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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRDM16
Full Name:
PR domain zinc finger protein 16
Alias:
PR domain-containing protein 16;Transcription factor MEL1
Type:
Mass (Da):
140251
Number AA:
1276
UniProt ID:
Q9HAZ2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
R
A
R
K
L
A
K
S
D
G
D
V
V
N
N
Site 2
Y22
G
D
V
V
N
N
M
Y
E
P
N
R
D
L
L
Site 3
S31
P
N
R
D
L
L
A
S
H
S
A
E
D
E
A
Site 4
S33
R
D
L
L
A
S
H
S
A
E
D
E
A
E
D
Site 5
S41
A
E
D
E
A
E
D
S
A
M
S
P
I
P
V
Site 6
S44
E
A
E
D
S
A
M
S
P
I
P
V
G
P
P
Site 7
S52
P
I
P
V
G
P
P
S
P
F
P
T
S
E
D
Site 8
T56
G
P
P
S
P
F
P
T
S
E
D
F
T
P
K
Site 9
S57
P
P
S
P
F
P
T
S
E
D
F
T
P
K
E
Site 10
T61
F
P
T
S
E
D
F
T
P
K
E
G
S
P
Y
Site 11
S66
D
F
T
P
K
E
G
S
P
Y
E
A
P
V
Y
Site 12
Y68
T
P
K
E
G
S
P
Y
E
A
P
V
Y
I
P
Site 13
Y73
S
P
Y
E
A
P
V
Y
I
P
E
D
I
P
I
Site 14
S89
A
D
F
E
L
R
E
S
S
I
P
G
A
G
L
Site 15
S90
D
F
E
L
R
E
S
S
I
P
G
A
G
L
G
Site 16
T133
F
G
W
E
Q
I
L
T
D
V
E
V
S
P
Q
Site 17
T145
S
P
Q
E
G
C
I
T
K
I
S
E
D
L
G
Site 18
S148
E
G
C
I
T
K
I
S
E
D
L
G
S
E
K
Site 19
S153
K
I
S
E
D
L
G
S
E
K
F
C
V
D
A
Site 20
Y193
C
Q
I
S
E
Q
I
Y
Y
K
V
I
K
D
I
Site 21
Y194
Q
I
S
E
Q
I
Y
Y
K
V
I
K
D
I
E
Site 22
T219
E
G
V
Y
P
L
G
T
V
P
P
G
L
D
E
Site 23
T229
P
G
L
D
E
E
P
T
F
R
C
D
E
C
D
Site 24
S241
E
C
D
E
L
F
Q
S
K
L
D
L
R
R
H
Site 25
Y251
D
L
R
R
H
K
K
Y
T
C
G
S
V
G
A
Site 26
T252
L
R
R
H
K
K
Y
T
C
G
S
V
G
A
A
Site 27
Y294
E
R
M
F
P
N
K
Y
S
L
E
Q
H
M
V
Site 28
Y309
I
H
T
E
E
R
E
Y
K
C
D
Q
C
P
K
Site 29
S330
N
L
I
R
H
Q
M
S
H
D
S
G
K
R
F
Site 30
S333
R
H
Q
M
S
H
D
S
G
K
R
F
E
C
E
Site 31
S350
V
K
V
F
T
D
P
S
N
L
Q
R
H
I
R
Site 32
S358
N
L
Q
R
H
I
R
S
Q
H
V
G
A
R
A
Site 33
S379
G
K
T
F
A
T
S
S
G
L
K
Q
H
K
H
Site 34
T421
R
M
H
A
D
C
R
T
Q
I
K
C
K
D
C
Site 35
S433
K
D
C
G
Q
M
F
S
T
T
S
S
L
N
K
Site 36
T434
D
C
G
Q
M
F
S
T
T
S
S
L
N
K
H
Site 37
T435
C
G
Q
M
F
S
T
T
S
S
L
N
K
H
R
Site 38
S437
Q
M
F
S
T
T
S
S
L
N
K
H
R
R
F
Site 39
Y451
F
C
E
G
K
N
H
Y
T
P
G
G
I
F
A
Site 40
T452
C
E
G
K
N
H
Y
T
P
G
G
I
F
A
P
Site 41
T464
F
A
P
G
L
P
L
T
P
S
P
M
M
D
K
Site 42
S466
P
G
L
P
L
T
P
S
P
M
M
D
K
A
K
Site 43
S475
M
M
D
K
A
K
P
S
P
S
L
N
H
A
S
Site 44
S477
D
K
A
K
P
S
P
S
L
N
H
A
S
L
G
Site 45
S482
S
P
S
L
N
H
A
S
L
G
F
N
E
Y
F
Site 46
Y488
A
S
L
G
F
N
E
Y
F
P
S
R
P
H
P
Site 47
S491
G
F
N
E
Y
F
P
S
R
P
H
P
G
S
L
Site 48
S497
P
S
R
P
H
P
G
S
L
P
F
S
T
A
P
Site 49
S501
H
P
G
S
L
P
F
S
T
A
P
P
T
F
P
Site 50
T502
P
G
S
L
P
F
S
T
A
P
P
T
F
P
A
Site 51
S521
F
P
G
I
F
P
P
S
L
Y
P
R
P
P
L
Site 52
T532
R
P
P
L
L
P
P
T
S
L
L
K
S
P
L
Site 53
S533
P
P
L
L
P
P
T
S
L
L
K
S
P
L
N
Site 54
S537
P
P
T
S
L
L
K
S
P
L
N
H
T
Q
D
Site 55
S549
T
Q
D
A
K
L
P
S
P
L
G
N
P
A
L
Site 56
S560
N
P
A
L
P
L
V
S
A
V
S
N
S
S
Q
Site 57
T570
S
N
S
S
Q
G
T
T
A
A
A
G
P
E
E
Site 58
S581
G
P
E
E
K
F
E
S
R
L
E
D
S
C
V
Site 59
S586
F
E
S
R
L
E
D
S
C
V
E
K
L
K
T
Site 60
T593
S
C
V
E
K
L
K
T
R
S
S
D
M
S
D
Site 61
S595
V
E
K
L
K
T
R
S
S
D
M
S
D
G
S
Site 62
S596
E
K
L
K
T
R
S
S
D
M
S
D
G
S
D
Site 63
S599
K
T
R
S
S
D
M
S
D
G
S
D
F
E
D
Site 64
S602
S
S
D
M
S
D
G
S
D
F
E
D
V
N
T
Site 65
T609
S
D
F
E
D
V
N
T
T
T
G
T
D
L
D
Site 66
T611
F
E
D
V
N
T
T
T
G
T
D
L
D
T
T
Site 67
T617
T
T
G
T
D
L
D
T
T
T
G
T
G
S
D
Site 68
T618
T
G
T
D
L
D
T
T
T
G
T
G
S
D
L
Site 69
T619
G
T
D
L
D
T
T
T
G
T
G
S
D
L
D
Site 70
S623
D
T
T
T
G
T
G
S
D
L
D
S
D
V
D
Site 71
S627
G
T
G
S
D
L
D
S
D
V
D
S
D
P
D
Site 72
S631
D
L
D
S
D
V
D
S
D
P
D
K
D
K
G
Site 73
S642
K
D
K
G
K
G
K
S
A
E
G
Q
P
K
F
Site 74
S670
A
E
V
P
V
F
Y
S
Q
H
S
F
F
P
P
Site 75
S673
P
V
F
Y
S
Q
H
S
F
F
P
P
P
D
E
Site 76
T684
P
P
D
E
Q
L
L
T
A
T
G
A
A
G
D
Site 77
S718
M
Q
E
K
K
L
G
S
L
P
Y
H
S
A
F
Site 78
Y721
K
K
L
G
S
L
P
Y
H
S
A
F
P
F
Q
Site 79
S736
F
L
P
N
F
P
H
S
L
Y
P
F
T
D
R
Site 80
Y738
P
N
F
P
H
S
L
Y
P
F
T
D
R
A
L
Site 81
T741
P
H
S
L
Y
P
F
T
D
R
A
L
A
H
N
Site 82
S757
L
V
K
A
E
P
K
S
P
R
D
A
L
K
V
Site 83
T776
A
E
C
P
F
D
L
T
T
K
P
K
D
V
K
Site 84
S793
L
P
M
P
K
G
P
S
A
P
A
S
G
E
E
Site 85
S797
K
G
P
S
A
P
A
S
G
E
E
Q
P
L
D
Site 86
S806
E
E
Q
P
L
D
L
S
I
G
S
R
A
R
A
Site 87
S809
P
L
D
L
S
I
G
S
R
A
R
A
S
Q
N
Site 88
S814
I
G
S
R
A
R
A
S
Q
N
G
G
G
R
E
Site 89
Y828
E
P
R
K
N
H
V
Y
G
E
R
K
L
G
A
Site 90
Y855
P
Q
Q
P
P
L
H
Y
A
K
P
S
P
F
F
Site 91
S859
P
L
H
Y
A
K
P
S
P
F
F
M
D
P
I
Site 92
Y867
P
F
F
M
D
P
I
Y
S
R
V
E
K
R
K
Site 93
T876
R
V
E
K
R
K
V
T
D
P
V
G
A
L
K
Site 94
Y886
V
G
A
L
K
E
K
Y
L
R
P
S
P
L
L
Site 95
S890
K
E
K
Y
L
R
P
S
P
L
L
F
H
P
Q
Site 96
T903
P
Q
M
S
A
I
E
T
M
T
E
K
L
E
S
Site 97
S910
T
M
T
E
K
L
E
S
F
A
A
M
K
A
D
Site 98
S918
F
A
A
M
K
A
D
S
G
S
S
L
Q
P
L
Site 99
S920
A
M
K
A
D
S
G
S
S
L
Q
P
L
P
H
Site 100
S921
M
K
A
D
S
G
S
S
L
Q
P
L
P
H
H
Site 101
S934
H
H
P
F
N
F
R
S
P
P
P
T
L
S
D
Site 102
T938
N
F
R
S
P
P
P
T
L
S
D
P
I
L
R
Site 103
S940
R
S
P
P
P
T
L
S
D
P
I
L
R
K
G
Site 104
Y951
L
R
K
G
K
E
R
Y
T
C
R
Y
C
G
K
Site 105
Y955
K
E
R
Y
T
C
R
Y
C
G
K
I
F
P
R
Site 106
S963
C
G
K
I
F
P
R
S
A
N
L
T
R
H
L
Site 107
T967
F
P
R
S
A
N
L
T
R
H
L
R
T
H
T
Site 108
T974
T
R
H
L
R
T
H
T
G
E
Q
P
Y
R
C
Site 109
Y983
E
Q
P
Y
R
C
K
Y
C
D
R
S
F
S
I
Site 110
S987
R
C
K
Y
C
D
R
S
F
S
I
S
S
N
L
Site 111
S989
K
Y
C
D
R
S
F
S
I
S
S
N
L
Q
R
Site 112
S991
C
D
R
S
F
S
I
S
S
N
L
Q
R
H
V
Site 113
S1038
E
H
E
N
A
P
V
S
Q
H
P
G
V
L
T
Site 114
T1045
S
Q
H
P
G
V
L
T
N
H
L
G
T
S
A
Site 115
T1050
V
L
T
N
H
L
G
T
S
A
S
S
P
T
S
Site 116
S1051
L
T
N
H
L
G
T
S
A
S
S
P
T
S
E
Site 117
S1053
N
H
L
G
T
S
A
S
S
P
T
S
E
S
D
Site 118
S1054
H
L
G
T
S
A
S
S
P
T
S
E
S
D
N
Site 119
S1057
T
S
A
S
S
P
T
S
E
S
D
N
H
A
L
Site 120
S1059
A
S
S
P
T
S
E
S
D
N
H
A
L
L
D
Site 121
S1071
L
L
D
E
K
E
D
S
Y
F
S
E
I
R
N
Site 122
Y1072
L
D
E
K
E
D
S
Y
F
S
E
I
R
N
F
Site 123
S1074
E
K
E
D
S
Y
F
S
E
I
R
N
F
I
A
Site 124
S1089
N
S
E
M
N
Q
A
S
T
R
T
E
K
R
A
Site 125
S1133
L
E
E
D
D
E
D
S
L
A
G
K
S
Q
D
Site 126
S1138
E
D
S
L
A
G
K
S
Q
D
D
T
V
S
P
Site 127
T1142
A
G
K
S
Q
D
D
T
V
S
P
A
P
E
P
Site 128
S1144
K
S
Q
D
D
T
V
S
P
A
P
E
P
Q
A
Site 129
S1164
E
D
E
E
P
A
A
S
L
A
V
G
F
D
H
Site 130
T1172
L
A
V
G
F
D
H
T
R
R
C
A
E
D
H
Site 131
S1214
E
V
K
D
V
L
N
S
T
L
D
S
E
A
L
Site 132
S1218
V
L
N
S
T
L
D
S
E
A
L
K
H
T
L
Site 133
S1241
Y
A
M
M
L
S
L
S
E
D
T
P
L
H
T
Site 134
T1244
M
L
S
L
S
E
D
T
P
L
H
T
P
S
Q
Site 135
T1248
S
E
D
T
P
L
H
T
P
S
Q
G
S
L
D
Site 136
S1250
D
T
P
L
H
T
P
S
Q
G
S
L
D
A
W
Site 137
S1253
L
H
T
P
S
Q
G
S
L
D
A
W
L
K
V
Site 138
S1265
L
K
V
T
G
A
T
S
E
S
G
A
F
H
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation