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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EHMT1
Full Name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
Alias:
EC 2.1.1.43; Euchromatic histone-lysine N-methyltransferase 1; EUHMTASE1; Eu-HMTase1; G9a like protein; G9a-like protein 1; GLP; GLP1; H3-K9-HMTase 5; Histone H3-K9 methyltransferase 5
Type:
Nucleus protein
Mass (Da):
138254
Number AA:
1267
UniProt ID:
Q9H9B1
International Prot ID:
IPI00015526
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0018024
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016571
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
A
D
G
E
T
N
G
S
C
E
N
S
D
A
S
Site 2
S30
T
N
G
S
C
E
N
S
D
A
S
S
H
A
N
Site 3
S34
C
E
N
S
D
A
S
S
H
A
N
A
A
K
H
Site 4
S45
A
A
K
H
T
Q
D
S
A
R
V
N
P
Q
D
Site 5
S66
R
I
A
E
N
G
V
S
E
R
D
S
E
A
A
Site 6
S70
N
G
V
S
E
R
D
S
E
A
A
K
Q
N
H
Site 7
S87
A
D
D
F
V
Q
T
S
V
I
G
S
N
G
Y
Site 8
T109
Q
A
Q
P
L
R
T
T
S
T
L
A
S
S
L
Site 9
S110
A
Q
P
L
R
T
T
S
T
L
A
S
S
L
P
Site 10
T111
Q
P
L
R
T
T
S
T
L
A
S
S
L
P
G
Site 11
S114
R
T
T
S
T
L
A
S
S
L
P
G
H
A
A
Site 12
T123
L
P
G
H
A
A
K
T
L
P
G
G
A
G
K
Site 13
T133
G
G
A
G
K
G
R
T
P
S
A
F
P
Q
T
Site 14
S135
A
G
K
G
R
T
P
S
A
F
P
Q
T
P
A
Site 15
T140
T
P
S
A
F
P
Q
T
P
A
A
P
P
A
T
Site 16
T147
T
P
A
A
P
P
A
T
L
G
E
G
S
A
D
Site 17
T155
L
G
E
G
S
A
D
T
E
D
R
K
L
P
A
Site 18
T175
K
V
H
R
A
R
K
T
M
P
K
S
V
V
G
Site 19
S179
A
R
K
T
M
P
K
S
V
V
G
L
H
A
A
Site 20
S211
E
E
I
N
K
N
I
S
D
F
G
R
Q
Q
L
Site 21
S224
Q
L
L
P
P
F
P
S
L
H
Q
S
L
P
Q
Site 22
S228
P
F
P
S
L
H
Q
S
L
P
Q
N
Q
C
Y
Site 23
Y235
S
L
P
Q
N
Q
C
Y
M
A
T
T
K
S
Q
Site 24
S255
F
V
L
A
A
A
V
S
R
K
K
K
R
R
M
Site 25
T264
K
K
K
R
R
M
G
T
Y
S
L
V
P
K
K
Site 26
Y265
K
K
R
R
M
G
T
Y
S
L
V
P
K
K
K
Site 27
S266
K
R
R
M
G
T
Y
S
L
V
P
K
K
K
T
Site 28
S291
M
F
K
S
I
T
H
S
T
V
G
S
K
G
E
Site 29
S295
I
T
H
S
T
V
G
S
K
G
E
K
D
L
G
Site 30
S304
G
E
K
D
L
G
A
S
S
L
H
V
N
G
E
Site 31
S305
E
K
D
L
G
A
S
S
L
H
V
N
G
E
S
Site 32
S312
S
L
H
V
N
G
E
S
L
E
M
D
S
D
E
Site 33
S317
G
E
S
L
E
M
D
S
D
E
D
D
S
E
E
Site 34
S322
M
D
S
D
E
D
D
S
E
E
L
E
E
D
D
Site 35
S344
A
A
F
P
T
E
D
S
R
T
S
K
E
S
M
Site 36
T346
F
P
T
E
D
S
R
T
S
K
E
S
M
S
E
Site 37
S347
P
T
E
D
S
R
T
S
K
E
S
M
S
E
A
Site 38
S350
D
S
R
T
S
K
E
S
M
S
E
A
D
R
A
Site 39
S352
R
T
S
K
E
S
M
S
E
A
D
R
A
Q
K
Site 40
S364
A
Q
K
M
D
G
E
S
E
E
E
Q
E
S
V
Site 41
S370
E
S
E
E
E
Q
E
S
V
D
T
G
E
E
E
Site 42
T373
E
E
Q
E
S
V
D
T
G
E
E
E
E
G
G
Site 43
S383
E
E
E
G
G
D
E
S
D
L
S
S
E
S
S
Site 44
S386
G
G
D
E
S
D
L
S
S
E
S
S
I
K
K
Site 45
S387
G
D
E
S
D
L
S
S
E
S
S
I
K
K
K
Site 46
S389
E
S
D
L
S
S
E
S
S
I
K
K
K
F
L
Site 47
S390
S
D
L
S
S
E
S
S
I
K
K
K
F
L
K
Site 48
T402
F
L
K
R
K
G
K
T
D
S
P
W
I
K
P
Site 49
S404
K
R
K
G
K
T
D
S
P
W
I
K
P
A
R
Site 50
S417
A
R
K
R
R
R
R
S
R
K
K
P
S
G
A
Site 51
S422
R
R
S
R
K
K
P
S
G
A
L
G
S
E
S
Site 52
S427
K
P
S
G
A
L
G
S
E
S
Y
K
S
S
A
Site 53
S429
S
G
A
L
G
S
E
S
Y
K
S
S
A
G
S
Site 54
Y430
G
A
L
G
S
E
S
Y
K
S
S
A
G
S
A
Site 55
S432
L
G
S
E
S
Y
K
S
S
A
G
S
A
E
Q
Site 56
S433
G
S
E
S
Y
K
S
S
A
G
S
A
E
Q
T
Site 57
S436
S
Y
K
S
S
A
G
S
A
E
Q
T
A
P
G
Site 58
T440
S
A
G
S
A
E
Q
T
A
P
G
D
S
T
G
Site 59
T446
Q
T
A
P
G
D
S
T
G
Y
M
E
V
S
L
Site 60
Y448
A
P
G
D
S
T
G
Y
M
E
V
S
L
D
S
Site 61
S452
S
T
G
Y
M
E
V
S
L
D
S
L
D
L
R
Site 62
S455
Y
M
E
V
S
L
D
S
L
D
L
R
V
K
G
Site 63
S466
R
V
K
G
I
L
S
S
Q
A
E
G
L
A
N
Site 64
S490
L
Q
E
V
P
L
C
S
C
R
M
E
T
P
K
Site 65
T495
L
C
S
C
R
M
E
T
P
K
S
R
E
I
T
Site 66
S498
C
R
M
E
T
P
K
S
R
E
I
T
T
L
A
Site 67
T502
T
P
K
S
R
E
I
T
T
L
A
N
N
Q
C
Site 68
S514
N
Q
C
M
A
T
E
S
V
D
H
E
L
G
R
Site 69
T523
D
H
E
L
G
R
C
T
N
S
V
V
K
Y
E
Site 70
S525
E
L
G
R
C
T
N
S
V
V
K
Y
E
L
M
Site 71
Y529
C
T
N
S
V
V
K
Y
E
L
M
R
P
S
N
Site 72
S535
K
Y
E
L
M
R
P
S
N
K
A
P
L
L
V
Site 73
S577
M
E
C
Q
P
E
S
S
I
S
H
R
F
H
K
Site 74
Y595
S
R
V
N
N
A
S
Y
C
P
H
C
G
E
E
Site 75
S604
P
H
C
G
E
E
S
S
K
A
K
E
V
T
I
Site 76
T619
A
K
A
D
T
T
S
T
V
T
P
V
P
G
Q
Site 77
T621
A
D
T
T
S
T
V
T
P
V
P
G
Q
E
K
Site 78
T638
A
L
E
G
R
A
D
T
T
T
G
S
A
A
G
Site 79
T640
E
G
R
A
D
T
T
T
G
S
A
A
G
P
P
Site 80
S642
R
A
D
T
T
T
G
S
A
A
G
P
P
L
S
Site 81
S649
S
A
A
G
P
P
L
S
E
D
D
K
L
Q
G
Site 82
S659
D
K
L
Q
G
A
A
S
H
V
P
E
G
F
D
Site 83
T668
V
P
E
G
F
D
P
T
G
P
A
G
L
G
R
Site 84
T677
P
A
G
L
G
R
P
T
P
G
L
S
Q
G
P
Site 85
S681
G
R
P
T
P
G
L
S
Q
G
P
G
K
E
T
Site 86
T688
S
Q
G
P
G
K
E
T
L
E
S
A
L
I
A
Site 87
S691
P
G
K
E
T
L
E
S
A
L
I
A
L
D
S
Site 88
S698
S
A
L
I
A
L
D
S
E
K
P
K
K
L
R
Site 89
Y712
R
F
H
P
K
Q
L
Y
F
S
A
R
Q
G
E
Site 90
S714
H
P
K
Q
L
Y
F
S
A
R
Q
G
E
L
Q
Site 91
S744
M
E
H
Q
N
K
R
S
P
L
H
A
A
A
E
Site 92
S772
G
A
N
I
D
T
C
S
E
D
Q
R
T
P
L
Site 93
T777
T
C
S
E
D
Q
R
T
P
L
M
E
A
A
E
Site 94
Y826
G
H
Y
E
V
V
Q
Y
L
L
S
N
G
Q
M
Site 95
Y852
P
M
I
W
A
T
E
Y
K
H
V
D
L
V
K
Site 96
S866
K
L
L
L
S
K
G
S
D
I
N
I
R
D
N
Site 97
S932
V
L
F
L
S
R
D
S
D
V
T
L
K
N
K
Site 98
T935
L
S
R
D
S
D
V
T
L
K
N
K
E
G
E
Site 99
T943
L
K
N
K
E
G
E
T
P
L
Q
C
A
S
L
Site 100
S949
E
T
P
L
Q
C
A
S
L
N
S
Q
V
W
S
Site 101
S952
L
Q
C
A
S
L
N
S
Q
V
W
S
A
L
Q
Site 102
S956
S
L
N
S
Q
V
W
S
A
L
Q
M
S
K
A
Site 103
S967
M
S
K
A
L
Q
D
S
A
P
D
R
P
S
P
Site 104
S973
D
S
A
P
D
R
P
S
P
V
E
R
I
V
S
Site 105
S980
S
P
V
E
R
I
V
S
R
D
I
A
R
G
Y
Site 106
Y987
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
Site 107
S1000
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
Site 108
S1005
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
Site 109
Y1007
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
Site 110
Y1009
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
Site 111
S1011
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
Site 112
S1017
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
Site 113
S1048
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
Site 114
Y1053
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
Site 115
Y1100
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
Site 116
T1102
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
Site 117
S1111
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
Site 118
S1130
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
Site 119
S1132
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
Site 120
Y1142
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
Site 121
Y1211
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
Site 122
S1224
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
Site 123
S1229
L
F
S
C
R
C
G
S
P
K
C
R
H
S
S
Site 124
S1235
G
S
P
K
C
R
H
S
S
A
A
L
A
Q
R
Site 125
S1236
S
P
K
C
R
H
S
S
A
A
L
A
Q
R
Q
Site 126
S1245
A
L
A
Q
R
Q
A
S
A
A
Q
E
A
Q
E
Site 127
T1258
Q
E
D
G
L
P
D
T
S
S
A
A
A
A
D
Site 128
S1260
D
G
L
P
D
T
S
S
A
A
A
A
D
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation