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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CARS2
Full Name:
Probable cysteinyl-tRNA synthetase, mitochondrial
Alias:
Cysteine--tRNA ligase
Type:
Mass (Da):
62206
Number AA:
564
UniProt ID:
Q9HA77
International Prot ID:
IPI00336016
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005739
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004812
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006139
GO:0006399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
W
P
A
G
R
A
A
S
G
G
R
G
R
A
W
Site 2
T46
G
R
A
W
L
Q
P
T
G
R
E
T
G
V
Q
Site 3
T50
L
Q
P
T
G
R
E
T
G
V
Q
V
Y
N
S
Site 4
Y55
R
E
T
G
V
Q
V
Y
N
S
L
T
G
R
K
Site 5
S57
T
G
V
Q
V
Y
N
S
L
T
G
R
K
E
P
Site 6
T59
V
Q
V
Y
N
S
L
T
G
R
K
E
P
L
I
Site 7
Y83
Y
S
C
G
P
T
V
Y
D
H
A
H
L
G
H
Site 8
S111
L
T
K
V
F
G
C
S
I
V
M
V
M
G
I
Site 9
S135
R
A
N
E
M
N
I
S
P
A
S
L
A
S
L
Site 10
S138
E
M
N
I
S
P
A
S
L
A
S
L
Y
E
E
Site 11
S141
I
S
P
A
S
L
A
S
L
Y
E
E
D
F
K
Site 12
Y143
P
A
S
L
A
S
L
Y
E
E
D
F
K
Q
D
Site 13
S187
I
A
R
G
N
A
Y
S
T
A
K
G
N
V
Y
Site 14
Y194
S
T
A
K
G
N
V
Y
F
D
L
K
S
R
G
Site 15
S199
N
V
Y
F
D
L
K
S
R
G
D
K
Y
G
K
Site 16
Y204
L
K
S
R
G
D
K
Y
G
K
L
V
G
V
V
Site 17
S221
P
V
G
E
P
A
D
S
D
K
R
H
A
S
D
Site 18
S227
D
S
D
K
R
H
A
S
D
F
A
L
W
K
A
Site 19
S244
P
Q
E
V
F
W
A
S
P
W
G
P
G
R
P
Site 20
S319
K
G
K
E
E
K
M
S
K
S
L
K
N
Y
I
Site 21
S321
K
E
E
K
M
S
K
S
L
K
N
Y
I
T
I
Site 22
Y325
M
S
K
S
L
K
N
Y
I
T
I
K
D
F
L
Site 23
T327
K
S
L
K
N
Y
I
T
I
K
D
F
L
K
T
Site 24
T334
T
I
K
D
F
L
K
T
F
S
P
D
V
F
R
Site 25
S336
K
D
F
L
K
T
F
S
P
D
V
F
R
F
F
Site 26
S347
F
R
F
F
C
L
R
S
S
Y
R
S
A
I
D
Site 27
S348
R
F
F
C
L
R
S
S
Y
R
S
A
I
D
Y
Site 28
Y349
F
F
C
L
R
S
S
Y
R
S
A
I
D
Y
S
Site 29
S351
C
L
R
S
S
Y
R
S
A
I
D
Y
S
D
S
Site 30
Y355
S
Y
R
S
A
I
D
Y
S
D
S
A
M
L
Q
Site 31
S356
Y
R
S
A
I
D
Y
S
D
S
A
M
L
Q
A
Site 32
Y380
F
L
E
D
A
R
A
Y
M
K
G
Q
L
A
C
Site 33
S400
A
M
L
W
E
R
L
S
S
T
K
R
A
V
K
Site 34
S401
M
L
W
E
R
L
S
S
T
K
R
A
V
K
A
Site 35
S437
G
N
G
Q
L
R
A
S
L
K
E
P
E
G
P
Site 36
S446
K
E
P
E
G
P
R
S
P
A
V
F
G
A
I
Site 37
Y473
I
S
L
A
N
Q
Q
Y
V
S
G
D
G
S
E
Site 38
S475
L
A
N
Q
Q
Y
V
S
G
D
G
S
E
A
T
Site 39
S479
Q
Y
V
S
G
D
G
S
E
A
T
L
H
G
V
Site 40
T482
S
G
D
G
S
E
A
T
L
H
G
V
V
D
E
Site 41
T534
D
T
L
R
R
G
L
T
A
H
G
I
N
I
K
Site 42
S544
G
I
N
I
K
D
R
S
S
T
T
S
T
W
E
Site 43
S545
I
N
I
K
D
R
S
S
T
T
S
T
W
E
L
Site 44
T546
N
I
K
D
R
S
S
T
T
S
T
W
E
L
L
Site 45
S548
K
D
R
S
S
T
T
S
T
W
E
L
L
D
Q
Site 46
T549
D
R
S
S
T
T
S
T
W
E
L
L
D
Q
R
Site 47
T557
W
E
L
L
D
Q
R
T
K
D
Q
K
S
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation