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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMURF2
Full Name:
E3 ubiquitin-protein ligase SMURF2
Alias:
E3 ubiquitin ligase SMURF2; EC 6.3.2.-; SMAD specific E3 ubiquitin protein ligase 2; Smad ubiquitination regulatory factor 2; Smad-specific; SMUF2
Type:
Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase
Mass (Da):
86196
Number AA:
748
UniProt ID:
Q9HAU4
International Prot ID:
IPI00329664
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0045121
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0016481
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
A
K
V
V
V
D
G
S
G
Q
C
H
S
T
D
Site 2
S49
D
G
S
G
Q
C
H
S
T
D
T
V
K
N
T
Site 3
T50
G
S
G
Q
C
H
S
T
D
T
V
K
N
T
L
Site 4
T52
G
Q
C
H
S
T
D
T
V
K
N
T
L
D
P
Site 5
T56
S
T
D
T
V
K
N
T
L
D
P
K
W
N
Q
Site 6
Y65
D
P
K
W
N
Q
H
Y
D
L
Y
I
G
K
S
Site 7
Y68
W
N
Q
H
Y
D
L
Y
I
G
K
S
D
S
V
Site 8
T76
I
G
K
S
D
S
V
T
I
S
V
W
N
H
K
Site 9
S78
K
S
D
S
V
T
I
S
V
W
N
H
K
K
I
Site 10
T110
A
I
N
R
L
K
D
T
G
Y
Q
R
L
D
L
Site 11
Y112
N
R
L
K
D
T
G
Y
Q
R
L
D
L
C
K
Site 12
T127
L
G
P
N
D
N
D
T
V
R
G
Q
I
V
V
Site 13
S135
V
R
G
Q
I
V
V
S
L
Q
S
R
D
R
I
Site 14
S138
Q
I
V
V
S
L
Q
S
R
D
R
I
G
T
G
Site 15
T144
Q
S
R
D
R
I
G
T
G
G
Q
V
V
D
C
Site 16
S152
G
G
Q
V
V
D
C
S
R
L
F
D
N
D
L
Site 17
T168
D
G
W
E
E
R
R
T
A
S
G
R
I
Q
Y
Site 18
S170
W
E
E
R
R
T
A
S
G
R
I
Q
Y
L
N
Site 19
Y175
T
A
S
G
R
I
Q
Y
L
N
H
I
T
R
T
Site 20
T183
L
N
H
I
T
R
T
T
Q
W
E
R
P
T
R
Site 21
T189
T
T
Q
W
E
R
P
T
R
P
A
S
E
Y
S
Site 22
S193
E
R
P
T
R
P
A
S
E
Y
S
S
P
G
R
Site 23
Y195
P
T
R
P
A
S
E
Y
S
S
P
G
R
P
L
Site 24
S196
T
R
P
A
S
E
Y
S
S
P
G
R
P
L
S
Site 25
S197
R
P
A
S
E
Y
S
S
P
G
R
P
L
S
C
Site 26
S203
S
S
P
G
R
P
L
S
C
F
V
D
E
N
T
Site 27
T210
S
C
F
V
D
E
N
T
P
I
S
G
T
N
G
Site 28
S213
V
D
E
N
T
P
I
S
G
T
N
G
A
T
C
Site 29
S224
G
A
T
C
G
Q
S
S
D
P
R
L
A
E
R
Site 30
S235
L
A
E
R
R
V
R
S
Q
R
H
R
N
Y
M
Site 31
Y241
R
S
Q
R
H
R
N
Y
M
S
R
T
H
L
H
Site 32
T249
M
S
R
T
H
L
H
T
P
P
D
L
P
E
G
Site 33
Y257
P
P
D
L
P
E
G
Y
E
Q
R
T
T
Q
Q
Site 34
T262
E
G
Y
E
Q
R
T
T
Q
Q
G
Q
V
Y
F
Site 35
Y268
T
T
Q
Q
G
Q
V
Y
F
L
H
T
Q
T
G
Site 36
T272
G
Q
V
Y
F
L
H
T
Q
T
G
V
S
T
W
Site 37
S289
P
R
V
P
R
D
L
S
N
I
N
C
E
E
L
Site 38
T308
P
G
W
E
I
R
N
T
A
T
G
R
V
Y
F
Site 39
Y314
N
T
A
T
G
R
V
Y
F
V
D
H
N
N
R
Site 40
T323
V
D
H
N
N
R
T
T
Q
F
T
D
P
R
L
Site 41
T326
N
N
R
T
T
Q
F
T
D
P
R
L
S
A
N
Site 42
S331
Q
F
T
D
P
R
L
S
A
N
L
H
L
V
L
Site 43
S354
Q
Q
Q
Q
Q
V
V
S
L
C
P
D
D
T
E
Site 44
T360
V
S
L
C
P
D
D
T
E
C
L
T
V
P
R
Site 45
T364
P
D
D
T
E
C
L
T
V
P
R
Y
K
R
D
Site 46
Y368
E
C
L
T
V
P
R
Y
K
R
D
L
V
Q
K
Site 47
S384
K
I
L
R
Q
E
L
S
Q
Q
Q
P
Q
A
G
Site 48
Y434
R
G
E
E
G
L
D
Y
G
G
V
A
R
E
W
Site 49
Y453
S
H
E
M
L
N
P
Y
Y
G
L
F
Q
Y
S
Site 50
Y454
H
E
M
L
N
P
Y
Y
G
L
F
Q
Y
S
R
Site 51
Y459
P
Y
Y
G
L
F
Q
Y
S
R
D
D
I
Y
T
Site 52
Y465
Q
Y
S
R
D
D
I
Y
T
L
Q
I
N
P
D
Site 53
T466
Y
S
R
D
D
I
Y
T
L
Q
I
N
P
D
S
Site 54
S473
T
L
Q
I
N
P
D
S
A
V
N
P
E
H
L
Site 55
Y482
V
N
P
E
H
L
S
Y
F
H
F
V
G
R
I
Site 56
Y499
M
A
V
F
H
G
H
Y
I
D
G
G
F
T
L
Site 57
Y509
G
G
F
T
L
P
F
Y
K
Q
L
L
G
K
S
Site 58
S516
Y
K
Q
L
L
G
K
S
I
T
L
D
D
M
E
Site 59
S532
V
D
P
D
L
H
N
S
L
V
W
I
L
E
N
Site 60
Y556
F
C
V
E
H
N
A
Y
G
E
I
I
Q
H
E
Site 61
Y581
N
E
E
N
K
K
E
Y
V
R
L
Y
V
N
W
Site 62
Y585
K
K
E
Y
V
R
L
Y
V
N
W
R
F
L
R
Site 63
T616
I
P
Q
H
L
L
K
T
F
D
E
K
E
L
E
Site 64
T647
N
T
R
L
K
H
C
T
P
D
S
N
I
V
K
Site 65
Y725
N
R
I
D
I
P
P
Y
E
S
Y
E
K
L
Y
Site 66
S727
I
D
I
P
P
Y
E
S
Y
E
K
L
Y
E
K
Site 67
T737
K
L
Y
E
K
L
L
T
A
I
E
E
T
C
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation