P
Site 169
S2169
Q
S
V
L
S
Y
F
S
S
H
Y
P
P
S
I
Site 170
S2175
F
S
S
H
Y
P
P
S
I
I
L
A
K
E
S
Site 171
S2198
L
K
V
S
A
G
L
S
I
P
T
D
S
Q
K
Site 172
S2203
G
L
S
I
P
T
D
S
Q
K
H
L
D
A
V
Site 173
S2259
F
N
P
P
D
M
D
S
Q
T
R
H
M
A
L
Site 174
T2261
P
P
D
M
D
S
Q
T
R
H
M
A
L
S
S
Site 175
S2291
T
A
E
F
L
R
G
S
I
R
T
W
I
G
Q
Site 176
T2294
F
L
R
G
S
I
R
T
W
I
G
Q
K
M
H
Site 177
S2315
L
L
T
A
A
C
Q
S
L
A
S
V
R
H
M
Site 178
S2318
A
A
C
Q
S
L
A
S
V
R
H
M
A
E
T
Site 179
T2325
S
V
R
H
M
A
E
T
T
E
A
C
I
T
A
Site 180
T2331
E
T
T
E
A
C
I
T
A
Y
F
K
E
S
P
Site 181
Y2333
T
E
A
C
I
T
A
Y
F
K
E
S
P
L
N
Site 182
S2337
I
T
A
Y
F
K
E
S
P
L
N
Q
N
S
G
Site 183
S2343
E
S
P
L
N
Q
N
S
G
W
G
P
I
L
V
Site 184
T2358
S
L
Q
V
P
E
L
T
M
E
E
F
L
Q
E
Site 185
S2385
Y
L
L
Q
C
L
N
S
E
Q
T
L
R
N
E
Site 186
T2388
Q
C
L
N
S
E
Q
T
L
R
N
E
M
K
V
Site 187
Y2407
S
K
W
L
E
Q
V
Y
P
S
S
V
E
E
E
Site 188
S2410
L
E
Q
V
Y
P
S
S
V
E
E
E
A
K
L
Site 189
T2432
L
Q
L
S
L
I
Q
T
E
Q
N
D
S
V
L
Site 190
S2437
I
Q
T
E
Q
N
D
S
V
L
T
E
S
V
I
Site 191
S2476
A
I
G
F
G
R
K
S
P
L
S
N
R
F
R
Site 192
S2479
F
G
R
K
S
P
L
S
N
R
F
R
V
V
A
Site 193
S2509
Q
I
R
L
R
P
G
S
E
L
H
L
T
P
K
Site 194
T2514
P
G
S
E
L
H
L
T
P
K
A
Q
Q
A
L
Site 195
S2526
Q
A
L
N
A
L
E
S
M
A
S
S
K
Q
Y
Site 196
S2529
N
A
L
E
S
M
A
S
S
K
Q
Y
V
E
Y
Site 197
S2530
A
L
E
S
M
A
S
S
K
Q
Y
V
E
Y
Q
Site 198
Y2533
S
M
A
S
S
K
Q
Y
V
E
Y
Q
D
Q
I
Site 199
Y2536
S
S
K
Q
Y
V
E
Y
Q
D
Q
I
L
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation