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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRDD
Full Name:
Leucine-rich repeat and death domain-containing protein
Alias:
p53-induced protein with a death domain; PIDD
Type:
Mass (Da):
99712
Number AA:
910
UniProt ID:
Q9HB75
International Prot ID:
IPI00171737
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005123
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
A
A
T
V
E
G
P
E
L
E
Site 2
S20
A
A
A
A
G
D
A
S
E
D
S
D
A
G
S
Site 3
S23
A
G
D
A
S
E
D
S
D
A
G
S
R
A
L
Site 4
S27
S
E
D
S
D
A
G
S
R
A
L
P
F
L
G
Site 5
S39
F
L
G
G
N
R
L
S
L
D
L
Y
P
G
G
Site 6
Y43
N
R
L
S
L
D
L
Y
P
G
G
C
Q
Q
L
Site 7
S70
Q
V
E
F
L
R
L
S
T
H
E
D
P
Q
L
Site 8
T71
V
E
F
L
R
L
S
T
H
E
D
P
Q
L
L
Site 9
T105
K
G
G
Q
R
R
D
T
L
G
A
C
L
R
G
Site 10
T185
V
T
H
N
R
L
Q
T
L
P
P
A
L
G
A
Site 11
S202
T
L
Q
R
L
D
L
S
Q
N
L
L
D
T
L
Site 12
T208
L
S
Q
N
L
L
D
T
L
P
P
E
I
G
G
Site 13
T266
L
A
R
L
P
L
L
T
R
L
D
L
R
D
N
Site 14
S299
G
N
P
L
G
E
A
S
P
D
A
P
S
S
P
Site 15
T320
E
M
P
R
L
F
L
T
S
D
L
D
S
F
P
Site 16
S325
F
L
T
S
D
L
D
S
F
P
V
T
P
Q
G
Site 17
T329
D
L
D
S
F
P
V
T
P
Q
G
C
S
V
T
Site 18
S378
G
P
H
D
A
L
L
S
H
V
L
E
L
Q
P
Site 19
S420
V
R
T
R
N
D
N
S
W
G
D
L
E
T
Y
Site 20
Y427
S
W
G
D
L
E
T
Y
L
E
E
E
A
P
Q
Site 21
S470
P
E
G
T
L
L
C
S
S
G
H
P
G
V
K
Site 22
T485
V
I
F
P
P
G
A
T
E
E
P
R
R
V
S
Site 23
S492
T
E
E
P
R
R
V
S
M
Q
V
V
R
M
A
Site 24
S546
P
S
G
I
T
G
L
S
L
D
R
S
R
L
H
Site 25
S550
T
G
L
S
L
D
R
S
R
L
H
L
L
Y
W
Site 26
Y556
R
S
R
L
H
L
L
Y
W
A
P
P
A
A
T
Site 27
T643
P
R
N
K
V
D
A
T
L
R
R
L
L
E
R
Site 28
Y651
L
R
R
L
L
E
R
Y
R
G
P
E
P
S
D
Site 29
S657
R
Y
R
G
P
E
P
S
D
T
V
E
M
F
E
Site 30
T659
R
G
P
E
P
S
D
T
V
E
M
F
E
G
E
Site 31
Y705
L
K
N
V
K
E
V
Y
V
T
T
T
L
D
R
Site 32
S722
Q
A
V
R
G
Q
V
S
F
Y
R
G
A
V
P
Site 33
S763
K
L
P
R
L
R
G
S
E
G
P
R
R
G
A
Site 34
S773
P
R
R
G
A
G
L
S
L
A
P
L
N
L
G
Site 35
T784
L
N
L
G
D
A
E
T
G
F
L
T
Q
S
N
Site 36
T788
D
A
E
T
G
F
L
T
Q
S
N
L
L
S
V
Site 37
Y814
A
L
H
L
G
V
S
Y
R
E
V
Q
R
I
R
Site 38
S860
L
V
Q
A
L
E
Q
S
D
R
Q
D
V
A
E
Site 39
Y880
L
E
L
G
R
R
K
Y
Q
D
S
I
R
R
M
Site 40
S883
G
R
R
K
Y
Q
D
S
I
R
R
M
G
L
A
Site 41
S899
K
D
P
A
L
P
G
S
S
A
P
Q
P
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation