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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
exportin 5
Full Name:
Exportin-5
Alias:
Exp5; Exportin 5; KIAA1291; Ran-binding protein 21; RANBP21; XPO5
Type:
Karyopherin
Mass (Da):
136310
Number AA:
UniProt ID:
Q9HAV4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0000049
PhosphoSite+
KinaseNET
Biological Process:
GO:0031047
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
E
Q
L
V
K
A
V
T
V
M
M
D
P
N
S
Site 2
S25
T
V
M
M
D
P
N
S
T
Q
R
Y
R
L
E
Site 3
T26
V
M
M
D
P
N
S
T
Q
R
Y
R
L
E
A
Site 4
Y29
D
P
N
S
T
Q
R
Y
R
L
E
A
L
K
F
Site 5
T58
G
L
R
L
A
E
K
T
Q
V
A
I
V
R
H
Site 6
Y89
M
S
R
L
E
K
V
Y
L
K
N
S
V
M
E
Site 7
T141
D
M
L
I
E
L
D
T
L
S
K
Q
G
E
T
Site 8
S143
L
I
E
L
D
T
L
S
K
Q
G
E
T
Q
T
Site 9
T166
R
L
A
E
D
V
V
T
F
Q
T
L
P
P
Q
Site 10
T169
E
D
V
V
T
F
Q
T
L
P
P
Q
R
R
R
Site 11
T181
R
R
R
D
I
Q
Q
T
L
T
Q
N
M
E
R
Site 12
T183
R
D
I
Q
Q
T
L
T
Q
N
M
E
R
I
F
Site 13
S191
Q
N
M
E
R
I
F
S
F
L
L
N
T
L
Q
Site 14
Y204
L
Q
E
N
V
N
K
Y
Q
Q
V
K
T
D
T
Site 15
T209
N
K
Y
Q
Q
V
K
T
D
T
S
Q
E
S
K
Site 16
S212
Q
Q
V
K
T
D
T
S
Q
E
S
K
A
Q
A
Site 17
S276
E
C
L
L
I
A
V
S
R
K
G
K
L
E
D
Site 18
S341
C
A
L
L
G
A
D
S
D
V
E
T
P
S
N
Site 19
T345
G
A
D
S
D
V
E
T
P
S
N
F
G
K
Y
Site 20
Y352
T
P
S
N
F
G
K
Y
L
E
S
F
L
A
F
Site 21
S355
N
F
G
K
Y
L
E
S
F
L
A
F
T
T
H
Site 22
S364
L
A
F
T
T
H
P
S
Q
F
L
R
S
S
T
Site 23
S370
P
S
Q
F
L
R
S
S
T
Q
M
T
W
G
A
Site 24
T371
S
Q
F
L
R
S
S
T
Q
M
T
W
G
A
L
Site 25
T374
L
R
S
S
T
Q
M
T
W
G
A
L
F
R
H
Site 26
T403
K
Y
L
R
A
S
M
T
N
L
V
K
M
G
F
Site 27
S412
L
V
K
M
G
F
P
S
K
T
D
S
P
S
C
Site 28
T414
K
M
G
F
P
S
K
T
D
S
P
S
C
E
Y
Site 29
S416
G
F
P
S
K
T
D
S
P
S
C
E
Y
S
R
Site 30
S418
P
S
K
T
D
S
P
S
C
E
Y
S
R
F
D
Site 31
S422
D
S
P
S
C
E
Y
S
R
F
D
F
D
S
D
Site 32
S428
Y
S
R
F
D
F
D
S
D
E
D
F
N
A
F
Site 33
S438
D
F
N
A
F
F
N
S
S
R
A
Q
Q
G
E
Site 34
T457
A
C
R
L
D
P
K
T
S
F
Q
M
A
G
E
Site 35
Y468
M
A
G
E
W
L
K
Y
Q
L
S
T
F
L
D
Site 36
S471
E
W
L
K
Y
Q
L
S
T
F
L
D
A
G
S
Site 37
S483
A
G
S
V
N
S
C
S
A
V
G
T
G
E
G
Site 38
T487
N
S
C
S
A
V
G
T
G
E
G
S
L
C
S
Site 39
T520
V
I
T
Q
M
F
R
T
L
N
R
E
E
I
P
Site 40
T582
S
K
L
F
S
S
V
T
F
E
T
V
E
E
S
Site 41
T585
F
S
S
V
T
F
E
T
V
E
E
S
K
A
P
Site 42
S589
T
F
E
T
V
E
E
S
K
A
P
R
T
R
A
Site 43
S606
N
V
R
R
H
A
C
S
S
I
I
K
M
C
R
Site 44
S607
V
R
R
H
A
C
S
S
I
I
K
M
C
R
D
Site 45
Y627
L
P
N
F
D
M
L
Y
N
H
V
K
Q
L
L
Site 46
Y662
I
S
N
Q
F
K
N
Y
E
R
Q
K
V
F
L
Site 47
Y698
D
V
D
A
F
I
A
Y
V
G
T
D
Q
K
S
Site 48
S705
Y
V
G
T
D
Q
K
S
C
D
P
G
L
E
D
Site 49
T739
V
K
R
T
C
W
P
T
D
L
E
E
A
K
A
Site 50
Y753
A
G
G
F
V
V
G
Y
T
S
S
G
N
P
I
Site 51
S755
G
F
V
V
G
Y
T
S
S
G
N
P
I
F
R
Site 52
S756
F
V
V
G
Y
T
S
S
G
N
P
I
F
R
N
Site 53
Y787
I
R
T
H
N
T
L
Y
A
P
E
M
L
A
K
Site 54
T800
A
K
M
A
E
P
F
T
K
A
L
D
M
L
D
Site 55
S811
D
M
L
D
A
E
K
S
A
I
L
G
L
P
Q
Site 56
S826
P
L
L
E
L
N
D
S
P
V
F
K
T
V
L
Site 57
T831
N
D
S
P
V
F
K
T
V
L
E
R
M
Q
R
Site 58
Y863
P
S
M
Q
Q
D
F
Y
T
V
E
D
L
A
T
Site 59
T864
S
M
Q
Q
D
F
Y
T
V
E
D
L
A
T
Q
Site 60
Y886
N
L
N
N
I
P
D
Y
R
L
R
P
M
L
R
Site 61
Y922
I
L
G
P
L
F
T
Y
L
H
M
R
L
S
Q
Site 62
S953
A
A
D
E
N
P
E
S
Q
E
M
L
E
E
Q
Site 63
S986
S
K
K
G
A
D
H
S
S
A
P
P
A
D
G
Site 64
S987
K
K
G
A
D
H
S
S
A
P
P
A
D
G
D
Site 65
T1001
D
D
E
E
M
M
A
T
E
V
T
P
S
A
M
Site 66
T1041
N
S
L
A
W
K
D
T
L
S
C
Q
R
T
T
Site 67
S1043
L
A
W
K
D
T
L
S
C
Q
R
T
T
S
Q
Site 68
T1047
D
T
L
S
C
Q
R
T
T
S
Q
L
C
W
P
Site 69
T1048
T
L
S
C
Q
R
T
T
S
Q
L
C
W
P
L
Site 70
Y1101
V
H
L
A
F
Q
I
Y
E
A
L
R
P
R
Y
Site 71
Y1108
Y
E
A
L
R
P
R
Y
L
E
I
R
A
V
M
Site 72
S1125
I
P
E
I
Q
K
D
S
L
D
Q
F
D
C
K
Site 73
S1137
D
C
K
L
L
N
P
S
L
Q
K
V
A
D
K
Site 74
S1177
V
H
I
K
N
L
P
S
L
F
K
K
T
K
P
Site 75
T1182
L
P
S
L
F
K
K
T
K
P
M
L
E
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation