PhosphoNET

           
Protein Info 
   
Short Name:  PLEKHA2
Full Name:  Pleckstrin homology domain-containing family A member 2
Alias:  PKHA2; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Tandem PH domain-containing protein 2; TAPP2; TAPP-2
Type:  Plasma membrane, Cytoplasm, Nucleus protein
Mass (Da):  47255
Number AA:  425
UniProt ID:  Q9HB19
International Prot ID:  IPI00455835
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0019898  GO:0005634 Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S22DIEEHENSGKFLRRY
Site 2Y29SGKFLRRYFILDTQA
Site 3S65ALQLTYISKVSIATP
Site 4T71ISKVSIATPKQKPKT
Site 5T78TPKQKPKTPFCFVIN
Site 6T115LNQASKITVPKGGGL
Site 7T125KGGGLPMTTEVLKSL
Site 8T148KPQVAYKTEIIGGVV
Site 9S161VVVHTPISQNGGDGQ
Site 10S171GGDGQEGSEPGSHTI
Site 11S175QEGSEPGSHTILRRS
Site 12T177GSEPGSHTILRRSQS
Site 13S182SHTILRRSQSYIPTS
Site 14S184TILRRSQSYIPTSGC
Site 15Y185ILRRSQSYIPTSGCR
Site 16T188RSQSYIPTSGCRAST
Site 17S189SQSYIPTSGCRASTG
Site 18S194PTSGCRASTGPPLIK
Site 19T195TSGCRASTGPPLIKS
Site 20S202TGPPLIKSGYCVKQG
Site 21Y204PPLIKSGYCVKQGNV
Site 22S214KQGNVRKSWKRRFFA
Site 23Y229LDDFTICYFKCEQDR
Site 24T241QDREPLRTIFLKDVL
Site 25S257THECLVKSGDLLMRD
Site 26T275EIITSSRTFYVQADS
Site 27Y277ITSSRTFYVQADSPE
Site 28S282TFYVQADSPEDMHSW
Site 29S288DSPEDMHSWIKEIGA
Site 30T307LKCHPRETSFSRSIS
Site 31S308KCHPRETSFSRSISL
Site 32S310HPRETSFSRSISLTR
Site 33S312RETSFSRSISLTRPG
Site 34S314TSFSRSISLTRPGSS
Site 35T316FSRSISLTRPGSSSL
Site 36S320ISLTRPGSSSLSSGP
Site 37S321SLTRPGSSSLSSGPN
Site 38S322LTRPGSSSLSSGPNS
Site 39S324RPGSSSLSSGPNSIL
Site 40S325PGSSSLSSGPNSILC
Site 41S329SLSSGPNSILCRGRP
Site 42S349KALCKAPSVASSWQP
Site 43S352CKAPSVASSWQPWTP
Site 44S353KAPSVASSWQPWTPV
Site 45T358ASSWQPWTPVPQAGE
Site 46T373KLLPPGDTSEDSLFT
Site 47S374LLPPGDTSEDSLFTP
Site 48S377PGDTSEDSLFTPRPG
Site 49T380TSEDSLFTPRPGEGA
Site 50S394APPGVLPSSRIRHRS
Site 51S395PPGVLPSSRIRHRSE
Site 52S401SSRIRHRSEPQHPKE
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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