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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2C3
Full Name:
Protein argonaute-3
Alias:
AGO3; Argonaute 3; Argonaute-3; EIF2C 3; EIF-2C 3; Eukaryotic translation initiation factor 2C 3; Eukaryotic translation initiation factor 2C, 3; I2C3
Type:
Protein synthesis protein, Translation
Mass (Da):
97360
Number AA:
860
UniProt ID:
Q9H9G7
International Prot ID:
IPI00304181
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006402
GO:0035278
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
M
V
P
R
R
P
G
Y
G
T
M
G
K
P
I
Site 2
T25
P
R
R
P
G
Y
G
T
M
G
K
P
I
K
L
Site 3
Y47
E
I
P
K
I
D
V
Y
L
Y
E
V
D
I
K
Site 4
Y49
P
K
I
D
V
Y
L
Y
E
V
D
I
K
P
D
Site 5
Y86
F
G
D
R
R
P
V
Y
D
G
K
R
S
L
Y
Site 6
S91
P
V
Y
D
G
K
R
S
L
Y
T
A
N
P
L
Site 7
Y93
Y
D
G
K
R
S
L
Y
T
A
N
P
L
P
V
Site 8
T94
D
G
K
R
S
L
Y
T
A
N
P
L
P
V
A
Site 9
T110
T
G
V
D
L
D
V
T
L
P
G
E
G
G
K
Site 10
S124
K
D
R
P
F
K
V
S
I
K
F
V
S
R
V
Site 11
T141
H
L
L
H
E
V
L
T
G
R
T
L
P
E
P
Site 12
S156
L
E
L
D
K
P
I
S
T
N
P
V
H
A
V
Site 13
Y175
R
H
L
P
S
M
K
Y
T
P
V
G
R
S
F
Site 14
T176
H
L
P
S
M
K
Y
T
P
V
G
R
S
F
F
Site 15
S181
K
Y
T
P
V
G
R
S
F
F
S
A
P
E
G
Site 16
Y189
F
F
S
A
P
E
G
Y
D
H
P
L
G
G
G
Site 17
T252
D
E
Q
P
R
P
L
T
D
S
H
R
V
K
F
Site 18
S254
Q
P
R
P
L
T
D
S
H
R
V
K
F
T
K
Site 19
T271
K
G
L
K
V
E
V
T
H
C
G
T
M
R
R
Site 20
T275
V
E
V
T
H
C
G
T
M
R
R
K
Y
R
V
Site 21
Y280
C
G
T
M
R
R
K
Y
R
V
C
N
V
T
R
Site 22
T286
K
Y
R
V
C
N
V
T
R
R
P
A
S
H
Q
Site 23
S291
N
V
T
R
R
P
A
S
H
Q
T
F
P
L
Q
Site 24
T294
R
R
P
A
S
H
Q
T
F
P
L
Q
L
E
N
Site 25
T304
L
Q
L
E
N
G
Q
T
V
E
R
T
V
A
Q
Site 26
T308
N
G
Q
T
V
E
R
T
V
A
Q
Y
F
R
E
Site 27
Y312
V
E
R
T
V
A
Q
Y
F
R
E
K
Y
T
L
Site 28
Y317
A
Q
Y
F
R
E
K
Y
T
L
Q
L
K
Y
P
Site 29
Y323
K
Y
T
L
Q
L
K
Y
P
H
L
P
C
L
Q
Site 30
T338
V
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
Site 31
Y339
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
N
Site 32
T358
Q
R
C
I
K
K
L
T
D
N
Q
T
S
T
M
Site 33
T362
K
K
L
T
D
N
Q
T
S
T
M
I
K
A
T
Site 34
S363
K
L
T
D
N
Q
T
S
T
M
I
K
A
T
A
Site 35
T369
T
S
T
M
I
K
A
T
A
R
S
A
P
D
R
Site 36
S381
P
D
R
Q
E
E
I
S
R
L
V
R
S
A
N
Site 37
T427
Q
Y
G
G
R
N
R
T
V
A
T
P
S
H
G
Site 38
T430
G
R
N
R
T
V
A
T
P
S
H
G
V
W
D
Site 39
T445
M
R
G
K
Q
F
H
T
G
V
E
I
K
M
W
Site 40
S479
T
D
Q
L
R
K
I
S
K
D
A
G
M
P
I
Site 41
Y495
G
Q
P
C
F
C
K
Y
A
Q
G
A
D
S
V
Site 42
S501
K
Y
A
Q
G
A
D
S
V
E
P
M
F
R
H
Site 43
T512
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Site 44
T527
I
V
I
L
P
G
K
T
P
V
Y
A
E
V
K
Site 45
Y530
L
P
G
K
T
P
V
Y
A
E
V
K
R
V
G
Site 46
S557
V
K
N
V
I
K
T
S
P
Q
T
L
S
N
L
Site 47
S562
K
T
S
P
Q
T
L
S
N
L
C
L
K
I
N
Site 48
S586
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Site 49
T629
H
P
S
R
Y
C
A
T
V
R
V
Q
R
P
R
Site 50
Y655
R
E
L
L
I
Q
F
Y
K
S
T
R
F
K
P
Site 51
S657
L
L
I
Q
F
Y
K
S
T
R
F
K
P
T
R
Site 52
Y682
G
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
Site 53
Y683
Q
F
R
Q
V
L
Y
Y
E
L
L
A
I
R
E
Site 54
S694
A
I
R
E
A
C
I
S
L
E
K
D
Y
Q
P
Site 55
Y699
C
I
S
L
E
K
D
Y
Q
P
G
I
T
Y
I
Site 56
Y705
D
Y
Q
P
G
I
T
Y
I
V
V
Q
K
R
H
Site 57
T714
V
V
Q
K
R
H
H
T
R
L
F
C
A
D
R
Site 58
T722
R
L
F
C
A
D
R
T
E
R
V
G
R
S
G
Site 59
T739
P
A
G
T
T
V
D
T
D
I
T
H
P
Y
E
Site 60
T742
T
T
V
D
T
D
I
T
H
P
Y
E
F
D
F
Site 61
Y745
D
T
D
I
T
H
P
Y
E
F
D
F
Y
L
C
Site 62
Y750
H
P
Y
E
F
D
F
Y
L
C
S
H
A
G
I
Site 63
T760
S
H
A
G
I
Q
G
T
S
R
P
S
H
Y
H
Site 64
T790
L
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
Site 65
Y791
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
V
Site 66
S797
T
Y
V
R
C
T
R
S
V
S
I
P
A
P
A
Site 67
S799
V
R
C
T
R
S
V
S
I
P
A
P
A
Y
Y
Site 68
Y816
L
V
A
F
R
A
R
Y
H
L
V
D
K
E
H
Site 69
S825
L
V
D
K
E
H
D
S
A
E
G
S
H
V
S
Site 70
S829
E
H
D
S
A
E
G
S
H
V
S
G
Q
S
N
Site 71
S832
S
A
E
G
S
H
V
S
G
Q
S
N
G
R
D
Site 72
S835
G
S
H
V
S
G
Q
S
N
G
R
D
P
Q
A
Site 73
T853
A
V
Q
I
H
Q
D
T
L
R
T
M
Y
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation