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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP29
Full Name:
Ubiquitin carboxyl-terminal hydrolase 29
Alias:
Deubiquitinating enzyme 29; HOM-TES-84/86; Ubiquitin specific peptidase 29; Ubiquitin thiolesterase 29; Ubiquitin-specific processing protease 29; UBP29
Type:
Ubiquitin conjugating system; Protease; EC 3.1.2.15
Mass (Da):
104156
Number AA:
922
UniProt ID:
Q9HBJ7
International Prot ID:
IPI00011245
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
I
Q
I
W
S
Q
K
T
G
M
T
K
L
K
E
Site 2
T29
L
K
E
A
L
I
E
T
V
Q
R
Q
K
E
I
Site 3
S70
R
H
C
K
K
R
Q
S
H
L
R
L
T
L
K
Site 4
T75
R
Q
S
H
L
R
L
T
L
K
N
N
V
F
L
Site 5
S88
F
L
F
I
D
K
L
S
Y
R
D
A
K
Q
L
Site 6
S107
D
I
I
H
Q
N
K
S
Q
Q
P
M
K
S
D
Site 7
S113
K
S
Q
Q
P
M
K
S
D
D
D
W
S
V
F
Site 8
S133
L
K
E
I
D
K
T
S
F
Y
S
I
C
N
K
Site 9
Y143
S
I
C
N
K
P
S
Y
Q
K
M
P
L
F
M
Site 10
S153
M
P
L
F
M
S
K
S
P
T
H
V
K
K
G
Site 11
T155
L
F
M
S
K
S
P
T
H
V
K
K
G
I
L
Site 12
T172
Q
G
G
K
G
Q
N
T
L
S
S
D
V
Q
T
Site 13
S174
G
K
G
Q
N
T
L
S
S
D
V
Q
T
N
E
Site 14
S175
K
G
Q
N
T
L
S
S
D
V
Q
T
N
E
D
Site 15
T179
T
L
S
S
D
V
Q
T
N
E
D
I
L
K
E
Site 16
Y195
N
P
V
P
N
K
K
Y
K
T
D
S
L
K
Y
Site 17
T197
V
P
N
K
K
Y
K
T
D
S
L
K
Y
I
Q
Site 18
S199
N
K
K
Y
K
T
D
S
L
K
Y
I
Q
S
N
Site 19
S205
D
S
L
K
Y
I
Q
S
N
R
K
N
P
S
S
Site 20
S212
S
N
R
K
N
P
S
S
L
E
D
L
E
K
D
Site 21
S227
R
D
L
K
L
G
P
S
F
N
T
N
C
N
G
Site 22
T241
G
N
P
N
L
D
E
T
V
L
A
T
Q
T
L
Site 23
S256
N
A
K
N
G
L
T
S
P
L
E
P
E
H
S
Site 24
S263
S
P
L
E
P
E
H
S
Q
G
D
P
R
C
N
Site 25
S278
K
A
Q
V
P
L
D
S
H
S
Q
Q
L
Q
Q
Site 26
S280
Q
V
P
L
D
S
H
S
Q
Q
L
Q
Q
G
F
Site 27
Y295
P
N
L
G
N
T
C
Y
M
N
A
V
L
Q
S
Site 28
T315
S
F
A
D
D
L
L
T
Q
G
V
P
W
E
Y
Site 29
S343
L
A
L
K
D
F
C
S
T
K
I
K
R
E
L
Site 30
S406
K
E
C
G
D
E
N
S
S
P
Q
M
H
V
G
Site 31
S407
E
C
G
D
E
N
S
S
P
Q
M
H
V
G
S
Site 32
S435
F
E
F
E
L
Q
L
S
L
I
C
K
A
C
G
Site 33
Y453
L
K
V
E
P
N
N
Y
L
S
I
N
L
H
Q
Site 34
S468
E
T
K
P
L
P
L
S
I
Q
N
S
L
D
L
Site 35
Y484
F
K
E
E
E
L
E
Y
N
C
Q
M
C
K
Q
Site 36
T499
K
S
C
V
A
R
H
T
F
S
R
L
S
R
V
Site 37
S501
C
V
A
R
H
T
F
S
R
L
S
R
V
L
I
Site 38
Y530
V
K
N
N
E
Q
V
Y
I
P
K
S
L
S
L
Site 39
S534
E
Q
V
Y
I
P
K
S
L
S
L
S
S
Y
C
Site 40
S536
V
Y
I
P
K
S
L
S
L
S
S
Y
C
N
E
Site 41
S538
I
P
K
S
L
S
L
S
S
Y
C
N
E
S
T
Site 42
S539
P
K
S
L
S
L
S
S
Y
C
N
E
S
T
K
Site 43
Y540
K
S
L
S
L
S
S
Y
C
N
E
S
T
K
P
Site 44
S544
L
S
S
Y
C
N
E
S
T
K
P
P
L
P
L
Site 45
T545
S
S
Y
C
N
E
S
T
K
P
P
L
P
L
S
Site 46
S552
T
K
P
P
L
P
L
S
S
S
A
P
V
G
K
Site 47
S553
K
P
P
L
P
L
S
S
S
A
P
V
G
K
C
Site 48
S554
P
P
L
P
L
S
S
S
A
P
V
G
K
C
E
Site 49
S571
E
V
S
Q
E
M
I
S
E
I
N
S
P
L
T
Site 50
S575
E
M
I
S
E
I
N
S
P
L
T
P
S
M
K
Site 51
T578
S
E
I
N
S
P
L
T
P
S
M
K
L
T
S
Site 52
S580
I
N
S
P
L
T
P
S
M
K
L
T
S
E
S
Site 53
T584
L
T
P
S
M
K
L
T
S
E
S
S
D
S
L
Site 54
S585
T
P
S
M
K
L
T
S
E
S
S
D
S
L
V
Site 55
S587
S
M
K
L
T
S
E
S
S
D
S
L
V
L
P
Site 56
S590
L
T
S
E
S
S
D
S
L
V
L
P
V
E
P
Site 57
S614
Q
R
D
C
G
D
A
S
Q
E
Q
H
Q
R
D
Site 58
S626
Q
R
D
L
E
N
G
S
A
L
E
S
E
L
V
Site 59
S630
E
N
G
S
A
L
E
S
E
L
V
H
F
R
D
Site 60
S650
K
E
L
P
V
A
D
S
L
M
D
Q
G
D
I
Site 61
S658
L
M
D
Q
G
D
I
S
L
P
V
M
Y
E
D
Site 62
S671
E
D
G
G
K
L
I
S
S
P
D
T
R
L
V
Site 63
S672
D
G
G
K
L
I
S
S
P
D
T
R
L
V
E
Site 64
T675
K
L
I
S
S
P
D
T
R
L
V
E
V
H
L
Site 65
Y694
Q
H
P
E
L
Q
K
Y
E
K
T
N
T
F
V
Site 66
T699
Q
K
Y
E
K
T
N
T
F
V
E
F
N
F
D
Site 67
S707
F
V
E
F
N
F
D
S
V
T
E
S
T
N
G
Site 68
T709
E
F
N
F
D
S
V
T
E
S
T
N
G
F
Y
Site 69
Y716
T
E
S
T
N
G
F
Y
D
C
K
E
N
R
I
Site 70
S727
E
N
R
I
P
E
G
S
Q
G
M
A
E
Q
L
Site 71
T767
A
Q
E
H
T
E
E
T
L
N
Q
S
T
E
L
Site 72
S789
N
H
L
G
A
L
G
S
D
N
P
G
N
K
N
Site 73
T811
R
G
E
A
K
E
L
T
R
N
V
K
M
G
D
Site 74
S830
Y
R
L
I
S
V
V
S
H
I
G
S
S
P
N
Site 75
S834
S
V
V
S
H
I
G
S
S
P
N
S
G
H
Y
Site 76
S835
V
V
S
H
I
G
S
S
P
N
S
G
H
Y
I
Site 77
S838
H
I
G
S
S
P
N
S
G
H
Y
I
S
D
V
Site 78
Y841
S
S
P
N
S
G
H
Y
I
S
D
V
Y
D
F
Site 79
Y846
G
H
Y
I
S
D
V
Y
D
F
Q
K
Q
A
W
Site 80
S876
M
Q
E
A
R
L
H
S
G
Y
I
F
F
Y
M
Site 81
Y878
E
A
R
L
H
S
G
Y
I
F
F
Y
M
H
N
Site 82
Y882
H
S
G
Y
I
F
F
Y
M
H
N
G
I
F
E
Site 83
S898
L
L
R
K
A
E
N
S
R
L
P
S
T
Q
A
Site 84
S902
A
E
N
S
R
L
P
S
T
Q
A
G
V
I
P
Site 85
T903
E
N
S
R
L
P
S
T
Q
A
G
V
I
P
Q
Site 86
Y913
G
V
I
P
Q
G
E
Y
E
G
D
S
L
Y
R
Site 87
S917
Q
G
E
Y
E
G
D
S
L
Y
R
P
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation