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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHA3
Full Name:
Pleckstrin homology domain-containing family A member 3
Alias:
FAPP1; FAPP-1; Four-phosphate-adaptor protein 1; Phosphoinositol 4-phosphate adaptor protein 1; PKHA3; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3; Pleckstriny domain containing, family A (phosphoinositide binding specific) member 3
Type:
Mass (Da):
33860
Number AA:
UniProt ID:
Q9HB20
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005543
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
V
L
Y
K
W
T
N
Y
L
T
G
W
Q
P
R
Site 2
S28
V
L
D
N
G
I
L
S
Y
Y
D
S
Q
D
D
Site 3
Y30
D
N
G
I
L
S
Y
Y
D
S
Q
D
D
V
C
Site 4
S32
G
I
L
S
Y
Y
D
S
Q
D
D
V
C
K
G
Site 5
T59
K
V
H
S
A
D
N
T
R
M
E
L
I
I
P
Site 6
Y72
I
P
G
E
Q
H
F
Y
M
K
A
V
N
A
A
Site 7
T96
G
S
S
K
A
C
L
T
D
T
R
T
K
K
E
Site 8
T98
S
K
A
C
L
T
D
T
R
T
K
K
E
K
E
Site 9
T100
A
C
L
T
D
T
R
T
K
K
E
K
E
I
S
Site 10
S107
T
K
K
E
K
E
I
S
E
T
S
E
S
L
K
Site 11
T109
K
E
K
E
I
S
E
T
S
E
S
L
K
T
K
Site 12
S112
E
I
S
E
T
S
E
S
L
K
T
K
M
S
E
Site 13
T115
E
T
S
E
S
L
K
T
K
M
S
E
L
R
L
Site 14
S118
E
S
L
K
T
K
M
S
E
L
R
L
Y
C
D
Site 15
Y123
K
M
S
E
L
R
L
Y
C
D
L
L
M
Q
Q
Site 16
S146
H
H
D
E
N
H
S
S
P
S
A
E
N
M
N
Site 17
S157
E
N
M
N
E
A
S
S
L
L
S
A
T
C
N
Site 18
S196
H
H
P
D
P
L
V
S
P
V
S
P
S
P
V
Site 19
S201
L
V
S
P
V
S
P
S
P
V
Q
M
M
K
R
Site 20
S209
P
V
Q
M
M
K
R
S
V
S
H
P
G
S
C
Site 21
S211
Q
M
M
K
R
S
V
S
H
P
G
S
C
S
S
Site 22
S215
R
S
V
S
H
P
G
S
C
S
S
E
R
S
S
Site 23
S217
V
S
H
P
G
S
C
S
S
E
R
S
S
H
S
Site 24
S218
S
H
P
G
S
C
S
S
E
R
S
S
H
S
I
Site 25
S221
G
S
C
S
S
E
R
S
S
H
S
I
K
E
P
Site 26
S222
S
C
S
S
E
R
S
S
H
S
I
K
E
P
V
Site 27
S224
S
S
E
R
S
S
H
S
I
K
E
P
V
S
T
Site 28
S230
H
S
I
K
E
P
V
S
T
L
H
R
L
S
Q
Site 29
T231
S
I
K
E
P
V
S
T
L
H
R
L
S
Q
R
Site 30
S236
V
S
T
L
H
R
L
S
Q
R
R
R
R
T
Y
Site 31
T242
L
S
Q
R
R
R
R
T
Y
S
D
T
D
S
C
Site 32
Y243
S
Q
R
R
R
R
T
Y
S
D
T
D
S
C
S
Site 33
S244
Q
R
R
R
R
T
Y
S
D
T
D
S
C
S
D
Site 34
T246
R
R
R
T
Y
S
D
T
D
S
C
S
D
I
P
Site 35
S248
R
T
Y
S
D
T
D
S
C
S
D
I
P
L
E
Site 36
S250
Y
S
D
T
D
S
C
S
D
I
P
L
E
D
P
Site 37
S264
P
D
R
P
V
H
C
S
K
N
T
L
N
G
D
Site 38
S274
T
L
N
G
D
L
A
S
A
T
I
P
E
E
S
Site 39
T276
N
G
D
L
A
S
A
T
I
P
E
E
S
R
L
Site 40
S289
R
L
M
A
K
K
Q
S
E
S
E
D
T
L
P
Site 41
T294
K
Q
S
E
S
E
D
T
L
P
S
F
S
S
_
Site 42
S297
E
S
E
D
T
L
P
S
F
S
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation