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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF408
Full Name:
Zinc finger protein 408
Alias:
FLJ12827; PFM14; PR domain zinc finger 17; PRDM17; Zinc finger 408; ZN408
Type:
Mass (Da):
78440
Number AA:
UniProt ID:
Q9H9D4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0042802
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
D
L
G
W
N
P
S
G
E
G
C
T
Q
G
Site 2
S66
R
G
L
A
L
G
P
S
L
A
K
E
Q
R
L
Site 3
S97
P
L
E
E
E
S
A
S
K
E
K
G
E
G
V
Site 4
S113
P
R
Q
E
E
N
L
S
L
G
P
W
G
D
V
Site 5
S131
E
Q
S
S
G
W
T
S
L
V
Q
R
G
R
L
Site 6
S140
V
Q
R
G
R
L
E
S
E
G
N
V
A
P
V
Site 7
Y158
E
R
L
H
L
Q
V
Y
Q
L
V
L
P
G
S
Site 8
S174
L
L
L
W
P
Q
P
S
S
E
G
P
S
L
T
Site 9
S175
L
L
W
P
Q
P
S
S
E
G
P
S
L
T
Q
Site 10
S179
Q
P
S
S
E
G
P
S
L
T
Q
P
G
L
D
Site 11
T181
S
S
E
G
P
S
L
T
Q
P
G
L
D
K
E
Site 12
S207
A
V
Q
Q
E
V
A
S
P
G
E
D
A
A
E
Site 13
S221
E
P
C
I
D
P
G
S
Q
S
P
S
G
I
Q
Site 14
S223
C
I
D
P
G
S
Q
S
P
S
G
I
Q
A
E
Site 15
S225
D
P
G
S
Q
S
P
S
G
I
Q
A
E
N
M
Site 16
S234
I
Q
A
E
N
M
V
S
P
G
L
K
F
P
T
Site 17
T241
S
P
G
L
K
F
P
T
Q
D
R
I
S
K
D
Site 18
S246
F
P
T
Q
D
R
I
S
K
D
S
Q
P
L
G
Site 19
S249
Q
D
R
I
S
K
D
S
Q
P
L
G
P
L
L
Site 20
S277
Q
M
P
P
E
L
Q
S
N
S
A
T
Q
Q
D
Site 21
S279
P
P
E
L
Q
S
N
S
A
T
Q
Q
D
P
D
Site 22
T281
E
L
Q
S
N
S
A
T
Q
Q
D
P
D
G
S
Site 23
S288
T
Q
Q
D
P
D
G
S
G
A
S
F
S
S
S
Site 24
S291
D
P
D
G
S
G
A
S
F
S
S
S
A
R
G
Site 25
S293
D
G
S
G
A
S
F
S
S
S
A
R
G
T
Q
Site 26
S294
G
S
G
A
S
F
S
S
S
A
R
G
T
Q
P
Site 27
S295
S
G
A
S
F
S
S
S
A
R
G
T
Q
P
H
Site 28
T299
F
S
S
S
A
R
G
T
Q
P
H
G
Y
L
A
Site 29
Y304
R
G
T
Q
P
H
G
Y
L
A
K
K
L
H
S
Site 30
S311
Y
L
A
K
K
L
H
S
P
S
D
Q
C
P
P
Site 31
S313
A
K
K
L
H
S
P
S
D
Q
C
P
P
R
A
Site 32
T322
Q
C
P
P
R
A
K
T
P
E
P
G
A
Q
Q
Site 33
S330
P
E
P
G
A
Q
Q
S
G
F
P
T
L
S
R
Site 34
T334
A
Q
Q
S
G
F
P
T
L
S
R
S
P
P
G
Site 35
S336
Q
S
G
F
P
T
L
S
R
S
P
P
G
P
A
Site 36
S338
G
F
P
T
L
S
R
S
P
P
G
P
A
G
S
Site 37
S345
S
P
P
G
P
A
G
S
S
P
K
Q
G
R
R
Site 38
S346
P
P
G
P
A
G
S
S
P
K
Q
G
R
R
Y
Site 39
Y353
S
P
K
Q
G
R
R
Y
R
C
G
E
C
G
K
Site 40
T384
G
H
K
P
F
L
C
T
E
C
G
K
S
Y
S
Site 41
S389
L
C
T
E
C
G
K
S
Y
S
S
E
E
S
F
Site 42
S391
T
E
C
G
K
S
Y
S
S
E
E
S
F
K
A
Site 43
S392
E
C
G
K
S
Y
S
S
E
E
S
F
K
A
H
Site 44
S395
K
S
Y
S
S
E
E
S
F
K
A
H
M
L
G
Site 45
Y418
C
P
Q
C
D
K
A
Y
G
T
Q
R
D
L
K
Site 46
T420
Q
C
D
K
A
Y
G
T
Q
R
D
L
K
E
H
Site 47
S451
K
A
F
A
R
R
P
S
L
R
L
H
R
K
T
Site 48
T458
S
L
R
L
H
R
K
T
H
Q
V
P
A
A
P
Site 49
S482
R
P
L
A
N
Q
G
S
L
R
N
H
M
R
L
Site 50
T491
R
N
H
M
R
L
H
T
G
E
K
P
F
L
C
Site 51
T519
R
G
H
L
R
L
H
T
G
E
R
P
Y
R
C
Site 52
Y524
L
H
T
G
E
R
P
Y
R
C
P
H
C
A
D
Site 53
S545
E
L
R
R
H
L
I
S
H
T
G
E
A
H
L
Site 54
T565
K
A
L
R
D
P
H
T
L
R
A
H
E
R
L
Site 55
S574
R
A
H
E
R
L
H
S
G
E
R
P
F
P
C
Site 56
Y588
C
P
Q
C
G
R
A
Y
T
L
A
T
K
L
R
Site 57
T589
P
Q
C
G
R
A
Y
T
L
A
T
K
L
R
R
Site 58
S600
K
L
R
R
H
L
K
S
H
L
E
D
K
P
Y
Site 59
Y607
S
H
L
E
D
K
P
Y
R
C
P
T
C
G
M
Site 60
T611
D
K
P
Y
R
C
P
T
C
G
M
G
Y
T
L
Site 61
Y616
C
P
T
C
G
M
G
Y
T
L
P
Q
S
L
R
Site 62
T617
P
T
C
G
M
G
Y
T
L
P
Q
S
L
R
R
Site 63
S621
M
G
Y
T
L
P
Q
S
L
R
R
H
Q
L
S
Site 64
S628
S
L
R
R
H
Q
L
S
H
R
P
E
A
P
C
Site 65
S636
H
R
P
E
A
P
C
S
P
P
S
V
P
S
A
Site 66
S639
E
A
P
C
S
P
P
S
V
P
S
A
A
S
E
Site 67
S642
C
S
P
P
S
V
P
S
A
A
S
E
P
T
V
Site 68
T661
A
E
P
Q
L
L
D
T
H
R
E
E
E
V
S
Site 69
S668
T
H
R
E
E
E
V
S
P
A
R
D
V
V
E
Site 70
T677
A
R
D
V
V
E
V
T
I
S
E
S
Q
E
K
Site 71
S679
D
V
V
E
V
T
I
S
E
S
Q
E
K
C
F
Site 72
S697
E
E
P
D
A
A
P
S
L
V
L
I
H
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation