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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZWILCH
Full Name:
Protein zwilch homolog
Alias:
FLJ10036; KNTC1AP; ZWILC; zwilch, kinetochore associated; Zwilch, kinetochore associated,
Type:
Mass (Da):
67214
Number AA:
591
UniProt ID:
Q9H900
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0007093
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
N
C
A
A
E
D
F
Y
S
R
L
L
Q
K
F
Site 2
Y34
I
R
K
D
P
F
L
Y
E
A
D
V
Q
V
Q
Site 3
T74
V
P
L
E
K
E
E
T
S
H
I
E
E
L
Q
Site 4
S75
P
L
E
K
E
E
T
S
H
I
E
E
L
Q
S
Site 5
S82
S
H
I
E
E
L
Q
S
E
E
T
A
I
S
D
Site 6
T85
E
E
L
Q
S
E
E
T
A
I
S
D
F
S
T
Site 7
S88
Q
S
E
E
T
A
I
S
D
F
S
T
G
E
N
Site 8
S91
E
T
A
I
S
D
F
S
T
G
E
N
V
G
P
Site 9
T92
T
A
I
S
D
F
S
T
G
E
N
V
G
P
L
Site 10
S142
P
L
W
V
R
C
D
S
S
D
P
E
G
T
C
Site 11
Y178
S
C
K
A
D
K
N
Y
S
V
N
L
E
N
L
Site 12
S179
C
K
A
D
K
N
Y
S
V
N
L
E
N
L
K
Site 13
S196
H
K
K
R
H
H
L
S
T
V
T
S
K
G
F
Site 14
T197
K
K
R
H
H
L
S
T
V
T
S
K
G
F
A
Site 15
S200
H
H
L
S
T
V
T
S
K
G
F
A
Q
Y
E
Site 16
Y206
T
S
K
G
F
A
Q
Y
E
L
F
K
S
S
A
Site 17
S211
A
Q
Y
E
L
F
K
S
S
A
L
D
D
T
I
Site 18
T217
K
S
S
A
L
D
D
T
I
T
A
S
Q
T
A
Site 19
T248
P
P
L
S
S
T
A
T
L
N
I
K
V
E
S
Site 20
Y266
R
G
P
L
N
H
L
Y
R
E
L
K
F
L
L
Site 21
T284
D
G
L
R
T
G
V
T
E
W
L
E
P
L
E
Site 22
S294
L
E
P
L
E
A
K
S
A
V
E
L
V
Q
E
Site 23
S315
K
L
D
G
F
G
D
S
T
K
K
D
T
E
V
Site 24
T316
L
D
G
F
G
D
S
T
K
K
D
T
E
V
E
Site 25
T320
G
D
S
T
K
K
D
T
E
V
E
T
L
K
H
Site 26
T324
K
K
D
T
E
V
E
T
L
K
H
D
T
A
A
Site 27
S335
D
T
A
A
V
D
R
S
V
K
R
L
F
K
V
Site 28
S344
K
R
L
F
K
V
R
S
D
L
D
F
A
E
Q
Site 29
S362
K
M
S
S
S
V
I
S
Y
Q
D
L
V
K
C
Site 30
S388
D
I
Q
P
W
L
H
S
G
S
N
S
L
L
S
Site 31
S390
Q
P
W
L
H
S
G
S
N
S
L
L
S
K
L
Site 32
S392
W
L
H
S
G
S
N
S
L
L
S
K
L
I
H
Site 33
S395
S
G
S
N
S
L
L
S
K
L
I
H
Q
S
Y
Site 34
Y402
S
K
L
I
H
Q
S
Y
H
G
T
M
D
T
V
Site 35
T405
I
H
Q
S
Y
H
G
T
M
D
T
V
S
L
S
Site 36
T408
S
Y
H
G
T
M
D
T
V
S
L
S
G
T
I
Site 37
Y432
L
D
K
L
K
K
D
Y
I
S
F
F
I
G
Q
Site 38
S434
K
L
K
K
D
Y
I
S
F
F
I
G
Q
E
L
Site 39
Y462
V
D
I
Q
E
Q
V
Y
R
V
Q
K
L
H
H
Site 40
Y498
L
T
Q
I
C
I
K
Y
Y
K
Q
N
P
L
D
Site 41
T517
F
Q
L
P
V
R
P
T
A
V
K
N
L
Y
Q
Site 42
Y523
P
T
A
V
K
N
L
Y
Q
S
E
K
P
Q
K
Site 43
S537
K
W
R
V
E
I
Y
S
G
Q
K
K
I
K
T
Site 44
T544
S
G
Q
K
K
I
K
T
V
W
Q
L
S
D
S
Site 45
S549
I
K
T
V
W
Q
L
S
D
S
S
P
I
D
H
Site 46
S551
T
V
W
Q
L
S
D
S
S
P
I
D
H
L
N
Site 47
S552
V
W
Q
L
S
D
S
S
P
I
D
H
L
N
F
Site 48
S565
N
F
H
K
P
D
F
S
E
L
T
L
N
G
S
Site 49
T568
K
P
D
F
S
E
L
T
L
N
G
S
L
E
E
Site 50
S572
S
E
L
T
L
N
G
S
L
E
E
R
I
F
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation