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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR1B
Full Name:
DNA-directed RNA polymerase I subunit RPA2
Alias:
DNA-directed RNA polymerase I 135 kDa polypeptide; FLJ10816; FLJ21921; Polymerase (RNA) I polypeptide B; RNA polymerase I polypeptide B; RNA polymerase I subunit 2; RPA135; RPA2; Rpo1-2
Type:
Transcription initiation complex; Transferase; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 2.7.7.6
Mass (Da):
128229
Number AA:
1135
UniProt ID:
Q9H9Y6
International Prot ID:
IPI00418797
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
S
R
W
R
N
L
P
S
G
P
S
L
K
H
L
Site 2
S15
R
N
L
P
S
G
P
S
L
K
H
L
T
D
P
Site 3
T20
G
P
S
L
K
H
L
T
D
P
S
Y
G
I
P
Site 4
Y24
K
H
L
T
D
P
S
Y
G
I
P
R
E
Q
Q
Site 5
S45
L
T
R
A
H
V
E
S
F
N
Y
A
V
H
E
Site 6
Y48
A
H
V
E
S
F
N
Y
A
V
H
E
G
L
G
Site 7
Y99
I
C
K
E
A
N
V
Y
P
A
E
C
R
G
R
Site 8
S108
A
E
C
R
G
R
R
S
T
Y
R
G
K
L
T
Site 9
T109
E
C
R
G
R
R
S
T
Y
R
G
K
L
T
A
Site 10
Y110
C
R
G
R
R
S
T
Y
R
G
K
L
T
A
D
Site 11
Y136
I
I
K
Q
F
L
G
Y
V
P
I
M
V
K
S
Site 12
Y169
E
A
E
E
M
G
G
Y
F
I
I
N
G
I
E
Site 13
T200
M
I
R
P
K
W
K
T
R
G
P
G
Y
T
Q
Site 14
Y205
W
K
T
R
G
P
G
Y
T
Q
Y
G
V
S
M
Site 15
T206
K
T
R
G
P
G
Y
T
Q
Y
G
V
S
M
H
Site 16
Y208
R
G
P
G
Y
T
Q
Y
G
V
S
M
H
C
V
Site 17
S276
I
K
G
K
E
D
D
S
F
L
R
N
S
V
S
Site 18
S281
D
D
S
F
L
R
N
S
V
S
Q
M
L
R
I
Site 19
T296
V
M
E
E
G
C
S
T
Q
K
Q
V
L
N
Y
Site 20
Y318
K
L
N
V
P
D
W
Y
P
N
E
Q
A
A
E
Site 21
S368
C
M
E
D
N
P
D
S
L
V
N
Q
E
V
L
Site 22
S408
D
K
K
A
Q
K
T
S
V
S
M
N
T
D
N
Site 23
Y432
D
L
T
K
P
F
E
Y
L
F
A
T
G
N
L
Site 24
T443
T
G
N
L
R
S
K
T
G
L
G
L
L
Q
D
Site 25
Y465
D
K
L
N
F
I
R
Y
L
S
H
F
R
C
V
Site 26
T484
D
F
A
K
M
R
T
T
T
V
R
R
L
L
P
Site 27
T485
F
A
K
M
R
T
T
T
V
R
R
L
L
P
E
Site 28
T502
G
F
L
C
P
V
H
T
P
D
G
E
P
C
G
Site 29
Y550
D
G
A
P
H
R
S
Y
S
E
C
Y
P
V
L
Site 30
S551
G
A
P
H
R
S
Y
S
E
C
Y
P
V
L
L
Site 31
Y554
H
R
S
Y
S
E
C
Y
P
V
L
L
D
G
V
Site 32
T636
G
K
E
E
L
I
G
T
M
E
Q
I
F
M
N
Site 33
S677
I
A
N
F
I
P
F
S
D
H
N
Q
S
P
R
Site 34
Y687
N
Q
S
P
R
N
M
Y
Q
C
Q
M
G
K
Q
Site 35
T702
T
M
G
F
P
L
L
T
Y
Q
D
R
S
D
N
Site 36
Y703
M
G
F
P
L
L
T
Y
Q
D
R
S
D
N
K
Site 37
S707
L
L
T
Y
Q
D
R
S
D
N
K
L
Y
R
L
Site 38
Y712
D
R
S
D
N
K
L
Y
R
L
Q
T
P
Q
S
Site 39
T716
N
K
L
Y
R
L
Q
T
P
Q
S
P
L
V
R
Site 40
S719
Y
R
L
Q
T
P
Q
S
P
L
V
R
P
S
M
Site 41
Y729
V
R
P
S
M
Y
D
Y
Y
D
M
D
N
Y
P
Site 42
Y730
R
P
S
M
Y
D
Y
Y
D
M
D
N
Y
P
I
Site 43
Y735
D
Y
Y
D
M
D
N
Y
P
I
G
T
N
A
I
Site 44
S772
E
R
G
F
A
H
G
S
V
Y
K
S
E
F
I
Site 45
Y774
G
F
A
H
G
S
V
Y
K
S
E
F
I
D
L
Site 46
S776
A
H
G
S
V
Y
K
S
E
F
I
D
L
S
E
Site 47
S782
K
S
E
F
I
D
L
S
E
K
I
K
Q
G
D
Site 48
S790
E
K
I
K
Q
G
D
S
S
L
V
F
G
I
K
Site 49
S791
K
I
K
Q
G
D
S
S
L
V
F
G
I
K
P
Site 50
Y821
F
I
G
A
K
L
Q
Y
G
D
P
Y
Y
S
Y
Site 51
Y825
K
L
Q
Y
G
D
P
Y
Y
S
Y
L
N
L
N
Site 52
Y826
L
Q
Y
G
D
P
Y
Y
S
Y
L
N
L
N
T
Site 53
Y828
Y
G
D
P
Y
Y
S
Y
L
N
L
N
T
G
E
Site 54
S836
L
N
L
N
T
G
E
S
F
V
M
Y
Y
K
S
Site 55
Y840
T
G
E
S
F
V
M
Y
Y
K
S
K
E
N
C
Site 56
Y841
G
E
S
F
V
M
Y
Y
K
S
K
E
N
C
V
Site 57
S856
V
D
N
I
K
V
C
S
N
D
T
G
S
G
K
Site 58
T878
M
R
V
P
R
N
P
T
I
G
D
K
F
A
S
Site 59
S894
H
G
Q
K
G
I
L
S
R
L
W
P
A
E
D
Site 60
T905
P
A
E
D
M
P
F
T
E
S
G
M
V
P
D
Site 61
T948
H
G
L
C
H
D
A
T
P
F
I
F
S
E
E
Site 62
S953
D
A
T
P
F
I
F
S
E
E
N
S
A
L
E
Site 63
S957
F
I
F
S
E
E
N
S
A
L
E
Y
F
G
E
Site 64
Y961
E
E
N
S
A
L
E
Y
F
G
E
M
L
K
A
Site 65
Y971
E
M
L
K
A
A
G
Y
N
F
Y
G
T
E
R
Site 66
T976
A
G
Y
N
F
Y
G
T
E
R
L
Y
S
G
I
Site 67
Y980
F
Y
G
T
E
R
L
Y
S
G
I
S
G
L
E
Site 68
S981
Y
G
T
E
R
L
Y
S
G
I
S
G
L
E
L
Site 69
S1007
Q
R
L
R
H
M
V
S
D
K
F
Q
V
R
T
Site 70
T1015
D
K
F
Q
V
R
T
T
G
A
R
D
R
V
T
Site 71
T1022
T
G
A
R
D
R
V
T
N
Q
P
I
G
G
R
Site 72
S1062
H
D
R
L
F
N
C
S
D
R
S
V
A
H
V
Site 73
S1087
L
L
E
K
P
P
P
S
W
S
A
M
R
N
R
Site 74
S1089
E
K
P
P
P
S
W
S
A
M
R
N
R
K
Y
Site 75
Y1096
S
A
M
R
N
R
K
Y
N
C
T
L
C
S
R
Site 76
T1099
R
N
R
K
Y
N
C
T
L
C
S
R
S
D
T
Site 77
T1106
T
L
C
S
R
S
D
T
I
D
T
V
S
V
P
Site 78
T1109
S
R
S
D
T
I
D
T
V
S
V
P
Y
V
F
Site 79
S1111
S
D
T
I
D
T
V
S
V
P
Y
V
F
R
Y
Site 80
Y1118
S
V
P
Y
V
F
R
Y
F
V
A
E
L
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation