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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHA1
Full Name:
Pleckstrin homology domain-containing family A member 1
Alias:
PKHA1; Pleckstriny domain containing, family A (phosphoinositide binding specific) member 1; Tandem PH domain containing protein-1; Tandem PH domain-containing 1; Tandem PH domain-containing protein 1; TAPP1; TAPP-1
Type:
Lipid binding protein
Mass (Da):
45553
Number AA:
404
UniProt ID:
Q9HB21
International Prot ID:
IPI00306354
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005543
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
D
I
E
E
N
E
N
S
G
K
F
L
R
R
Y
Site 2
Y29
S
G
K
F
L
R
R
Y
F
I
L
D
T
R
E
Site 3
T34
R
R
Y
F
I
L
D
T
R
E
D
S
F
V
W
Site 4
Y42
R
E
D
S
F
V
W
Y
M
D
N
P
Q
N
L
Site 5
S51
D
N
P
Q
N
L
P
S
G
S
S
R
V
G
A
Site 6
S53
P
Q
N
L
P
S
G
S
S
R
V
G
A
I
K
Site 7
T62
R
V
G
A
I
K
L
T
Y
I
S
K
V
S
D
Site 8
Y63
V
G
A
I
K
L
T
Y
I
S
K
V
S
D
A
Site 9
S68
L
T
Y
I
S
K
V
S
D
A
T
K
L
R
P
Site 10
Y90
M
N
A
G
M
R
K
Y
F
L
Q
A
N
D
Q
Site 11
S119
K
I
T
V
P
K
Q
S
D
S
Q
P
N
S
D
Site 12
S121
T
V
P
K
Q
S
D
S
Q
P
N
S
D
N
L
Site 13
S125
Q
S
D
S
Q
P
N
S
D
N
L
S
R
H
G
Site 14
S129
Q
P
N
S
D
N
L
S
R
H
G
E
C
G
K
Site 15
S140
E
C
G
K
K
Q
V
S
Y
R
T
D
I
V
G
Site 16
Y141
C
G
K
K
Q
V
S
Y
R
T
D
I
V
G
G
Site 17
S166
E
V
N
E
C
G
E
S
I
D
R
N
N
L
K
Site 18
S175
D
R
N
N
L
K
R
S
Q
S
H
L
P
Y
F
Site 19
S177
N
N
L
K
R
S
Q
S
H
L
P
Y
F
T
P
Site 20
Y181
R
S
Q
S
H
L
P
Y
F
T
P
K
P
P
Q
Site 21
T183
Q
S
H
L
P
Y
F
T
P
K
P
P
Q
D
S
Site 22
Y212
M
K
N
W
K
R
R
Y
F
Q
L
D
E
N
T
Site 23
Y222
L
D
E
N
T
I
G
Y
F
K
S
E
L
E
K
Site 24
S225
N
T
I
G
Y
F
K
S
E
L
E
K
E
P
L
Site 25
S249
K
V
Q
E
C
K
Q
S
D
I
M
M
R
D
N
Site 26
T266
E
I
V
T
T
S
R
T
F
Y
V
Q
A
D
S
Site 27
Y268
V
T
T
S
R
T
F
Y
V
Q
A
D
S
P
E
Site 28
S273
T
F
Y
V
Q
A
D
S
P
E
E
M
H
S
W
Site 29
S279
D
S
P
E
E
M
H
S
W
I
K
A
V
S
G
Site 30
S297
A
Q
R
G
P
G
R
S
A
S
S
E
H
P
P
Site 31
S299
R
G
P
G
R
S
A
S
S
E
H
P
P
G
P
Site 32
S300
G
P
G
R
S
A
S
S
E
H
P
P
G
P
S
Site 33
S307
S
E
H
P
P
G
P
S
E
S
K
H
A
F
R
Site 34
T316
S
K
H
A
F
R
P
T
N
A
A
T
A
T
S
Site 35
S325
A
A
T
A
T
S
H
S
T
A
S
R
S
N
S
Site 36
T326
A
T
A
T
S
H
S
T
A
S
R
S
N
S
L
Site 37
S328
A
T
S
H
S
T
A
S
R
S
N
S
L
V
S
Site 38
S330
S
H
S
T
A
S
R
S
N
S
L
V
S
T
F
Site 39
S332
S
T
A
S
R
S
N
S
L
V
S
T
F
T
M
Site 40
S335
S
R
S
N
S
L
V
S
T
F
T
M
E
K
R
Site 41
T336
R
S
N
S
L
V
S
T
F
T
M
E
K
R
G
Site 42
T338
N
S
L
V
S
T
F
T
M
E
K
R
G
F
Y
Site 43
Y345
T
M
E
K
R
G
F
Y
E
S
L
A
K
V
K
Site 44
S347
E
K
R
G
F
Y
E
S
L
A
K
V
K
P
G
Site 45
T360
P
G
N
F
K
V
Q
T
V
S
P
R
E
P
A
Site 46
S362
N
F
K
V
Q
T
V
S
P
R
E
P
A
S
K
Site 47
S368
V
S
P
R
E
P
A
S
K
V
T
E
Q
A
L
Site 48
S380
Q
A
L
L
R
P
Q
S
K
N
G
P
Q
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation