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Updated November 2019
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Protein Info
Short Name:
TNS1
Full Name:
Tensin-1
Alias:
DKFZp586K0617; MXRA6; TENS1; Tensin 1; TNS
Type:
Adapter/scaffold protein
Mass (Da):
185701
Number AA:
1735
UniProt ID:
Q9HBL0
International Prot ID:
IPI00307545
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
V
S
R
T
M
E
D
S
C
E
L
Site 2
S10
V
S
R
T
M
E
D
S
C
E
L
D
L
V
Y
Site 3
S26
T
E
R
I
I
A
V
S
F
P
S
T
A
N
E
Site 4
T30
I
A
V
S
F
P
S
T
A
N
E
E
N
F
R
Site 5
S38
A
N
E
E
N
F
R
S
N
L
R
E
V
A
Q
Site 6
S49
E
V
A
Q
M
L
K
S
K
H
G
G
N
Y
L
Site 7
Y55
K
S
K
H
G
G
N
Y
L
L
F
N
L
S
E
Site 8
S61
N
Y
L
L
F
N
L
S
E
R
R
P
D
I
T
Site 9
T68
S
E
R
R
P
D
I
T
K
L
H
A
K
V
L
Site 10
T84
F
G
W
P
D
L
H
T
P
A
L
E
K
I
C
Site 11
Y150
R
F
A
M
K
R
F
Y
E
D
K
I
V
P
I
Site 12
Y165
G
Q
P
S
Q
R
R
Y
V
H
Y
F
S
G
L
Site 13
Y168
S
Q
R
R
Y
V
H
Y
F
S
G
L
L
S
G
Site 14
S170
R
R
Y
V
H
Y
F
S
G
L
L
S
G
S
I
Site 15
S174
H
Y
F
S
G
L
L
S
G
S
I
K
M
N
N
Site 16
Y210
C
R
P
F
L
R
I
Y
Q
A
M
Q
P
V
Y
Site 17
Y217
Y
Q
A
M
Q
P
V
Y
T
S
G
I
Y
N
I
Site 18
Y222
P
V
Y
T
S
G
I
Y
N
I
P
G
D
S
Q
Site 19
T230
N
I
P
G
D
S
Q
T
S
V
C
I
T
I
E
Site 20
Y251
G
D
I
L
L
K
C
Y
H
K
K
F
R
S
P
Site 21
S257
C
Y
H
K
K
F
R
S
P
A
R
D
V
I
F
Site 22
Y297
K
D
D
R
F
P
E
Y
G
K
V
E
F
V
F
Site 23
S305
G
K
V
E
F
V
F
S
Y
G
P
E
K
I
Q
Site 24
S322
E
H
L
E
N
G
P
S
V
S
V
D
Y
N
T
Site 25
S324
L
E
N
G
P
S
V
S
V
D
Y
N
T
S
D
Site 26
Y327
G
P
S
V
S
V
D
Y
N
T
S
D
P
L
I
Site 27
T329
S
V
S
V
D
Y
N
T
S
D
P
L
I
R
W
Site 28
S330
V
S
V
D
Y
N
T
S
D
P
L
I
R
W
D
Site 29
S338
D
P
L
I
R
W
D
S
Y
D
N
F
S
G
H
Site 30
Y339
P
L
I
R
W
D
S
Y
D
N
F
S
G
H
R
Site 31
S343
W
D
S
Y
D
N
F
S
G
H
R
D
D
G
M
Site 32
T357
M
E
E
V
V
G
H
T
Q
G
P
L
D
G
S
Site 33
S364
T
Q
G
P
L
D
G
S
L
Y
A
K
V
K
K
Site 34
Y366
G
P
L
D
G
S
L
Y
A
K
V
K
K
K
D
Site 35
S374
A
K
V
K
K
K
D
S
L
H
G
S
T
G
A
Site 36
S378
K
K
D
S
L
H
G
S
T
G
A
V
N
A
T
Site 37
T388
A
V
N
A
T
R
P
T
L
S
A
T
P
N
H
Site 38
S390
N
A
T
R
P
T
L
S
A
T
P
N
H
V
E
Site 39
T392
T
R
P
T
L
S
A
T
P
N
H
V
E
H
T
Site 40
T399
T
P
N
H
V
E
H
T
L
S
V
S
S
D
S
Site 41
S401
N
H
V
E
H
T
L
S
V
S
S
D
S
G
N
Site 42
S406
T
L
S
V
S
S
D
S
G
N
S
T
A
S
T
Site 43
T410
S
S
D
S
G
N
S
T
A
S
T
K
T
D
K
Site 44
T413
S
G
N
S
T
A
S
T
K
T
D
K
T
D
E
Site 45
T418
A
S
T
K
T
D
K
T
D
E
P
V
P
G
A
Site 46
S433
S
S
A
T
A
A
L
S
P
Q
E
K
R
E
L
Site 47
S445
R
E
L
D
R
L
L
S
G
F
G
L
E
R
E
Site 48
Y458
R
E
K
Q
G
A
M
Y
H
T
Q
H
L
R
S
Site 49
T460
K
Q
G
A
M
Y
H
T
Q
H
L
R
S
R
P
Site 50
S465
Y
H
T
Q
H
L
R
S
R
P
A
G
G
S
A
Site 51
S471
R
S
R
P
A
G
G
S
A
V
P
S
S
G
R
Site 52
S475
A
G
G
S
A
V
P
S
S
G
R
H
V
V
P
Site 53
S476
G
G
S
A
V
P
S
S
G
R
H
V
V
P
A
Site 54
S494
V
N
G
G
A
L
A
S
E
R
E
T
D
I
L
Site 55
T498
A
L
A
S
E
R
E
T
D
I
L
D
D
E
L
Site 56
S512
L
P
N
Q
D
G
H
S
A
G
S
M
G
T
L
Site 57
S515
Q
D
G
H
S
A
G
S
M
G
T
L
S
S
L
Site 58
S521
G
S
M
G
T
L
S
S
L
D
G
V
T
N
T
Site 59
T526
L
S
S
L
D
G
V
T
N
T
S
E
G
G
Y
Site 60
S529
L
D
G
V
T
N
T
S
E
G
G
Y
P
E
A
Site 61
Y533
T
N
T
S
E
G
G
Y
P
E
A
L
S
P
L
Site 62
S538
G
G
Y
P
E
A
L
S
P
L
T
N
G
L
D
Site 63
S547
L
T
N
G
L
D
K
S
Y
P
M
E
P
M
V
Site 64
Y548
T
N
G
L
D
K
S
Y
P
M
E
P
M
V
N
Site 65
Y559
P
M
V
N
G
G
G
Y
P
Y
E
S
A
S
R
Site 66
Y561
V
N
G
G
G
Y
P
Y
E
S
A
S
R
A
G
Site 67
S563
G
G
G
Y
P
Y
E
S
A
S
R
A
G
P
A
Site 68
S581
H
T
A
P
M
R
P
S
Y
S
A
Q
E
G
L
Site 69
Y582
T
A
P
M
R
P
S
Y
S
A
Q
E
G
L
A
Site 70
S583
A
P
M
R
P
S
Y
S
A
Q
E
G
L
A
G
Site 71
Y591
A
Q
E
G
L
A
G
Y
Q
R
E
G
P
H
P
Site 72
T605
P
A
W
P
Q
P
V
T
T
S
H
Y
A
H
D
Site 73
T606
A
W
P
Q
P
V
T
T
S
H
Y
A
H
D
P
Site 74
S607
W
P
Q
P
V
T
T
S
H
Y
A
H
D
P
S
Site 75
Y609
Q
P
V
T
T
S
H
Y
A
H
D
P
S
G
M
Site 76
S614
S
H
Y
A
H
D
P
S
G
M
F
R
S
Q
S
Site 77
S619
D
P
S
G
M
F
R
S
Q
S
F
S
E
A
E
Site 78
S621
S
G
M
F
R
S
Q
S
F
S
E
A
E
P
Q
Site 79
S623
M
F
R
S
Q
S
F
S
E
A
E
P
Q
L
P
Site 80
S638
P
A
P
V
R
G
G
S
S
R
E
A
V
Q
R
Site 81
S674
Q
E
R
A
H
L
E
S
L
V
A
S
R
P
S
Site 82
S678
H
L
E
S
L
V
A
S
R
P
S
P
Q
P
L
Site 83
S681
S
L
V
A
S
R
P
S
P
Q
P
L
A
E
T
Site 84
T688
S
P
Q
P
L
A
E
T
P
I
P
S
L
P
E
Site 85
S692
L
A
E
T
P
I
P
S
L
P
E
F
P
R
A
Site 86
S701
P
E
F
P
R
A
A
S
Q
Q
E
I
E
Q
S
Site 87
S708
S
Q
Q
E
I
E
Q
S
I
E
T
L
N
M
L
Site 88
S731
A
A
A
P
L
H
K
S
Q
S
V
P
G
A
W
Site 89
S733
A
P
L
H
K
S
Q
S
V
P
G
A
W
P
G
Site 90
S742
P
G
A
W
P
G
A
S
P
L
S
S
Q
P
L
Site 91
S745
W
P
G
A
S
P
L
S
S
Q
P
L
S
G
S
Site 92
S746
P
G
A
S
P
L
S
S
Q
P
L
S
G
S
S
Site 93
S750
P
L
S
S
Q
P
L
S
G
S
S
R
Q
S
H
Site 94
S752
S
S
Q
P
L
S
G
S
S
R
Q
S
H
P
L
Site 95
S753
S
Q
P
L
S
G
S
S
R
Q
S
H
P
L
T
Site 96
S756
L
S
G
S
S
R
Q
S
H
P
L
T
Q
S
R
Site 97
T760
S
R
Q
S
H
P
L
T
Q
S
R
S
G
Y
I
Site 98
S762
Q
S
H
P
L
T
Q
S
R
S
G
Y
I
P
S
Site 99
S764
H
P
L
T
Q
S
R
S
G
Y
I
P
S
G
H
Site 100
Y766
L
T
Q
S
R
S
G
Y
I
P
S
G
H
S
L
Site 101
S769
S
R
S
G
Y
I
P
S
G
H
S
L
G
T
P
Site 102
T775
P
S
G
H
S
L
G
T
P
E
P
A
P
R
A
Site 103
S783
P
E
P
A
P
R
A
S
L
E
S
V
P
P
G
Site 104
S786
A
P
R
A
S
L
E
S
V
P
P
G
R
S
Y
Site 105
S792
E
S
V
P
P
G
R
S
Y
S
P
Y
D
Y
Q
Site 106
Y793
S
V
P
P
G
R
S
Y
S
P
Y
D
Y
Q
P
Site 107
S794
V
P
P
G
R
S
Y
S
P
Y
D
Y
Q
P
C
Site 108
Y796
P
G
R
S
Y
S
P
Y
D
Y
Q
P
C
L
A
Site 109
Y798
R
S
Y
S
P
Y
D
Y
Q
P
C
L
A
G
P
Site 110
S811
G
P
N
Q
D
F
H
S
K
S
P
A
S
S
S
Site 111
S813
N
Q
D
F
H
S
K
S
P
A
S
S
S
L
P
Site 112
S816
F
H
S
K
S
P
A
S
S
S
L
P
A
F
L
Site 113
S817
H
S
K
S
P
A
S
S
S
L
P
A
F
L
P
Site 114
S818
S
K
S
P
A
S
S
S
L
P
A
F
L
P
T
Site 115
T825
S
L
P
A
F
L
P
T
T
H
S
P
P
G
P
Site 116
T826
L
P
A
F
L
P
T
T
H
S
P
P
G
P
Q
Site 117
S828
A
F
L
P
T
T
H
S
P
P
G
P
Q
Q
P
Site 118
S838
G
P
Q
Q
P
P
A
S
L
P
G
L
T
A
Q
Site 119
S849
L
T
A
Q
P
L
L
S
P
K
E
A
T
S
D
Site 120
S855
L
S
P
K
E
A
T
S
D
P
S
R
T
P
E
Site 121
S858
K
E
A
T
S
D
P
S
R
T
P
E
E
E
P
Site 122
T860
A
T
S
D
P
S
R
T
P
E
E
E
P
L
N
Site 123
S899
P
L
R
R
R
A
A
S
D
G
Q
Y
E
N
Q
Site 124
Y903
R
A
A
S
D
G
Q
Y
E
N
Q
S
P
E
A
Site 125
S907
D
G
Q
Y
E
N
Q
S
P
E
A
T
S
P
R
Site 126
T911
E
N
Q
S
P
E
A
T
S
P
R
S
P
G
V
Site 127
S912
N
Q
S
P
E
A
T
S
P
R
S
P
G
V
R
Site 128
S915
P
E
A
T
S
P
R
S
P
G
V
R
S
P
V
Site 129
S920
P
R
S
P
G
V
R
S
P
V
Q
C
V
S
P
Site 130
Y949
K
E
P
H
L
H
S
Y
K
E
A
F
E
E
M
Site 131
T959
A
F
E
E
M
E
G
T
S
P
S
S
P
P
P
Site 132
S960
F
E
E
M
E
G
T
S
P
S
S
P
P
P
S
Site 133
S962
E
M
E
G
T
S
P
S
S
P
P
P
S
G
V
Site 134
S963
M
E
G
T
S
P
S
S
P
P
P
S
G
V
R
Site 135
S967
S
P
S
S
P
P
P
S
G
V
R
S
P
P
G
Site 136
S971
P
P
P
S
G
V
R
S
P
P
G
L
A
K
T
Site 137
S1019
G
K
V
V
V
R
L
S
E
E
P
R
S
Y
V
Site 138
S1024
R
L
S
E
E
P
R
S
Y
V
E
S
V
A
R
Site 139
Y1025
L
S
E
E
P
R
S
Y
V
E
S
V
A
R
T
Site 140
S1028
E
P
R
S
Y
V
E
S
V
A
R
T
A
V
A
Site 141
S1042
A
G
P
R
A
Q
D
S
E
P
K
S
F
S
A
Site 142
S1046
A
Q
D
S
E
P
K
S
F
S
A
P
A
T
Q
Site 143
S1048
D
S
E
P
K
S
F
S
A
P
A
T
Q
A
Y
Site 144
T1052
K
S
F
S
A
P
A
T
Q
A
Y
G
H
E
I
Site 145
Y1055
S
A
P
A
T
Q
A
Y
G
H
E
I
P
L
R
Site 146
S1069
R
N
G
T
L
G
G
S
F
V
S
P
S
P
L
Site 147
S1074
G
G
S
F
V
S
P
S
P
L
S
T
S
S
P
Site 148
S1079
S
P
S
P
L
S
T
S
S
P
I
L
S
A
D
Site 149
S1080
P
S
P
L
S
T
S
S
P
I
L
S
A
D
S
Site 150
S1084
S
T
S
S
P
I
L
S
A
D
S
T
S
V
G
Site 151
S1092
A
D
S
T
S
V
G
S
F
P
S
G
E
S
S
Site 152
S1095
T
S
V
G
S
F
P
S
G
E
S
S
D
Q
G
Site 153
S1099
S
F
P
S
G
E
S
S
D
Q
G
P
R
T
P
Site 154
T1105
S
S
D
Q
G
P
R
T
P
T
Q
P
L
L
E
Site 155
T1107
D
Q
G
P
R
T
P
T
Q
P
L
L
E
S
G
Site 156
S1113
P
T
Q
P
L
L
E
S
G
F
R
S
G
S
L
Site 157
S1117
L
L
E
S
G
F
R
S
G
S
L
G
Q
P
S
Site 158
S1119
E
S
G
F
R
S
G
S
L
G
Q
P
S
P
S
Site 159
S1124
S
G
S
L
G
Q
P
S
P
S
A
Q
R
N
Y
Site 160
S1126
S
L
G
Q
P
S
P
S
A
Q
R
N
Y
Q
S
Site 161
Y1131
S
P
S
A
Q
R
N
Y
Q
S
S
S
P
L
P
Site 162
S1133
S
A
Q
R
N
Y
Q
S
S
S
P
L
P
T
V
Site 163
S1134
A
Q
R
N
Y
Q
S
S
S
P
L
P
T
V
G
Site 164
S1135
Q
R
N
Y
Q
S
S
S
P
L
P
T
V
G
S
Site 165
T1139
Q
S
S
S
P
L
P
T
V
G
S
S
Y
S
S
Site 166
S1142
S
P
L
P
T
V
G
S
S
Y
S
S
P
D
Y
Site 167
S1143
P
L
P
T
V
G
S
S
Y
S
S
P
D
Y
S
Site 168
Y1144
L
P
T
V
G
S
S
Y
S
S
P
D
Y
S
L
Site 169
S1145
P
T
V
G
S
S
Y
S
S
P
D
Y
S
L
Q
Site 170
S1146
T
V
G
S
S
Y
S
S
P
D
Y
S
L
Q
H
Site 171
Y1149
S
S
Y
S
S
P
D
Y
S
L
Q
H
F
S
S
Site 172
S1150
S
Y
S
S
P
D
Y
S
L
Q
H
F
S
S
S
Site 173
S1155
D
Y
S
L
Q
H
F
S
S
S
P
E
S
Q
A
Site 174
S1156
Y
S
L
Q
H
F
S
S
S
P
E
S
Q
A
R
Site 175
S1157
S
L
Q
H
F
S
S
S
P
E
S
Q
A
R
A
Site 176
S1160
H
F
S
S
S
P
E
S
Q
A
R
A
Q
F
S
Site 177
S1167
S
Q
A
R
A
Q
F
S
V
A
G
V
H
T
V
Site 178
S1177
G
V
H
T
V
P
G
S
P
Q
A
R
H
R
T
Site 179
T1184
S
P
Q
A
R
H
R
T
V
G
T
N
T
P
P
Site 180
T1187
A
R
H
R
T
V
G
T
N
T
P
P
S
P
G
Site 181
T1189
H
R
T
V
G
T
N
T
P
P
S
P
G
F
G
Site 182
S1192
V
G
T
N
T
P
P
S
P
G
F
G
W
R
A
Site 183
S1203
G
W
R
A
I
N
P
S
M
A
A
P
S
S
P
Site 184
S1208
N
P
S
M
A
A
P
S
S
P
S
L
S
H
H
Site 185
S1209
P
S
M
A
A
P
S
S
P
S
L
S
H
H
Q
Site 186
S1211
M
A
A
P
S
S
P
S
L
S
H
H
Q
M
M
Site 187
S1213
A
P
S
S
P
S
L
S
H
H
Q
M
M
G
P
Site 188
T1223
Q
M
M
G
P
P
G
T
G
F
H
G
S
T
V
Site 189
S1228
P
G
T
G
F
H
G
S
T
V
S
S
P
Q
S
Site 190
T1229
G
T
G
F
H
G
S
T
V
S
S
P
Q
S
S
Site 191
S1231
G
F
H
G
S
T
V
S
S
P
Q
S
S
A
A
Site 192
S1232
F
H
G
S
T
V
S
S
P
Q
S
S
A
A
T
Site 193
S1235
S
T
V
S
S
P
Q
S
S
A
A
T
T
P
G
Site 194
S1236
T
V
S
S
P
Q
S
S
A
A
T
T
P
G
S
Site 195
T1239
S
P
Q
S
S
A
A
T
T
P
G
S
P
S
L
Site 196
T1240
P
Q
S
S
A
A
T
T
P
G
S
P
S
L
C
Site 197
S1243
S
A
A
T
T
P
G
S
P
S
L
C
R
H
P
Site 198
S1245
A
T
T
P
G
S
P
S
L
C
R
H
P
A
G
Site 199
Y1254
C
R
H
P
A
G
V
Y
Q
V
S
G
L
H
N
Site 200
S1257
P
A
G
V
Y
Q
V
S
G
L
H
N
K
V
A
Site 201
T1265
G
L
H
N
K
V
A
T
T
P
G
S
P
S
L
Site 202
T1266
L
H
N
K
V
A
T
T
P
G
S
P
S
L
G
Site 203
S1269
K
V
A
T
T
P
G
S
P
S
L
G
R
H
P
Site 204
S1271
A
T
T
P
G
S
P
S
L
G
R
H
P
G
A
Site 205
S1285
A
H
Q
G
N
L
A
S
G
L
H
S
N
A
I
Site 206
S1289
N
L
A
S
G
L
H
S
N
A
I
A
S
P
G
Site 207
S1294
L
H
S
N
A
I
A
S
P
G
S
P
S
L
G
Site 208
S1297
N
A
I
A
S
P
G
S
P
S
L
G
R
H
L
Site 209
S1299
I
A
S
P
G
S
P
S
L
G
R
H
L
G
G
Site 210
S1307
L
G
R
H
L
G
G
S
G
S
V
V
P
G
S
Site 211
S1309
R
H
L
G
G
S
G
S
V
V
P
G
S
P
C
Site 212
S1314
S
G
S
V
V
P
G
S
P
C
L
D
R
H
V
Site 213
Y1323
C
L
D
R
H
V
A
Y
G
G
Y
S
T
P
E
Site 214
Y1326
R
H
V
A
Y
G
G
Y
S
T
P
E
D
R
R
Site 215
S1327
H
V
A
Y
G
G
Y
S
T
P
E
D
R
R
P
Site 216
T1328
V
A
Y
G
G
Y
S
T
P
E
D
R
R
P
T
Site 217
T1335
T
P
E
D
R
R
P
T
L
S
R
Q
S
S
A
Site 218
S1337
E
D
R
R
P
T
L
S
R
Q
S
S
A
S
G
Site 219
S1340
R
P
T
L
S
R
Q
S
S
A
S
G
Y
Q
A
Site 220
S1341
P
T
L
S
R
Q
S
S
A
S
G
Y
Q
A
P
Site 221
S1343
L
S
R
Q
S
S
A
S
G
Y
Q
A
P
S
T
Site 222
Y1345
R
Q
S
S
A
S
G
Y
Q
A
P
S
T
P
S
Site 223
S1349
A
S
G
Y
Q
A
P
S
T
P
S
F
P
V
S
Site 224
T1350
S
G
Y
Q
A
P
S
T
P
S
F
P
V
S
P
Site 225
S1352
Y
Q
A
P
S
T
P
S
F
P
V
S
P
A
Y
Site 226
S1356
S
T
P
S
F
P
V
S
P
A
Y
Y
P
G
L
Site 227
Y1359
S
F
P
V
S
P
A
Y
Y
P
G
L
S
S
P
Site 228
Y1360
F
P
V
S
P
A
Y
Y
P
G
L
S
S
P
A
Site 229
S1364
P
A
Y
Y
P
G
L
S
S
P
A
T
S
P
S
Site 230
S1365
A
Y
Y
P
G
L
S
S
P
A
T
S
P
S
P
Site 231
T1368
P
G
L
S
S
P
A
T
S
P
S
P
D
S
A
Site 232
S1369
G
L
S
S
P
A
T
S
P
S
P
D
S
A
A
Site 233
S1371
S
S
P
A
T
S
P
S
P
D
S
A
A
F
R
Site 234
S1374
A
T
S
P
S
P
D
S
A
A
F
R
Q
G
S
Site 235
S1381
S
A
A
F
R
Q
G
S
P
T
P
A
L
P
E
Site 236
T1383
A
F
R
Q
G
S
P
T
P
A
L
P
E
K
R
Site 237
S1393
L
P
E
K
R
R
M
S
V
G
D
R
A
G
S
Site 238
S1400
S
V
G
D
R
A
G
S
L
P
N
Y
A
T
I
Site 239
Y1404
R
A
G
S
L
P
N
Y
A
T
I
N
G
K
V
Site 240
T1406
G
S
L
P
N
Y
A
T
I
N
G
K
V
S
S
Site 241
S1413
T
I
N
G
K
V
S
S
P
V
A
S
G
M
S
Site 242
S1417
K
V
S
S
P
V
A
S
G
M
S
S
P
S
G
Site 243
S1420
S
P
V
A
S
G
M
S
S
P
S
G
G
S
T
Site 244
S1421
P
V
A
S
G
M
S
S
P
S
G
G
S
T
V
Site 245
S1423
A
S
G
M
S
S
P
S
G
G
S
T
V
S
F
Site 246
S1426
M
S
S
P
S
G
G
S
T
V
S
F
S
H
T
Site 247
T1427
S
S
P
S
G
G
S
T
V
S
F
S
H
T
L
Site 248
S1429
P
S
G
G
S
T
V
S
F
S
H
T
L
P
D
Site 249
S1431
G
G
S
T
V
S
F
S
H
T
L
P
D
F
S
Site 250
T1433
S
T
V
S
F
S
H
T
L
P
D
F
S
K
Y
Site 251
S1438
S
H
T
L
P
D
F
S
K
Y
S
M
P
D
N
Site 252
Y1440
T
L
P
D
F
S
K
Y
S
M
P
D
N
S
P
Site 253
S1441
L
P
D
F
S
K
Y
S
M
P
D
N
S
P
E
Site 254
S1446
K
Y
S
M
P
D
N
S
P
E
T
R
A
K
V
Site 255
Y1462
F
V
Q
D
T
S
K
Y
W
Y
K
P
E
I
S
Site 256
S1490
G
A
F
I
I
R
D
S
H
S
F
R
G
A
Y
Site 257
S1492
F
I
I
R
D
S
H
S
F
R
G
A
Y
G
L
Site 258
Y1497
S
H
S
F
R
G
A
Y
G
L
A
M
K
V
S
Site 259
T1509
K
V
S
S
P
P
P
T
I
M
Q
Q
N
K
K
Site 260
T1520
Q
N
K
K
G
D
M
T
H
E
L
V
R
H
F
Site 261
S1549
P
N
E
P
N
F
G
S
L
S
A
L
V
Y
Q
Site 262
S1551
E
P
N
F
G
S
L
S
A
L
V
Y
Q
H
S
Site 263
T1576
V
I
P
N
R
D
P
T
D
E
S
K
D
S
S
Site 264
S1579
N
R
D
P
T
D
E
S
K
D
S
S
G
P
A
Site 265
S1582
P
T
D
E
S
K
D
S
S
G
P
A
N
S
T
Site 266
S1583
T
D
E
S
K
D
S
S
G
P
A
N
S
T
A
Site 267
S1588
D
S
S
G
P
A
N
S
T
A
D
L
L
K
Q
Site 268
S1611
V
N
S
V
D
M
E
S
L
T
G
P
Q
A
I
Site 269
T1613
S
V
D
M
E
S
L
T
G
P
Q
A
I
S
K
Site 270
S1619
L
T
G
P
Q
A
I
S
K
A
T
S
E
T
L
Site 271
S1623
Q
A
I
S
K
A
T
S
E
T
L
A
A
D
P
Site 272
T1649
S
A
Q
G
I
T
L
T
D
N
Q
R
K
L
F
Site 273
Y1661
K
L
F
F
R
R
H
Y
P
L
N
T
V
T
F
Site 274
T1665
R
R
H
Y
P
L
N
T
V
T
F
C
D
L
D
Site 275
T1667
H
Y
P
L
N
T
V
T
F
C
D
L
D
P
Q
Site 276
T1681
Q
E
R
K
W
M
K
T
E
G
G
A
P
A
K
Site 277
T1700
V
A
R
K
Q
G
S
T
T
D
N
A
C
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation