KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NCoA5
Full Name:
Nuclear receptor coactivator 5
Alias:
BA465L10.6; CIA; Coactivator independent of AF-2; NCoA-5; Nuclear receptor coactivator 5
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
65536
Number AA:
579
UniProt ID:
Q9HCD5
International Prot ID:
IPI00288941
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004812
GO:0004812
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
GO:0006412
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
N
T
A
P
S
R
P
S
P
Site 2
S6
_
_
M
N
T
A
P
S
R
P
S
P
T
R
R
Site 3
S9
N
T
A
P
S
R
P
S
P
T
R
R
D
P
Y
Site 4
T11
A
P
S
R
P
S
P
T
R
R
D
P
Y
G
F
Site 5
Y16
S
P
T
R
R
D
P
Y
G
F
G
D
S
R
D
Site 6
S24
G
F
G
D
S
R
D
S
R
R
D
R
S
P
I
Site 7
S29
R
D
S
R
R
D
R
S
P
I
R
G
S
P
R
Site 8
S34
D
R
S
P
I
R
G
S
P
R
R
E
P
R
D
Site 9
S51
N
G
R
D
A
R
D
S
R
D
I
R
D
P
R
Site 10
S66
D
L
R
D
H
R
H
S
R
D
L
R
D
H
R
Site 11
S75
D
L
R
D
H
R
D
S
R
S
V
R
D
V
R
Site 12
S77
R
D
H
R
D
S
R
S
V
R
D
V
R
D
V
Site 13
S96
D
F
R
D
L
R
D
S
R
D
F
R
D
Q
R
Site 14
Y107
R
D
Q
R
D
P
M
Y
D
R
Y
R
D
M
R
Site 15
Y110
R
D
P
M
Y
D
R
Y
R
D
M
R
D
S
R
Site 16
S116
R
Y
R
D
M
R
D
S
R
D
P
M
Y
R
R
Site 17
Y121
R
D
S
R
D
P
M
Y
R
R
E
G
S
Y
D
Site 18
S126
P
M
Y
R
R
E
G
S
Y
D
R
Y
L
R
M
Site 19
Y127
M
Y
R
R
E
G
S
Y
D
R
Y
L
R
M
D
Site 20
Y130
R
E
G
S
Y
D
R
Y
L
R
M
D
D
Y
C
Site 21
Y136
R
Y
L
R
M
D
D
Y
C
R
R
K
D
D
S
Site 22
Y144
C
R
R
K
D
D
S
Y
F
D
R
Y
R
D
S
Site 23
Y148
D
D
S
Y
F
D
R
Y
R
D
S
F
D
G
R
Site 24
S151
Y
F
D
R
Y
R
D
S
F
D
G
R
G
P
P
Site 25
S162
R
G
P
P
G
P
E
S
Q
S
R
A
K
E
R
Site 26
S164
P
P
G
P
E
S
Q
S
R
A
K
E
R
L
K
Site 27
Y181
E
R
R
R
E
E
L
Y
R
Q
Y
F
E
E
I
Site 28
Y184
R
E
E
L
Y
R
Q
Y
F
E
E
I
Q
R
R
Site 29
S201
A
E
R
P
V
D
C
S
V
I
V
V
N
K
Q
Site 30
Y212
V
N
K
Q
T
K
D
Y
A
E
S
V
G
R
K
Site 31
S239
L
N
T
E
V
S
L
S
Q
A
L
E
D
V
S
Site 32
S246
S
Q
A
L
E
D
V
S
R
G
G
S
P
F
A
Site 33
T267
H
Q
I
H
R
S
C
T
V
N
I
M
F
G
T
Site 34
T274
T
V
N
I
M
F
G
T
P
Q
E
H
R
N
M
Site 35
Y294
M
V
L
V
A
R
N
Y
E
R
Y
K
N
E
C
Site 36
Y297
V
A
R
N
Y
E
R
Y
K
N
E
C
R
E
K
Site 37
Y354
N
L
L
A
D
N
R
Y
L
T
A
E
E
T
D
Site 38
T356
L
A
D
N
R
Y
L
T
A
E
E
T
D
K
I
Site 39
Y366
E
T
D
K
I
I
N
Y
L
R
E
R
K
E
R
Site 40
S377
R
K
E
R
L
M
R
S
S
T
D
S
L
P
G
Site 41
S378
K
E
R
L
M
R
S
S
T
D
S
L
P
G
P
Site 42
T379
E
R
L
M
R
S
S
T
D
S
L
P
G
P
I
Site 43
S381
L
M
R
S
S
T
D
S
L
P
G
P
I
S
R
Site 44
S387
D
S
L
P
G
P
I
S
R
Q
P
L
G
A
T
Site 45
T394
S
R
Q
P
L
G
A
T
S
G
A
S
L
K
T
Site 46
S395
R
Q
P
L
G
A
T
S
G
A
S
L
K
T
Q
Site 47
S398
L
G
A
T
S
G
A
S
L
K
T
Q
P
S
S
Site 48
T401
T
S
G
A
S
L
K
T
Q
P
S
S
Q
P
L
Site 49
S404
A
S
L
K
T
Q
P
S
S
Q
P
L
Q
S
G
Site 50
S405
S
L
K
T
Q
P
S
S
Q
P
L
Q
S
G
Q
Site 51
S410
P
S
S
Q
P
L
Q
S
G
Q
V
L
P
S
A
Site 52
S416
Q
S
G
Q
V
L
P
S
A
T
P
T
P
S
A
Site 53
T418
G
Q
V
L
P
S
A
T
P
T
P
S
A
P
P
Site 54
T420
V
L
P
S
A
T
P
T
P
S
A
P
P
T
S
Site 55
S422
P
S
A
T
P
T
P
S
A
P
P
T
S
Q
Q
Site 56
T426
P
T
P
S
A
P
P
T
S
Q
Q
E
L
Q
A
Site 57
S427
T
P
S
A
P
P
T
S
Q
Q
E
L
Q
A
K
Site 58
T443
L
S
L
F
N
S
G
T
V
T
A
N
S
S
S
Site 59
T445
L
F
N
S
G
T
V
T
A
N
S
S
S
A
S
Site 60
S448
S
G
T
V
T
A
N
S
S
S
A
S
P
S
V
Site 61
S449
G
T
V
T
A
N
S
S
S
A
S
P
S
V
A
Site 62
S452
T
A
N
S
S
S
A
S
P
S
V
A
A
G
N
Site 63
S454
N
S
S
S
A
S
P
S
V
A
A
G
N
T
P
Site 64
T460
P
S
V
A
A
G
N
T
P
N
Q
N
F
S
T
Site 65
T467
T
P
N
Q
N
F
S
T
A
A
N
S
Q
P
Q
Site 66
S471
N
F
S
T
A
A
N
S
Q
P
Q
Q
R
S
Q
Site 67
S477
N
S
Q
P
Q
Q
R
S
Q
A
S
G
N
Q
P
Site 68
S480
P
Q
Q
R
S
Q
A
S
G
N
Q
P
P
S
I
Site 69
S486
A
S
G
N
Q
P
P
S
I
L
G
Q
G
G
S
Site 70
S493
S
I
L
G
Q
G
G
S
A
Q
N
M
G
P
R
Site 71
S505
G
P
R
P
G
A
P
S
Q
G
L
F
G
Q
P
Site 72
S513
Q
G
L
F
G
Q
P
S
S
R
L
A
P
A
S
Site 73
S514
G
L
F
G
Q
P
S
S
R
L
A
P
A
S
N
Site 74
S520
S
S
R
L
A
P
A
S
N
M
T
S
Q
R
P
Site 75
S524
A
P
A
S
N
M
T
S
Q
R
P
V
S
S
T
Site 76
S529
M
T
S
Q
R
P
V
S
S
T
G
I
N
F
D
Site 77
T531
S
Q
R
P
V
S
S
T
G
I
N
F
D
N
P
Site 78
S539
G
I
N
F
D
N
P
S
V
Q
K
A
L
D
T
Site 79
T546
S
V
Q
K
A
L
D
T
L
I
Q
S
G
P
A
Site 80
S555
I
Q
S
G
P
A
L
S
H
L
V
S
Q
T
T
Site 81
S559
P
A
L
S
H
L
V
S
Q
T
T
A
Q
M
G
Site 82
T562
S
H
L
V
S
Q
T
T
A
Q
M
G
Q
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation