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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHA5
Full Name:
Pleckstrin homology domain-containing family A member 5
Alias:
FLJ10667; KIAA1686; PEPP2; PEPP-2; Phosphoinositol 3-phosphate-binding protein 2; Phosphoinositol 3-phosphate-binding protein-2; PKHA5; Pleckstrin homology domain-containing protein family A member 5; Pleckstriny domain containing, family A member 5
Type:
Lipid binding protein
Mass (Da):
127464
Number AA:
1116
UniProt ID:
Q9HAU0
International Prot ID:
IPI00029515
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005545
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
I
S
L
P
R
S
W
T
Y
G
I
T
R
G
G
Site 2
Y18
S
L
P
R
S
W
T
Y
G
I
T
R
G
G
R
Site 3
T36
I
N
E
E
A
K
S
T
T
W
L
H
P
V
T
Site 4
T49
V
T
G
E
A
V
V
T
G
H
R
R
Q
S
T
Site 5
S55
V
T
G
H
R
R
Q
S
T
D
L
P
T
G
W
Site 6
T56
T
G
H
R
R
Q
S
T
D
L
P
T
G
W
E
Site 7
Y66
P
T
G
W
E
E
A
Y
T
F
E
G
A
R
Y
Site 8
T67
T
G
W
E
E
A
Y
T
F
E
G
A
R
Y
Y
Site 9
Y73
Y
T
F
E
G
A
R
Y
Y
I
N
H
N
E
R
Site 10
Y74
T
F
E
G
A
R
Y
Y
I
N
H
N
E
R
K
Site 11
T83
N
H
N
E
R
K
V
T
C
K
H
P
V
T
G
Site 12
T89
V
T
C
K
H
P
V
T
G
Q
P
S
Q
D
N
Site 13
S120
E
K
K
E
R
P
I
S
M
I
N
E
A
S
N
Site 14
S126
I
S
M
I
N
E
A
S
N
Y
N
V
T
S
D
Site 15
Y128
M
I
N
E
A
S
N
Y
N
V
T
S
D
Y
A
Site 16
T131
E
A
S
N
Y
N
V
T
S
D
Y
A
V
H
P
Site 17
S132
A
S
N
Y
N
V
T
S
D
Y
A
V
H
P
M
Site 18
Y134
N
Y
N
V
T
S
D
Y
A
V
H
P
M
S
P
Site 19
S140
D
Y
A
V
H
P
M
S
P
V
G
R
T
S
R
Site 20
T145
P
M
S
P
V
G
R
T
S
R
A
S
K
K
V
Site 21
S146
M
S
P
V
G
R
T
S
R
A
S
K
K
V
H
Site 22
S149
V
G
R
T
S
R
A
S
K
K
V
H
N
F
G
Site 23
S161
N
F
G
K
R
S
N
S
I
K
R
N
P
N
A
Site 24
Y177
V
V
R
R
G
W
L
Y
K
Q
D
S
T
G
M
Site 25
Y201
L
S
D
L
C
L
F
Y
Y
R
D
E
K
E
E
Site 26
Y202
S
D
L
C
L
F
Y
Y
R
D
E
K
E
E
G
Site 27
T225
S
F
Q
I
A
L
L
T
S
E
D
H
I
N
R
Site 28
Y234
E
D
H
I
N
R
K
Y
A
F
K
A
A
H
P
Site 29
Y247
H
P
N
M
R
T
Y
Y
F
C
T
D
T
G
K
Site 30
T281
V
K
R
V
D
K
I
T
S
E
N
A
P
T
K
Site 31
T287
I
T
S
E
N
A
P
T
K
E
T
N
N
I
P
Site 32
Y327
K
A
L
E
A
E
K
Y
G
F
Q
K
D
G
Q
Site 33
T339
D
G
Q
D
R
P
L
T
K
I
N
S
V
K
L
Site 34
S343
R
P
L
T
K
I
N
S
V
K
L
N
S
L
P
Site 35
S348
I
N
S
V
K
L
N
S
L
P
S
E
Y
E
S
Site 36
S351
V
K
L
N
S
L
P
S
E
Y
E
S
G
S
A
Site 37
Y353
L
N
S
L
P
S
E
Y
E
S
G
S
A
C
P
Site 38
S355
S
L
P
S
E
Y
E
S
G
S
A
C
P
A
Q
Site 39
S357
P
S
E
Y
E
S
G
S
A
C
P
A
Q
T
V
Site 40
T363
G
S
A
C
P
A
Q
T
V
H
Y
R
P
I
N
Site 41
Y366
C
P
A
Q
T
V
H
Y
R
P
I
N
L
S
S
Site 42
S372
H
Y
R
P
I
N
L
S
S
S
E
N
K
I
V
Site 43
S374
R
P
I
N
L
S
S
S
E
N
K
I
V
N
V
Site 44
S382
E
N
K
I
V
N
V
S
L
A
D
L
R
G
G
Site 45
T394
R
G
G
N
R
P
N
T
G
P
L
Y
T
E
A
Site 46
Y398
R
P
N
T
G
P
L
Y
T
E
A
D
R
V
I
Site 47
T399
P
N
T
G
P
L
Y
T
E
A
D
R
V
I
Q
Site 48
T408
A
D
R
V
I
Q
R
T
N
S
M
Q
Q
L
E
Site 49
S410
R
V
I
Q
R
T
N
S
M
Q
Q
L
E
Q
W
Site 50
S435
E
E
T
R
G
V
I
S
Y
Q
T
L
P
R
N
Site 51
Y436
E
T
R
G
V
I
S
Y
Q
T
L
P
R
N
M
Site 52
T438
R
G
V
I
S
Y
Q
T
L
P
R
N
M
P
S
Site 53
S445
T
L
P
R
N
M
P
S
H
R
A
Q
I
M
A
Site 54
Y454
R
A
Q
I
M
A
R
Y
P
E
G
Y
R
T
L
Site 55
Y458
M
A
R
Y
P
E
G
Y
R
T
L
P
R
N
S
Site 56
T460
R
Y
P
E
G
Y
R
T
L
P
R
N
S
K
T
Site 57
S465
Y
R
T
L
P
R
N
S
K
T
R
P
E
S
I
Site 58
T467
T
L
P
R
N
S
K
T
R
P
E
S
I
C
S
Site 59
S471
N
S
K
T
R
P
E
S
I
C
S
V
T
P
S
Site 60
S474
T
R
P
E
S
I
C
S
V
T
P
S
T
H
D
Site 61
T476
P
E
S
I
C
S
V
T
P
S
T
H
D
K
T
Site 62
S478
S
I
C
S
V
T
P
S
T
H
D
K
T
L
G
Site 63
T479
I
C
S
V
T
P
S
T
H
D
K
T
L
G
P
Site 64
T483
T
P
S
T
H
D
K
T
L
G
P
G
A
E
E
Site 65
S494
G
A
E
E
K
R
R
S
M
R
D
D
T
M
W
Site 66
T499
R
R
S
M
R
D
D
T
M
W
Q
L
Y
E
W
Site 67
Y504
D
D
T
M
W
Q
L
Y
E
W
Q
Q
R
Q
F
Site 68
Y512
E
W
Q
Q
R
Q
F
Y
N
K
Q
S
T
L
P
Site 69
T517
Q
F
Y
N
K
Q
S
T
L
P
R
H
S
T
L
Site 70
S522
Q
S
T
L
P
R
H
S
T
L
S
S
P
K
T
Site 71
T523
S
T
L
P
R
H
S
T
L
S
S
P
K
T
M
Site 72
S525
L
P
R
H
S
T
L
S
S
P
K
T
M
V
N
Site 73
S526
P
R
H
S
T
L
S
S
P
K
T
M
V
N
I
Site 74
T529
S
T
L
S
S
P
K
T
M
V
N
I
S
D
Q
Site 75
S534
P
K
T
M
V
N
I
S
D
Q
T
M
H
S
I
Site 76
T537
M
V
N
I
S
D
Q
T
M
H
S
I
P
T
S
Site 77
S540
I
S
D
Q
T
M
H
S
I
P
T
S
P
S
H
Site 78
T543
Q
T
M
H
S
I
P
T
S
P
S
H
G
S
I
Site 79
S544
T
M
H
S
I
P
T
S
P
S
H
G
S
I
A
Site 80
S546
H
S
I
P
T
S
P
S
H
G
S
I
A
A
Y
Site 81
S549
P
T
S
P
S
H
G
S
I
A
A
Y
Q
G
Y
Site 82
Y553
S
H
G
S
I
A
A
Y
Q
G
Y
S
P
Q
R
Site 83
S557
I
A
A
Y
Q
G
Y
S
P
Q
R
T
Y
R
S
Site 84
T561
Q
G
Y
S
P
Q
R
T
Y
R
S
E
V
S
S
Site 85
Y562
G
Y
S
P
Q
R
T
Y
R
S
E
V
S
S
P
Site 86
S564
S
P
Q
R
T
Y
R
S
E
V
S
S
P
I
Q
Site 87
S568
T
Y
R
S
E
V
S
S
P
I
Q
R
G
D
V
Site 88
T576
P
I
Q
R
G
D
V
T
I
D
R
R
H
R
A
Site 89
Y590
A
H
H
P
K
H
V
Y
V
P
D
R
R
S
V
Site 90
T602
R
S
V
P
A
G
L
T
L
Q
S
V
S
P
Q
Site 91
S605
P
A
G
L
T
L
Q
S
V
S
P
Q
S
L
Q
Site 92
S607
G
L
T
L
Q
S
V
S
P
Q
S
L
Q
G
K
Site 93
S610
L
Q
S
V
S
P
Q
S
L
Q
G
K
T
L
S
Site 94
T615
P
Q
S
L
Q
G
K
T
L
S
Q
D
E
G
R
Site 95
S617
S
L
Q
G
K
T
L
S
Q
D
E
G
R
G
T
Site 96
T624
S
Q
D
E
G
R
G
T
L
Y
K
Y
R
P
E
Site 97
Y626
D
E
G
R
G
T
L
Y
K
Y
R
P
E
E
V
Site 98
Y628
G
R
G
T
L
Y
K
Y
R
P
E
E
V
D
I
Site 99
Y664
Q
Q
L
H
K
E
K
Y
T
L
E
Q
A
L
L
Site 100
S672
T
L
E
Q
A
L
L
S
A
S
Q
E
I
E
M
Site 101
S674
E
Q
A
L
L
S
A
S
Q
E
I
E
M
H
A
Site 102
S703
D
L
Q
N
G
L
L
S
T
C
R
E
L
S
R
Site 103
T704
L
Q
N
G
L
L
S
T
C
R
E
L
S
R
A
Site 104
S709
L
S
T
C
R
E
L
S
R
A
T
A
E
L
E
Site 105
T712
C
R
E
L
S
R
A
T
A
E
L
E
R
A
W
Site 106
Y722
L
E
R
A
W
R
E
Y
D
K
L
E
Y
D
V
Site 107
Y727
R
E
Y
D
K
L
E
Y
D
V
T
V
T
R
N
Site 108
T730
D
K
L
E
Y
D
V
T
V
T
R
N
Q
M
Q
Site 109
S750
L
G
E
V
Q
T
E
S
A
G
I
Q
R
A
Q
Site 110
T781
K
H
K
Q
Q
R
G
T
T
E
I
G
M
I
G
Site 111
T782
H
K
Q
Q
R
G
T
T
E
I
G
M
I
G
S
Site 112
S789
T
E
I
G
M
I
G
S
K
P
F
S
T
V
K
Site 113
S793
M
I
G
S
K
P
F
S
T
V
K
Y
K
N
E
Site 114
T794
I
G
S
K
P
F
S
T
V
K
Y
K
N
E
G
Site 115
Y797
K
P
F
S
T
V
K
Y
K
N
E
G
P
D
Y
Site 116
Y804
Y
K
N
E
G
P
D
Y
R
L
Y
K
S
E
P
Site 117
Y807
E
G
P
D
Y
R
L
Y
K
S
E
P
E
L
T
Site 118
S809
P
D
Y
R
L
Y
K
S
E
P
E
L
T
T
V
Site 119
T814
Y
K
S
E
P
E
L
T
T
V
A
E
V
D
E
Site 120
S822
T
V
A
E
V
D
E
S
N
G
E
E
K
S
E
Site 121
S828
E
S
N
G
E
E
K
S
E
P
V
S
E
I
E
Site 122
S832
E
E
K
S
E
P
V
S
E
I
E
T
S
V
V
Site 123
T836
E
P
V
S
E
I
E
T
S
V
V
K
G
S
H
Site 124
S837
P
V
S
E
I
E
T
S
V
V
K
G
S
H
F
Site 125
S842
E
T
S
V
V
K
G
S
H
F
P
V
G
V
V
Site 126
S855
V
V
P
P
R
A
K
S
P
T
P
E
S
S
T
Site 127
T857
P
P
R
A
K
S
P
T
P
E
S
S
T
I
A
Site 128
S860
A
K
S
P
T
P
E
S
S
T
I
A
S
Y
V
Site 129
S861
K
S
P
T
P
E
S
S
T
I
A
S
Y
V
T
Site 130
T862
S
P
T
P
E
S
S
T
I
A
S
Y
V
T
L
Site 131
S865
P
E
S
S
T
I
A
S
Y
V
T
L
R
K
T
Site 132
Y866
E
S
S
T
I
A
S
Y
V
T
L
R
K
T
K
Site 133
T868
S
T
I
A
S
Y
V
T
L
R
K
T
K
K
M
Site 134
T872
S
Y
V
T
L
R
K
T
K
K
M
M
D
L
R
Site 135
T880
K
K
M
M
D
L
R
T
E
R
P
R
S
A
V
Site 136
S885
L
R
T
E
R
P
R
S
A
V
E
Q
L
C
L
Site 137
S895
E
Q
L
C
L
A
E
S
T
R
P
R
M
T
V
Site 138
T901
E
S
T
R
P
R
M
T
V
E
E
Q
M
E
R
Site 139
S930
G
L
N
V
I
G
A
S
D
Q
S
P
L
Q
S
Site 140
S933
V
I
G
A
S
D
Q
S
P
L
Q
S
P
S
N
Site 141
S937
S
D
Q
S
P
L
Q
S
P
S
N
L
R
D
N
Site 142
S939
Q
S
P
L
Q
S
P
S
N
L
R
D
N
P
F
Site 143
T949
R
D
N
P
F
R
T
T
Q
T
R
R
R
D
D
Site 144
T961
R
D
D
K
E
L
D
T
A
I
R
E
N
D
V
Site 145
T974
D
V
K
P
D
H
E
T
P
A
T
E
I
V
Q
Site 146
T977
P
D
H
E
T
P
A
T
E
I
V
Q
L
K
E
Site 147
S993
E
P
Q
N
V
D
F
S
K
E
L
K
K
T
E
Site 148
T999
F
S
K
E
L
K
K
T
E
N
I
S
Y
E
M
Site 149
S1003
L
K
K
T
E
N
I
S
Y
E
M
L
F
E
P
Site 150
Y1004
K
K
T
E
N
I
S
Y
E
M
L
F
E
P
E
Site 151
S1017
P
E
P
N
G
V
N
S
V
E
M
M
D
K
E
Site 152
T1035
D
K
M
P
E
D
V
T
F
S
P
Q
D
E
T
Site 153
S1037
M
P
E
D
V
T
F
S
P
Q
D
E
T
Q
T
Site 154
S1060
P
E
E
N
T
K
N
S
V
D
E
Q
E
E
T
Site 155
T1067
S
V
D
E
Q
E
E
T
V
I
S
Y
E
S
T
Site 156
S1070
E
Q
E
E
T
V
I
S
Y
E
S
T
P
E
V
Site 157
S1073
E
T
V
I
S
Y
E
S
T
P
E
V
S
R
G
Site 158
T1074
T
V
I
S
Y
E
S
T
P
E
V
S
R
G
N
Site 159
T1083
E
V
S
R
G
N
Q
T
M
A
V
K
S
L
S
Site 160
S1088
N
Q
T
M
A
V
K
S
L
S
P
S
P
E
S
Site 161
S1090
T
M
A
V
K
S
L
S
P
S
P
E
S
S
A
Site 162
S1092
A
V
K
S
L
S
P
S
P
E
S
S
A
S
P
Site 163
S1095
S
L
S
P
S
P
E
S
S
A
S
P
V
P
S
Site 164
S1096
L
S
P
S
P
E
S
S
A
S
P
V
P
S
T
Site 165
S1098
P
S
P
E
S
S
A
S
P
V
P
S
T
Q
P
Site 166
S1102
S
S
A
S
P
V
P
S
T
Q
P
Q
L
T
E
Site 167
T1103
S
A
S
P
V
P
S
T
Q
P
Q
L
T
E
G
Site 168
T1108
P
S
T
Q
P
Q
L
T
E
G
S
H
F
M
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation