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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DCLRE1B
Full Name:
5' exonuclease Apollo
Alias:
DCR1B; DKFZp686C24187; FLJ12810; FLJ13998; SNM1B
Type:
Mass (Da):
60002
Number AA:
532
UniProt ID:
Q9H816
International Prot ID:
IPI00010223
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
F
F
L
S
H
M
H
S
D
H
T
V
G
L
S
Site 2
T37
S
H
M
H
S
D
H
T
V
G
L
S
S
T
W
Site 3
S42
D
H
T
V
G
L
S
S
T
W
A
R
P
L
Y
Site 4
T43
H
T
V
G
L
S
S
T
W
A
R
P
L
Y
C
Site 5
Y49
S
T
W
A
R
P
L
Y
C
S
P
I
T
A
H
Site 6
S77
Q
A
L
E
V
G
E
S
H
V
L
P
L
D
E
Site 7
T91
E
I
G
Q
E
T
M
T
V
T
L
L
D
A
N
Site 8
T93
G
Q
E
T
M
T
V
T
L
L
D
A
N
H
C
Site 9
Y117
G
Y
F
G
T
I
L
Y
T
G
D
F
R
Y
T
Site 10
Y123
L
Y
T
G
D
F
R
Y
T
P
S
M
L
K
E
Site 11
T124
Y
T
G
D
F
R
Y
T
P
S
M
L
K
E
P
Site 12
S126
G
D
F
R
Y
T
P
S
M
L
K
E
P
A
L
Site 13
T134
M
L
K
E
P
A
L
T
L
G
K
Q
I
H
T
Site 14
Y143
G
K
Q
I
H
T
L
Y
L
D
N
T
N
C
N
Site 15
T147
H
T
L
Y
L
D
N
T
N
C
N
P
A
L
V
Site 16
T251
R
W
N
Q
T
H
P
T
I
A
I
L
P
T
S
Site 17
T257
P
T
I
A
I
L
P
T
S
R
K
I
H
S
S
Site 18
S258
T
I
A
I
L
P
T
S
R
K
I
H
S
S
H
Site 19
S264
T
S
R
K
I
H
S
S
H
P
D
I
H
V
I
Site 20
Y273
P
D
I
H
V
I
P
Y
S
D
H
S
S
Y
S
Site 21
S274
D
I
H
V
I
P
Y
S
D
H
S
S
Y
S
E
Site 22
S277
V
I
P
Y
S
D
H
S
S
Y
S
E
L
R
A
Site 23
S278
I
P
Y
S
D
H
S
S
Y
S
E
L
R
A
F
Site 24
S280
Y
S
D
H
S
S
Y
S
E
L
R
A
F
V
A
Site 25
S309
P
C
G
G
F
Q
D
S
L
S
P
R
I
S
V
Site 26
S311
G
G
F
Q
D
S
L
S
P
R
I
S
V
P
L
Site 27
S315
D
S
L
S
P
R
I
S
V
P
L
I
P
D
S
Site 28
S322
S
V
P
L
I
P
D
S
V
Q
Q
Y
M
S
S
Site 29
Y326
I
P
D
S
V
Q
Q
Y
M
S
S
S
S
R
K
Site 30
S328
D
S
V
Q
Q
Y
M
S
S
S
S
R
K
P
S
Site 31
S329
S
V
Q
Q
Y
M
S
S
S
S
R
K
P
S
L
Site 32
S330
V
Q
Q
Y
M
S
S
S
S
R
K
P
S
L
L
Site 33
S331
Q
Q
Y
M
S
S
S
S
R
K
P
S
L
L
W
Site 34
S335
S
S
S
S
R
K
P
S
L
L
W
L
L
E
R
Site 35
T349
R
R
L
K
R
P
R
T
Q
G
V
V
F
E
S
Site 36
S356
T
Q
G
V
V
F
E
S
P
E
E
S
A
D
Q
Site 37
S360
V
F
E
S
P
E
E
S
A
D
Q
S
Q
A
D
Site 38
S364
P
E
E
S
A
D
Q
S
Q
A
D
R
D
S
K
Site 39
S370
Q
S
Q
A
D
R
D
S
K
K
A
K
K
E
K
Site 40
S379
K
A
K
K
E
K
L
S
P
W
P
A
D
L
E
Site 41
S390
A
D
L
E
K
Q
P
S
H
H
P
L
R
I
K
Site 42
Y405
K
Q
L
F
P
D
L
Y
S
K
E
W
N
K
A
Site 43
S406
Q
L
F
P
D
L
Y
S
K
E
W
N
K
A
V
Site 44
S418
K
A
V
P
F
C
E
S
Q
K
R
V
T
M
L
Site 45
T423
C
E
S
Q
K
R
V
T
M
L
T
A
P
L
G
Site 46
S437
G
F
S
V
H
L
R
S
T
D
E
E
F
I
S
Site 47
T438
F
S
V
H
L
R
S
T
D
E
E
F
I
S
Q
Site 48
S444
S
T
D
E
E
F
I
S
Q
K
T
R
E
E
I
Site 49
S455
R
E
E
I
G
L
G
S
P
L
V
P
M
G
D
Site 50
S474
P
E
A
T
G
N
Q
S
A
W
M
G
H
G
S
Site 51
S481
S
A
W
M
G
H
G
S
P
L
S
H
S
S
K
Site 52
S484
M
G
H
G
S
P
L
S
H
S
S
K
G
T
P
Site 53
S486
H
G
S
P
L
S
H
S
S
K
G
T
P
L
L
Site 54
S487
G
S
P
L
S
H
S
S
K
G
T
P
L
L
A
Site 55
T490
L
S
H
S
S
K
G
T
P
L
L
A
T
E
F
Site 56
S517
N
F
F
Q
A
G
Y
S
S
R
R
F
D
Q
Q
Site 57
S518
F
F
Q
A
G
Y
S
S
R
R
F
D
Q
Q
V
Site 58
Y528
F
D
Q
Q
V
E
K
Y
H
K
P
C
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation